• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2409-2412
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• 2015

Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases. Materials and Methods: This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed. Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut-off value for the neutrophil/lymphocyte ratio was 2.56. Conclusions: According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.2101-2105
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• 2013

Background: Long-term survival is a problem with locally advanced and metastatic renal cell carcinomas. Sunitinib malate is an oral multitargeted tyrosine kinase inhibitor, but data on sunitinib use as a second line treatment in metastatic renal cell carcinoma (mRCC) are limited. Prognostic and predictive value of peripheral blood markers has been shown for many cancers. Materials and Methods: Efficacy and safety profiles of sunitinib after interferon alpha (IFN-${\alpha}$) were evaluated based on retrospective data for 23 patients with mRCC. Hematological parameters (neutrophils, lymphocytes, platelets, mean platelet volume, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio) were recorded at the time of metastasis. It was evaluated whether hematological parameters were prognostic and predictive factors. Results: Median progression-free survival (PFS) time was 16.5 months (95%CI: 0-34.5). Median overall survival (OS) time was 25.7 months (95%CI: 10.8-40.0). Most common side effects were neutropenia (52.2%), stomatitis (26.1%) and hand-food syndrome (26.1%). PFS was found 3.13 vs 17.1 months in patients with neutrophil / lymphocyte ratio (NLR)>3 vs $NLR{\leq}3$ (p:0.012). Median OS was 6.96 vs 27.1 months in patients with NLR>3 vs $NLR{\leq}3$ (p:0.001).While 75% of patients who responded to sunitinib had $NLR{\leq}3$, in 72% of patients with no response to sunitinib NLR>3 was detected (p:0.036). The association between the Memorial Sloan-Kettering Cancer Center (MSKCC) criteria and NLR was statistically significant (p:0.022). Conclusions: Data on second line sunitinib treatment following cytokine in mRCC are limited. In our study, we observed second line sunitinib treatment following IFN-${\alpha}$ to be effective and tolerable. NLRappeared to have prognostic and predictive value.

• Asian-Australasian Journal of Animal Sciences
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• 제15권9호
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• pp.1348-1353
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• 2002

The purpose of this study was to evaluate the changes and readjustment capacity in the hematological characteristics of the horse during and after a prolonged training program. One pony and two hot-blooded horses were used in this study. Resting or basal blood parameters were assessed by collecting blood samples of the animals for 1 to 2 months prior to start of the training program. Each animal was subjected to arbitrary exercise for 30 min by an automatic hot trotter and was bled at 0, 15, 30, 45 (15 min of recovery), 60 (30 min of recovery), and 75 min (45 min of recovery) after onset of exercise. All animals were exercised 3 times a week over a fivemonth period. Hematological parameters including average white blood cell counts (WBC, ${\times}$$10^3$/$\mu$l), erythrocyte concentrations (RBC, ${\times}$$10^6$/$\mu$l), hematocrit (HCT, %), mean corpuscular volume (MCV, fl), number of platelets (PLT, ${\times}$$10^4$/$\mu$l), hemoglobin concentration (Hb, g/dl), mean corpuscular hemoglobin (MCH, pg), and mean corpuscular hemoglobin concentration (MCHC, g/dl) were analyzed using an automatic cell counter. All animals showed that RBC, WBC, and HCT were significantly (p<0.05) increasing from 7.09, 8.55, and 43.5 to 8.11, 9.67, and 49.5, respectively, during the 30 min of exercise and were back to or lower than the initial basis (resting and 0 min) 30 min after exercise. However, no significant differences were detected in MCV (50.3-51.3 fl), MCH (17.2-17.4 pg), and MCHC (33.7-34.4 g/dl) values (p>0.05) regardless of the training periods. Similar trends were observed after 1, 3, 4, and 5 months of training when compared to the resting state. When these parameters were analyzed by the effect of training periods (month), mean WBC concentrations significantly reduced in the fourth and fifth month after onset of training compared to that in resting condition or the first month of training program (p<0.05). The RBC values elevated at the second month (9.40) and reaching a significantly low level (p<0.001) at the fifth month (8.62) after training compared to the first month of training (7.89). In conclusion, a mild training program enhances blood parameters gradually in both the horse and the pony. Therefore, an optimized training program is beneficial in promoting the endurance performance of the horse.

• 정보처리학회논문지B
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• 제14B권5호
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• pp.377-382
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• 2007

본 논문에서는 방사 기저함수 네트워크의 파라미터를 전 영역에서 최적화하는 학습 알고리즘을 제안한다. 기존의 학습 알고리즘들은 지역 최적화만을 수행하기 때문에 성능의 한계가 있고 최종 결과가 초기 네트워크 파라미터 값에 크게 의존하는 단점이 있다. 본 논문에서 제안하는 하이브리드 모의 담금질 기법은 모의 담금질 기법의 전 영역 탐색 능력과 경사 기반 학습 알고리즘의 지역 최적화 능력을 조합하여 전 파라미터 영역에서 해를 찾을 수 있도록 한다. 제안하는 기법을 함수 근사화 문제에 적용하여 기존의 학습 알고리즘에 비해 더 좋은 학습 및 일반화 성능을 보이는 네트워크 파라미터를 찾을 수 있으며, 초기 파라미터 값의 영향을 크게 줄일 수 있음을 보인다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1954-1957
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• 2005

A quantitative evaluation of postural balance training using a virtual reality bicycle system was performed. In the experiment, the effectiveness of virtual reality bicycle system on postural balance training was analyzed with four male subjects in their twenties. The parameters measured during cycling were cycling time, average velocity, number of times subject deviated from path, and weight shift. Those parameters were evaluated for the quantification of the extent of control. We also measured the parameters on postural control capability after 5th trial and 10th trial in a balance testing system with a force plate to find out the effectiveness of the training. In the balance test with force plate, it was found out that the weight shift was almost zero and the deviation from the target trace reduced significantly after the training with the virtual cycle. The result showed that the virtual bicycle system was an effective system as a rehabilitation training device.

