• Medical Lasers
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• 제9권1호
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• pp.12-24
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• 2020

Human fibroblast-derived multi-peptide factors (MPFs) have been used during treatments with energy-delivering modalities to enhance energy-induced tissue reactions. Human fibroblast-derived MPFs, which include a range of growth factors and chemoattractive factors, activate and recruit fibroblasts and endothelial cells, as well as promote extracellular matrix deposition, all of which are crucial to wound repair. Interestingly, fibroblasts from different species or anatomical sites exhibit distinct transcriptional properties with high heterogeneity. In addition, the patterns of MPF secretion can differ under a range of experimental conditions. Therefore, the use of allogeneic fibroblasts and proper cultivation thereof are necessary to obtain MPFs that can enhance the epithelial-mesenchymal interactions during wound repair. Moreover, energy-delivering devices should be selected according to evidence demonstrating their therapeutic efficacy and safety on a pathological skin condition and the major target skin layers. This paper reviewed the histologic patterns of post-treatment tissue reactions elicited by several energy sources, including non-ablative and ablative fractional lasers, intense focused ultrasound, non-invasive and invasive radiofrequency, picosecond-domain lasers, and argon and nitrogen plasma. The possible role of the immediate application of human fibroblast-derived MPFs during wound repair was proposed.

• 한국임상약학회지
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• 제32권3호
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• pp.226-237
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• 2022

Background: Monoclonal antibodies for the treatment of patients with different types of cancer, such as cetuximab, have been widely used for the past 10 years in oncology. Although drug information package insert contains some representative adverse events which were observed in the clinical trials for drug approval, the overall adverse event patterns on the real-world cetuximab use were less investigated. Also, there have been no published papers that deal with the full spectrums of adverse drug events of cetuximab using national-wide drug safety surveillance systems. Methods: In this study, we detected new adverse event signals of cetuximab in the Korea Adverse Event Reporting System (KAERS) by utilizing proportional reporting ratios, reporting odds ratios, and information components indices. Results: The KAERS database included 869,819 spontaneous adverse event reports, among which 2,116 reports contained cetuximab. We compared the labels of cetuximab among the United States, European Union, Australia, Japan, and Korea to compare the current labeling information and newly detected signals of our study. Some of the signals including hyperkeratosis, tenesmus, folliculitis, esophagitis, neuralgia, disseminated intravascular coagulopathy, and skin/throat tightness were not labeled in the five countries. Conclusion: We identified new signals that were not known at the time of market approval.

• 비만대사연구학술지
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• 제2권1호
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• pp.6-10
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• 2023

Compensatory changes in energy consumption and neuro-hormonal changes following weight loss make it difficult to maintain the reduced weight and may cause weight regain. Therefore, establishing a long-term weight control plan and strategy starting from the initial weight loss period is necessary. Both the patient and doctor should know that weight loss cannot occur continuously, and that maintaining weight after the weight loss period is the basic course of obesity treatment. No single dietary pattern is effective for weight maintenance, and a variety of dietary control methods - such as calorie restriction and healthy proportions of carbohydrates, proteins, fats, and meal replacements - should be used to target an integrated and healthy dietary habit. An increase in physical activity is needed for weight loss and maintenance; however, rather than recommending an excessive amount of exercise, it is better to set realistic and long-term achievable goals. It is necessary to reset the goal according to the patient's weight maintenance stage and continuously apply behavioral therapies, such as self-monitoring and stress management. In previous studies, since the degree of weight loss and changes in behavioral patterns over the course of one year were important factors in maintaining long-term weight loss, obesity therapists should closely examine patient data and behavioral patterns across a period of one year and actively intervene when needed.

• 한국식생활문화학회지
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• 제5권2호
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• pp.235-241
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• 1990

두릅나무 Aralia elata순의 saponin을 분리하여 조사한 결과는 다음과 같다. 1. Saponin의 함량과 종류는 자연산이 온상산보다 많고, 가열에 의해서는 모두 감소하였으며, 잎이 자랄수록 그 함량은 증가하였다. 자연산 날것 식용적기(Nr2)의 총 saponin 종류는 37개였다. 2. 자연산의 saponin 패턴은 생육시기에 따라 변하였으며 날것 식용적기(Nr2)가 다른 것에 비해서 크게 달랐다. 그러나 가열 처리한 결과는 saponin 패턴이 변화되어 시기적 차가 줄었다. 온상산은 자연산에 비해 피크가 단순하고 시기별 차이는 적었지만 가열에 의한 패턴의 차도 적었다. 3. 자연산 날것 식용적기는 ‘b’ saponin이 특이하게 많았고 나머지에서는 ‘d’ saponin이 가장 많았다.

