• Proceedings of the Korean Environmental Health Society Conference
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• 2005.11a
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• pp.169-174
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• 2005

의약품은 일반적으로 치료를 목적으로 제조되었기 때문에 독특한 약리학적 작용을 띤다. 의약품잔류물이 환경 중으로 배출되어 비표적 생물(non-target organism)에 노출될 경우 의도하지 않은 독성영향이 나타날 가능성이 있다. 본 연구에서는 우리나라에서 널리 사용되는 10개의 의약품(4종의 일반 의약품 acetaminophen, carbamazepine, diltiazem, cimetidine과 6종의 설파계 항생제 sulfamethoxazole, sulfamethazine, trimethoprim, sulfachloropyridazine, sulfadimethoxine)을 대상으로 환경중 예상잔류농도와 생태 무영향농도를 예측하여 대상의약품의 생태위해성을 평가하였다. 연구대상 의약품의 예측환경농도는 0.14 ${\sim}$ 16.5 ppb이었으며, 예측환경농도와 예측무영향농도비(PEC/PNEC ratio)를 산출한 결과 acetaminophen과 suifamethoxazole이 각각 1.8과 6.3으로 나타나 이 의약품들이 물생태계에 미치는 위해성에 대한 정밀한 추가연구의 필요성이 제시되었다.

• Pediatric Infection and Vaccine
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• v.4 no.1
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• pp.174-182
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• 1997

Pneumocystis carinii pneumonia mainly occurs in immunocompromised patients and it is also known of major cause of death in children with acute lymphoblastic leukemia. After consolidation chemotherapy, acute lymphoblastic leukemia children is developed Pneumocystis carinii pneumonia frequently no an opportunistic infection but there were no controlled studies which have been performed to evaluate the usefulness of corticosteroid in Pneumocystis carinii pneumonia with acute lymphoblastic leukemia. We experienced a case of Pneumocystis carinii pneumonia in acute lymphoblastic leukemia with febrile neutropenic 6 years old girl. She was treated with trimethoprim-sulfamethoxazole and prednisone. We report this case with brief review of related literature.

• Journal of Veterinary Clinics
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• v.21 no.2
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• pp.129-132
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• 2004

Causative agents of mastitis were isolated from glandular tissues of 101 culled Holstein cow udders and tested with antimicrobials by standardized disc diffusion method. Pathogens most commonly isolated were coagulase-negative staphylococci (43.9%) and streptococci (21.4%). Most of the udders (88.5%) showed mixed infections with more than two species of bacteria. Antimicrobial sensitivity tests revealed that 90.0% and 84.5% of the isolated organisms were susceptible to amoxicillin and gentamicin, while most organisms were resistant to erythromycin. Coliforms were resistant to ampicillin, cephalothin, cefazolin, erythromycin, kanamycin, neomycin, penicillin and tetracycline and streptococci to erythromycin, kanamycin, neomycin, trimethoprim/sulfamethoxazole and tetracycline.

• Journal of Microbiology and Biotechnology
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• v.20 no.4
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• pp.666-669
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• 2010

A target bacterial strain of interest for use in Red-based recombineering may already encode resistance to antibiotic markers used with current Red recombination tools, such that the resistance cannot be removed. Such cases include those where markers are needed to maintain an unstable genetic element co-resident in the strain or those where the genetic source of resistance is not known. We report the availability of PCR templates with FRT-flanked mutagenesis cassettes and plasmids encoding Red recombination functions that contain marker combinations not currently available on widely disseminated lambda Red molecular reagents. The functionality of these convenient alternative tools is demonstrated.

• Journal of Korean Neurosurgical Society
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• v.50 no.4
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• pp.396-398
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• 2011

Nocardia brain abscess is rare. We report on a unique case of N. farcinica brain abscess in a liver transplant recipient, following Aspergillus fumigatus pneumonia. A 43-year-old liver transplant recipient presented with altered mentality at 2 months after A. fumigates pneumonia. He was successfully treated with surgical removal and antibiotic therapy with trimethoprim-sulfamethoxazole and ceftriaxone.

