• The Korean journal of helicobacter and upper gastrointestinal research
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• v.18 no.4
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• pp.277-279
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• 2018

전 세계적으로 Helicobacter pylori의 항생제 내성률은 지속적으로 증가하고 있으며, 기존의 제균 치료에 실패한 H. pylori 감염 환자들에 대한 효과적인 구제요법(rescue therapy)의 필요성 역시 증가하고 있다. 이 연구는 두 개 기관, 공개, 평행 그룹, 무작위 배정 연구로서 불응성 H. pylori 감염 환자들의 구제요법으로 유전자형 내성을 기반한 치료(genotype resistance-guided therapy)와 경험적 치료(empirical therapy) 중 어느 것이 보다 효과적인지를 비교하고자 하였다. 2012년 10월부터 2017년 9월까지 20세 이상의 불응성 H. pylori 감염 환자들을 대상으로 하였으며, 불응성 H. pylori 감염은 과거 두 종류 이상의 H. pylori 제균 치료를 받았음에도 불구하고 H. pylori 제균에 실패한 환자들로 정의하였다. 이들에게서 한 군은 14일간의 유전자형 내성을 기반한 순차 치료(n=21 in trial 1, n=205 in trial 2)를, 다른 한 군은 환자들의 과거 제균 치료 종류를 감안한 14일간의 경험적 순차 치료(n=20 in trial 1, n=205 in trial 2)를 시행하였다. 순차 치료법은 첫 7일은 esomeprazole 40 mg과 amoxicillin 1 g을 하루 두 번 복용한 다음, 나머지 7일은 esomeprazole 40 mg과 metronidazole 500 mg, 그리고 1) levofloxacin 250 mg 또는 2) clarithromycin 500 mg 또는 3) tetracycline 500 mg을 하루 두 번 복용하는 것으로 구성하였다. 23S ribosomal RNA (rRNA)나 gyrase A에 대한 내성 관련 돌연변이 여부는 direct sequencing을 통한 중합효소연쇄반응(polymerase chain reaction, PCR) 검사를 이용하였고, 제균 성공 여부는 요소호기검사를 통해 확인하였다. 일차 결과 지표는 치료 방법에 따른 제균율로 정하였다. Trial 1에서는 tetracycline 대신 doxycycline 100 mg을 사용하였는데, 제균 성공률이 유전자형 내성을 기반한 치료군에서는 17명(81%), 경험적 치료군에서는 12명(60%)으로 나타났다(P=0.181). 하지만, 다른 순차 치료군들과 비교하였을 때, doxycycline을 포함한 순차 치료군의 제균율이 현저히 낮은 것으로 나타나서(15/26, 57.7%) doxycycline을 포함한 순차 치료법은 종결하기로 하고, trial 2부터는 doxycycline 대신 tetracycline으로 교체하여 연구를 지속하였다. Trial 2의 intention-to-treat (ITT) 분석 결과, 유전자형 내성을 기반한 치료군에서는 160/205명(78%), 경험적 치료군에서는 148/205명(72.2%)으로 두 그룹 간의 통계적인 제균율의 차이는 보여주지 못하였다(P=0.170). 부작용 및 환자 순응도에서도 양 군 간의 의미 있는 차이는 없었다. 따라서, 두 종류 이상 H. pylori 제균 치료에 실패한 환자들이라고 할지라도 기존의 제균 치료력을 바탕으로 적절한 경험적 치료를 시행하는 것은 유전자형 내성을 기반한 치료 정도의 효과는 있으며 접근성, 비용, 환자들의 선호도 등의 여러 가지 부가적인 사항들을 고려할 때, 제균 치료력을 고려한 경험적 치료는 간단한 수준의 유전자형 내성을 기반한 치료의 대안으로 받아들여질 수 있을 것으로 제안하였다.

