• 제목/요약/키워드: transitional type

검색결과 135건 처리시간 0.033초

전남 고금도 지역 지하수의 수리지구화학 (Hydrogeochemistry of Groundwaters at the Gogum island area in Jeonnam, Korea)

  • 박천영;안건상;정연중;신인현
    • 한국지구과학회지
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    • 제23권6호
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    • pp.474-485
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    • 2002
  • 본 연구의 목적은 전라남도 완도군 고금도 지역 지하수의 수리지구화학과 수소-산소동위원소를 파악하여 해수침투경로와 오염여부를 규명하는데 있다. 연구지역 지하수의 물리적인 특성은 중성과 전이환경에 속하며, 해수와 지표수의 영향을 받은 것으로 나타났다. 화학적인 특성에서도 해수의 침투, 육상의 오 ${\cdot}$ 폐수 및 농약이나 폐기물에 의해 오염이 진행되고 있다. 특히 지하수 중 여섯 지역에서 Cl은 먹는 샘물 기준치를 초과하는 것으로 나타났다. 파이퍼도에서 GG-4와 14지역은 해수의 침투로 오염되었으며, 수질유형을 구분하여 보면 GG-3, 7 및 13지역은 Na와 HCO$_{3}$가 지배적이고, GG-14지역은 해수와 같이 Na와 Cl이 지배적으로 나타났다. 수리지구화학적인 모델링 분석결과 해수의 방해석과 백운석 포화지수는 과포화상태이며, GG-3, 14 및 18지역에서 포화영역에 접근하고 있다. 수소-산소동위원소비에서 본 역 지하수의 기원은 순환수이며, GG-1, 5 및 14지역의 높은 산소동위원소는 지표수의 유입과 해수 침투에 의한 것이다. 본 연구결과 GG-14지역의 지하수는 해수의 침투에 의해 오염되어 있으며, GG-3, 7 및 13지역을 제외한 지하수들은 해수의 침투 및 인위적인 오염원에 의해 오염이 진행되고 있다.

No Relationship between the Amount of DNA Damage and the Level of hMLH1 and RASSF1A Gene Expression in Bladder Cancer Cells Treated with Cisplatin and Gemcitabine

  • de Camargo, Elaine Aparecida;da Silva, Glenda Nicioli;Gobette, Camila Pereira;de Castro Marcondes, Joao Paulo;Salvadori, Daisy Maria Favero
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권10호
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    • pp.5941-5948
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    • 2013
  • Tumor response to antineoplastic drugs is not always predictable. This is also true for bladder carcinoma, a highly recurrent neoplasia. Currently, the combination of cisplatin and gemcitabine is well accepted as a standard protocol for treating bladder carcinoma. However, in some cases, this treatment protocol causes harmful side effects. Therefore, we investigated the roles of the genes TP53, RASSF1A (a tumor suppressor gene) and hMLH1 (a gene involved in the mismatch repair pathway) in cell susceptibility to cisplatin/gemcitabine treatment. Two bladder transitional carcinoma cell (TCC) lines, RT4 (wild-type TP53) and 5637 (mutated TP53), were used in this study. First, we evaluated whether the genotoxic potential of cisplatin/gemcitabine was dependent on TP53 status. Then, we evaluated whether the two antineoplastic drugs modulated RASSF1A and hMLH1 expression in the two cell lines. Increased DNA damage was observed in both cell lines after treatment with cisplatin or gemcitabine and with the two drugs simultaneously, as depicted by the comet assay. A lack of RASSF1A expression and hypermethylation of its promoter were observed before and after treatment in both cell lines. On the other hand, hMLH1 downregulation, unrelated to methylation status, was observed in RT4 cells after treatment with cisplatin or with cisplatin and gemcitabine simultaneously (wild-type TP53); in 5637 cells, hMLH1 was upregulated only after treatment with gemcitabine. In conclusion, the three treatment protocols were genotoxic, independent of TP53 status. However, cisplatin was the most effective, causing the highest level of DNA damage in both wild-type and mutated TP53 cells. Gemcitabine was the least genotoxic agent in both cell lines. Furthermore, no relationship was observed between the amount of DNA damage and the level of hMLH1 and RASSF1A expression. Therefore, other alternative pathways might be involved in cisplatin and gemcitabine genotoxicity in these two bladder cancer cell lines.

