• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1789-1792
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• 2006

To develop the Korean Standard Differentiation of the symptoms and signs for the Stroke(KSDS), the committee on Stroke Diagnosis Standardization of Korean Traditional Medicine was organized by nineteen experts in College of Korean Medicine, The Consensus of the second Consultation Meeting was as follows : First is the definition of the stroke on the Korean Traditional Medicine. Second is the five categories to the Differentiation of the symptoms and signs for the Stroke - fire and heat, dampness and phlegm, blood stasis, qi deficiency, yin deficiency. Third is the indices of the Differentiation of the symptoms and signs for the Stroke respectively. KSDS-1 will be applied to the clinical practice and revised. The Consensus of the third Consultation Meeting had agreed 81 symptoms indexes of KSDS.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.273-278
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• 2006

This survey was accomplished in order to find out the necessity of creation of Korean standard differentiation of the symptoms and signs for the stroke(KSDS) in clinical practice. The survey questions were developed by the consensus from the professors who major in internal traditional Korean medicine(TKM). May 11th to July 31th 2005, the questionnaire was given to 800 TKM doctors in the whole country of Korea listed on the National Korean Medical Hospital Associations address book dy postal mail. Total of 358(44.7%) questionnaires were retrieved out of the 800 subjects. The 311 (86.9%) of 358 TKM doctors given an answer to the survey responded to need development of KSDS, and 176(56.6%) of 311 TKM doctors who answered to need development of KSDS responded to have to consider consensus of clinical experts on the stroke for creation of KSDS. These results support a role for new KSDS might be usefully applied in diagnosis and treatment of the stroke.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.2
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• pp.295-303
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• 2005

YangDongChangHwaHuRok(兩東唱和後錄)is a book that organized the conversation between Joseon physician Ki-DuMun(奇斗文) and Japanese Acupuncture specialist Murakami Tanio(村上溪南) and others when they visited the quarters where the Choson Delegation(朝鮮通信使) were staying in, while the Choson Delegation party were visiting Japan in 1711. YangDongChangHwaHuRok(兩東唱和後錄) was discovered in the process of gathering medicine-related historical documents of the Choson Dynasty that is spread out all over the Japanese region, with the help from Japanese and Chinese scholars. This was part of the Co-Examination-Research-Process of korean medical documents that are located in the East Asia traditional medical region, which was promoted by the Korean Institute of Oriental Medicine in 2003. This paper has analyzed in-depth, with an inner-medical view, the academic exchange content of YangDongChangHwaHuRok(兩東唱和後錄) by following the order of the main text. With this examination, we were able discover new facts about the interest in Primary Symptom(是動病) and Secondary Symptom(所生病) of 17th century doctors, a new hypothesis on the diffusion of HeoYim(許任)'s ChimGuKyungHeomBang(鍼灸經驗方) in Japan, the existence of a new acupuncture tool called ChongChim(腫鍼), and the influence of the 18th comtemporay famous traditional medical books (it is called UiHakYipMun(醫學入門) and ShinEungKyung(神應經) on the 18th century East Asian medical circle. We were also able to ascertain the specific medical content that was diffused to the Japanese medical circle by the Korean medical circle.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.6
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• pp.1418-1430
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• 2006

In the 18th century, Joseon and Japan corresponded politically and culturally through the Joseon Missionary. During this time, the people in Japan who received the Joseon Missionary left many records of their visits and among them were numerous accounts related to medicine, In the years 2003 and 2004, the Korea Institute of Oriental Medicine gathered records that were dispersed throughout japan, and in 20005, it organized the information and put it up on the web along with the original text. This research is an overall report on the documentary records. It analyzes individual documents and looks into what the mainly interested the joseon and Japanese medical worlds at that time. The documents located up till now are 21 medical dialogue records from the 18th century. Through the process of these medical dialogues, the Joseon medical circle discovered a different side of japanese medicine, and the japanese medical world had a chance to directly receive advanced medical skills. Through these medical dialogues, the two countries also exchanged bountiful information about clinical patients. The japanese scholars showed deep interest in Joseon's ginseng, and asked many questions about practical usages of the contents in the medical documents. It is thought that these medical dialogue records will greatly assist studies on the medical history of this time, because it reveals new research data on Korean medical history and Japanese medical history in the latter half of the Joseon Dynasty that has never been reported in the academia before.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.3
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• pp.642-646
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• 2007

