• Molecular & Cellular Toxicology
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• v.2 no.2
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• pp.134-140
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• 2006

Because shipyard workers are involved with various manufacturing process in shipyard industry, and they are exposed to many kinds of hazardous materials. Especially, painting workers were exposed polycyclic aromatic hydrocarbons (PAH). This study was conducted to assess the exposure status of PAH based on job-exposure matrix. We investigated the effect of genetic polymorphism of xenobiotic metabolism enzymes involved in PAH metabolism on levels of urinary metabolite. A total of 93 shipbuilding workers were recruited in this study. Questionnaire variables were age, sex, use of personal protective equipment, smoking, drinking, and work duration. The urinary metabolite was collected in the afternoon and corrected by urinary creatinine concentration. The genotypes of CYP1A1, CYP2E1, GSTM1, GSTT1 and UGT1A6 were investigated by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods with DNA extracted from venous blood. Urinary 1-OHP levels were significantly higher in direct exposured group (spray and touch-up) than indirect exposed group. Urinary 1-OHP, concentration of the high exposure with wild type of UGT1A6 was significantlyhigher than that of the high exposure with other UGT1A6 genotype. In multiple regression analysis of urinary 1-OHP, the regression coefficient of job grade was statistically significant (p<0.05) and UGT1A6 was not significant but a trend (p<0.1). The grade of exposure affected urinary PAH concentration was statistically significant. But genetic polymorphism of xenobiotics metabolism enzymes was not statistically significant. Further investigation of genetic polymorphism with large sample size is needed.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3239-3245
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• 2014

Background: College students are recommended as the target groups for catch-up human papillomavirus (HPV) vaccination. Systematical exploration of awareness, acceptability, and decision-making factors of HPV vaccination among Chinese college students has been limited. Materials and Methods: A multi-center survey was conducted in mainland China between November 2011 and May 2012. College students aged 18-22 years were stratified by their grade, gender, and major for sampling. Socio-demographic and HPV-related information such as knowledge, perceptions, acceptability, and attitudes were collected through a questionnaire. Results: A total of 3,497 undergraduates completed the questionnaire, among which 1,686 were males. The acceptability of the HPV vaccine was high (70.8%). Undergraduates from high-level universities, at lower grade, or with greater prior knowledge of HPV vaccines showed higher acceptability of HPV vaccination ($p_{trend}$ <0.001). Additionally, undergraduates with vaccination experience outside the National Expanded Program on Immunization (OR=1.29; 95%CI: 1.10-1.51) or fear of HPV-related diseases (OR=2.79; 95%CI: 2.28-3.41) were more willing to accept HPV vaccination. General knowledge of HPV vaccine was low among undergraduates, and safety was a major concern (71.05%). The majority of students wished to pay less than 300RMB for HPV vaccine and chose the Chinese Center for Disease Control and Prevention as the most appropriate venue for vaccination. Conclusions: Although most undergraduates demonstrate positive attitudes towards HPV vaccination, challenges pertaining to introduction exist in China. Corresponding proactive education and governmental subsidy to do so are urgently needed by this age-group population. Suggestions and potential strategies indicated may help shape the future HPV vaccination program in China.

• The Journal of Sustainable Design and Educational Environment Research
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• v.5 no.2
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• pp.53-66
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• 2006

Recent color plans in school buildings are made by experts through public offerings for prizes for designs etc in relatively many cases. But it is necessary to review if such color plans are actually well conform to students' emotions and what trend the color plans made as such have. Therefore, this study examined and analyzed the exterior colors of the school buildings planned by public offerings for prizes for designs and reviewed the result comparing to the color preferences of students that had already been studied to figure out the differences between existing theories and the realities. And it was examined what differences were existing in the trends of color plans and color images examined between each of school levels. The result of the study compared to theories is as follows. First, when the color distributions were reviewed for each school level, it could be confirmed that the overall distributions moved from Y category to B category and whereas warm colors were more widely distributed and the number of colors were greater compared to cold colors in case of elementary schools, the distributions of warm colors gradually decreased as school level moves to high schools. Second, the color use distributions of elementary school students were revealed to be more diversified than middle and high school students and also the number of colors used was 9.5 in average in elementary school and middle schools and high schools were similar to each other with average 5.86 colors in middle schools and 6.33 colors in high schools showing a little differences in color use distributions among school levels of elementary schools, middle schools and high schools. Third, in case of elementary schools, except main colors, both of subsidiary colors and emphasizing colors had the distributions of warm colors of R, YR, Y categories and cold colors of B, PB categories and this is also consistent with the results of existing research results indicating that low grade students prefor for warm colors and high grade students prefer for cold colors. Fourth, in case of middle schools and high schools, although the distributions of warm colors decreased, the distributions of warm colors and cold colors were revealed to be similar. This is considered to be consistent with the existing research results indicating that girl students prefer for warm colors even if their ages go up. Fifth, as for the images of main colors, subsidiary colors and emphasizing colors resulted from the comparisons by solid color Image Scales and adjective Image Scales, first, in case of main colors, natural images or clear images appeared the most in all of elementary schools, middle schools and high schools indicating that basically calmness is emphasized with soft images rather than hard images and static images rather than dynamic images. Also, in case of subsidiary colors or emphasizing colors, cheerful images or splendid images are also seen to decrease as school level goes from elementary schools to high schools in adjective Image Scales and this is considered to reflect the color sentiment differences between children and juveniles based on ages.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5225-5230
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• 2013

Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patients as well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38 glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercial ELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and 5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in their sera ($0.29{\pm}0.54$, $0.03{\pm}0.15$ and $0.16{\pm}0.68$ vs. $0.00{\pm}0.00pg/ml$; p=0.01, p=0.01 and p=0.001, respectively). There was also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls ($2.34{\pm}4.35$ vs. $4.67{\pm}4.32pg/ml$; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients (p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared to the young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 was observed in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Our data suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6 and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarker and/or immunotherapeutic target in glioma cases.

• Journal of The Korean Association For Science Education
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• v.11 no.2
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• pp.161-178
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• 1991

This study was designed to investigate the effect of test anxiety, intelligence, and item arrangement order on test performance in Earth Science. The main purposes in this study were to investigate (1) (2) (3) (4) on test performance.: (1) the effect of test anxiety components on test performance in Earth Science. (2) the effect of item arrangement order on test performance in Earth Science. (3) the effect of test anxiety This study was designed to investigate the effect of test anxiety, intelligence, and item arrangement order on test performance in Earth Science. The main purposes in this study were to investigate (1) (2) (3) (4) on test performance.: (1) the effect of test anxiety components on test performance in Earth Science. (2) the effect of item arrangement order on test performance in Earth Science. (3) the effect of test anxiety components on test performance in Earth Science according to learner's intelligence levels. (4) test effect of item arrangement order on learner's intelligence. The hypothesis was that there is difference among test achievements scores according to (1) test anxiety-worry levels. (2) item arrangement orders. (3) item arrangement orders on test anxiety-worry levels. (4) test anxiety-worry levels on intelligence levels. (5) test anxiety-emotionality levels. (6) item arrangement orders on test anxiety-emotionality levels. (7) test anxiety-emotionality levels on intelligence levels. (8) item arrangement orders on intelligence levels. The test items selected for this study were derived from the text Science (part 1) first grade of high school. The subjects of this study were 164 of high school first grade boy students in Pusan. They were assigned to one of the three groups, according to test anxiety levels.: (1) upper 25% of total subjects designated to high group (2) middle 50% (3) low group, lower 25% of total subjects And according to LQ. (1) upper 25% of total subjects designated to high group. (2) middle 50%. (3) low group, lower 25% of total subjects Analysis of variance was used in this study for hypothesis examination. The dependent variable was the achievement scores of Earth Science test and independent variables were test anxiety(worry, emotionality) level, LQ. level, item arrangement orders. The principal findings of the present study are as follows: (1)Test achievement score trend decreases as the test anxiety (worry, emotionality) increases although the result is not statistically significant. (2)There is no significant difference among test achievement scores according to item arrangement orders. (3)The higher the LQ. is, the more effective test anxiety. And the LQ. has significant interaction effect with test anxiety. (4)There is significant interaction effect between the LQ. levels and itemqr arrangement orders.

• Korean Journal of Head & Neck Oncology
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• v.17 no.1
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• pp.32-37
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• 2001

Objectives: We performed this study to compare the short term results of induction chemotherapy and radiotherapy versus concurrent chemoradiotherapy in patients with locally advanced head and neck cancer. Materials and Methods: From Oct. 1985 to May 1998, 121 patients with locally advanced head and neck cancer were treated with induction chemotherapy and radiotherapy (induction group) or concurrent chemoradiotherapy (concurrent group), and a retrospective analysis was done. Induction chemotherapy was done for 97 patients, and concurrent chemotherapy for 24 patients. Age, sex, performance status, and pathologic types were evenly distributed between two groups. Primary site showed nasopharynx(72.2%), oropharynx(27.8%) in induction group, and nasopharynx(50%), oropharynx(50%) in concurrent group. Chemotherapy regimen was CF(cisplatin and 5-fluorouracil) for 67 patients and CVB (cisplatin, vincristine, bleomycin) for 30 patients in induction group, and CF for all of 24 patients in concurrent group. Proportion of patients treated with more than 2 cycles of planned chemotherapy was 94.8% in induction group and 87.5% in concurrent group. Conventionally fractionated radiotherapy with daily fraction size of 1.8-2.0Gy and 5 fractions/week was done. Total dose was 61-95Gy (median 73.4Gy) for induction group, and 69.4-75.4Gy (median 69.4Gy) for concurrent group. Follow-up time was 4-161 months (median 38 months) for induction group, 7-35 months (median 21.5 months) for concurrent group, respectively. Results: According to treatment modality, overall 2-year survival rates were 68.0% for induction group, 74.3% for concurrent group (p>0.05). two-year disease-free survival rates were 51 % and 74% (p=0.05). Complete response rates were 67.4% for induction group and 83.3% for concurrent group (p=0.09). The incidence of grade 3-4 hematologic toxicity (2.1% vs. 25%, p=0.001) and grade 3-4 mucositis (9.3% vs. 37.5%, p=0.002) during radiotherapy was higher in concurrent group. Conclusion: Concurrent chemoradiotherapy showed a trend of improvement in short-term survival and treatment response when compared with induction chemotherapy and radiotherapy in locally advanced head and neck cancer. A more controlled randomized trial is needed.

