• Journal of Veterinary Clinics
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• v.13 no.2
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• pp.212-215
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• 1996

Chemotherapy of transmissible venereal tumor (TVT) in a dog has been tried, using vincritstine, cyclophosphamide, and methotrexate. The dog was hiven an combination chemotherapy and underwent complete regression of the tumors with on recurrence. The result of our clinical trial indicates that combination chemotherapy is an effective modality for dogs with TVT.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.360-362
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• 2002

A 9-year-old male Maltese with foamy nasal discharge, respiratory distress, and sneezing followed by epistaxis was presented to the Veterinary Medical Teaching Hospital of Seoul National University. Radiography showed no significant findings from an open mouth view. Rhinoscopy also did not find any remarkable lesions in the nasal cavity. But when vigorously swabbing the nasal cavity, numerous cells having round nuclei, coarse reticular chromatin, one large nucleolus and distinct cytoplasmic vacuoles, which is typical for canine transmissible venereal tumor cells were collected. We thoroughly searched for any primary transmissible venereal tumor at the other areas of the body other than the nasal cavity, but found none. The patient responded well to vincristine, and the clinical signs resolved with no respiratory distress, sneezing or epistaxis.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.363-366
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• 2002

Transmissible venereal tumor (TVT) is a contagious, sexually transmitted tumor and, in the natural setting, affects only dogs. We surveyed two cases which were serviced in veterinary medical teaching hospital of Seoul National University. Through this report we studied the method for treatment or n by chemotherapy and surgical resection. in treatment or TVT, surgical resection is not considered an effective method, but chemotherapy and radiation. In these two cases, chemotherapy was very effective and in the second case, there was no effect of surgical method. For treatment of TVT, chemotherapy was very effective, but surgical resection was not recommended.

• Journal of Veterinary Clinics
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• v.33 no.2
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• pp.122-123
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• 2016

A dog (Maltese, 4-year-old, intact male) was referred to the hospital because of the multiple cabbage-shaped nodular masses on penis, preputial fornix and inner layer of prepuce with the free-roaming history. Those appearance was similar with the characteristic of transmissible venereal tumor (TVT). As a result, it was tentatively diagnosed as TVT by the veterinarian of a local clinic and treated with vincristine sulfate. However, the lesion did not regress. Histologically, the mass was consisted of fibrovascular connective tissue stalks and keratinized stratified squamous epithelium, and koilocytosis and intranuclear inclusion body were not shown in the epithelial layer. In addition, inflammatory changes were minimal in the tissue of mass. Based on these findings, this case was diagnosed as venereal squamous papilloma. As the treatments of TVT and papilloma differs, practitioners must be cautious with the diagnosis.

• Journal of the korean veterinary medical association
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• v.24 no.9
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• pp.553-562
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• 1988

Transmissible venereal sarcoma cells in developing, mature and regressing stages from 6 Jindo dogs were examined ultrastructurally. Developing stage tumor appeared to be composed of loosely arranged and comprised most of large. round and ovoid cells with

• Applied Microscopy
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• v.17 no.1
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• pp.169-176
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• 1987

Naturally occurring canine transmissible venereal tumors of genital organs in mature and regressive stages from 6 dogs were examined by transmission electron microscope. The tumor cells at the stage of maturation were comprised of large round and ovoid cells with prominent nuclei and nucleoli, a few spindle-shaped cells, and irregularly shaped cells. The mature round cells were characterized by the presence of a central ovoid to irregularly round nucleus with a large eccentric nucleolus, vesicular endoplasmic reticulum, round to oval swollen mitochondria with few cristae, Golgi's apparatus, and plasma membranes with numerous microvilli. As the tumor degenerated, the tumor cells were increased in the number of spindle-shaped, fibroblast-like and irregularly shaped cells, collagen bundles, and mainly lymphocytes, in contrast to those of the stage of maturation. Regressing tumor cells were characterized by the swelling and vacuolation of mitochondria and endoplasmic reticulum, membrane-bound granules, lamellar complex, tubular structures, and dense bundles of collagen. It was suggested that transformation might occur in the course of tumor growth causing morphological change from the round to the fibroblast-like cells, and that there was the evidence of cell-mediated tumor cell lysis by lymphocyte infiltration.