• 대한물리의학회지
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• 제5권4호
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• pp.587-596
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• 2010

Purpose : This study was performed to investigate the effects of somatosensory training on the spatiotemporal gait parameters and balance in patients with stroke patients. Methods : 24 stroke survivors were allocated in this study, and randomly divided into experimental(n=12) and control group(n=12), independently. Experimental group was applied somatosensory training program plus conventional physical therapy, and control group was applied only conventional physical therapy. All subjects were administered for 30 minutes per day during 8 weeks(5 times a week). Results : Spatiotemporal parameters of gait were significant difference between pre and post intervention in experimental group, except of step length asymmetry ratio(SLAR) and single support time asymmetry ratio (SSAR)(p<.05). But control group had no statistical significance(p>.05). And also there was significant difference between experimental and control group(p<.05), except of cadence and SSAR(p>.05). Balance parameters were significant difference between pre and post intervention in experimental group(p<.05). But control group had no statistical significance(p>.05). And experimental timed up and go test was significantly decreased than control group(p<.05), but berg balance scale and functional reach test were not significant difference between experimental and control group(p>.05). Conclusion : This study was suggested that somatosensory training has effectiveness on the spatiotemporal gait parameters and balance in patients with stroke survivors. So this therapeutic intervention will be effectivelyapply to the stroke survivors in the clinical setting.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.153.1-153
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• 2001

This paper describes a development of rehabilitation training system for the postural balance control. A new rehabilitation training system, designated as a virtual cycling system, was developed to improve postural balance control by combining virtual reality technology with an unfixed bicycle. In this experiment, 20 normal adults were tested to investigate the influencing parameters of postural balance control. In order to evaluate the usefulness and the training effects of the system, several parameters Including path deviation, cycling velocity, cycling time, center of pressure, and head movement were evaluated and analyzed quantitatively. Also, to improve the effect of balance training, the visual feedback information related to the subject´s weight shift was ...

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.181.6-181
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• 2001

This paper describes a development of rehabilitation training system for the postural balance control. A new rehabilitation training system, designated as a virtual cycling system, was developed to improve postural balance control by combining virtual reality technology with an unfixed bicycle. In this experiment, 20 normal adults were tested to investigate the influencing parameters of postural balance control. In order to evaluate the usefulness and the training effects of the system, several parameters including path deviation, cycling velocity, cycling time, center of pressure, and head movement were evaluated and analyzed quantitatively. Also, to improve the effect of balance training, the visual feedback information related to the subject's weight shift was assessed to identify whether it was useful. It could be also known ...

• 한국엔터테인먼트산업학회논문지
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• 제14권2호
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• pp.141-153
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• 2020

본 연구의 목적은 발음, 강세, 목소리의 톤, 속도, 휴지(Pause), 감정표현 등 유사언어 활용 훈련이 오디오북 텍스트 형상화에 영향을 미치는 과정에서 교수자의 우호적 행동의 매개역할 관계를 알아보고자 함에 있다. 본 연구결과는 오디오북 텍스트의 동적(動的)형상화를 위한 유사언어 활용 훈련과 매개변수인 교수자의 우호적 행동에 대한 필요성과 영향력을 인식하는 참고자료가 될 것이다. 연구의 결과는 다음과 같다. 첫째, 유사언어 활용 훈련은 오디오북 텍스트 형상화에 긍정적인 영향을 미치는 것으로 나타났으며 텍스트 본래의 의미를 전달하는 핵심 요인으로 작용하였다. 이에 따라 유사언어 활용 훈련의 의의와 내용을 살펴보고 유사언어 활용 훈련을 지속한다면 오디오북 텍스트 형상화에 도움이 될 것이다. 둘째, 교수자의 우호적 행동은 유사언어의 활용 훈련과 오디오북 텍스트 형상화 간에 부분 매개역할을 하였다. 교수자의 우호적 행동은 훈련생에게 호의와 신뢰를 갖게 하여 유사언어 활용 훈련에 도움을 주었으며 오디오북 텍스트 형상화에 대한 완성도를 높일 것이다. 따라서 유사언어 활용 훈련은 교수자의 우호적 행동과 함께 이루어질 때 오디오북 텍스트 형상화에 보다 효과적이라는 결과를 도출할 수 있었다.

• 천문학회보
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• 제41권2호
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• pp.54.2-54.2
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• 2016

We present a machine learning approach to estimating stellar atmospheric parameters, effective temperature (Teff), surface gravity (log g), and metallicity ([Fe/H]) for stars observed during the course of the Sloan Digital Sky Survey (SDSS). For training a neural network, we randomly sampled the SDSS data with stellar parameters available from SEGUE Stellar Parameter Pipeline (SSPP) to cover the parameter space as wide as possible. We selected stars that are not included in the training sample as validation sample to determine the accuracy and precision of each parameter. We also divided the training and validation samples into four groups that cover signal-to-noise ratio (S/N) of 10-20, 20-30, 30-50, and over 50 to assess the effect of S/N on the parameter estimation. We find from the comparison of the network-driven parameters with the SSPP ones the range of the uncertainties of 73~123 K in Teff, 0.18~0.42 dex in log g, and 0.12~0.25 dex in [Fe/H], respectively, depending on the S/N range adopted. We conclude that these precisions are high enough to study the chemical and kinematic properties of the Galactic disk and halo stars, and we will attempt to apply this technique to Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST), which plans to obtain about 8 million stellar spectra, in order to estimate stellar parameters.