• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.7
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• pp.1453-1463
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• 2004

The conventional image segmentation method using level set has been disadvantage since level set function in the gradient-based model evolves depending on the local profile of the edge. In this paper, a new model is introduced by hybridizing level set formulation and complementary smooth function in order to smooth the driving force. We consider an alternative way of getting the complementary function(CF) which is much easier to simulate and makes sense for most cases having no triple junctions. The rule of thumb is that CF must be computed such that the difference between their average and the original CF function should be able to introduce a reliable driving force for the evolution of the level set function. This proposed hybrid method tries to minimize drawbacks the conventional level set method.

• International Journal of Aeronautical and Space Sciences
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• v.3 no.1
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• pp.74-85
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• 2002

The numerical experiment has been conducted to investigate the unsteady shock wave reflecting phenomena. The cell-vertex finite-volume, Roe's upwind flux difference splitting method with unstructured grid is implemented to solve unsteady Euler equations. The $4^{th}$-order Runge-Kutta method is applied for time integration. A linear reconstruction of the flux vector using the least-square method is applied to obtain the $2^{nd}$-order accuracy for the spatial derivatives. For a better resolution of the shock wave and slipline, the dynamic grid adaptation technique is adopted. The new concept of grid adaptation technique, which is much simpler than that of conventional techniques, is introduced for the current study. Three error indicators (divergence and curl of velocity, and gradient of density) are used for the grid adaptation procedure. Considering the quality of the solution and the numerical efficiency, the grid adaptation procedure was updated up to $2^{nd}$ level at every 20 time steps. For the convenience of comparison with other experimental and analytical results, the case of interaction between the straight incoming shock wave and a sharp wedge is simulated for various flow conditions. The numerical results show good agreement with other experimental and analytical results, in the shock wave reflecting structure, slipline, and the trajectory of the triple points. Some critical cases show disagreement with the analytical results, but these cases also have been proven to show hysteresis phenomena.

• Earthquakes and Structures
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• v.23 no.1
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• pp.87-100
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• 2022

Limiting the displacement of seismic isolators causes a pounding phenomenon under severe earthquakes. Therefore, the ASCE 7-16 has provided minimum criteria for the design of the isolated building. In this research the seismic response of isolated buildings by Triple Friction Pendulum Isolator (TFPI) under the impact, expected, and unexpected mass eccentricity was evaluated. Also, the effect of different design parameters on the seismic behavior of structural and nonstructural elements was found. For this, a special steel moment frame structure with a surrounding moat wall was designed according to the criteria, by considering different response modification coefficients (RI), and 20% mass eccentricity in one direction. Then, different values of these parameters and the damping of the base isolation were evaluated. The results show that the structural elements have acceptable behavior after impact, but the nonstructural components are placed in a moderate damage range after impact and the used improved methods could not ameliorate the level of damage. The reduction in the RI and the enhancement of the isolator's damping are beneficial up to a certain point for improving the seismic response after impact. The moat wall reduces torque and maximum absolute acceleration (MAA) due to unexpected enhancement of mass eccentricity. However, drifts of some stories increase. Also, the difference between the response of story drift by expected and unexpected mass eccentricity is less. This indicates that the minimum requirement displacement according to ASCE 7-16 criteria lead to acceptable results under the unexpected enhancement of mass eccentricity.

• Journal of Applied and Pure Mathematics
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• v.5 no.3_4
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• pp.187-196
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• 2023

This study is about spin half add operations in 𝓑₂ and 𝓑₃. The burden of technological structures has increased due to the increase in the use of today's technological applications or the processes in the digital systems used. This has increased the importance of fast transactions and storage areas. For this, less transactions, more gain and storage space are foreseen. We have handle tit (triple digit) system instead of bit (binary digit). 729 is reached in 3⁶ in 𝓑₃ while 256 is reached with 2⁸ in 𝓑₂. The volume and number of transactions are shortened in 𝓑₃. The limited storage space at the maximum level is storaged. The logic connectors and the complement of an element in 𝓑₂ and the course of the connectors and the complements of the elements in 𝓑₃ are examined. "Carry" calculations in calculating addition and "borrow" in calculating difference are given in 𝓑₃. The logic structure 𝓑₂ is seen to embedded in the logic structure 𝓑₃. This situation enriches the logic structure. Some theorems and lemmas and properties in logic structure 𝓑₂ are extended to logic structure 𝓑₃.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.131-133
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• 2016

