• Journal of Korean Society of Forest Science
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• v.78 no.3
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• pp.287-301
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• 1989

A tree of Ailanthus altissima Swingle was fastened with a plastic band, 19mm wide, around the stem 180cm above ground level and was left to grow under this condition for one year, By removal of this band the tumorous tissue gradually developed and the tree bearing distinct tumorous tissue, an overgrowth surrounding the stem, was harvested two years after the band removal. For the investigation of this tumorous part and its comparison with adjacent normal parts in the anatomical features of individual elements, the tumorous part and parts directly and 40cm above and below the tumorous part were obtained from the tree. The tumor wood having remarkably wider growth increment occurred in the 3rd growth ring the first year after removal of the fastened band, and the barrier zone which delimited the discolored wood from the normal-colored wood inwards appeared u1 the intra-2nd growth ring produced during the fastened period in the tumorous part and the false ring-like zones equivalent to barrier Zone were shown in the normal-colored 2nd growth rings of the parts directly and 40cm above and below the tumorous part, as well. The tumor wood, the 3rd growth ring, and proportion of the 2nd growth ring formed after barrier zone in the tumorous part shared common characteristics in the irregular growth ring boundary, misshapen and shorter individual fibers and vessel elements, and large ray widths and heights. The springwood pores were smaller in diameter in the tumor wood, and the larger radial and smaller tangential diameters of summerwood solitary pores and individual pores consisting of pore multiples in proportion of the 2nd growth ring formed after the barrier zone were transformed into near-isodiametric in the tumor wood, the 3rd growth ring, in the tumorous part. Only in proportion of the 2nd growth ring formed after the barrier zone were transformed into near-isodiametric in the tumor wood, the 3rd growth ring, in the tumorous part, ray densities greatly increased. And the massive tumor wood was caused not by cell size but by cell number because the radial and tangential diameters of fibers in the tumor wood, the 3rd growth ring, in the tumorous part were not sufficiently different from those in the same aged growth rings of the directly and 40cm above and below the tumorous part.

• Korean Journal of Bronchoesophagology
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• v.7 no.2
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• pp.174-177
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• 2001

Previously, we used a rigid bronchoscope in removal of endotracheal granulation tissue and foreign body. But these method has poor visual field and difficulty in handling of the instruments, therefore there were restriction in removing the endotracheal granulation tissue and foreign body. Recently we underwent one case each of endotracheal granulation tissue and foreign body causing dyspnea and removed them by right angled forceps under visualization via nasal rigid endoscope inserted through the tracheal stoma. We suggest this method for removal of tracheal foreign body, granulation tissue and excision of tumorous condition in patients with tracheocutaneous fistula.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3379-3383
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• 2012

Objective: To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis. Methods: Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis. Results: Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.05), the two being linked (P <0.05). In addition, uPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05), with relation to clinical pathological staging, differentiation and lymph node metastasis (P < 0.05). Conclusion: In esophageal cancer tissue, uPA and VEGF proteins are overexpressed and promote tumor angiogenesis, indicative of a poor prognosis.

• International Journal of Computer Science & Network Security
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• v.22 no.8
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• pp.343-351
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• 2022

A brain tumor forms when some tissue becomes old or damaged but does not die when it must, preventing new tissue from being born. Manually finding such masses in the brain by analyzing MRI images is challenging and time-consuming for experts. In this study, our main objective is to detect the brain's tumorous part, allowing rapid diagnosis to treat the primary disease instantly. With image processing techniques and deep learning prediction algorithms, our research makes a system capable of finding a tumor in MRI images of a brain automatically and accurately. Our tumor segmentation adopts the U-Net deep learning segmentation on the standard MICCAI BRATS 2018 dataset, which has MRI images with different modalities. The proposed approach was evaluated and achieved Dice Coefficients of 0.9795, 0.9855, 0.9793, and 0.9950 across several test datasets. These results show that the proposed system achieves excellent segmentation of tumors in MRIs using deep learning techniques such as the U-Net algorithm.

• Journal of Yeungnam Medical Science
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• v.8 no.2
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• pp.217-221
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• 1991

The fibromatosis is a rare tumorous with local invasion, but is not metastasized distantly. This term should not be applied to nonspecific reactive fibrous proliferations that are part of an inflammatory process of are secondary to injury of hemorrhage and have no tendency toward growth or recurrence. It arises principally from the connnective tissue of muscle and overlying fascia or aponeurosis(musculaponeurotic fibromatosis), and chiefly affects the muscle of shoulder, pelvic girdle, and extremity. The term 'aggressive fibromatosis' is also employed to describe this disease, but it is impossible to predict the clinical course in the individual case. The fibromatosis arising in the mediastinum is very rare, and the report about it is nearly absent. The plain radiography shows merely mass with soft tissue density. The CT demonstrates a poorly defined homogenous or heterogenous mass, isodense with skeletal muscle on precontrast-images, and slightly hyperdense to muscle on postcontrast-scan. Accurate delineation between the tumor & surrounding tissue is vague or frequently impossible. The authors experienced one case of the mediastinal fibromatosis recently and report the case with review of concerned literature.

