• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.05a
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• pp.55-55
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• 2003

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2005.05a
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• pp.107-107
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• 2005

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2005.05a
• /
• pp.136-136
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• 2005

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2002.05a
• /
• pp.136-136
• /
• 2002

• Proceedings of the Korean Society of Toxicology Conference
• /
• 1998.10a
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• pp.50-50
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• 1998

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.135.1-135.1
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• 2000

• Toxicological Research
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• v.26 no.4
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• pp.293-300
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• 2010

tert-Butyl acetate (TBAc) is an organic solvent, which is commonly used in architectural coatings and industrial solvents. It has recently been exempted from the definition of a volatile organic compound (VOC) by the Air Resources Board (ARB). Since the use of TBAc as a substitute for other VOCs has increased, thus its potential risk in humans has also increased. However, its inhalation toxicity data in the literature are very limited. Hence, inhalation exposure to TBAc was carried out to investigate its toxic effects in this study. Adult male rats were exposed to TBAc for 4 h for 1 day by using a nose-only inhalation exposure chamber (low dose, $2370\;mg/m^3$ (500 ppm); high dose, $9482\;mg/m^3$ (2000 ppm)). Shamtreated control rats were exposed to clean air in the inhalation chamber for the same period. The animals were killed at 2, 7, and 15 days after exposure. At each time point, body weight measurement, bronchoalveolar lavage fluid (BALF) analysis, histopathological examination, and biochemical assay were performed. No treatment-related abnormal effects were observed in any group according to time course. Based on those findings, the median lethal concentration ($LC_{50}$) of TBAc was over $9482\;mg/m^3$ in this study. According to the MSDS, the 4 h $LC_{50}$ for TBAc for rats is over $2230\;mg/m^3$. We suggested that this value is changed and these findings may be applied in the risk assessment of TBAc which could be beneficial in a sub-acute study.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2001.05a
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• pp.147-147
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• 2001

To establish a test protocol for the rodent 20-day thyroid/pubertal assay, we dosed flutamide(fl), a non-steroidal androgen antagonist to intact male SD rats from postnatal day 33 for 20 days, and examined several reproductive endpoints for assessing the sensitivity of a list of parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2002.05a
• /
• pp.136-136
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• 2002

Polycyclic aromatic hydrocarbons(PAHs) vary in their carcinogenic potencies. The more potent PAHs carcinogens are 3-methylcholantheren and 7, 12- dimethyl benzo(a)anthracene, while dibenzo(a, c)anthracene has very little carcinogenic activity. Risk assessment of chemical mixture containing various congeners which toxic potency are each different, are conducted using toxic equivalency factors(TEFs).(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.05a
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• pp.55-55
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• 2003

The Bupleuri Radix, called as "Siho" in Korea has been widely used in Korea, China, and Japan as Traditional Herbal Medicine since ancient times and currently. Although saikosaponins isolated from the Bupleuri Radix had metabolic and anti-inflammatory action, it's toxicity was not screened completely. Recently, many herbal medicines are imported from China but safety of these was not evaluated. (omitted) (omitted)