Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model |
Fujita, Masahide
(Department of Anesthesiology, Tsukuba University Hospital)
Fukuda, Taeko (Department of Anesthesiology, Tsuchiura Center for Medical Education and Training, Faculty of Medicine, University of Tsukuba (National Hospital Organization, Kasumigaura Medical Center)) Sato, Yasuhiro (Social Welfare Organization, Mito-Saiseikai Hospital) Takasusuki, Toshifumi (Department of Anesthesiology, School of Medicine, Dokkyo Medical University) Tanaka, Makoto (Department of Anesthesiology, University of Tsukuba, Faculty of Medicine) |
1 | Gilbert AK, Franklin KB. GABAergic modulation of descending inhibitory systems from the rostral ventromedial medulla (RVM). Dose-response analysis of nociception and neurological deficits. Pain 2001; 90: 25-36. DOI |
2 | Wang JM, Singh C, Liu L, Irwin RW, Chen S, Chung EJ, et al. Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2010; 107: 6498-503. DOI |
3 | Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cellcycle gene and protein expression. J Neurosci 2005; 25: 4706-18. DOI |
4 | Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet 2006; 367: 1618-25. DOI |
5 | Macrae WA. Chronic post-surgical pain: 10 years on. Br J Anaesth 2008; 101: 77-86. DOI |
6 | Zhang Y, Zhao S, Rodriguez E, Takatoh J, Han BX, Zhou X, et al. Identifying local and descending inputs for primary sensory neurons. J Clin Invest 2015; 125: 3782-94. DOI |
7 | Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, et al. Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci 2011; 31: 8134-42. DOI |
8 | Tan M, Law LS, Gan TJ. Optimizing pain management to facilitate enhanced recovery after surgery pathways. Can J Anaesth 2015; 62: 203-18. DOI |
9 | Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003; 97: 534-40. DOI |
10 | Kim SH, Yoon KB, Yoon DM, Kim CM, Shin YS. Patientcontrolled epidural analgesia with ropivacaine and fentanyl: experience with 2,276 surgical patients. Korean J Pain 2013; 26: 39-45. DOI |
11 | Frye CA, Duncan JE. Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats. Brain Res 1994; 643: 194-203. DOI |
12 | Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain 2005; 117: 326-39. DOI |
13 | Meyer L, Venard C, Schaeffer V, Patte-Mensah C, Mensah-Nyagan AG. The biological activity of 3alpha-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury. Neurobiol Dis 2008; 30: 30-41. DOI |
14 | Ocvirk R, Pearson Murphy BE, Franklin KB, Abbott FV. Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test. Pain 2008; 138: 402-9. DOI |
15 | Kawano T, Soga T, Chi H, Eguchi S, Yamazaki F, Kumagai N, et al. Role of the neurosteroid allopregnanolone in the hyperalgesic behavior induced by painful nerve injury in rats. J Anesth 2011; 25: 942-5. DOI |
16 | Charlet A, Lasbennes F, Darbon P, Poisbeau P. Fast nongenomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms. Pain 2008; 139: 603-9. DOI |
17 | Patte-Mensah C, Meyer L, Schaeffer V, Mensah-Nyagan AG. Selective regulation of 3 alpha-hydroxysteroid oxidoreductase expression in dorsal root ganglion neurons: a possible mechanism to cope with peripheral nerve injuryinduced chronic pain. Pain 2010; 150: 522-34. DOI |
18 | Meyer L, Patte-Mensah C, Taleb O, Mensah-Nyagan AG. Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence. Pain 2011; 152: 170-81. DOI |
19 | Afrazi S, Esmaeili-Mahani S. Allopregnanolone suppresses diabetes-induced neuropathic pain and motor deficit through inhibition of GABAA receptor down-regulation in the spinal cord of diabetic rats. Iran J Basic Med Sci 2014; 17: 312-7. |
20 | Marvizon JC, Wang X, Matsuka Y, Neubert JK, Spigelman I. Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord. Neuroscience 2003; 118: 535-45. DOI |
21 | Mantyh PW. Neurobiology of substance P and the NK1 receptor. J Clin Psychiatry 2002; 63 Suppl 11: 6-10. |
22 | Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, et al. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 2005; 25: 3651-60. DOI |
23 | Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain 1996; 64: 493-501. DOI |
24 | Belelli D, Lambert JJ. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci 2005; 6: 565-75. DOI |
25 | Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63. DOI |
26 | Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, et al. The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain 2011; 7: 55. |
27 | Takasusuki T, Yaksh TL. Regulation of spinal substance P release by intrathecal calcium channel blockade. Anesthesiology 2011; 115: 153-64. DOI |
28 | Maksay G, Laube B, Betz H. Subunit-specific modulation of glycine receptors by neurosteroids. Neuropharmacology 2001; 41: 369-76. DOI |
29 | Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, et al. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain 2005; 114: 429-43. DOI |
30 | Kawashiri T, Egashira N, Kurobe K, Tsutsumi K, Yamashita Y, Ushio S, et al. L type channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats. Mol Pain 2012; 8: 7. |
31 | Dogrul A, Bilsky EJ, Ossipov MH, Lai J, Porreca F. Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesth Analg 2005; 101: 1730-5. |
32 | Jasmin L, Wu MV, Ohara PT. GABA puts a stop to pain. Curr Drug Targets CNS Neurol Disord 2004; 3: 487-505. DOI |
33 | Roychowdhury SM, Fields HL. Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray. Neuroscience 1996; 74: 863-72. DOI |