• 대한산업공학회지
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• 제40권2호
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• pp.172-183
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• 2014

This paper measures and compares the efficiency of national health technology R&D programs focused on translational research program increasing importance using data envelopment analysis (DEA). Three input variables and three output variables are selected for DEA. Inputs are funds, researchers, and project period and outputs are SCI (E) papers, applied and granted patents, and impact factor. This study uses a three-stage approach. In the first stage, output-based DEA model is applied to evaluate the efficiency of decision making unit (DMU). In the second stage, based on efficiency scores of target diseases high-efficiency group and low-efficiency group are classified. And then strategic portfolio matrix of translational research program is composed of four dimensions combining research types. Mann-Whitney U test is then run to compare average efficiency scores among four groups. In the final stage, Tobit regression model is used to estimate factors likely to influence the efficiency. The results are expected to provide policy implications for effectively establishing investment strategy and managing performance of R&D program.

• Archives of Pharmacal Research
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• 제23권4호
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• pp.267-282
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• 2000

Cytochrome P45O (CYP) 2E1 catalyzes the metabolism of a wide variety of therapeutic agents, procarcinogens, and low molecular weight solvents. CYP2E1-catalyzed metabolism may cause toxicity or DNA damage through the production of toxic metabolites, oxygen radicals, and lipid peroxidation. CYP2E1 also plays a role in the metabolism of endogenous compounds including fatty acids and ketone bodies. The regulation of CYP2E1 expression is complex, and involves transcriptional, post-transcriptional, translational, and post-translational mechanisms. CYP2E1 is transcriptionally activated in the first few hours after birth. Xenobiotic inducers elevate CYP2E1 protein levels through both increased translational efficiency and stabilization of the protein from degradation, which appears to occur primarily through ubiquitination and proteasomal degradation. CYP2E1 mRNA and protein levels are altered in response to pathophysiologic conditions by hormones including insulin, glucagon, growth hormone, and leptin, and growth factors including epidermal growth factor and hepatocyte growth factor, providing evidence that CYP2E1 expression is under tight homeostatic control.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.800-801
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• 2005

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1280-1285
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• 2004

Retron is a prokaryotic genetic element, producing a short single-stranded DNA covalently linked to RNA (msDNA-RNA) by a reverse transcriptase (RT). In retron EC83, msDNA is further processed at between the 4th and the $5^{th}$ nucleotides, leaving a 79 nucleotide-long single-stranded DNA as a final product. To investigate this site-specific cleavage in msDNA synthesis, we purified the RT protein of retron EC83. Initially, RT ORF was cloned under the tac promoter, but the expression was very poor largely because of poor translation. In order to facilitate translation, the nucleotide sequence for the first nine amino acids was randomized with synonymous codons. This change of downstream sequence of translational initiation codon greatly affected the efficiency of translation. We could isolate clones which greatly increased RT production, and their sequences were compared to those of the low producers. The overproduced protein was purified and was shown to have RT activity.

• Journal of Advanced Marine Engineering and Technology
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• 제33권4호
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• pp.476-483
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• 2009

A linear compressor used in a refrigerator has higher energy efficiency than a reciprocating compressor, but its vibration level is still severe than others. The vibration level of linear compressor at the frequency of 60Hz is dominant since it is the exciting frequency of a motor. In this paper, a simulation tool to predict the shell vibration of the linear compressor was developed. The shell and body parts in a compressor were assumed to be 3-dimensional rigid body having both translational and rotational motion, while the reciprocating piston part has only 1-dimensional translational motion. The flexible loop-pipe was modeled by in-house code of finite element method. To verify the developed tool, five cases of different loop-pipe shapes were examined experimentally. The results by the developed tool showed good agreements with those by experiments.

• 대한전기학회논문지:전력기술부문A
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• 제48권3호
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• pp.313-320
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• 1999

The Lane-Curvature Method(LCM) presented in this paper is a new local obstacle avoidance method for indoor mobile robots. The method combines Curvature-Velocith Method(CVM) with a new directional method called the Lane Method. The Lane Method divides the environment into lanes taking the information on obstacles and desired heading of the robot into account ; then it chooses the best lane to follow to optimize travel along a desired heading. A local heading is then calculated for entering and following the best lane, and CVM uses this heading to determine the optimal translational and rotational velocity space methods, LCM yields safe collision-free motion as well as smooth motion taking the dynamics of the robot Xavier, show the efficiency of the proposed method.

