• 치위생과학회지
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• 제15권1호
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• pp.60-66
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• 2015

본 연구는 제5기 국민건강영양조사 자료를 이용하여 65세 이상(4,521명) 노인을 대상으로 Andersen과 Davidson이 제안한 모델을 적용하여, 소인성 요인, 가능 요인, 필요 요인, 구강건강행태 요인과 치과의료이용의 관계를 파악한 후, 노인들의 치과의료이용에 영향을 미치는 요인을 분석하여 다음과 같은 결론을 얻었다. 소인성, 가능, 필요 요인과 틀니 필요여부에서는 소인성 요인에서 교육수준이 낮을수록, 가능 요인에서 소득수준이 낮을수록 틀니의 필요도가 높았으며, 통계적으로 유의미하고, 필요 요인에서 미충족 치과의료를 경험한 노인 중 39.89%, 저작 불편을 호소한 노인 중 67.79%가 틀니 장착을 필요로 하는 것으로 나타났으며, 통계적으로 유의미하였다. 노인의 치과의료이용 여부에 영향을 미치는 요인에서는 Model 1에서 여자가 남자에 비해 1.23배, 교육수준이 높을수록 치과의료이용이 높게 나타났으며, 성별과 결혼상태, 교육수준, 민간건강보험 가입여부에서 통계적으로 유의미하였다. Model 2는 Model 1에서 필요 요인을 보정한(adjusted) 결과 미충족 치과의료를 경험하지 않은 경우 1.35배, 저작 불편을 호소한 경우 1.34배 치과의료이용을 더하는 것으로 나타났으며, 성별, 연령, 결혼상태, 교육수준, 민간건강보험 가입여부, 미충족 치과의료, 저작 불편에서 통계적으로 유의미하였다. 구강건강상태를 포함한 Model 3은 연령, 미충족 치과의료경험, 저작 불편 호소여부에서 통계적으로 유의미하였다. 이상의 연구결과를 통해 소인성 요인과 가능요인, 필요 요인 등이 노인의 치과의료 이용에 영향을 주는 요인으로 드러났다. 노인에 치과의료 이용에 다양한 요인들이 함께 작용하기 때문에 노인의 치과의료 이용의 접근성을 개선함으로써 구강건강을 증진시키기 위해서는 다면적인 노력들이 필요할 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.3981-3986
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• 2014

Ganoderma lucidum polysaccharides (GLP) extracted from Ganoderma lucidum have been shown to induce cell death in some kinds of cancer cells. This study investigated the cytotoxic and apoptotic effect of GLP on HCT-116 human colon cancer cells and the molecular mechanisms involved. Cell proliferation, cell migration, lactate dehydrogenase (LDH) levels and intracellular free calcium levels ($[Ca^{2+}]i$) were determined by MTT, wound-healing, LDH release and fluorescence assays, respectively. Cell apoptosis was observed by scanning and transmission electron microscopy. For the mechanism studies, caspase-8 activation, and Fas and caspase-3 expression were evaluated. Treatment of HCT-116 cells with various concentrations of GLP (0.625-5 mg/mL) resulted in a significant decrease in cell viability (P< 0.01). This study showed that the antitumor activity of GLP was related to cell migration inhibition, cell morphology changes, intracellular $Ca^{2+}$ elevation and LDH release. Also, increase in the levels of caspase-8 activity was involved in GLP-induced apoptosis. Western blotting indicated that Fas and caspase-3 protein expression was up-regulated after exposure to GLP. This investigation demonstrated for the first time that GLP shows prominent anticancer activities against the HCT-116 human colon cancer cell line through triggering intracellular calcium release and the death receptor pathway.

• Journal of Preventive Medicine and Public Health
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• 제43권6호
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• pp.513-522
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• 2010

Objectives: The purpose of this study was to define the association between the medical utilization of osteoarthritis patient and its related factors. Methods: We used the 2005 Korean National Health and Nutrition Survey data and we enrolled 2833 participants who were forty or older and who were diagnosed as having osteoarthritis by a doctor within 1 year and who had suffered from osteoarthritis for more than 3 months. The Andersen behavioral model was used as the analytic framework, and the variables were categorized into predisposing, enabling, and need factors. To determine the influence of each variable on the medical utilization of osteoarthritis patient, we applied hierarchical logistic regression analysis with two stages: the first stage included the predisposing and enabling factors and the second stage included the need factors. Results: On the hierarchical logistic analysis, the variables of personal income, the type of medical security, the duration of arthritis related symptoms within 1 month, the subjective health status and the duration of osteoarthritis showed a statistically significant association with medical utilization in men. And the variables of age, limitation activity due to osteoarthritis, arthritis related symptoms within 1 month, and the subjective health status had a statistically significant association with medical utilization in women. Conclusions: The patients who tend to receive less care are those who suffer less from symptoms of osteoarthritis, those who are within the initial phase, or those with a low-level severity of osteoarthritis. It is necessary to encourage patients to receive the treatment in the initial phase.