• Korean Journal of Veterinary Service
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• v.18 no.2
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• pp.124-132
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• 1995

The present study was conducted to investigate the incidence of Pasteurella multocida infection in cheju swine from March 1994 to December 1994 isolated organisms were identified by the biochemical properties, cellulose serological type and antibiotic susceptibilities. Pasteurella multocida was isolated from the Lungs of 96 pigs with pneumonia(51 %) among 188 slaughtered pigs. The majority of p multocida isolates were identical to those of the standard strains. On the classification of the capsular type of the isolated p multocida it consist of the 88 isolates of type A(91.6%) 2 isolates of type D (2%) and un classified 6 types(6.2%). The majority of the 96 isolates of p multocida highly susceptible to the antibiotics including ampicillin(Am), cephalotin(Ce), erythromycin(Em), gentamycin(Gm), kanamycin(Km), lincomycin(Lm), neomycin(Nm), penicillin(Pc), streptomycin(Sm), solfametoxazol/trimethoprim(Sxt) and tetracycline(Te)

• Korean Journal of Veterinary Service
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• v.22 no.3
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• pp.257-262
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• 1999

Riemerella anatipestifer (RA) infection is a contagious disease of domestic ducks, turkey, and various other birds. In a flock of mallard ducklings, about 30% of the birds, 3 weeks old, showed lethergy, greenish diarrhea, tremor of head and neck, and died 2-3 days after signs appeared. Grossly, fibrinous exudates covered the heart and surface of the live. Microscopically, mononuclear cells and heterophils were primarily inflammatory cells in the exudate. These were also observed in the meninges in brain. Microbiologically, gram (-) short rod bipolar shaped bacteria were recovered on blood agar and agglutinated by antisera of R anatipestifer. Sulfamethoxasole/trimethoprim were administered and clinically effective. This case was a R anatipestifer infection caused fibrinous pericarditis, hepatitis and meningitis in mallards.

• Korean Journal of Veterinary Service
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• v.13 no.1
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• pp.69-74
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• 1990

The present study was conducted to investigate the incidence of pasteurella multocida infection in kyungbuk swine herds during the period from July 1989 to November 1989 and some properties of the isolated organisms. P. multocida was isolated from lungs of 155 slaughtered pigs, 43(27.7%) pigs were culture positive. The majority of biochemical and cultural properties of the P. multocida isolates were identical to those of the standard strains. The capsular serogroups and drug susceptibility of 43 isolates of P. multocida from pigs with pneumonic lesions were investigated. P. multocida isolates were typed for capsular serogroupes A by hyaluronidase inhibition of capsule and D by acriflavin auto agglutination. Most isolates(60.4%) were type A, 18.6% were type D, and the remaining 21.0% were untypable. In antimicrobial susceptibility test these isolates of P. multocida were susceptible in order of ampicillin (86.0%), trimethoprim sulfamethoxazole(83.7%), colistin(81.4%), chloramphenicol(79.1%), but the majority of them were resistant in order of streptomycin(30.2%), triple sulfa (4.6%).

• Journal of Microbiology and Biotechnology
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• v.15 no.3
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• pp.477-483
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• 2005

Corynebacterium ammoniagenes ATCC 6872, which does not accumulate pyrimidine nucleoside or nucleotide, was metabolically engineered to secrete a large amount of thymidine. Characteristics of 5-fluorouracil resistance ($FU^r$), hydroxyurea resistance ($HU^r$), trimethoprim resistance ($TM^r$), thymidylate phosphorylase deficiency ($deoA^-$), inosine auxotrophy ($ino^-$), 5-fluorocytosine resistance ($FC^r$), thymidine kinase deficiency, and thymidine resistance ($thym^r$) were successively introduced into mutant strains KR3 and DY5T9-5, and shake-flask cultures were able to accumulate 408.1 mg/l and 428.2 mg/l of thymidine, respectively, as a major product. The mutant strains did not accumulate thymine at all and accumulated less than 10 mg/l of other pyrimidine nucleosides, such as cytosine, cytidine, and deoxycytidine, as byproducts.

• Journal of Veterinary Clinics
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• v.17 no.2
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• pp.475-479
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• 2000

The purpose of this study was to investigate the cause of chronic diarrhea from anaerobic bacteria isolated from Siberian tiger with chronic diarrhea. Major anaerobic bacteria isolated from faces were Clostridium perfringens and their population was $6 {\times} 10^3$ cfu/g feces. Antibiotic sensi- tivity test against Clostridium perfringens was performed using 6 antibiotic drugs including colistin gentamicin, trimethoprim/sulfamethoxazole, amikacin, enofloxacin and penicillin. Clostridium per- fringens were sensitive to amikacin, enrofloxacin and penicillin while they were resistant to colistin. gentamicin and trmetboprim/sulfamethoxazole. And we found that chronic diarrhea of Siberian tiger was treated successfully with penicillin. These results suggested that Clostridium perfringens may bee a cause of chronic diarrhea in Siberian tiger.