• Korean Journal of Pharmacognosy
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• v.47 no.3
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• pp.211-216
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• 2016

In the course of our continuing search for biologically active components from Korean medicinal plants, we isolated the main compound, luteolin 5-glucoside from aqueous fraction of Ajuga spectabilis. The structure was elucidated by the basis of $^1H$ and $^{13}C$ NMR and TOF ESI-MS data. Quantitative analysis of luteolin 5-glucoside was carried out on a XBridge C18 column ($S-5{\mu}m$, $4.6{\times}250mm$) with gradient elution composed of acetonitrile:water. The results exhibit that the average content of main compound in A. spectabilis were 0.048%. Oxidative stress plays a major role Alzheimer's disease (AD) and other neurodogenerative disease. AD is major health problem and there is currently no clinically accepted treatment to cure or stop its progression. Pretreatment with luteolin 5-glucoside markedly attenuated $H_2O_2$-induced cell viability loss in a dose-dependent manner. Luteolin 5-glucoside also inhibited the formation of intracellular reactive oxygen species in SH-SY5Y. The results suggest that luteolin 5-glucoside from A. spectabilis has protective effects against oxidative stress-induced cytotoxicity, which might be a potential therapeutic compound for treating and/or preventing neurodegenerative disease implicated with oxidative stress.

• Korean Journal of Pharmacognosy
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• v.49 no.1
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• pp.47-54
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• 2018

Astilbe rubra (AR) is a perennial, belongs to the Saxifragaceae family, it contains tannin and triterpene. AR has been used in republic korea to improve toxication, fever, pain and convulsion. Recently, number of natural products have been analyzed for potential pharmacological activities including anti-cancer, anti-obesity and anti-diabetic medication. Consequently, we investigated the growth inhibition effect of Astilbe rubra water extract (WAC), ethanol extract (EAC) and bergenin on Hela cell (human adenocarcinoma cell). From whole plant of A. rubra, bergenin was isolated by column chromatography and its structures were identified by $^1H$, $^{13}C$ NMR and IT TOF-ESI MS. High extraction efficiency of bergenin was shown at 0.95% under 60 min reflux extraction with 50% MeOH. The MTS assay showed that EAC (ethanol extract) treatment increased cell death in a dose-dependent manner. Moreover, EAC treatment on Hela cell increased apoptotic cell death and caspase-3 activity. Results suggest that EAC has growth inhibition effect on Hela cells, but not WAC and bergenin. $500{\mu}g/mL$ EAC treatment inhibited Hela cell at $60.2{\pm}1.5%$.

• The Korean Journal of Food & Health Convergence
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• v.7 no.6
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• pp.9-16
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• 2021

There are two forms of medicine that have existed over time and are important in the delivery of expert health care. The forms of medicine are traditional and modern medicine. This study was aimed at assessing the awareness and perspective on the use and integration of traditional and modern medicine in a rural area of Sokoto State, Nigeria. Two hundred and seventy-one (271) respondents were recruited and a self-administered questionnaire on the awareness and perspective on use and integration of traditional and modern medicine was used to assess the participant's view. Among the participants, 200(73.8%) were females. The mean±SD age of respondents was 30.55±9.73 years. 80.8% of the respondents were aware of traditional medicine while 100% were aware of modern medicine. All respondents prefer modern medicine but about 28.8% support integration of both healthcare services. The results were considered significant when p-value was less than 0.005. There is a statistically significant relationship between the integration of traditional and modern forms of medicine and age, gender, religion, education, ethnicity and occupation but not for marital status. Though all the respondents preferred modern medicine to traditional medicine, some people still feel it will be good to combine both for a better healthcare system.

