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http://dx.doi.org/10.7314/APJCP.2013.14.9.5225

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma  

Doroudchi, Mehrnoosh (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences)
Pishe, Zahra Ghanaat (Shiraz University of Medical Sciences)
Malekzadeh, Mahyar (Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences)
Golmoghaddam, Hossein (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences)
Taghipour, Mousa (Shiraz University of Medical Sciences)
Ghaderi, Abbas (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.9, 2013 , pp. 5225-5230 More about this Journal
Abstract
Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patients as well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38 glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercial ELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and 5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in their sera ($0.29{\pm}0.54$, $0.03{\pm}0.15$ and $0.16{\pm}0.68$ vs. $0.00{\pm}0.00pg/ml$; p=0.01, p=0.01 and p=0.001, respectively). There was also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls ($2.34{\pm}4.35$ vs. $4.67{\pm}4.32pg/ml$; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients (p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared to the young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 was observed in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Our data suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6 and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarker and/or immunotherapeutic target in glioma cases.
Keywords
Glioma; meningioma; schwannoma; IL-17A; IL-6; serum;
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1 Benchetrit F, Ciree A, Vives V, et al (2002). Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism. Blood, 99, 2114-21.   DOI
2 Alvarez-Rodriguez L, Lopez-Hoyos M, Munoz-Cacho P, Martinez-Taboada VM (2012). Aging is associated with circulating cytokine dysregulation. Cell Immunol, 273, 124-32.   DOI   ScienceOn
3 Arima T, Natsume A, Hatano H, et al (2005). Intraventricular chordoid meningioma presenting with Castleman disease due to overproduction of interleukin-6. Case report. J Neurosurg, 102, 733-7.   DOI   ScienceOn
4 Bondy ML, Scheurer ME, Malmer B, et al (2008). Brain tumor epidemiology consortium. brain tumor epidemiology: consensus from the brain tumor epidemiology consortium. Cancer, 113, 1953-68.   DOI   ScienceOn
5 Damasceno M (2011). Bevacizumab for the first-line treatment of human epidermal growth factor receptor 2-negative advanced breast cancer. Curr Opin Oncol, 23, 3-9.   DOI   ScienceOn
6 Doroudchi M, Saidi M, Malekzadeh M, et al (2013). Elevated IL-17A levels in early stages of bladder cancer regardless of smoking status. Future Oncol, 992, 295-304.
7 Gridley DS, Loredo LN, Slater JD, et al (1998). Pilot evaluation of cytokine levels in patients undergoing radiotherapy for brain tumor. Cancer Detect Prev, 22, 20-9.   DOI
8 Gutierrez C, Schiff R (2011). HER2: biology, detection, and clinical implications. Arch Pathol Lab Med, 135, 55-62.
9 Kantelhardt SR, Caarls W, de Vries AH, et al (2010). Specific visualization of glioma cells in living low-grade tumor tissue. PLoS One, 5, 11323.   DOI   ScienceOn
10 Hu J, Mao Y, Li M, Lu Y (2011). The profile of Th17 subset in glioma. Int Immunopharmacol, 11, 1173-9.   DOI   ScienceOn
11 Jarnicki A, Putoczki T, Ernst M (2010). Stat3: linking inflammation to epithelial cancer- more than a "gut" feeling? Cell Div, 5, 14.   DOI   ScienceOn
12 Jiang Y, Uhrbom L (2012). On the origin of glioma. Ups J Med Sci, 117, 113-21.   DOI   ScienceOn
13 Kryczek I, Wei S, Zou L, et al (2007). Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol, 178, 6730-3.   DOI
14 Kujas M (1993). Meningioma. Curr Opin Neurol, 6, 882-7.   DOI
15 Mantovani A, Allavena P, Sica A, Balkwill F (2008). Cancerrelated inflammation. Nature, 454, 436-44.   DOI   ScienceOn
16 Kumar R, Kamdar D, Madden L, et al (2006). Th1/Th2 cytokine imbalance in meningioma, anaplastic astrocytoma and glioblastoma multiforme patients. Oncol Rep, 15, 1513-6.
17 Louis DN, Ohgaki H, Wiestler OD, et al (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol, 114, 97-109.   DOI
18 MacKenzie DJ (1926). A classification of the tumours of the glioma group on a histogenetic basis with a correlated study of prognosis. Can Med Assoc J, 16, 872.