It was examined that the effect of fermented traditional wine made by using mycelium of Phellinus linteus (TWPL) on the expression of inflammation-related proteins in rat liver. Levels of aspartate aminotransferase (AST) was significantly increased in the serum of ethanol-treated rats compared to normal. However, the level of AST showed no significant changes in the TWPL-treated rat compared normal. Slight histopathological changes of liver such as cloudy swelling, inflammatory cells infiltration, Kupffer cell reaction were demonstrated in the rats challenged with ethanol compared with normal. Fewer scores of these changes were observed in TWPL-treated rat with recovered glycogen in hepatocytes of whole hepatic lobule. The RT-PCR and Western analysis showed that the expression of inflammatory proteins such as cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor (TNF)-${\alpha}$ were decreased in the TWPL-treated rat compared with ethanol-treated ones. Immunohistochemical analysis showed that the expression of interleukin-lf and TNF-${\alpha}$ tended to decrease in TWPL-treated rat compared with ethanol-treated ones. These results suggest that TWPL may contains some protective agent for alcohol-induced liver injury through a regulating inflammation-related proteins.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.5
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• pp.284-293
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• 2017

Thread embedding therapy is used increasingly for various disease including neck pain. However, the evidence of thread embedding therapy on neck pain and the assessment of their methodology are still limited. This study aimed to investigate the clinical research methodology using thread embedding therapy on neck pain. Thread embedding therapy is used increasingly for various disease including neck pain. However, the evidence of thread embedding therapy on neck pain and the assessment of their methodology are still limited. This study aimed to investigate the clinical research methodology using thread embedding therapy on neck pain. Total 31 studies were included in analysis. Thread embedding therapy usually was used once a week(32.3%), once per 10days(29.0%), once per two weeks (25.8%). The most common concurrent treatment used with thread embedding therapy was Chinese medicine. Among acupuncture points, EX-B2 (61.3%) was most commonly used, followed by GV14(45.2%), GB20(29.0%), GB21(22.6%). For control group, acupuncture were most commonly used(58.1%). All studies reported that the effect of thread embedding therapy was more effective compared to control group. and 11 studies reported side effects. Only 13 studies(41.9%) reported the appropriate randomization method, and the mean Jadad score of included studies was 1.52. Previous clinical trials included in this study showed the effect of thread embedding therapy for neck pain. However, the quality of the studies was not high. Further rigorous clinical trials are need to assess the effect of thread embedding therapy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.6
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• pp.361-369
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• 2018

The purpose of this study was to review the herbal medications of asthma through clinical studies in Korea and to be utilized in the treatment of asthma and in other clinical studies. All clinical researches about asthma published up to 13th February 2018 were found in two domestic electric databases, Oriental Medicine Advanced Searching Integrated System(OASIS) and National Discovery for Science Library(NDSL). Twenty-seven articles were selected and of these, there were 14 articles of before and after studies(BAS), 8 of case series(CS), 4 of case reports(CR) and 1 of the randomized controlled trial(RCT). The most frequently used prescription was "Cheongsangboha-tang(淸上補下湯)". There were various TCM patterns, and Tae-Eum-In(太陰人) was the most common Sasang constitution(四象體質). Frequently used evaluations to assess treatment effects were lung function tests such as Forced expiratory volume at one second (FEV1) and Quality of Life Questionnaire for Adult Korean Asthmatics(QLQAKA) questionnaire responses. We have found that herbal medicine treatment can be an effective treatment to improve the symptoms and the quality of life of asthmatic patients. But we consider that large-scale systematically designed clinical researches are needed additionally.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.4
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• pp.239-248
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• 2019