• 대한의용생체공학회:의공학회지
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• 제33권2호
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• pp.78-88
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• 2012

Knee joint instability by anterior cruciate ligament(ACL) rupture is allowing the abnormal loading condition at the tibial epiphysis locally, resulting in producing locally different bone bruise. The study examined difference between local alteration patterns of trabecular bone microarchitecture at medial and lateral parts of the tibial epiphysis by ACL rupture. Fourteen SD rats were divided into Control(CON; n = 7) and Anterior Cruciate Ligament Transection(ACLT; n = 7) groups. The tibial joints were then scanned by in vivo ${\mu}$-CT at 0, 4, and 8 weeks post-surgery. The results showed that alteration pattern on trabecular bone microarchitecture at medial part was significantly higher than that at lateral part of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). Tb.Th and Tb.Sp distributions were well corresponded with differences between aforementioned trabecular bone microarchitectural alteration pattens at medial and lateral parts of the tibial epiphysis in ACLT group from 0 to 8 weeks(P < 0.05). These findings suggest that the alteration patterns of trabecular bone microarchitecture should be locally and periodically considered, particularly with respect to the prediction of bone fracture risk by ACL rupture. Improved understanding of the alteration patterns at medial and lateral trabecular bone microarchitectures at the tibial epiphysis may assist in developing more targeted treatment interventions for knee joint instability secondary to ACL rupture.

• 한국운동역학회지
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• 제13권3호
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• pp.163-180
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• 2003

This paper aims at collecting the guantitative data of kenematic variables by analysing the gait patterns of the normal adult men and the handicapped. The gait motions were taped with 4 video cameras, the cinematographic analyses were performed by the DLT technique of three dimensional image treatment. The following results were obtained in the analysis of the variables: 1. The ratio of stance time and swing time did not show any significant difference in the groups of the normal men and the handicapped when both foot of the former and the right feet of the latter were compared. The stride peeriod time of these two groups were 1.12 and 1.11 second, respectively. 2. In the handicapped group, the step width was wider, the step length and stride length were shorter, and especially, the step length of the right foot was shorter, 3. The small vertical displacement of left toes of the handicapped group showed that the heal contact and the left midstance are almost simultaneous. 4. The two groups have almost the same horizontal displacement of the center of gravity and the same vertical rate of extension. In view of the velocity of the center of gravity the normal adults showed the constant speed of movement. However, the handicapped adults were reduced from the right midstance to the right toe-off. 5. The handicapped showed prominently low angle on the left toe-off in the ankle joint angle, they also had the tendency to walk in the patterns of extended knee in the knee joint angle. Both the handicapped and the normal had the hyperextension on the toe-off in the hip joint angle. In the back and front angle of body, both showed the slightly back-sided walking positions. 6. Both groups had the abduction of both feet in foot placement angle, but the handicapped did not show serious abduction of left midstance.

• 대한한의학회지
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• 제40권4호
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• pp.29-40
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• 2019

Objectives: To analyze the prescription frequency of various herbs as either individual or major herbs (in terms of dosage) and their usage patterns in the treatment of different diseases for standardization of traditional Korean medicine. Methods: We analyzed the prescription database of patients at the Pusan National University Korean Medicine Hospital from the date of establishment of the hospital to February 2013. The complete prescription data were extracted from the electronic medical records of patients, and the prescription frequencies of individual herbs, particularly, of major herbs, were analyzed in terms of gender, age, and international classification of diseases (ICD) code. Results: The prescription frequency of individual herbs based on age and gender showed a similar pattern. Herbal mixtures were also distributed in a similar manner. The use of some herbs differed according to age and gender (Table 1.). The herbs that were used at high frequencies for a given ICD code had similar usage patterns in different categories. However, some major herbs in the "Jun (King)" category were used uniquely for a given ICD code (Table 2.). There was significant difference between male and female on ICD code E and N, but the other ICD codes had small differences. The ratio of herbal medicine by gender showed different usage patterns in each gender. Conclusions: The findings of our study provide fundamental data that reflect the real clinical conditions in South Korea, and therefore, can contribute to the standardization of TKM.

