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Oxidation and Isomerization of Lycopene under Thermal Treatment and Light Irradiation in Food Processing

  • John Shi;Ying Wu;Mike Bryan;Maguer, Le Marc
    • Preventive Nutrition and Food Science
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    • v.7 no.2
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    • pp.179-183
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    • 2002
  • Lycopene as a natural antioxidant may provide protection against a broad range of epithelial cancers and chronic diseases. Lycopene concentrate extracted from tomatoes can be used as functional food. Lycopene would undergo degradation via isomerization and oxidation under different processing conditions, which impact its bioactivity and reduce the fuuctionality for health benefits. Heat and light induce lycopene oxidation and isomerization of all-trans form to cis form. The effects of thermal treatment and light irradiation on the stability of lycopene were determined. Results have shown that lycopene stability depends on the extent of oxidation and isomerization. Cir-isomers are less stable than trans-isomers. The level of cis-isomers increased as treatment time increased but only for a short period during the beginning of the treatment. The major effect of thermal treatment and light irradiation was a significant decrease in the total lycopene content. A true assessment of health benefits of lycopene concentrate depends on the lycopene content and the composition of all trans-isomers and cia-isomers.

Neuraminidase Inhibitors from Reynoutria elliptica

  • Lee, Chu-Hyun;Kim, Sang-In;Lee, Kyung-Bok;Yoo, Yung-Choon;Ryu, Si-Young;Song, Kyung-Sik
    • Archives of Pharmacal Research
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    • v.26 no.5
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    • pp.367-374
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    • 2003
  • In the course of screening neuraminidase inhibitors from herbal medicines, Reynoutria elliptica exhibited high inhibitory activity. Four active compounds were isolated from the ethyl acetate soluble fraction by consecutive purification using sillica gel, Sephadex LH-20 chromatography, and recrystallization. The chemical structures of these compounds were identified as 1,3,8-trihydroxy-6-methylanthraquinone (emodin) 1,8-dihydroxy-3-methoxy-6-methylanthraquinone (emodin 3-methyl ether; physcion), 1,3,8-trihydroxy-6-hydoxymethylanthraquinone ($\omega$-hydroxyemodin), and 3,5,4 -trihydroxystilbene (trans-resvertrol) by spectral data including MS, $^1 H-, and ^{13}C-NMR. The IC_{50}$ values of emodin, emodin 3-methyl ether, $\omega$-hydroxyemodin, and trans-resvertrol were 2.81, 74.07, 10.49, and 8.77 $\mu$M, respectively. They did not inhibit other glycosidase such as glucosidase, mannosidase, and galactosidase, indicating that they were relatively specific inhibitors of neuraminidase.

Sorption Isotherms and KocS Estimation of Pyrethroids in Sediments

  • Lee, Sang-Jin;Shin, Hyun-Moo
    • Journal of Environmental Science International
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    • v.12 no.11
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    • pp.1173-1179
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    • 2003
  • Laboratory sorption isotherm batch studies have been attempted to elucidate interaction of synthetic pyrethroids (bifenthrin and permethrin) with sediments and their fractions. As a nonlinear isothermal model, the Freundlich equation was applied to sorption results obtained from sediments to investigate the relationship between synthetic pyrethroids and sediments containing different amounts of organic carbon. Results demonstrated that the sorption capabilities of bifenthrin and cis- and trans-permethrin was in the order of bifenthrin, cis-permethrin and trans-permethrin, respectively, indicating that adsorbed bifenthrin was the most stable followed by cis- and trans-permethrin in all sediments. Their sorption capability was closely related to organic carbon contents in sediments. Higher sorption was observed in sediments containing higher organic carbon contents. Sorption study extended into the fractions, clay and humic acids, extracted from a sediment, indicated that higher sorption capacity in humic acids occurred than in the clay of both examined bifenthrin and permethrin. This study demonstrates the sorption of synthetic pyrethroids with sediments, and will help in the understanding of the transport and fate of synthetic pyrethroids existing in field sediments.

RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3'-Untranslated Region Transcripts

  • Song, Min-Sun;Lee, Seong-Wook
    • Genomics & Informatics
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    • v.7 no.4
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    • pp.181-186
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    • 2009
  • Myotonic dystrophy type 1 (DM1), which is a dominantly inherited neurodegenerative disorder, results from a CTG trinucleotide repeat expansion in the 3'-untranslated region (3'-UTR) of the myotonic dystrophy protein kinase (DMPK) gene. Retention of mutant DMPK (mDMPK) transcripts in the nuclei of affected cells has been known to be the main cause of pathogenesis of the disease. Thus, reducing the RNA toxicity through elimination of the mutant RNA has been suggested as one therapeutic strategy against DM1. In this study, we suggested RNA replacement with a trans -splicing ribozyme as an alternate genetic therapeutic approach for amelioration of DM1. To this end, we identified the regions of mDMPK 3'-UTR RNA that were accessible to ribozymes by using an RNA mapping strategy based on a trans-splicing ribozyme library. We found that particularly accessible sites were present not only upstream but also downstream of the expanded repeat sequence. Repair or replacement of the mDMPK transcript with the specific ribozyme will be useful for DM1 treatment through reduction of toxic mutant transcripts and simultaneously restore wild-type DMPK or release nucleus-entrapped mDMPK transcripts to the cytoplasm.

Lipoxygenase Inhibitors from Paeonia lactiflora Seeds

  • Kim, Hyo-Jin;Chung, Shin-Kyo;Park, Sang-Won
    • Preventive Nutrition and Food Science
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    • v.4 no.3
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    • pp.163-166
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    • 1999
  • Previously, the methanolic extract of Paeonia lactiflora seeds was shown to have strong ingibitory activity against soybean liposygenase (SLO). Four phenolic compounds were isolated from the seeds by solvent fractionation Sephadex LJ-20 column chromatography and preparative HPLC, and three of them showed strong SLO inhibitio and were characterized as trans-resveratrol, $\varepsilon$-viniferin and luteolin by UV, IR, 1H-NMR, 13C-NMR and MS spectrometry. trans-Resveratrol (IC50=1.02$\mu$M), $\varepsilon$-viniferin (IC50=0.81$\mu$M) and luteolin (IC50=10.01$\mu$M), first found in the above seeds, exhibited a potent SLO inhibitory activity although their activity was lower than that of a well-known lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA) (IC50=0.57$\mu$M). These results suggest that Paenia lactiflora seeds, now an unused plant seed, may be developed into useful sources of anti-inflammatory drugs.

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The Effects of Pressure, Temperature and Solvent Composition on Solvolysis of trans-[Co(N-eten)$_2Cl_2]^+$ in Water-t-butyl Alcohol Mixture

  • Park Yu Chul;Cho Young Je
    • Bulletin of the Korean Chemical Society
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    • v.9 no.1
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    • pp.1-4
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    • 1988
  • Rates of solvolysis of trans-[Co$(N-eten)_2Cl_2$]$^+$ have been investigated using spectrophotometric method at various pressures and temperatures in the mixtures of water with the t-butyl alcohol which possesses a high structure inducing capacity in water. The values of ${\Delta}V^{\neq}$ obtained from pressure effect on the rate constants were 2.55∼ 5.83 $cm^3mol^{-1}$. These values were discussed in terms of dissociative mechanism. Extrema found in the variation of ${\Delta}H^{\neq}$ and ${\Delta}S^{\neq}$ with solvent composition correlated with extrema in the variation of the physical properties of the mixtures. The logarithms of rate constants correlated linearly with both Grunwald-Winstein parameter and the reciprocal of dielectric constant ($Ds^{-1}$). The gradient, m of Grunwald-Winstein plot for the trans-[Co$(N-eten)_2Cl_2$]$^+$ was 0.09, which is significantly lower than those for the other cobalt (Ⅲ)-dichloro complexes. It was suggested that the reaction is an Id mechanism with long extension of Co-Cl bond in the transition state, as found for the C-Cl bond in the transition state for the solvolysis of t-butyl chloride.

Theoretical Study of the Hydration Effects on the Conformation of N-pivaloyl-L-prolyl-N-methyl-N'-isopropyl-L-alaninamide

  • Choe, Sang-Joon;Kim, Un-Sik;Kang, Young-Kee;Jhon, Mu-Shik
    • Bulletin of the Korean Chemical Society
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    • v.5 no.1
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    • pp.27-32
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    • 1984
  • To investigate the hydration effects on the conformational changes of N-pivaloly-L-prolyl-N-methyl-N'-isopropyl-L-alanin amide (PPMIA), the conformational free energy changes have been calculated by using an empirical potential function varying all the independent degrees of freedom of PPMIA backbones. It is found that cis conformers are folded by a strong intramolecular hydrogen bond involving both terminal CO and NH groups whereas trans conformers accommodate the open conformation. Conformers in the free state are proved to be less stable than in the hydrated state. The free energy changes of cis and trans PPMIA due to the hydration are -50.5 and -39.8 kcal/mole, their conformational energy changes are -52.3 and -41.0 kcal/mole, and their conformational entropy changes are -5.9 and -4.0 e.u., respectively. The free energy changes of cis PPMIA to trans PPMIA in the free and hydrated states are 5.3 and 16.0 kcal/mole, their conformational energy changes are 7.6 and 18.8 kcal/mole, and the entropy changes due to the conformational transitions correspond to 7.5 and 9.4 e.u., respectively. From these results, it is found that the bound water molecules play an important role in stabilizing the conformation of PPMIA.