• Journal of the Korean Wood Science and Technology
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• v.17 no.4
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• pp.1-25
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• 1989

가죽나무 (Alianthus altissima Swingle) 수간(樹幹)의 지항고(地上高) 180cm 부위(部位)에 19mm 너비의 플라스틱 밴드를 결체(結締)하여 1년간(年間) 방치(放置)한 후 이 밴드를 결체(結締)하여 주므로써 수가(樹幹)을 둘러싸는 원반형태(圓盤形態)의 과대(過大)한 비대생장(肥大生長) 조직(組織)인 종양상조직(腫瘍狀組織)(tumorous tissue)이 형성(形成)되고 이러한 종양상(腫瘍狀) 조직(組織)의 원반(圓盤)과 상하(上下)에 위치(位置)한 정상형태(正常形態)의 원반(圓盤)을 채취(採取)하여 해부학적(解剖學的) 차이(差異)를 조직학적(組織學的) 특성(特性)면에서 조사(調査) 비교(比較)하였다. 종양상(腫瘍狀) 부위(部位)에서는 이상적(異常的)으로 넓은 연륜폭(年輪幅)을 지니는 중양재(腫瘍材)(tumor wood)가 밴드 해체(解締) 다음 해인 제(第)3연륜(年輪)에서 형성(形成)되었으며 밴드 결체기간(結締期間)중에 생장(生長)한 제(第)2연륜내(年輪內)에서는 내부(內部)로 발달(發達)된 변색재(變色材)(discolored wood)와 외부(外部)로 발달(發達)한 정상재색(正常材色)을 구분하는 방어대(防禦帶)(barrier zone)가 형성(形成)되어 있었으며 이 종양상(腫瘍狀) 부위(部位)의 상하(上下)에 위치(位置)한 정상형태(正常形態)의 부위(部位)에서는 정상재색(正常材色)을 나타내는 제(第)2연륜내(年輪內)에 방어대(防禦帶)에 해당하는 위연륜상대(僞年輪狀帶)(false ring-like zones)가 형성(形成)되어 있었는데 이러한 방어대(防禦帶)와 위연륜상대(僞年輪狀帶)는 비정상적(非正常的)으로 과다한 이상형태(異常形態)의 유세포(柔細胞)와 상해(傷害)검구(溝) 및 검강(腔)으로 구성되어 있는 특징(特徵)을 나타내고 있다. 종양상(腫瘍狀) 부위(部位)에 있어서 종양재((腫瘍材)인 제(第)3연륜(年輪)과 방어대(防禦帶)후에 발달(發達)한 제(第)2연륜부분(年輪部分)은 불규칙(不規則)한 연륜계(年輪界), 매우 불규칙적(不規則的)인 구조(構造)를 지니는 이상조직(異常組織), 비정상적(非正常的)인 형태(形態)를 나타내는 목섬유(木纖維) 및 도관요소(導管要素), 비정상적(非正常的)인 형태(形態)를 지니는 방사조직(放射組織)을 가지며 추재부(秋材部)에 고립관공(孤立管孔) 및 복합관공(複台管孔)이 발달(發達)하며 스트랜드유세포(柔細胞)와 방사유세포(放射柔細胞)에 결정(結晶)이 존재(存在)한다는 면에서 서로 유사(類似)하였다. 그리고 제(第)3연륜(年輪)인 종양재(腫瘍材)의 춘재부(春材部) 관공(管孔)의 수(數)는 정상재(正常材)보다 작은 것으로 나타났다.