• Journal of Digital Contents Society
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• v.17 no.5
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• pp.317-327
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• 2016

Flipped learning is a new learning technique which can maximize the learning effect by mixing two or more different learning environments including online & offline, and recently introduced system: 'Google classroom' is the optimized internet platform for flipped learning. This study tried to apply flipped learning to regular course 2nd grade dental students(n=70) and evaluated the satisfaction of students. The subjects of periodontology and operative dentistry were chosen to evaluate flipped learning model for regular course 2nd grade dental students(n=70). Each class consisted of six classes, and three times of them were performed in conventional classes and the other three times were in flipped learning method by using Google classroom. Evaluation of satisfaction progressed at the end of class. In this study, application of flipped learning in the dental college classes showed high efficiency in terms of degree of understanding, self-directed learning and motivation. Collectively, it was shown that flipped learning using Google classroom can be a reliable platform in dental classes.

• The Journal of Engineering Geology
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• v.24 no.1
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• pp.101-110
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• 2014

This study presents the results of a regression analysis of the point-load strength ($I_{s(50)}$) and the uniaxial compressive strength (UCS) of granites in Korea. The regression was carried out for three cases using the least-squares method, reclassifying the granite samples based on their physical properties. The first regression analysis through the origin according to the weathering grade did not give a result with a sufficient degree of confidence, due to the small number of samples. However, the general trend of the correlation between UCS and $I_{s(50)}$according to weathering grade shows that the slope of the linear regression for weathered granite is steeper than that for fresh granite. The second analysis was a simple linear regression for all the granite samples using the least-squares method as well as a linear regression using the bootstrap resampling method in order to increase the confidence level and the accuracy of the regression results. The third regression considered the average strength of granite groups reclassified according to physical properties. These linear regression analyses yielded linear regression equations with slopes of 14 and small standard deviations being similar to values reported in previous studies on Korean granites, but whose intercept values range from 16 to 43 and have a larger standard deviation than those of the present study. In conclusion, it would be advisable to estimate UCS from $I_{s(50)}$, considering the error range derived from the deviation of the regression equations.

• Korean Journal of Construction Engineering and Management
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• v.20 no.5
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• pp.21-30
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• 2019

Environmental and energy issues such as abnormal climate and depletion of fossil fuel due to global warming have emerged as a critical task to threaten human survival. As a result, interest in the Zero Energy Building is increasing as it is an innovative building that can significantly contribute to building energy reduction and greenhouse gas reduction. In the market, however, the added cost of construction is a major stumbling block to the revitalization of the Zero Energy certification. In this study, general private apartment complexes were selected for research, detailed elements for Zero Energy certification were presented based on the construction criteria for eco-friendly houses from the initial design stage, and the cost efficiency analysis of the components for certification were presented. It has been analyzed that only Grade 3 certification can be implemented in apartments due to technical level and physical limitations. Also, after reviewing the cost trend during the lifecycle cost, all expenses can be recovered within 13 years after completion only in the case of grade 5 of the Zero Energy Building. The additional costs proposed in the present study are reflected appropriately in the review of projects for apartments scheduled for order in the future to contribute to the revitalization of the Zero Energy Building certification.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.5
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• pp.439-458
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• 2013

Temporal and spatial variations of water quality were investigated in the Cheonsu Bay of Yellow Sea, Korea from 2010 to 2011. Water samples were collected at 16 stations and physicochemical parameters were analyzed including water temperature, salinity, suspended solids (SS), chemical oxygen demand (COD), dissolved oxygen (DO), Chlorophyll a and nutrients. Spatial distribution patterns of all survey items were not clear among stations but the bimonthly variations were distinct except the bottom water of the suspended solids. The trend analysis by principal component analysis (PCA) during 2 years revealed the significant variations in water quality in the study area. Spatial water qualities were discriminated into 3 clusters by PCA; station cluster in the surface water 1, 2~11, and 12~16, the bottom water 1, 2~7, and 8~16. Annual bimonthly water qualities were clearly discriminated into 3 clusters by PCA. But tend of cluster in the surface and bottom water was difference, period most of the research was low in nutrient. Ecology-based water quality criteria was a good level of grade II. Bimonthly results are shown as III grade(normal) at June and August, II grade(good) at October and December and I grade for February and April. Water quality was showed by the input of fresh water same as those of Kyoungin coastal area, Asan coastal area, Gunsan coastal and Mokpo coastal area in the Cheonsu.