• The Journal of Korean Medical History
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• v.35 no.2
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• pp.45-67
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• 2022

Currently, there are about 20,000 or so known ancient medical texts from the East Asian medical traditions. Although the most famous texts are widely known, many texts still exist only as original manuscripts. We are interested exploring these texts to uncover the potential benefits of their therapeutic knowledge. This study aims to develop a database program that automatically converts the treatment skills described in the text version into a more structured version. In the previous study, our team analyzed patterns in the way that treatment skills are described and then tried to design a database program algorithm that identified every meaningful keyword used to describe treatment skills and put that word in the right cell of a structured table. This study continues the development of this program. East Asian medical herbal treatment information is broken down into 4 elements: the first one is the name or title of treatment skills, and the second is the symptoms to which the treatment is applied, the third is ingredients used, the fourth is how information is processed and the indications taken. This study presents the algorithm's principles on how to analyze and structure the fourth element, the processing of information and taking of indications, which is described in a form of ancient natural language.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.3
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• pp.180-190
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• 2014

Background and Objective : Atopic dermatitis is a type of dermatitis, an inflammatory, relapsing, non-contagious and itchy skin disorder and affecting up to 30% of children in the Korea. In this study, Huini-san, which is mentioned in Shanghanlun(傷寒論), and acupunture treatment on Atopic Disease was investigated. Methods : We have classified the patients according to the Shanghanlun six meridian patterns diagnostic system and the patients are treated with Huini-san. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Results : After the treatment the SCORAD index and VAS of 2 patients dicreased significantly. Conclusions : Huini-san and acupunture treatment has improved the symptoms of Atopic dermatitis in this study.

• The Journal of the Korean dental association
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• v.50 no.2
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• pp.64-71
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• 2012

Recently, the presurgical orthodontic duration tends to be shortened by virtue of the advancement of surgical and orthodontic techniques in class III orthognathic surgery cases. But the predictability of the surgical results should be secured by removing several uncertain factors in presurgical orthodontic treatment. The purpose of this study is to investigate the influence of immediate postsurgical occlusal stability on postsurgical mandibular change. The study includes 40 patients who underwent orthognathic surgery to correct skeletal class III malocclusion. The patients were divided into two groups based on the numbers of occlusal contact in surgical setup occlusion: group 1 (stable surgical occlusion, n=24) and group 2(unstable surgical occlusion, n=16). Changes of horizontal and vertical mandibular measurements during postsurgical follow up period(from 1 week postsurgery to 12month after debonding) were compared to examine the differences between two groups. The stability of surgical occlusion is one of the factors influencing postsurgical mandibular changes in class III malocclusion. The various class III malocclusion cases have specific prerequisites for the orthognathic surgery according to the skeletal patterns. The prerequisites should be obtained by minimum presurgical orthodontics to increase the predictability of the surgical results.

• Journal of Korean Academy of Nursing
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• v.36 no.1
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• pp.136-143
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• 2006

Purpose: The purpose of this study was to explore the effects of the lavender fragrance on sleep and depression in women college students, Method: Forty-two women college students who complained of insomnia were studied during a four-weekprotocol( control treatment week, $60\%$ lavender fragrance treatment week, washout week, $100\%$ lavender fragrance treatment week), All subjects were in the department of nursing in 'K' college and the study was a single blind repeated measurements experiment For the duration of the study, weekly evaluations of sleep, patterns of sleep disturbance, severity of insomnia scale, self satisfaction with sleep, and severity of depression were performed. Result: Among sleep variables, length of time taken to fall asleep, severity of insomnia, and self satisfaction with sleep were improved for the $60\%$(p=.000, p=.000, p=.000) and $100\%$(p=.000, p=.000, p=.000) week while the severity of depression was improved only for the $100\%$(p=.002)week. Conclusion: According to the study results, it can be concluded that the lavender fragrance had a beneficial effect on insomnia and depression in women college students. Repeated studies are needed to confirm effective proportions of lavender oil and carrier oil for insomnia and depression.

• Journal of Korean Academy of Nursing
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• v.33 no.3
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• pp.321-330
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• 2003

Purpose: This was to describe the emotions that patients face when diagnosed with cancer to know the problems and coping styles that cancer patients experience during the treatment. Method: The qualitative method was used for this study. The participants were 90 cancer patients at five general hospital in Pusan, Korea. Data were collected by interviews with a semi-structured questionnaire from November 2000 to June 2001, and were analyzed using the modified constant comparative method. Result: The most common emotions on the diagnosis of cancer were shock(36.7%), followed by despair(25.6%), acceptance(24.4%), denial(l8.9%), complaint(16.7%), and fear(8.9%). The problems identified were the unpleasantness and physical discomfort related with the treatment(50.0%), the feelings of burden(41.1%), finance/occupation(38.8%), and fear of the future(26.6%). Coping styles to problems that the subjects have faced on the course of the treatment were compliance(36.6%), health care(31.l %), positive thinking(22.2%), despair/avoidance( 15.5%), seeking social support( 6.6%), information seeking(3.3%) and self-control(2.2%). Conclusion: It is very important to develop nursing interventions which can mitigate shock that patients experience, can help cancer patients to have hope for the future and to positively cope with cancer.