19 Martin-Orozco N, Muranski P, Chung Y, et al (2009). T helper 17 cells promote cytotoxic T cell activation in tumor immunity. Immunity, 31, 787-98.   DOI   ScienceOn
20 Minniti G, Amichetti M, Enrici RM (2009). Radiotherapy and radiosurgery for benign skull base meningiomas. Radiat Oncol, 4, 42.   DOI   ScienceOn
21 Martin-Villalba A, Okuducu AF, von Deimling A (2008). The evolution of our understanding on glioma. Brain Pathol, 18, 455-63.   DOI   ScienceOn
22 Merlo A, Juretic A, Zuber M, et al (1993). Cytokine gene expression in primary brain tumours, metastases and meningiomas suggests specific transcription patterns. Eur J Cancer, 29, 2118-25.   DOI   ScienceOn
23 Michaud DS, Gallo V, Schlehofer B, et al (2010). Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiol Biomarkers Prev, 19, 2562-9.   DOI   ScienceOn
24 Miyahara Y, Odunsi K, Chen W, et al (2008). Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci USA, 105, 15505-10.   DOI   ScienceOn
25 Pfisterer WK, Hank NC, Preul MC, et al (2004). Diagnostic and prognostic significance of genetic regional heterogeneity in meningiomas. Neuro Oncol, 6, 290-9.   DOI   ScienceOn
26 Norden DA, Reardon AD, Wen YCP (2010). Primary central nervous system tumors: pathogenesis and therapy (Current Clinical Oncology). New York: Hummana: 2011 edition.
27 Numasaki M, Fukushi J, Ono M, et al (2003). Interleukin-17 promotes angiogenesis and tumor growth. Blood, 101, 2620-7.   DOI   ScienceOn
28 Park KJ, Kang SH, Chae YS, et al (2010). Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas. J Neurosurg, 112, 73-80.   DOI   ScienceOn
29 Pouratian N, Schiff D (2010). Management of low-grade glioma. Curr Neurol Neurosci Rep, 10, 224-31.   DOI   ScienceOn
30 Rittierodt M, Tschernig T, Samii M, et al (2001). Evidence of recurrent atypical meningioma with rhabdoid transformation and expression of pyrogenic cytokines in a child presenting with a marked acute-phase response: case report and review of the literature. J Neuroimmunol, 120, 129-37.   DOI   ScienceOn
31 Rahaman SO, Harbor PC, Chernova O, et al (2002). Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene, 21, 8404-13.   DOI   ScienceOn
32 Riemenschneider MJ, Jeuken JW, Wesseling P, Reifenberger G (2010). Molecular diagnostics of gliomas: state of the art. Acta Neuropathol, 120, 567-84.   DOI
33 Sato T, Sugiyama T, Kawataki T, et al (2010). Clear cell meningioma causing Castleman syndrome in a child. J Neurosurg Pediatr, 5, 622-5.   DOI   ScienceOn
34 Sreekanthreddy P, Srinivasan H, Kumar DM, et al (2010). Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis. Cancer Epidemiol Biomarkers Prev, 19, 1409-22.   DOI   ScienceOn
35 Sfanos KS, Bruno TC, Maris CH, et al (2008). Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res, 14, 3254-61.   DOI   ScienceOn
36 Sherry MM, Reeves A, Wu JK, Cochran BH (2009). STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells, 27, 2383-92.   DOI   ScienceOn
37 Sim M, Dawson B, Landers G, et al (2013). Effect of exercise modality and intensity on post-exercise interleukin-6 and hepcidin levels. Int J Sport Nutr Exerc Metab, 23, 178-86.   DOI
38 Wernicke AG, Dicker AP, Whiton M, et al (2010). Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma. Radiat Oncol, 5, 46.   DOI   ScienceOn
39 Tofaris GK, Patterson PH, Jessen KR, Mirsky R (2002). Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J Neurosci, 22, 6696-703.
40 Van Meir E, Sawamura Y, Diserens AC, et al (1990). Human glioblastoma cells release interleukin 6 in vivo and in vitro. Cancer Res, 50, 6683-8.
41 Wiemels J, Wrensch M, Claus EB (2010). Epidemiology and etiology of meningioma. J Neurooncol, 99, 307-14.   DOI
42 Zhang B, Rong G, Wei H, et al (2008). The prevalence of Th17 cells in patients with gastric cancer. Biochem Biophys Res Commun, 374, 533-7.   DOI   ScienceOn
43 Wang L, Yi T, Kortylewski M, et al (2009). IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med, 206, 1457-64.   DOI   ScienceOn
44 Zhang Y, Yu J, Qu L, Li Y (2012). Calcification of vestibular schwannoma: a case report and literature review. World J Surg Oncol, 10, 207.   DOI
45 Zhou J, Tryggestad E, Wen Z, et al (2011). Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med, 17, 130-4.   DOI   ScienceOn
46 Fong B, Barkhoudarian G, Pezeshkian P, et al (2011). The molecular biology and novel treatments of vestibular schwannomas. J Neurosurg, 115, 906-14.   DOI   ScienceOn
47 Lee HK, Seo IA, Suh DJ, et al (2009). Interleukin-6 is required for the early induction of glial fibrillary acidic protein in Schwann cells during Wallerian degeneration. J Neurochem, 108, 776-86.   DOI   ScienceOn
48 Reihmane D, Jurka A, Tretjakovs P, Dela F (2013). Increase in IL-6, TNF-$\alpha$, and MMP-9, but not sICAM-1 concentrations depends on exercise duration. Eur J Appl Physiol, 113, 851-8.   DOI   ScienceOn