Perpendicular Interpenetration of Independent Square Grid Sheets. Synthesis and Structural Properties of $[Co(NCS)_2(Py_2L)_2]_n$($Py_2L$=trans-1,2-Bis(4-pyridyl)ethylene, 1,2-Bis(4-pyridyl)ethane)

  • 박성호;김관묵;이상기;정옥상
    • Bulletin of the Korean Chemical Society
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    • v.19 no.1
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    • pp.79-82
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    • 1998
  • Novel coordination polymers of general form $[Co(NCS)_2(Py_2L)_2]_n\; (Py_2L=trans-1,2-bis(4-pyridyl)ethylene$ (bpee), 1; 1,2-bis(4-pyridyl)ethane (bpea), 2) have been synthesized by slow diffusion of aqueous solution of $Co(NCS)_2$ with ethanolic solution of appropriate spacer ligand, $Py_2L$, in a mole ratio of 1 : 2. X-ray analyses on both 1 and 2 have provided similar unit and infinite structures with space group Ibam. The local geometry around the cobalt(Ⅱ) atoms is an octahedral arrangement with two NCS groups in trans position (N-Co-N, 180.0° (1); 180.0°(2)) and four pyridine units in propeller fashion. Each spacer ligand connects two cobalt(Ⅱ) ions defining the edges of a $[Co(II)]_4$ rhombus. The most fascinating feature is the occurrence of perpendicular interwoven of independent square grid sheets: this is, one molecular network is perpendicularly interpenetrated through the centers of the $[Co(II)]_4$ rhombuses of another independent network with all of the cobalt(Ⅱ) atoms in a coplanar sheet. The physicochemical properties of the present unique structures were studied.

Per-Endoscopic Trans-Tympanic Traction Treatment of an Aural Inflammatory Polyp in a Cat

  • Park, Won-Keun;Song, Doo-Won;Shin, Dong-Hoon;Kim, So-Yeon;Lee, Ga-Won;Kang, Dong-Jae;Ro, Woong-Bin;Cho, Jong-Mun;Park, Hee-Myung
    • Journal of Veterinary Clinics
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    • v.38 no.3
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    • pp.147-151
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    • 2021
  • A 5-year-old castrated male Maine Coon cat presented with chronic otitis on the right ear. The clinical signs, scratching and head shaking, were recurrent despite symptomatic treatment, including antibiotics and antifungal agents. Video otoscopic examination and computed tomography (CT) examination revealed a polyp in the right ear canal. The polyp was removed via per-endoscopic trans-tympanic traction (PTT) with a grasping forceps. After treatment, Horner's syndrome occurred in the right eye but spontaneously resolved a week later. The mass was diagnosed as inflammatory polyp with a fibrovascular stroma containing plasma cells, lymphocytes, and neutrophils. All clinical signs were improved, and no recurrence was observed after 3 weeks of follow-up. This case report demonstrates that CT scan is effective in identifying the margin of polyp and PTT technique is non-invasive method for treating inflammatory polyp in cats without severe complications.

Analysis of the Phenomenon of Integrated Consciousness as a Global Scientific Issue

  • Semenkova, Svetlana Nikolaevna;Goncharenko, Olga Nikolaevna;Galanov, Alexandr Eduardovich
    • International Journal of Computer Science & Network Security
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    • v.22 no.7
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    • pp.359-365
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    • 2022
  • Scholars are paying increasingly close attention to brain research and the creation of biological neural networks, artificial neural networks, artificial intelligence, neurochips, brain-computer interfaces, prostheses, new research instruments and methods, methods of treatment, as well as the prevention of neurodegenerative diseases based on these data. The authors of the study propose their hypothesis on the understanding of the phenomenon of consciousness that answers questions concerning the criteria of consciousness, its localization, and principles of operation. In the study of the hard problem of consciousness, the philosophical and scientific categories of consciousness, and prominent hypotheses and theories of consciousness, the authors distinguish "the area of the conscious mind", which encompasses several states of consciousness united by the phenomenon of integrated consciousness. According to the authors, consciousness is a kind of executor of the phenomenological idea of the "chalice", so the search for it should be conducted deeper than the processes in the power of thought consciousness and transconsciousness, to which integrated consciousness can act as a lever. However, integrated consciousness may have the capacity to transcend into lower states of consciousness, which requires further study.