집박쥐 신유두(腎乳頭) 및 신우상피(腎盂上皮)에 미세구조(微細構造) (The Papillar and Pelvic Epithelia of the Bat: A Scanning and Transmission Electron Microscopic Study)

  • 김진;오수자;정진웅
    • Applied Microscopy
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    • 제16권2호
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    • pp.61-74
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    • 1986
  • The anatomy of the renal papilla and pelvis of the bat(Pipistrellus abramus abramus Temminck) and their ultrastructure of the epithelium has been studied by means of light, scanning and transmission electron microscopy. The bats were captured at Ondal cave located in Yangchun-Myun, Tanyang-Kun, Chungchongpuk-Do, Korea in the active(July) and hibernating(January) phases. A conical renal papilla with several papillary foramina at the apex was curved toward the ureter. At the margin of the funnel-shaped renal pelvis, the fornix extended deeply into the kidney parenchyme was formed between the outer zone of the medulla and the cortex. The epithelium of the papilla covered the inner zone of the medulla. The epithelium of the fornix medially overlayed the outer zone of the medulla, and laterally the cortex. The surface epithelium of the papilla was simple columnar in shape with the scanty organelles and the short microvilli on their luminal surface. The fornix was Jined with $1{\sim}2$ cell layered squamous epithelium. On the medial surface of the fornix, two types of the superficial epithelial cells were identified; one had numerous short microvilli and the other had the microplicae and plaques on their luminal surface. The lateral surface of the fornix lined with the epithelial cells showed microridges and plaques on the luminal surface. The epithelial cells on the medial and lateral surfaces of the fornix were similar to their internal ultrastructures. The pelvic epithelium was a typical transitional type, which was composed of a layer of basal cells, one or two layers of intermediate cells, and a layer of superficial(facet) cells. The fusiform vesicles were observed in the cytoplasm of the intermediate and facet cells. There were no noticeable morphological changes in the epithelium of the papilla, fornix and pelvis except the medial epithelium of the fornix in the hibernating cycle. The microvillar cells were more numerous in the hibernating phase than in the active phase. The morphology, of the renal papilla and fornix of bats, indicates that a functional relationship may exist between the pelvic urine and the renal parenchyme.

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슬롯버너에서 농도차이에 따른 예혼합화염과 삼지화염의 거동 (Behaviors of Premixed Flames and Triple Flames with its Concentration Difference in a Slot Burner)

  • 김태권;장준영;박정;전성화
    • 한국연소학회:학술대회논문집
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    • 한국연소학회 2004년도 제29회 KOSCI SYMPOSIUM 논문집
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    • pp.85-90
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    • 2004
  • We have presented characteristics of a transitional behavior from a premixed flame to a triple flame in a lifted flame according to the change of equivalence ratio. The experimental apparatus consisted of a slot burner and a contraction nozzle for a lifted flame. As concentration difference of the both side of slot burner increases, the shape of flame changed from a premixed flame to a triple flame, and the liftoff height is decreased to the minimum value and then increase again. Around this minimum point, it is confirmed a transition regime from premixed flame to triple flame. Consequently, the experimental results of the liftoff height, flame curvature and luminescence intensity showed that the stabilized laminar lifted flame regime is categorized by regimes of premixed flame, triple flame and critical flame. In the visualization experiment of smoke wire, the flow divergence and redirection reappeared in premixed flame as well as triple flame. Thus we cannot express the flame front of lifted flame has a behavior of triple flame with only flow divergence and redirection. To differentiate triple flame and premixed flame, ${\Phi}$ value of partially premixed fraction is employed. The partially premixed fraction ${\Phi}$ was constant in premixed flame. In critical flame small gradient appears over the whole regime. In triple flame, typical diffusion flame shape is obtained as parabolic distribution type due to diffusion flame trailing.

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충주지역 희토류 광상의 성인: 산출상태와 지화학적 특성 (Genesis of the REE Ore Deposits, Chungju District, Korea: Occurrence Features and Geochemical Characteristics)

  • 박맹언;김근수
    • 자원환경지질
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    • 제28권6호
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    • pp.599-612
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    • 1995
  • Some REE ore deposits are located in the middle part the of Korean peninsula. Geotectonically, the REE ore deposits situated on the Kyemyeongsan Formation of northern margin of the Okcheon geosynclinal belt and in the transitional zone between Kyeonggi massif and the Okcheon belt, with a deep-seated fracture separating the two tectonic units. The Kyemyeongsan Formation are different in lithology and metamorphic grade from the Gyeonggi massif and the Okcheon super group. The sequence of Kyemyeongsan Formation is dominantly composed of acidic metavolcanic and volcaniclastic rocks associated with alkaline igneous rocks which are related to volcano-plutonism. The REE ore deposits contain mainly Ce-La, Ta-Nb, Y, Y-Nd and Nd-Th group minerals. More than 15 RE and REE minerals have been found in the deposits, such as allanite, fergusonite, thorite bestnaesite, euxenite, polyclase, monazite, columbite, (Nb)-rutile, okanoganite, sphene, zircon, illmenite and some other unknown minerals. According to the characteristics of the mineral association, the REE ore deposits may be divided into 4 ore types; Zircon-REE, allanite-REE, feldspar-REE and fluorite-REE type. The Sm-Nd isochron age of the REE ore is 330 Ma, and the Sm-Nd model age is 1.11 Ga with ${\varepsilon}_{Nd(t)}$ being - 2.9. This data suggest that the REE ore deposit was formed in the early Carboniferous, and the ore-forming material came from the mantle. The REE ores show distinct light REE enrichment with strong negative Eu anomaly. The REE patterns of schistose rocks from Kyemyeongsan Formation are similar to felsic volcanics from rifts or back arc basins in or near continental crust. The genesis of the REE ore deposit is quite complicated. Different geologic processes are displayed in the studied area; sedimentation, volcanic activity, metamorphism and hydrothermal replacement. Alkali granite has suffered extensive post-magmatic metasomatism of a high temperature to produce alkali metasomatites. Geochemical charateristics show that metasomatism of alkaline fluid was probably the dominant ore-forming process in Chungju district.