• Nutrition Research and Practice
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• 제7권2호
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• pp.139-145
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• 2013

There is a lack of data on metabolic risk factors during pre-puberty, which is important for identifying the subgroups of youth, at whom early interventions should be targeted. In this study, we evaluated the prevalence of metabolic risk factors and its subsequent relations with dietary patterns in Korean pre-pubertal children through a cross-sectional sample (n = 1,008; boys = 513) of pre-pubertal children (aged 8-9 years) from a sub-study of the Korea Metabolic Syndrome Research Initiatives (KMSRI) in Seoul, Korea. Measures of anthropometry and blood pressure as well as fasting blood samples were used in the analysis. A three-day food records were collected. The metabolic syndrome was defined according to the age-adjusted National Cholesterol Education Program Adult Treatment Panel III guidelines. An added metabolic risk score was calculated for each subject by summing the quintile values of the five individual risk factors. Among the 5 risk components of metabolic syndrome, high waist circumference (WC) was the major factor (P < 0.001). A significant increasing trend of the added metabolic syndrome risk score was observed with the increase of WC (P (trend) < 0.001) among both genders. The cutoff point for high WC for pre-pubertal children was 61.3 cm for boys and 59.9 cm for girls. The prevalence of high triglyceride (TG) values was significantly higher in girls than it was in boys (P < 0.01). Girls in the highest quintile of balanced dietary pattern scores had lower TG values (P (trend) = 0.032) than did those in the lowest quintile. Moreover, girls in the highest quintile of western dietary pattern scores showed increasing trend for the added metabolic risk score (P (trend) = 0.026) compared with those in the lowest quintile. Adverse associations exist between western dietary patterns and the accumulation of metabolic risks among girls, not in boys, even during pre-puberty.

• 한국정보과학회논문지:소프트웨어및응용
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• 제35권3호
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• pp.169-178
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• 2008

암환자들은 암의 진행과 항암화학요법 등의 치료로 인해 심신의 불안정과 항상성의 저하로 큰 고통을 겪고 있다. 간편하면서 인체에 아무 해를 주지 않는 뇌파를 기반으로 하는 뇌-컴퓨터-인터페이스(BCI) 기술로서 암 환자의 상태를 모니터링하여 적절한 처치를 취할 수 있다는 것은 매우 중요한 일이다. 암환자들의 전전두엽에 헤드밴드 형태의 건성전극단자를 부착하고, 컴퓨터와 연결된 휴대용 뇌파측정 장치로 전전두엽 뇌파(Fp1, Fp2)를 측정하였다. 컴퓨터를 통하여 파장대 별로 얻어진 뇌파를 상호 연관성에 따라 뇌지수로 구분한 후 통계 처리하여 유의성을 검증하였다. 암환자군과 정상대조군을 비교한 결과 암환자군에 비하여 정상대조군이 기초율동지수, 주의지수, 정서지수, 항스트레지수와 좌우뇌균형지수에서 유의하게 높은 차이를 나타냈다. 따라서 뇌파 측정이 환자의 상태를 모니터링하는 중요한 도구로서의 가능성을 보였다.

• 대한감각통합치료학회지
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• 제14권2호
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• pp.22-32
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• 2016

목적 : 본 연구는 대학생에서 감각처리유형과 우울, 불안과의 상관관계를 알아보고자 하였다. 연구방법 : 연구기간은 2016년 10월 10일부터 10월 29일까지로 174명의 대학생에게 설문조사를 실시하였다. 설문조사의 내용은 개인적 특징, 청소년/성인감각프로파일, Beck 우울척도 2판, Beck 불안척도로 구성하였다. 통계처리는 SPSS version 22.0을 사용하여 기술통계, 교차분석, Pearson상관분석을 하였다. 결과 : 감각처리유형 중 낮은등록, 감각민감, 감각회피는 우울과 양의 상관관계를 보였다. 불안은 모든 감각처리유형과 관련성이 있었다. 결론 : 본 연구 결과를 바탕으로 대학생과 함께 생활하는 부모, 교수, 그리고 보건의료분야의 전문가들은 감각처리와 감정과의 관련성을 고려하여 지도 및 교육, 치료프로그램을 계획할 필요가 있다.