There are no published data on Gyeongokgo (GOK) safety or efficacy despite being commonly use. The Gyeongokgo (GOK) is commonly used in traditional Korean medicine to promote a health qi and blood, but their objective data was not sufficient in clinical field. To investigate the safety and efficacy of GOK with hematologic and serologic testing and the change of the quality of life in healthy individuals. Randomized, subject-assessor-blind, placebo-controlled, single-center pilot study Participants and Interventions 29 healthy volunteer subjects were randomly placed into the GOK group (n = 20) or placebo control group (n = 9) and instructed to take one treatment packet (GOK or placebo) twice daily for 4 weeks. Subjects were assessed using the Fatigue Severity Scale (FSS) and Short Form 36 Health Survey (SF-36) and underwent hematologic and serologic tests and body composition analysis. The FSS total score (p = 0.093) and SF-36 general health index (p = 0.002) were improved following treatment in the GOK group. Post-treatment thyroid-stimulating hormone levels were increased in the GOK group compared with pre-treatment levels (p = 0.0042). C-reactive protein levels decreased (p = 0.0256) in the GOK group compared with that the placebo group. In time-series tests, GOK did not affect post-prandial serum triglycerides, glucose, insulin, or C-peptide levels. Notably, elevations in serum fasting triglycerides at 2- (p = 0.0333) and 4-hours (p = 0.0414) post-prandial were lower than those in the placebo group. GOK reduced fatigue levels and did not significantly affect laboratory test results performed to measure safety, serum glucose, and lipid profiles. Post-meal triglyceride levels were effectively reduced with treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.4
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• pp.184-190
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• 2020

This study was performed to find antibacterial substances contained in Scutellariae Radix (SR) using a systems pharmacological analysis method and to establish an effective strategy for the prevention and treatment of infectious diseases. Analysis of the main active ingredients of SR was performed using Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. 36 active compounds were screened by the parameter values of Drug-Likeness (DL), Oral Bioavailability (OB), and Caco-2 permeability (Caco-2), which were based on the drug absorption, distribution, metabolism, and excretion indicators. The UniProt database was used to obtain information on 159 genes associated with active compounds. The main active compounds with antibacterial effects were wogonin, β-sitosterol, baicalein, acacetin and oroxylin-A. Target proteins associated with the antibacterial action were chemokine ligand 2, interleukin-6, tumor necrosis factor, caspase-8,9 and mitogen-activated protein kinase 14. In the future, systems pharmacological analysis of traditional medicine will be able to make it easy to find the important mechanism of action of active substances present in natural medicines and to optimize the efficacy of medicinal effects for combinations of major ingredients to help treat certain diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.5
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• pp.139-150
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• 2021

This paper examines whether the conceptual metaphor theory, which has been recently treated as important research topic in the field of cognitive linguistics, can be a new method that can promote the modernization of basic Korean medicine (KM) theory. In addition, the significance and potential of this study are reviewed by looking at Chinese research cases that applied this theory to Traditional Chinese Medicine theories and terminologies. The results are summarized as follows. From the viewpoint of metaphoric cognition, KM is a medicine that attempts to understand the human body (microcosm) through nature (great universe) by metaphorically projecting human experiences of nature on the human body based on the thought of correspondence between nature and human (天人相應). The language system of KM is based on a metaphor that extends our experience of nature to the human body, and an abundance of metaphors can be seen throughout the language of KM. Understanding and interpreting KM theories and terminologies from a metaphorical point of view allow us to understand the nature of KM theoretical key terms more deeply than now. And this understanding can help define and describe KM theoretical key terms and promote the modernization of KM theory research. In addition, various image schema that plays an important role in the metaphorical expansion of physical experience can be used for modeling KM theory. Research of KM theories and terminologies from a metaphorical point of view can serve as a bridge between traditional KM theory and modernization research, opening a new path to the modernization of basic KM theory in difficult situations.