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런던 호니만 박물관 소장 한복 유물에 관한 연구 (Korean Dress Collection of the Horniman Museum in London)

  • 김순영
    • 한국의류학회지
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    • 제36권1호
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    • pp.99-111
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    • 2012
  • This paper investigates the formative features and the historical meaning of the Korean dress collection held in the Horniman Museum in London. The Museum holds eighteen items of Korean dresses donated by Mrs. C. de J. Luxmore in 1948 and by Mrs. Bowra in 1953. Male dresses consist of white silk outer robe (durumagi), a pale violet silk waistcoat (jokki), a jade green silk jacket (jeogori), pale yellow silk trousers (baji), a pair of ankle bands (daenim), a cotton waistband (dae), a silk purse (jumeoni), a rattan under-vest (deungbaeja), a pair of rattan wristlets (deungtosi), a top hat (gat) and a skullcap (tanggeon). Female dresses comprise a jade green silk jacket (jeogori), an ivory silk skirt (chima), a light blue silk petticoat (sokchima), two kinds of white cotton trousers (sokbaji and soksokgot), a pair of silk wristlets (tosi) and a pair of padded socks (beoseon). A Korean dress collection of the Horniman Museum shows a set of ordinary dress items worn by a married couple in the 1930s and the 1940s. Of these items, a silk petticoat (sokchima) and a rattan under-vest (deungbaeja) can be highly evaluated as object resources in the history of Korean dress. The petticoat is a rare and valuable example that represents an early type of modern petticoat that has replaced a traditional petticoat (dansokgot). The rattan under-vest has square neckline and two tiny sleeves similar to a Western cap sleeve. This kind of under-vest is a transitional form shown between under-vest similar to the Korean waistcoat (baeja) and one similar to the Western waistcoat (jokki).

박물관 빛 환경과 관람행태의 상관관계에 관한 연구 - 조도에 의한 관람확률과 관람빈도의 해석을 중심으로 - (A Study on the Relationship between Light Environment and Visitors' Behavior in a Museum - Focus on the Interpretation of Tracking Score and Tracking Frequency with Intensity of Illumination -)

  • 이미연;정성욱
    • 한국실내디자인학회논문집
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    • 제19권4호
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    • pp.82-89
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    • 2010
  • The studies published up to now, related to the correlation between spatial structure and visitors' behavior in a museum are rather relatively lacking when it comes to the in-depth consideration for the effect of the actual exhibition environment. So the main purpose of this study is to define the correlation between the light environment and the visitors' behavior. Towards this end, this study uses 'space syntax' to quantify the spatial structure with 'integration', 'connectivity' and 'control value'. Meanwhile, 'tracking score' and 'tracking frequency' were selected as the scope among the indices of behavior's analysis. The results of this study are as follows; First, integration and correlation of tracking score and tracking frequency are lowest when it comes to the extra large historical museums where the difference of intensity of illumination by each convex space. Meanwhile, the most considerable effect is exerted by control value. Compared to tracking score, tracking frequency is closely related to 'syntactic variables'. Second, visitors do not take the short cut the dark exhibition space even when very dark exhibition spaces continue after passing through relatively bright space. Analysis of visitors' behavior by control value in the exhibition space composed of this type of intensity of illumination environment is not valid. Third, visitors move to relatively brighter transitional space compared to the exhibition space with low intensity of illumination when passing through dark exhibition continually. Meanwhile, when visitors pass through the exhibition space there is some difference intensity of illumination they move to relatively dark exhibition center among the subsequent exhibition spaces. Accordingly, when the composition of exhibition space that continues onto the environment of low intensity of illumination is inevitable, differentiating intensity of illumination appropriately would be effective in inducing visit to the subsequent exhibition space.

