• Journal of applied mathematics & informatics
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• 제28권5_6호
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• pp.1073-1088
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• 2010

In this article we want to formulate a disease transmission model, MSEIR model, for a population with individuals travelling between patches i and i + 1 and we derive an explicit formula for the basic reproductive number, $R_0$, employing the spectral radius of the next generation operator. Also, in this article we show that a system of ordinary differential equations for this model has a unique disease-free equilibrium and it is locally asymptotically stable if $R_0$ < 1 and unstable if $R_0$ > 1.

• Journal of Preventive Medicine and Public Health
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• 제42권6호
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• pp.408-415
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• 2009

Objectives : This study was performed to investigate the mumps transmission control status and inapparent infection rate among middle and high school students in Daegu City during a mumps outbreak. Methods : Nine schools (two middle schools and seven high schools), which reported a number of mumps cases between 2007 and 2008 were selected for investigation. During March-May 2008, a standard questionnaire was distributed to gather information about case identification, instructed isolation measure, isolation status of mumps cases and related factors, and outdoor activities of nonisolated mumps case. Inapparent infection rate was estimated by serum mumps IgM and IgG antibodies status and self-reported mumps symptoms in three of the nine schools. Results : Among 2,560 respondents, more than half of students answered that they did not receive instructions in mumps transmission control measures during the outbreak. Among the 327 mumps cases identified by the questionnaire, 131 cases (40.1%) were considered as isolated and the isolation rates were significantly different among schools, grades, and gender. Of the non-isolated cases, 88.3% continued attending school. Inapparent mumps infection rates were between 56.3% and 70.2%. Conclusions : Mumps transmission control was inadequate to control the mumps outbreak. Although high inapparent infection rate would mitigate the transmission control effect of case isolation, this measure is fundamental for infection control. The reasons of this inadequate status need to be explored to develop an effective intervention strategy.

• Journal of the Korean Data and Information Science Society
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• 제26권1호
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• pp.161-168
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• 2015

전염병은 기초 감염 재생산 수가 시간에 따라 달라져서 상황을 관리하기 어렵기 때문에 확산을 통제하기 어려울 뿐 아니라 정확한 예측은 더욱 어렵다고 알려져 있다. 최근에 많은 모형들이 새롭게 제시되고 있으며 그에 따라 현저하게 다른 결과가 도출되고 있다. 연속된 시간에서 기초 감염 재생산 수는 일반적으로 확률과정이론이 적용되고 있다. 본 논문에서는 에볼라 바이러스 전염병 모형에서 전염확률분포의 추정 방법을 제시하였다. 이 방법은 대규모 전염병 발생에서 실시간 추정을 가능하게 함으로 적절한 질병관리를 용이하게 한다. 기니에서 발생한 에볼라 바이러스 자료를 제시한 방법으로 분석하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제10권1호
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• pp.31-38
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• 2006

Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several receptors. Employing whole-cell patch clamp techniques in rat brain slice, we studied the effects of fluoxetine on corticostriatal synaptic transmission by measuring the change in spontaneous excitatory postsynaptic currents (sEPSC). Acute treatment of rat brain slice with fluoxetine ($10{\mu}M$) significantly decreased the amplitude of sEPSC ($8.1{\pm}3.3$%, n=7), but did not alter its frequency ($99.1{\pm}4.7$%, n=7). Serotonin ($10{\mu}M$) also significantly decreased the amplitude ($81.2{\pm}3.9$%, n=4) of sEPSC, but did not affect its frequency ($105.8{\pm}8.0$, n=4). The effect of fluoxetine was found to have the same trend as that of serotonin. We also found that the inhibitory effect of fluoxetine on sEPSC amplitude ($93.0{\pm}1.9$%, n=8) was significantly blocked, but not serotonin ($84.3{\pm}1.6$%, n=4), when the brain slice was incubated with p-chloroamphetamine ($10{\mu}M$), which depletes serotonin from the axon terminals and blocks its reuptake. These results suggest that fluoxetine inhibits corticostriatal synaptic transmission through postsynaptic, and that these effects are exerted through both serotonin dependent and independent mechanism.