• Journal of Dental Rehabilitation and Applied Science
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• v.22 no.4
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• pp.271-281
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• 2006

Long term prediction of surgical result of skeletal class III has not been evaluated adequately because the stability of orthognathic surgery would be affected by not only set back amount of mandible but also many other factors like skeletal pattern, hyoid position, and airway size. The aimof this study is to discriminate the factors which affect the stability of post-treatment result of surgical outcome of sagittal split ramus osteotomy. We have collected 37 patients (male: 17, female: 20) from patients who have been treated at Orthodontic Department in Dankook University. The patients underwent 3 times Cephalometric X-ray taking at pre-, post-orthognathic surgery and after 12 months retention. The subjects were divided into 2 groups (Stable group: 21, Relapse group: 16) according to their relapse amount. We have taken following results from Students t-test and discriminant analysis. The discriminant factors which discern relapse and stable groupe among treatment change variables were BX and Ba-HY. Hyoid bone moved to posterior and inferior position due to surgery and repositioned superiorly and posteriorly during retention period. Skeletal patterns of the relapse group are smaller mandibular plane angle, anterior mandibular position, and greater distance from hyoid bone to cervical bone and mandible respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.6
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• pp.1927-1932
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• 2004

This research study has been conducted to identify and evaluate the effectiveness of Sanjoin-Tang(酸棗仁湯) for insomnia relief. The clinical testing of Sanjoin-Tang(酸棗仁湯) was carried out at Oriental Medical Center of Dong-Eui University with the participation of 30 patients. The results of Sanjoin-Tang(酸棗仁湯) treatments show as follows: Change of total amount of sleep showed 1.75±2.23 hours of increase.(p-value=0.001, respectively) Change of average delaying bedtime before and after the treatment showed 1.57±2.50 hours of decrease.(p-value=0.001, respectively) Change of average bedtime arousal before and after the treatment showed 0.96±1.46 times of decrease. (p-value=0.004, respectively) Change of sleep quality after the treatment has improved. According to statistical results, Sanjoin-Tang(酸棗仁湯) has proven effective for reducing sleep disorders, and this, restoring normal sleep patterns.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.1
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• pp.122-128
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• 2008

An word relay game contributes to rehabilitation and treatment of language disorders such as aphasia. As a computer is better than human in memorizing very large vocabularies, the computer has much advantage over people in word relay game. Such the game result in decrease the motivation of players and patients in treatment of language disorders. To make people to continue word relay and to be effective to remedy language disorders, the game need to be intelligent and familar with a person. This paper proposes an implementation of intelligent Korean word relay game, which considers characteristics of Korean word usage patterns. The gaem is intelligent in constructing vocabulary database and choosing an answer considering the level of player.

• International Journal of Industrial Entomology and Biomaterials
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• v.37 no.1
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• pp.29-32
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• 2018

Silkworm powder's thermal property is an important factor for its storage and marketing. This study examined the effect of edible enzyme on the thermal property of silkworm powder using Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). Results of the TGA showed that regardless of the enzyme treatment, the weight loss patterns of silkworm powders exhibited 3 step thermal property deterioration at approximately $80^{\circ}C$, $280^{\circ}C$, and $480^{\circ}C$ due to water evaporation and thermal degradation. This is similar with the DSC which also resulted in all samples two endothermic peaks attributed also to water evaporation and thermal degradation. These results indicated that the use of enzyme such as protease and cellulase might not affect significantly the thermal properties of silkworm powder.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1571-1576
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• 2016

Alteration of the acetylation status of chromatin and other non-histone proteins by HDAC inhibitors has evolved as an excellent epigenetic strategy in treatment of cancers. The present study was sought to identify compounds with positive pharmacological profiles targeting HDAC1. Analogues of Vorinostat synthesized by Cai et al, 2015 formed the test compounds for the present pharmacological evaluation. Hydroxamte analogue 6H showed superior pharmacological profile in comparison to all the compounds in the analogue dataset owing to its better electrostatic interactions and hydrogen bonding patterns. In order to identify compounds with even better high affinity and pharmacological profile than 6H and Vorinostat, virtual screening was performed. A total of 83 compounds similar to Vorinostat and 154 compounds akin to analogue 6H were retrieved. SCHEMBL15675695 (PubCid: 15739209) and AKOS019005527 (PubCid: 80442147) similar to Vorinostat and 6H, were the best docked compounds among the virtually screened compounds. However, in spite of having good affinity, none of the virtually screened compounds had better affinity than that of 6H. In addition SCHEMBL15675695 was predicted to be a carcinogen while AKOS019005527 is Ames toxic. From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report Vorinostat hydroxamate analogue 6H to be a potential candidate for HDAC inhibition in treatment of cancers through an epigenetic strategy.