• Journal of Convergence for Information Technology
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• v.9 no.4
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• pp.59-67
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• 2019

Most of the prior researches in brand extension evaluation have utilized purchase intention as a n effective variable to assess the effectiveness of brand extensions. In contrast, the author proposes that trial intention is to better predict consumers' behavioral response in the newly launched brand extension markets where relate to high risk and uncertainty. Furthermore, the study explores the effects of attitude toward parent brand and consumers' characteristics (perceived similarity and consumption experience) on trial intention of brand extensions. In order to achieve the purpose of the study, the data collection was conducted for actual consumers who had experience using parent brand products. This study employed experiment and questionnaire survey and collected data of 186 was analyzed using clustering analysis and regression analysis. The main results are as follows. First, attitude toward parent brand has a positive effect on trial intention of the extensions. Second, perceived similarity and consumption experience of parent brand have moderating effects on the relation of attitude toward parent brand and trial intention of brand extensions. The results provide that both industry and academic researchers with a guide to process trial intention of brand extension from a comprehensive perspective.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.4
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• pp.349-354
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• 2023

Sunscreen is a product that protects against ultraviolet rays by blocking and scattering ultraviolet rays, and has now become a daily necessity beyond cosmetics. Applying sunscreen is a common and easy way to prevent skin damage caused by ultraviolet rays. Due to its significance, the evaluation of sunscreen has evolved since its regulation by the FDA in 1978, progressing to standardized methods established by ISO. Additionally, to assess the loss of sunscreen due to activities such as water exposure or sweating, the Ministry of Food and Drug Safety in Korea and ISO have established protocols for evaluating the water-resistant sun protection factor (SPF). However, existing evaluations of water resistance have been mainly confined to test methods involving plain water, and methods accounting for the impact of seawater during activities like beach leisure, sports, and recreation are yet to be established. Based on the existing guidelines for testing the water-resistant UV protection index, this study compared the water-resistant UV protection index in water, artificial seawater (salt water) and natural seawater (sea water) to evaluate the UV protection index in real-world situations such as marine leisure, sports, and leisure activities. Through these results, we were able to compare the differences between water resistance sun protection index tests in ordinary water, artificial seawater, and natural seawater, and suggest a method for water resistance sun protection index tests using natural seawater.

• Journal of the Society of Naval Architects of Korea
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• v.35 no.2
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• pp.29-37
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• 1998

Linear equations of motion for submersibles are one of the rest important design parameters, which are used as a governing equation for the shape design and the controller design. But, the estimated maneuvering coefficients in equations of motion by using empirical formulae, theoretical calculations or model tests might have some errors. Therefore the maneuvering coefficients should be verified from sea trial test. In this study, parallel extended Kalman filter method, Nelder & Mead Simplex method and genetic algorithm were applied to the parameter identification of roll maneuvering coefficients based on sea trial data. As a result, it was verified that Nelder & Mead Simplex method gave the most satisfactory results for the mathmatical models and the sea trial data used in this study.

• Journal of The Korean Society of Grassland and Forage Science
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• v.16 no.3
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• pp.208-214
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• 1996

This trial was conducted at two locations to compare forage yield, plant height, disease reaction, lodging and maturity of oat(Avm sativa L.) cultivars introduced from Western Australia in comparison with the control cultivar of oat 'Cayuse" over a period of 3 yr. At Suweon, Swan and Murray cultivars gave the highest forage yield, followed by Winjardie and Hay cultivars during 3 years of trial, but Cayuse cultivar gave the lowest forage yield. At Sunghwan, Hay and Swan cultivars tended to forage yield more than other cultivars, but Cayuse cultivar was among the lowest yielding. AU the cultivars in the trial were moderately resistant to BYDV and lodging at two locations although differences exist among cultivars. Murray cultivar was early in maturity, while Swan, Hay and Winjardie cultivars showed medium, and Cayuse cultivar was later. Murray and Swan cultivars were tall in height and gave a higher dry matter percentage of 18~20% at harvest. The results of the trial indicated that Swan and Murray cultivars could be recommended as the national recommended forage oat cultivar when forage performance was considered.ered.