Background: Combination chemotherapy regimes are common treatments for cancer. The aim of this study was to evaluation the effect of individual chemotherapeutic agents in comparison with a first line chemotherapy regime treatment in the AGS gastric cancer cell line by MTT assay. Materials and Methods: In this experimental study, AGS cells were grown in RPMI-1640 supplemented with 10% fetal calf serum and 100 IU/ml penicillin, and $10{\mu}g/ml$ streptomycinin, under a humidified condition at $37^{\circ}C$ with 5% CO2. All cells were washed with PBS and detached with trypsin, centrifuged and 8000 cells re-plated on to 96- well plates. LD50 doses of Epirubicin, Cisplatin and 5-fluorouracil were added to each well in mono or triple therapy. Anti-proliferative activities were determined by MTT assay after 24, 48 or 72 h. Results: Results of MTT assays showed that there were no significant differences among 3 drugs in monotherapy (p=0.088), but there was significant difference between combination therapy with epirubicin (P=0.031) and 5FU (p=0.013) on cell survival at 24 h. After 48 and 72 hours, cell viability showed significant differences between the 3 drugs (p=0.048 and P=0.000 for 48 and 72 h, respectively) and there was significant difference between combination therapy with epirubicin (P=0.035 and P=0.002 for 48 and 72 h, respectively). Conclusions: The results showed no significant differences between these chemotherapy drugs each given alone, but combination therapy with 3 drugs had significant effects on cell viability in comparison with epirubicin alone.

• Journal of Chest Surgery
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• v.14 no.3
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• pp.228-234
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• 1981

Measurement of cardiac output by thermodilution method is easy to perform and can be repeated at very short intervals and offers a number of theoretical and practical advantages. The purpose of this paper is to reevaluate the accuracy and reproducibility of the thermodilution cardiac output by comparing the results with those obtained by the direct Fick technique. From January through April 1981 [4 months], 26 simultaneous cardiac output measurements were made using thermodilution and direct Fick methods in 12 patients in the intensive care unit of Severance Hospital following open heart surgery. The average age of the patients was $34.8{\pm}12.0$ [SD] years [range; 17-57 years]. For cardiac output determination by thermodilution technique [$CO_TD$], a Swan-Ganz Thermodilution Catheter, Model 93A-131-7F [Edwards Laboratories], a Cardiac Output Computer, Model 9520A, and Strip Chart Recorder, Model 9810 [Edwards Laboratories] were used. For the determination of cardiac output by direct Fick principle [$CO_Fick$], a Van Slyke Manometric Apparatus [Thomas] for the measurements of arteriovenous oxygen content difference and a Collin`s Respirometer with Kymograph for the measurement of oxygen consumption were used. The correlation between the simultaneously measured $CO_TD$ and $CO_Fick$ was found to be $CO_Fick$ = 0.95.$CO_TD$ + 0.1073, [r= 0.9777, P < 0.001 ]. For 26 double or triple determinations of $CO_TD$, the values ranged from 1.77 L/min to 6.66 L/min, with a reproducibility of 2.18%. The maximum difference of $CO_TD$ for $CO_Fick$ was between +11.99% and -12,99% [$Mean{\pm}SD$ = $6.07{\pm}3.97$%]. Measurement of cardiac output by thermodilution method provides a simple, rapid, reproducible and highly accurate method for multiple cardiac output measurements suitable for use at the bedside. Comparison of Cardiac Output Determination by Direct Fick and Thermodilution Method in Man.

• Bulletin of the Korean Chemical Society
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• v.22 no.3
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• pp.298-302
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• 2001

A site preference of niobium atom in Rb2-xLa2Ti3-xNbxO10 (0.0 $\leq$ x $\leq1.0)$ and RbLa2-xCaxTi2-xNb1+xO10 (0.0 $\leq$ x $\leq2.0)$, which are the solid-solutions between Rb2La2Ti3O10 and RbCa2Nb3O10, has been investigated by Raman spectroscopy. The Raman spectra of Rb2-xLa2Ti3-xNbxO10 (0.0 $\leq$ x $\leq1.0)$ gave an evidence that niobium atoms substituted for titanium atoms preferably occupy the highly distorted outer octahedral sites rather than the central ones in triple-octahedral perovskite layers. In contrast, the Raman spectra of RbLa2-xCaxTi2-xNb1+xO10 (0.0 $\leq$ x $\leq2.0)$ showed no clear information for the cationic arrangement in perovskite slabs. This difference indicated that a site preference of niobium atoms is observed only when the linear Rb-O-Ti linkage can be replaced by much stronger terminal Nb-O bond with double bond character. From comparison with the Raman spectroscopic behavior of CsLa2-xA’xTi2-xNb1+xO10 (A’ = Ca and Ba; 0.0 $\leqx\leq2.0)$, it is also proposed that a local difference in arrangement of interlayer atoms causes a significantly different solid acidity and photocatalytic activity of the layered perovskite oxides, despite their crystallographically similar structures.