• 급식외식위생학회지
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• 제1권1호
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• pp.37-44
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• 2020

The virus isolated from patients with severe pneumonia of unknown etiology in Wuhan City, Hubei province in China was termed SARS-CoV-2 and the World Health Organization (WHO) named the disease caused by this virus as coronavirus disease 2019 (COVID-19). The COVID-19 infection has spread rapidly and become a pandemic. In July 2020, there were 13.25 million infected patients and over 570,000 deaths worldwide, and 13,711 infected patients and 294 deaths were reported in South Korea. Since the primary mode of transmission of COVID-19 is through respiratory droplets, the importance of preventive measures, including social distancing, has become important in daily life. In response to the continuous spread of COVID-19, this study developed three guidelines for preventing COVID-19 for the food service industry including childcare centers, institutional foodservices and restaurants by the integration of the manual of controlling foodborne illness. These are included the COVID-19 prevention action methods for food deliverers, for food service administrator, for foodservice works and for customers. All guidelines were designed for easy understanding using illustrations and have been systematically explained subject wise. Thus, these COVID-19 prevention guidelines can be appropriately applied depending on the specific situation and workplace. In addition, they are worthy as educational materials that contribute to the food safety.

• Parasites, Hosts and Diseases
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• 제54권5호
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• pp.585-590
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• 2016

Paleopathologists have begun exploring the pathoecology of parasitic diseases in relation to diet and environment. We are summarizing the parasitological findings from a mummy in the site of Lapa do Boquete, a Brazilian cave in the state of Minas Gerais. These findings in context of the archaeology of the site provided insights into the pathoecology of disease transmission in cave and rockshelter environments. We are presenting a description of the site followed by the evidence of hookworm, intestinal fluke, and Trypanosoma infection with resulting Chagas disease in the mummy discovered in the cave. These findings are used to reconstruct the transmission ecology of the site.

• Journal of applied mathematics & informatics
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• 제27권3_4호
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• pp.779-793
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• 2009

This paper deals with a delayed SEIRS epidemic model with pulse vaccination and crowded incidence rate. Moreover, the case of vertical and horizontal transmission is considered. By using the discrete dynamical system determined by the stroboscopic map, the exact infection-free periodic solution of the SEIRS model is obtained. Further, by employing the comparison arguments, we prove that under the condition that $R_*$ < 1 the infection-free periodic solution is globally attractive, and that under the condition that $R^*$ > 1 the disease is uniformly persistent, which means that after some period of time the disease will become endemic.

• Safety and Health at Work
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• 제11권2호
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• pp.241-243
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• 2020

Coronavirus disease 2019 poses an occupational health risk to health-care workers. Several thousand health-care workers have already been infected, mainly in China. Preventing intra-hospital transmission of the communicable disease is therefore a priority. Based on the Systems Engineering Initiative for Patient Safety model, the strategies and measures to protect health-care workers in an acute tertiary hospital are described along the domains of work task, technologies and tools, work environmental factors, and organizational conditions. The principle of zero occupational infection remains an achievable goal that all health-care systems need to strive for in the face of a potential pandemic.

• 시큐리티연구
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• 제4호
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• pp.29-46
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• 2001

This research is based on the protection of the social safty with the preventive measures against Creutzfedt-jakob's and Mad cow Disease which has been drawn an attention of the public. It also has Known as an epidemic with rapid transmission an severe conteminaton to hurt the health through beef. In this work, some fruitful suggestions have been made to prevent and to minimize the harms Creutzfedt-jakob's and Mad Cow Disease : 1) We should Pay attention to the prior preventive measures by detecting the modes and the causes of the contemination lute route ; 2) there should be a step to inoculate the cattles to provide non-conteminated fresh feed for cows ; and 3) a health official should be alert to prevent the rapid transmission to the public by breaking the infected route of it.

• 대한한의학원전학회지
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• 제28권4호
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• pp.139-154
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• 2015

Objectives : Zheng Zhi Xin Chuan(證治心傳) is a compact compilation of 14 discussions on medicine, written by Yuan Ban(袁班) in the late Ming-early Qing period. Methods : To survey the scholarly position of Yuan Ban(袁班) in the history of Wenbing by systematically analyzing and organizing Wenbing related theories in Zheng Zhi Xin Chuan (證治心傳). Results & Conclusions : In his book, YB suggests concepts such as 'mainly attack upper heater(多犯上焦)', 'transmission to the nutrient phase(轉入營分)', 'sequential transmission(順傳)', 'abnormal transmission(逆傳)', 'dryness invasion of human body in autumn(秋傷於燥)'. In the history of Wenbing, it has been widely acknowledged that the concept of weiqiyingxiebianzheng(衛氣營血辨證) and abnormal transmission to the pericardium(逆傳心包) were originally suggested by Ye Tianshi(葉天士). However, according to the findings of this study, these concepts are traced back to the contents of YB's publication, nearly a century before Ye's time. In addition, YB's discussion on '秋燥' was highly advanced than any other scholar of his time, hinting his influence on medicine thereafter.