• 한국환경과학회지
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• 제25권1호
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• pp.127-134
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• 2016

This study is conducted to get current state of data collection and utilization of the trees damaged by pine wilt disease, and to efficiently collect and utilize of the trees damaged by the pine wilt disease and abandoned fumigation-treated trees at forecasts. The method to control pine wilt disease damaged area is mostly fumigation treatment system, and there is no collection and utilization of damaged trees because of absence of efficient collection system, lack of collection cost, and absence of policy, etc. A survey is conducted that asked about the satisfaction degree for the trees damaged by pine wilt disease collection and use divided into 6 topics. It was positively recognized that the need and problem of the trees damaged by pine wilt disease, and results and satisfaction of forestry mechanization while it was mostly negatively recognized that the policy satisfaction for prevention and collection, satisfaction of collection and use, collection and forestry mechanization, and satisfaction of foundation equipment for forestry mechanization, etc. As a result of path analysis, it is necessary to promote a high-tech forestry mechanization to improve satisfaction level of results and satisfaction of forestry mechanization for the trees damaged by pine wilt disease collection and utilization, it is also need to make an effort in various ways for improve satisfaction level of satisfaction of collection and utilization.

• 한국병원경영학회지
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• 제5권2호
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• pp.22-39
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• 2000

The purpose of this study was to determine the difference between estimated profit and utilization of medical equipment upon purchasing and actual results at one teaching hospital in Seoul, Korea Medical equipments over $100,000 from 1992 to 1997 were selected and results were as follows: 1. Twenty equipments out of thirty exceeded estimated profits and the difference was 3.98 billion won and ten equipments did not reach the estimated profits and 5.5 billion won was the difference. Diagnostic equipment exceeded the estimated profit which surgical equipment didn't. 2. Eleven equipments exceeded estimated utilization, which showed 100%. In the mean time, eighteen equipments didn't reach the estimated utilization, which was 71%. Diagnostic equipment showed the less estimated utilization than surgical equipment 3. Twenty-one equipments showed the 6.83 billion won profits and nine equipments showed the 1.6 billion won deficits. Diagnostic equipment was more profitable than surgical equipment. Finally. diagnostic equipment helped improving hospital management than surgical equipment. 4. Main factors which showed the big difference from the initial plan were lacking reasonable estimated method, no evaluation system for purchase, emphasis in medical treatment, excessive expenditure in maintenance, duplicated investment for medical equipment and leadership commitment. As a result. Substantial planning is required from the requesting department in consideration of estimated profit and utilization and systematic quality control is needed to confirm. Also, One-sided decision making should be avoided to purchase a high cost medical equipment and efforts should be made in examining carefully and developing a reasonable analytic method.

• Journal of Preventive Medicine and Public Health
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• 제34권1호
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• pp.28-34
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• 2001

Objectives : To investigate the changing pattern of medical utilization claims following the economic crisis in Korea. Methods : The original data consisted of the claims of the 'Medical insurance program of self-employees' between 1997 and 1998. The data was selected by medical treatment day ranging between 8 January and 30 June. Medical utilizations were calculated each year by the frequency of claims, visit days for outpatients, length of stay for inpatients, total days of medication, and the sum of expenses. Results : The length of stay as an inpatient in 1998 was decreased 4.7 percent in comparison to 1997. However, inpatient expenses in 1998 increased 10.8 percent as compared to 1997. Inpatient hospital claims in 1998 increased 6.2 percent over 1997, although general hospital inpatient claims in 1998 decreased 3.3 percent in comparison to 1997. The outpatient claim frequency decreased 7.3 in 1998 percent as compared to 1997 Outpatient visit days of in 1998 were decreased 8.5 percent in comparison to that recorded in 1997. Outpatient claim frequencies of 'gu region' in 1998 decreased 10.5 percent comparison to that in 1997, but 'city and gun region' decreased less than 'gu region'. Conclusions : Medical utilization in 1998 deceased in relation to 1997 Medical utilization by outpatients decreased more than that of inpatients. Medical utilization by 'gu region' decreased mere than the other regions.