• Korean Journal of Veterinary Pathology
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• v.2 no.2
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• pp.127-138
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• 1998

Transmissible venereal tumor(TVT) is a naturally occurring contagious neoplasm which can be transmitted by mechanical contact during mating in dogs and transplanted as intact viable cells to dogs and other members of canine family such as coyotes, jackals, wolves, and foxes. The incidence of this tumors tends to increase in Korean native Jindo dogs. This is probably due to the high density and unrestrained management system. With time, TVT reaches the maximum size and then tends to regress spontaneously unless individuals are immunologically compromised. It consists of different types of cells depending on the stage. In this study, 10 tumors were selected from Jindo dogs. These were histologically calssified into three stages; progressive, steady-state, and regressive. Mitotic figures were counted, and their histological appearance at each stage is compared with their DNA ploidy. Histologically, 5 tumor cases were calssed as the progressors, 3 cases as the steady-state tumors, and 2 cases as regressors. Progressors were composed of round cells with large nuclei containing conspicuous nucleoli and frequent mitotic figures. A few spindle-shaped cells and inflammatory cells including mainly lymphocytes, a few neutrophils and macrophages were also seen. In the steady-state tumors, there was an increased number of spindle shaped cells and mitotic figures were rare. Six tumors were diploid and four were aneuploid with the variation coefficient of 7.02. Two of five progressive tumors were aneuploid. Two of three steady-state tumors were aneuploid while both tumors at the regressive stage were diploid. Progressive and steady-state tumors had a much larger S/G2M fraction and a higher mitotic index than regressive tumors. Two tumors which persisted for more than one year were aneuploid. These results suggest that the progressive and steady-state tumors had more active cell division than the regressive neoplasms.

• Journal of Veterinary Clinics
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• v.15 no.1
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• pp.214-218
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• 1998

2세의 암컷 진돗개가 3개월간 혈액성 질분비물과와 외음부 종창을 주증으로 내원하였다. 질에 형성된 종괴는 조직병리학적 검사로 개 전파성 생식기 육종으로 진단되어 vincristine sulfate$(0.5 mg/M^{2})$을 1주 간격으로 3회 정맥주사를 실시하면서 혈액, 병리조직 검사 를 병행하였다. 종괴의 크기는 투여 후 1주부터 급격히 감소되었으며 조직소견상 종양세포는 세포질의 공포변성, 핵농축 및 붕괴, 혹은 apoptosis가 관찰되었다. 4주째 종괴는 완전히 소실 되어 치료를 중단하였고 혈액학적 검사 결과 부작용은 없었다. 마지막 투여후 10주째 건강한 새끼 4마리를 자연 분만하여 개 전파성 생식기 육종에서 vincristine 단독 투여로 우수한 치료 효과를 얻었다.

• Journal of Veterinary Clinics
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• v.19 no.4
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• pp.429-432
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• 2002

Chronic Iymphocytic leukemia is a general disease that evolves over a longer duration and is characterized by more mature and well-differentiated Iymphocytes in blood and bone marrow than those seen in acute leukemia. This report presents a 2-year-old mix neutered male dog with seizure, ascites, and transmissible venereal tumor. Diagnostic works-up concluded chronic Iymphocytic leukemia. Chemotherapy composed of chlorambucil and prednisolone has been applied to the patient until now. Remission of almost manifestations was achieved, and the quality of life improved.

• Korean Journal of Veterinary Research
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• v.15 no.1
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• pp.27-38
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• 1975

The following tumors occurring naturally in the dog were studied pathologically and discussed briefly. Tumors of the skin and subcutis: Fibroma, Lipoma, Epidermal cyst, Melanosarcoma, Sweat gland adenoma, Mastocytoma (2 cases), Mastosarcoma, and Sebaceous gland carcinoma. Tumors of the spleen and lymph node: Fibrosarcoma of the capsule of spleen, Leiomysarcoma of the spleen, and Lymphosarcoma of the lymph node (2 cases). Tumors of the lung: Bronchogenic carcinoma (3 cases), Adenocarcinoma type, Squamous carcinoma type, and Undifferentiated (round cell) carcinoma type respectively. Tumors of the alimentary tract and liver: Fibroma of the stomach, Hemangioma of the liver, Bile duct carcinoma, Liver cell carcinoma, and Myelogenous leukemia manifested in the liver. Tumor of the peritoneum: Fibrosarcoma. Tumors of the urogenital system: Fibroma of the uterus, Fibroma of the prepuce, Follicular cyst of the ovary, Transmissible venereal tumor of the vagina (6 cases), Carcinoma of the kidney, Adenoma of the prostate (2 cases), and Seminoma of the testis. Tumors of the mammary gland: Mixed tumor (2 cases), and Myoepithelioma. Tumor of the nervous system: Neurofibrosarcoma of the thigh.