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Ethylenebis (isonitrosoethylacetoacetate imine) 과 유사화합물을 리간드로 하는 팔라듐 (II) 착물의 합성 및 성질 (Preparation and Properties of Palladium (II) Complexes with Ethylenebis (isonitrosoethylacetoacetate imine) and Its Analogue)

  • 김수한
    • 대한화학회지
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    • 제29권5호
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    • pp.490-495
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    • 1985

  • 팔라듐(II)의 새로운 착물인 $[Pd((ieaa)_2-en)]$ 및 [PdCl((ieaa)-l-pn)]을 합성하였다. 여기서 $(ieaa)_2-en$과 (ieaa)-l-pn은 각각 N,N'-ethylenebis(isonitrosoethylacetoacetate imine) 및 l-N-(2-aminopropyl)-isonitrosoethylacetoacetate imine을 표시한다. 합성된 이들 팔라듐(II) 착물들은 전자흡수(AB) 스펙트럼, 원이색성(CD) 스펙트럼, C-13핵자기공명스펙트럼, 적외선 및 라만스펙트럼등의 측정결과를 기초로 그 특성을 연구하였다. 염화팔라듐(II)과 ethylenediamine을 첨가한 isonitrosoethylacetoacetate (ieaa)와의 반응에서 생성된 팔라듐착물에서는 $(ieaa)_2-en$형의 Schiff 염기, 한편 ethylenediamine 대신 l-propylenediamine을 사용한 비슷한 반응으로 생성된 착물에서는 (ieaa)-l-pn형의 Schiff염기로 나타낸다. 이러한 구조형성의 차이를 사용된 diamine의 입체화학적 관점에서 검토한다.

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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

  • Fujita, Masahide;Fukuda, Taeko;Sato, Yasuhiro;Takasusuki, Toshifumi;Tanaka, Makoto
    • The Korean Journal of Pain
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    • 제31권1호
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    • pp.10-15
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    • 2018

  • Background: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the dorsal horn. Methods: In experiment 1, 45 rats were assigned to Control, Allo small-dose (0.16 mg/kg), and Allo large-dose (1.6 mg/kg) groups (n = 15 in each). The weight bearing and mechanical withdrawal thresholds of the hind limb were measured before and at 2, 24, 48, and 168 h after Brennan's surgery. In experiment 2, 16 rats were assigned to Control and Allo (0.16 mg/kg) groups (n = 8 in each). The degree of spontaneous pain was measured using the grimace scale after the surgery. Activities of the primary afferent fibers in the spinal cord (L6) were evaluated using immunohistochemical staining. Results: In experiment 1, the withdrawal threshold of the Allo small-dose group was significantly higher than that of the Control group at 2 h after surgery. Intergroup differences in weight bearing were not significant. In experiment 2, intergroup differences in the grimace scale scores were not significant. Substance P release in the Allo (0.16 mg/kg) group was significantly lower than that in the Control group. Conclusions: Systemic administration of Allo inhibited mechanical allodynia and activities of the primary afferent fibers at the dorsal horn in a rat postoperative pain model. Allo was proposed as a candidate for postoperative pain management.

  • https://doi.org/10.3344/kjp.2018.31.1.10 인용 PDF KSCI