단추와 단추구멍의 변천에 관한 연구 (A Study of the transitional Development of Buttons and Buttonholes)

  • 구애리나;이순홍
    • 복식
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    • 제18권
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    • pp.247-268
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    • 1992
  • The Clothing expresses people's desire of beauty most directly of all cultural inheritances, and it teach us how the human culture has changed and developed. In this study researched the history of buttonholes which make the clothes more functional and beautiful. Buttons and Buttonholes is one of detailed elements they used as a fastener or as a decoration on clothing. Button have been used since ancient times, in early times long before buttons were used as fasteners they had significant decorative and symbolic value. In ancient times, clothes fastened with pins, brooches, fibular and ties. In medieval Europe, it was not until the 13th century that they used the button in functional use, and then Chong Ryung-Lk was introduced from orient, and they became popular as fasteners on clothing during the 13th century when fitted clothes replaced loose garments. Garments were laced together or fastened with buttons, until buttonholes were invented in the 13th century. But as early as the 14th century it appears that someone discovered that a loop slipped over a button, or button pushed through a slit in the cloth, would make a good clothes fastener. Many buttons made during the modern ages were convex medallions set in metal rims and decorated with partraits of famous men and women. During the modern ages, buttons, with ligh-ographed pictures, covered with celluloid of glass were popular. In the 19th century, the mass production by machine made people use the button easily, and many different material of button easily and many different material of button was made. With the begining of the 20th century. the development of plastics led to various and functional buttons. The type of buttonholes also became various, as bound buttonhole, Tailred buttonhole, Worked buttonhole, Loop buttonhole and so on. The button has many forms which were imitated by nature, or made geometrically and the appearance of the button from behind is classified by what has holes and what has holes and what has a shank, and I also classified the kinds of button by the quality of the material design and use. Like this, with the passing of the time buttons and buttonholes have changed in appearance with the change of clothes, and they have standed for something meaningful as well as fixed the opening and made clothes more beautiful.

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공간관의 변화에 따른 사건과 장소의 관계 유형에 관한 연구 (A Study on Relative Type of Events and Place relevant to Change of Spatial View)

  • 황용섭;김주연
    • 한국실내디자인학회논문집
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    • 제18권2호
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    • pp.25-32
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    • 2009
  • To the human being, the space as the objective for fundamental thought called 'Being', and the space as the place for actual experience containing 'Life and Experience', have coexisted. Such dual characteristics owned by the space have come to the present creating various spatial viewpoints. As for the space as the objective for various thoughts and interpretations, its emphasis is nowadays being moved to the existence from such being. There is the event in the core of such change. Human's recognition for the space is originated from the observed events, which appears as an immense meaning, as it 'is accumulated as the experience. Therefore, the importance of the event in another viewpoint thinking the space is becoming bigger. This research has tried to grasp the tendency for the place-orientation by grasping the meaning owned by the event through the course that the viewpoint for such space has been changed. This research put its focus on clarifying the relationship between the place and event that are brought into relief by tracking down the transitional process of the viewpoint of space in the history of Occidental philosophy. Through this process, this research came to have a grip on the relationship in which a sense of place obviously stands out in bold relief as a result of an event, an emblem of an event, condition of an event, and as an event itself. Such four patterns are not mutually individual phenomenon, but form a discourse on modern space by traversing each other crisscross.

남극 드레이크 해협 피닉스 해령 P3구역 축부 해저현무암: K-Ar 연대측정과 지구화학 (Axial Seamount Basalts in P3 Segment of Phoenix Ridge, Drake Passage, Antarctica: K-Ar Age Determination and Geochemistry)

  • 이종익;허순도;이미정;김규중
    • Ocean and Polar Research
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    • 제25권1호
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    • pp.107-118
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    • 2003
  • The axial seamount basalts in the P3 segment of the Phoenix Ridge were obtained from dredging and the K-Ar age determination and whole-rock geochemical analyses have been done for understanding their origin. The K-Ar ages for PRS basalts sampled from 1,000m below sea level are 2.6-2.2 Ma and those for PR3 basalts from 800m are 1.6-1.5 Ma. The younger ages towards the crest of the seamount indicate that this submarine volcano has been grown by central eruptions. The youngest age of about 1.5 Ma for PR3 basalts corresponds to the final eruption period of this volcano. The seamount basalts contain small amounts of normative quartz and olivine. They have transitional geochemical nature between alkaline- and subalkaline-series basalts. Trace and rare earth elements compositions of the seamount basalts are very similar to those of ocean island basalts (OIB), and indicate that this seamount has been formed by a hotspot activity, not in association with a seafloor spreading. The melting degree from the source has decreased with time, and finally the volcanic activity has stopped when the basaltic magma reached mild alkaline composition.