• Toxicological Research
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• 제9권2호
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• pp.153-158
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• 1993

Pyridine and acetone are efficacious inducers of CYP2E1 in both rats and rabbits. The response in the elevation of CYP2E1 levels, changes in CYP2E1 mRNA levels, and enhanced translational processing of hepatic CYP2E1 mRNA during the early phase of CYP2E1 induction by the solvents pyridine and acetone were examined. Time-depen-dent incease in CYP2E1 levels occurred at early times (6-24h) following a single dose of pyridine treatmene, as assessed by Western immunoblot analysis, whereas the levels in CYP2E1 mRNA transiently decreased at 12h post-treatment, returning to the level present in untreated animals.

• Animal Bioscience
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• 제37권2_spc호
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• pp.346-359
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• 2024

Advanced and innovative breeding and management of meat-producing animals are needed to address the global food security and sustainability challenges. Beef production is an important industry for securing animal protein resources in the world and meat quality significantly contributes to the economic values and human needs. Improvement of cattle feed efficiency has become an urgent task as it can lower the environmental burden of methane gas emissions and the reduce the consumption of human edible cereal grains. Cattle depend on their symbiotic microbiome and its activity in the rumen and gut to maintain growth and health. Recent developments in high-throughput omics analysis (metagenome, metatranscriptome, metabolome, metaproteome and so on) have made it possible to comprehensively analyze microbiome, hosts and their interactions and to define their roles in affecting cattle biology. In this review, we focus on the relationships among gut microbiome and beef meat quality, feed efficiency, methane emission as well as host genetics in beef cattle, aiming to determine the current knowledge gaps for the development of the strategies to improve the sustainability of beef production.

• 전산구조공학
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• 제1권1호
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• pp.67-78
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• 1988

이 연구에서는 새로운 쉘요소분해의 방법을 정립하고, 이에 의거하여 간단하고, 효율성이 높고, 보편성이 큰 쉘 유한요소를 개발하고자 하였다. 실제의 요소는 개념적인 Translational Element와 Difference Element로 분해되며, 요소의 변위함수는 이 두 성분요소의 변위함수를 결합하여 얻는다. 요소분해의 기본가정을 달리함에 따라서 세가지의 기본형요소에 도달할 수 있다. 기본형요소를 보완하여 Locking현상을 제거하고 수렴성을 높히는 방안으로서 감착적분, 내용자유도의 추가 및 Mixed Fomulation을 검토하였으며, 요소의 Spurious Mode를 제어하는 방법을 고안하였다. 수치분석을 통해서 요소의 유효성과 효율성을 검정하였다.

• 전자공학회논문지S
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• 제35S권3호
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• pp.176-184
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• 1998

We present a sequential factorization method using singular value decomposition (SVD) for recovering both the three-dimensional shape of an object and the motion of camera from a sequence of images. We employ paraperpective projection [6] for camera model to handle significant translational motion toward the camera or across the image. The proposed mthod not only quickly gives robust and accurate results, but also provides results at each frame becauseit is a sequential method. These properties make our method practically applicable to real time applications. Considerable research has been devoted to the problem of recovering motion and shape of object from image [2] [3] [4] [5] [6] [7] [8] [9]. Among many different approaches, we adopt a factorization method using SVD because of its robustness and computational efficiency. The factorization method based on batch-type computation, originally proposed by Tomasi and Kanade [1] proposed the feature trajectory information using singular value decomposition (SVD). Morita and Kanade [10] have extenened [1] to asequential type solution. However, Both methods used an orthographic projection and they cannot be applied to image sequences containing significant translational motion toward the camera or across the image. Poleman and Kanade [11] have developed a batch-type factorization method using paraperspective camera model is a sueful technique, the method cannot be employed for real-time applications because it is based on batch-type computation. This work presents a sequential factorization methodusing SVD for paraperspective projection. Initial experimental results show that the performance of our method is almost equivalent to that of [11] although it is sequential.