• Imaging Science in Dentistry
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• v.51 no.2
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• pp.149-154
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• 2021

Purpose: This study aimed to investigate the computed tomography and magnetic resonance imaging features of giant cell tumors in the temporomandibular joint region to facilitate accurate diagnoses. Materials and Methods: From October 2007 to June 2020, 6 patients (2 men and 4 women) at Yonsei University Dental Hospital had histopathologically proven giant cell tumors in the temporomandibular joint. Their computed tomography and magnetic resonance imaging findings were reviewed retrospectively, and the cases were classified into 3 types based on the tumor center and growth pattern observed on the radiologic findings. Results: The age of the 6 patients ranged from 25 to 53 years. Trismus was found in 5 of the 6 cases. One case recurred. The mean size of the tumors, defined based on their greatest diameter, was 32 mm (range, 15-41 mm). The characteristic features of all cases were a heterogeneously-enhancing tumorous mass with a lobulated margin on computed tomographic images and internal multiplicity of signal intensity on T2-weighted magnetic resonance images. According to the site of origin, 3 tumors were bone-centered, 2 were soft tissue-centered, and 1 was peri-articular. Conclusion: Computed tomography and magnetic resonance imaging yielded a tripartite classification of giant cell tumors of the temporomandibular joint according to their location on imaging. This study could help clinicians in the differential diagnosis of giant cell tumors and assist in proper treatment planning for tumorous diseases of the temporomandibular joint.

• Journal of Chest Surgery
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• v.52 no.4
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• pp.205-220
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• 2019

Near-infrared (NIR) fluorescence imaging provides a safe and cost-efficient method for immediate data acquisition and visualization of tissues, with technical advantages including minimal autofluorescence, reduced photon absorption, and low scattering in tissue. In this review, we introduce recent advances in NIR fluorescence imaging systems for thoracic surgery that improve the identification of vital tissues and facilitate the resection of tumorous tissues. When coupled with appropriate NIR fluorophores, NIR fluorescence imaging may transform current intraoperative thoracic surgery methods by enhancing the precision of surgical procedures and augmenting postoperative outcomes through improvements in diagnostic accuracy and reductions in the remission rate.

• Molecules and Cells
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• v.39 no.8
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• pp.625-630
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• 2016

The RNA-binding protein Rbfox3 is a well-known splicing regulator that is used as a marker for post-mitotic neurons in various vertebrate species. Although recent studies indicate a variable expression of Rbfox3 in non-neuronal tissues, including lung tissue, its cellular function in lung cancer remains largely unknown. Here, we report that the number of RBFOX3-positive cells in tumorous lung tissue is lower than that in normal lung tissue. As the transforming growth factor-${\beta}$ (TGF-${\beta}$) signaling pathway is important in cancer progression, we investigated its role in RBFOX3 expression in A549 lung adenocarcinoma cells. TGF-${\beta}1$ treatment inhibited RBFOX3 expression at the transcriptional level. Further, RBFOX3 depletion led to a change in the expression levels of a subset of proteins related to epithelial-mesenchymal transition (EMT), such as E-cadherin and Claudin-1, during TGF-${\beta}1$-induced EMT. In immunofluorescence microscopic analysis, mesenchymal morphology was more prominent in RBFOX3-depleted cells than in control cells. These findings show that TGF-${\beta}$-induced RBFOX3 inhibition plays an important role in EMT and propose a novel role for RBFOX3 in cancer progression.

• Tuberculosis and Respiratory Diseases
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• v.42 no.1
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• pp.25-34
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• 1995

Background: Endobronchial tuberculosis is classified into 7 subtypes as fibrostenotic type, edematous-hyperemic type, actively caseating type, tumorous type, ulcerative type, granular type and nonspecific bronchitic type by bronchoscopic features, and we make a prospective study to follow up how bronchoscopic findings change during treatment-course in each subtype of active endobronchial tuberculosis. Methods: We planned to do follow-up bronchoscopic examination every month until there was no significant change in endobronchial lesion, then every 3 months and at the end of the treatment in each patient with biopsy proven endobronchial tuberculosis from May, 1990 to August, 1993. Results: 1) This study included 66 cases, but bronchoscopic follow-up was completed as scheduled in 47 cases. 2) In actively caseating and edematous-hyperemic type, bronchostenosis occurred within 2 or 3 months of treatment in about 2/3 of total cases. 3) In fibrostenotic type, bronchostenosis did not improve in spite of the treatment. 4) In tumorous type, the changes in bronchoscopic findings were unpredictable because new lesions occured on other sites even 4 or 6 months after treatment in 2 cases and the size of initial mass increased 6 months after treatment in 1 case (among 7 cases). 5) Granular and nonspecific bronchitic type improved without significant sequelae within 2 or 3 months of treatment. Conclusion: It may be necessary to follow up the patient with bronchoscopy repeatedly 2 or 3 months after starting treatment in active endobronchial tuberculosis, and it is better to perform bronchoscopic examination at 6 months of treatment, especially in patients with tumorous type because there is possibility that new endobronchial lesion occurs. Aggressive therapeutic modalities such as stent-insertion, laser therapy or electrocautery should be considered to prevent bronchostenosis in cases with granulation tissue, fibrostenotic and tumorous types of endobronchial tuberculosis.