• Journal of Microbiology and Biotechnology
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• 제30권10호
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• pp.1458-1466
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• 2020

Oligomeric proanthocyanidins (OPCs), classified as condensed tannins, have significant antioxidation, anti-inflammation and anti-cancer effects. This study was performed to investigate the anti-inflammatory effects of OPCs and the mechanism underlying these effects in lipopolysaccharide (LPS)-stimulated bovine mammary epithelial cells (MAC-T). Real-time PCR and ELISA assays indicated that OPC treatment at 1, 3 and 5 ㎍/ml significantly reduced the mRNA and protein, respectively, of oxidant indicators cyclooxygenase-2 (COX-2) (p < 0.05) and inducible nitric oxide synthase (iNOS) (p < 0.01) as well as inflammation cytokines interleukin (IL)-6 (p < 0.01), IL-1β (p < 0.01) and tumor necrosis factor-α (TNF-α) (p < 0.05) in LPS-induced MAC-T cells. Moreover, OPCs downregulated LPS-induced phosphorylation of p65 and inhibitor of nuclear factor kappa B (NF-κB) (IκB) in the NF-κB signaling pathway (p < 0.01), and they inhibited p65 translocation from the cytoplasm to the nucleus as revealed by immunofluorescence test and western blot. Additionally, OPCs decreased phosphorylation of p38, extracellular signal regulated kinase and c-jun NH₂-terminal kinase in the MAPK signaling pathway (p < 0.01). In conclusion, the anti-inflammatory and antioxidant activities of OPCs involve NF-κB and MAPK signaling pathways, thus inhibiting expression of pro-inflammatory factors and oxidation indicators. These findings provide novel experimental evidence for the further practical application of OPCs in prevention and treatment of bovine mastitis.

• Asian-Australasian Journal of Animal Sciences
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• 제12권4호
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• pp.597-603
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• 1999

Even though the development of livestock industry in Asia and Australasia has brought the economic growth and thus elevated the living standard in these areas, it has also brought the pollution caused by the increasing amount of animal wastes. Among them, Japan probably is the first country that suffered from the animal waste pollution as early as in 1970s. Nowadays, the animal waste pollution has been a common problem for almost every countries in this region. To solve it, different measures and regulations have been implemented in many countries. In this paper, different methods for animal waste disposal are discussed, including: manure-bed animal housing, composting, anaerobic treatment, odor control, utilization of biogas, aerobic treatment, three-step process, N and P removal, land application, cultivation of algae, anaerobic treatment of dead animals. It is hoped that an animal industry without pollution can be achieved in the future.

• 셀메드
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• 제2권3호
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• pp.25.1-25.6
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• 2012

The aim of the present study was to evaluate the possible roles of hyperforin against hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/kg). Biochemical parameters were measured following hyperforin treatment (10 mg/kg, i.p.) for 7 days. Hyperforin treatment significantly reversed the elevations in plasma glucose, triglycerides, total cholesterol and LDL-cholesterol. Hyperforin also reversed the declines in plasma HDL-cholesterol and liver glycogen, but did not reverse the change in plasma insulin levels when compared to the diabetic control rats. Hyperforin treatment also reversed the oxidative stress induced by streptozotocin. Moreover, the effect of the hyperforin on peripheral glucose utilization in normal rats was evaluated by an oral glucose tolerance test (OGTT). Hyperforin treatment significantly increased (p < 0.05) the glucose tolerance compared to the vehicle in OGTT. The antihyperglycemic, antihyperlipidemic and antioxidant activities of hyperforin (10 mg/kg, i.p.) were comparable qualitatively to glibenclamide (1 mg/kg, p.o.). In conclusion, we report for the first time through an in vivo study that hyperforin is potentially valuable for the treatment of diabetes and its associated hyperlipidemia and oxidative stress by enhancing the glucose utilization by peripheral tissues such as muscle and adipose tissues.

• 한국초지조사료학회지
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• 제18권3호
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• pp.251-258
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• 1998

To find out the effect of NPK-fertilization level and utilization method of pasture plants on the productivity of dry matter and nutrient of forages in hilly pasture, this experiment was arranged as a split block design with six treatments of 2 mainplots(N-$P_2O_5$-$K_2O$=210-150-180(wntrol), 280-200-240Kg/ha) and 3 subplots (cutting, grazing cutting+grazing alternative), and conducted at hilly land in Yeoju, Kyonggi Province 6om February, 1992 to October, 1993. In the treatment of grazing the early growth and cover degree of pasture plants wintered were more favorable. With increased NPK-application for two years, the average dry matter(DM) yield of 9,862kglha was incerased by 18% than that of the control, and the average DM yield of the cutting treatment of 10,434kaa was higher than that of others. In all treatments for two years, the average DM yield was composed of 94.0~95.1% grasses, 1.8~2.0% legumes and 2.8~4.2% weeds. The crude protein and energy productivity of forages in the treatment with increased NPK-fertilizer application increased by 20~23% than those of control, and those of cutting treatment were greatly increased than those of the grazing treatment. The average mineral content of forages in all treatments tended to be similar, Ca and Mg content and Ca/P ratio were slightly lower, and K content and K/(Ca+Mg) equivalent ratio of forages tended to be higher than the most desirable value of forages.