• The Journal of Korean Medicine
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• v.41 no.1
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• pp.107-116
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• 2020

Objectives: To overcome the limitations of randomized controlled trials, many other trials design is tested. The n-of-1 trial is a promising research method in the field of Korean medicine because of this methodology can examine the optimal treatment for each patient strictly. Therefore, we reviewed the status of N-of-1 studies on herbal medicine. Methods: A systematic literature review was conducted based on the pubmed database. The search term were 'N-of-1 Trial', 'Chinese Medicine', 'Herbal Medicine', 'Kampo'. There was no restriction in year. Results: Four clinical trials have been identified to demonstrate the effectiveness of herbal medicines for Kidney-yin-deficiency syndrome, bronchiectasis and gastric cancer. These studies suggest that the N-of-1 design is a study that encourages patient involvement, demonstrates the effectiveness of herbal medicines and helps reduce unnecessary medication. Conclusion: The N-of-1 clinical trial may be a rigorous methodology suitable for the clinical setting and may help the development of evidence-based Korean medicine. Attention is also needed in this research method in Korea.

• Journal of the Society of Naval Architects of Korea
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• v.48 no.5
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• pp.421-425
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• 2011

To know the speed performance of "ARAON" in Arctic ice field, the measurement of ice properties which is ice thickness & strength, snow depth and free board were performed on July 2010. The measuring method of nautical signals such as heading angle, power of engine, wind & current information etc. was described in this paper. The speed sea trials in ice were performed on the four different positions with different ice properties and engine powers because the uniform level ice is not detected in the Chukchi Sea. The test field was partially constrained ice floe with hummocks and it was superposed with small broken ice pieces each other. All of the measured ice properties were compared and evaluated according to the results of sea trial. The relations between speed, ice thickness, strength and power were summarized. Consequently according to the sea trial results, the speed of ARAON is 2.78knots at the 2.49m ice thickness with 6.55MW engine power.

• Journal of the Society of Naval Architects of Korea
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• v.52 no.6
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• pp.428-434
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• 2015

The objective of the present study is to analyze the results of the trial-test for the full-scale driving pump, which is arranged in the LCT (Large Cavitation Tunnel). Firstly, the reasons of selecting the final design pump are introduced in terms of the performance analysis in model tests. The trial-test items for the full-scale driving pump are measurements of output current/voltage at the inverter of the main motor and the flow velocity in the LCT test section. The test results show the increase in flow rate of about 10.7% and the decrease in pump head of about 26%, compared with those of final design-pump specification. The motor power has the margin of about 22%. The performance analysis for the full-scale pump is conducted using the commercial code (CFX-10). The delivered power calculated with CFX-10 shows good agreement with that extracted from the full-scale pump test. It is found that CFX-10 is useful to analyze a full-scale pump.

• The Journal of Korean Association of Computer Education
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• v.6 no.1
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• pp.121-130
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• 2003

As legal and technological actions to prevent and treat addiction to the Internet have reached their limit, the importance of educational methods as alternative measures is being recognized. The present study was attempted to propose the application of a cyber mock trial system as an educational method to prevent addiction to the Internet and to promote information communication ethics. The mock trial system was designed and implemented so that both open trials and closed trials could be held, and the process and results of trials could be discussed. To verify the effectiveness of learning method of cyber mock trial in preventing and treating addiction to the Internet, this study conducted and analyzed questionnaire survey about juveniles' class preparation, class participation, interest in classes, and the effects of classes.

• Korean Journal of Adult Nursing
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• v.25 no.1
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• pp.53-61
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• 2013

Purpose: The purpose of the study was to identify the levels of anxiety, depression and uncertainty of patients who participated in the clinical trials for anticancer drug, and to identify correlations among these variables. Methods: Cross-sectional survey used the Symptom Check List-90-Revision and the Mishel Uncertainty in Illness Scale from 106 subjects in 2011. The data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients. Results: The mean score of anxiety was 2.06, that of depression 2.35, and that of uncertainty 2.61. Anxiety and depression (r=.70), anxiety and uncertainty (r=.44), depression and uncertainty (r=.60) were significantly correlated each other. The levels of anxiety, depression and uncertainty were different in various characteristics of the subjects, such as education, recurrence, and economic burden. Conclusion: The results of the study indicate that when implementing psychosocial interventions for cancer patients who participate in clinical trial, factors such as education, economic burden, and recurrence should be integrated into the intervention. Further studies applying theoretical model would be helpful to identify directional relationships among the variables that are important in psychosocial well-being of cancer patients undergoing clinical trial.