• The Journal of Korean Medical History
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• v.21 no.2
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• pp.49-60
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• 2008

Burn is a malady that has tormented mankind for a while, and Traditional Korean Medicine techniques of treating it has constantly improved. Detailed description of treatment methods of burns are mentioned in Traditional Korean Medicine texts. To treat burns both medicines for internal and external use are needed, and appropriate first aid is necessary in the first stages. A total of eleven medical cases about burns could be found in the process of researching texts, and studying these 의안s indicated that burns were admirably cured with Korean Traditional Medicine methods of treating burns. Differences in the treatment methods between different schools could also be observed. Further research and development of Traditional Korean Medicine methods of burns is needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.6
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• pp.367-369
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• 2016

The recent introduction of the systems biology or systems medicine opens a new horizon in the field of traditional oriental medicine research. Until now many recent researches of traditional medicine have been conducted based upon reductionist approach, but traditional medicine should be treated by a holistic approach. In this short review, I outlined usefulness of systems approach in medicine and proposed a potential application area of traditional medicine research.

• Journal of Korean Medical classics
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• v.19 no.4
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• pp.70-79
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• 2006

Orthopraxia & Dermatology in traditional Korean medicine has taken a large part of our medicine from the ancient times. However, studies that have been carried out so far were mainly concerned with specific disease or treatment but studies on the history of orthopraxia & dermatology in traditional Korean medicine have not been done largely. Subsequently, it is confirmed that diseases belonging to the category of orthopraxia & dermatology in traditional Korean medicine are carried with no less weight in the books other than literatures specialized in orthopraxia & dermatology while Korean medical literature is being researched with interests in the history of orthopraxia & dermatology in traditional Korean medicine. This paper mainly introduced and analyzed medical literatures containing diseases in orthopraxia & dermatology among Korean medical literatures which were classified into books on emergency measures, general medical documents and surgically specialized records prior to DongUiBoGam.

• Proceedings of the Korean Nutrition Society Conference
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• 2003.05a
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• pp.269.1-269.1
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• 2003

• STIMA Bulletin
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• s.4
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• pp.25-31
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• 2006

We studied about the webdirectory of Korean traditional medicine which receives footlights from medical field in the research and the world traditional medicine. Korean traditional medicine is an integral part of Korean ancient folk medicine. It includes Korean medication, hebalogy, acupuncture, massage and Qigong. Hospitals in Korea are classified as specialized in western medical system. Korean traditional medicine or both. Scientific research and clinic experiments in Korean traditional medicine are continuously progressing. Successes have been made in many of the areas such as in circulating paths of meridians in healing emergency patients with shock, acute myocardial infarction and acute renal failure. Acupuncture anesthesia and acupuncture analgesia has promoted the acupuncture therapy to many patients. Cooperated in Korean traditional medicine has been established between china and Japan, the United State and the orther underdevelopment countries.ꤠ돐邰⨀塨?⨀梸?⨀脠

• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.1076-1084
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• 2017

Objectives: This report describes the case of a patient with progressive multifocal leukoencephalopathy (PML) with hemiplegia, who was treated with a combination of traditional Korean medicine and western medicine. Methods: The patient received traditional Korean medical treatments, including acupuncture, during robust antiretroviral therapy with rehabilitative exercise. Results: During 24 months of treatment, the patient showed improvement in hemiplegia on a manual muscle test. Conclusions: The combination of traditional Korean medicine and western medicine was effective in the treatment of PML in a patient with hemiplegia.

• The Journal of Korean Medicine
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• v.28 no.1 s.69
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• pp.94-104
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• 2007

Objectives : This study investigated the effects of teaching English medical journals to traditional Korean medical students as a way of integrated curriculum, focusing on evidence-based traditional Korean medicine (EBKM) in the light of globalization of traditional Korean Medicine. Methods : 232 students (l16 1st year and t 16 2nd year) were asked to complete a questionnaire at the end of the course in order to validate the course's efficacy on acquisition and utilization of the latest medical knowledge as well as change of attitude toward English itself. Results : The courses were very useful in reducing discomfort toward English journals and to applying the latest medical knowledge to academic reports, clinical practices, and finally to establish abilities for EBKM. The 1st year students who took the courses for two semesters consecutively showed more significant satisfaction than the 2nd year students with only one semester. Conclusion : The findings suggest that English medical journals are an essential curriculum f3r the advance of EBKM and globalization of traditional Korean Medicine and therefore developing adequate textbooks, teaching methods, and quality of instructors should be considered for successful achievements.