• Analytical Science and Technology
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• v.36 no.1
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• pp.22-31
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• 2023

As the use of e-liquid cigarettes is rapidly increasing worldwide, it multiplies the potential risk undisclosed to the health of non- and smokers. To reduce the hazard, each country has its own set of regulations for controlling e-liquids. In Korea, the narrow definition of tobacco makes it difficult and have been steadily occurring tax evasion exploiting the difference in natural and artificial nicotine. Therefore, it is very important to distinguish source of nicotine for their regulation. To find biochemical discriminant markers, this study established analysis methods based on high-performance liquid chromatography coupled with diode array detector (HPLC-DAD) and high-performance liquid chromatography coupled with triple Quadrupole mass spectrometry (HPLC-MS/MS) for nicotine enantiomers and tobacco alkaloids targeted using the difference in pathways of nicotine biosynthesis and chemical synthesis. The method was validated by experimenting linearity (R² > 0.999), recovery (80.99-108.41 %), accuracy (94.11-109.73 %) and precision (0.04-8.27 %). Then, the results for discrimination of the nicotine obtained from analysis of 65 commercial e-liquid products available in Korean market was evaluated. The method successfully applied to the e-liquids and one sample labelled 'synthetic nicotine' for tax exemption was found to contain a natural nicotine product. This method can be used to determine whether an e-liquid product uses natural or artificial nicotine and monitor non-taxable e-liquid products. The method is more scientific than the existing one, which relies only on field evidence.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.3
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• pp.45-55
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• 2015

Objective : The aim of this study was to survey the present utilization of pattern identification(PI) in the clinical field among Korean Medicine Doctors. Method : This survey was conducted from Oct. 1 to Oct. 31, 2014 by face-to-face interview using structured questionnaire. The subjects were 400 korean medicine doctors who worked in hospitals or clinics. The questionnaire consisted of two sections - a demographics section(i.e., sex, age, clinical experience, place of work, residence and so on) and the main research section(i.e., the PI utilization rate, the utilization of PI systems, the utilization of PI in the clinical domain and in the treatment domain, the correlation between utilization PI and so on). Results : This study revealed that subjects used the PI to 66.7% of their patients on average. The utilization rate of PI in patients was significantly higher for female physicians than for male physicians, for physicians worked in clinics than for physicians who worked in hospitals and for physicians with more than 10 years clinical experience than for physicians with less than 10 years clinical experience. In the utilization of PI systems, Visceral PI was most as 92.0%. There were significant difference on the PI utilization rate according to utilization of Meridian and Collateral PI, Triple Energizer PI, Defense, Qi, Nutrient and Blood PI, Six-Meridian PI and Six Excesses PI. As a result of analysing the PI utilization rate by clinical domain and in the treatment domain, the Treatment and the Drug Treatment showed the highest values. Among utilized PI systems, the correlation coefficients between Defense, Qi, Nutrient and Blood PI and Triple Energizer PI showed the highest value, but the correlation coefficients between Sasang Constitutional Medicine with the each PI showed substantially lower value. Conclusion : The results of this study demonstrate that usage of PI was higher than usage of U code(in KCD) usage in clinical field. we suggested that additional studies on using PI and developing more appropriate standardized tool should be conducted to widen scope of PI's utilization.

• Journal of Radiation Protection and Research
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• v.26 no.2
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• pp.101-111
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• 2001

To study the relationship between the DNA content of human chromosomes and their involvement in radiation-induced structural chromosome aberrations, the frequencies of translocations and dicentrics induced in human lymphocytes after in vitro exposure to 2Gy of x-tay were analysed by fluorescence in situ hybridization(FISH). Single whole chromosome probes(WCP), specific for chromosomes 1, 2, 4, 7, 8, 9, and 21 and triple combination of probes tot chromosome 1, 2 & 4 were used separately. A significant deviation of the frequency of symmetrical translocation and dicentrics from a DNA-proportional distribution was observed. Chromosomes 2, 7, 8, 9 and 21 were less frequently involved in the formation of symmetrical translocations and dicentrics than expected, whereas chromosomes 1 and 4 were more frequently involved. Chromosome 2 and 4 showed a higher frequency of acentric fragments. When triple combination probe for chromosome 1, 2 & 4 was used, no differences were found between the observed and expected frequency of exchange type aberrations. The results showed that the frequency of radiation-induced chromosome aberrations was not proportional to DNA contents, suggesting the difference in the susceptibility to specific aberrations among individual chromosomes. The results also indicated that the FISH technique with combination of probes for chromosome 1, 2 & 4 was useful for radiation biodosimetry.