• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2717-2722
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• 2013

Background: The objective of this research is the computed axial tomography (CT) imaging grading of radiation induced pneumonitis (RP) and its correlation with clinical and radiotherapeutic parameters. Materials and Methods: The chest CT films of 20 patients with non-small cell lung cancer who have undergone threedimensional conformal radiation therapy were reviewed. The proposed CT grading of RP is supported on solely radiological diagnosis criteria and distinguishes five grades. The manifestation of RP was also correlated with any positive pre-existing chronic obstructive pulmonary disease (COPD) history, smoking history, the FEV1 value, and the dosimetric variable V20. Results: The CT grading of RP was as follows: 3 patients (15%) presented with ground glass opacity (grade 1), 9 patients (45%) were classified as grade 2, 7 patients (35%) presented with focal consolidation, with or without elements of fibrosis (grade 3), and only one patient (5%) presented with opacity with accompanying atelectasis and loss of pulmonary volume (grade 4). Both univariate and multivariate analysis revealed as prognostic factors for the radiological grading of RP the reduction of FEV1 and the V20 (P=0.026 and P=0.003, respectively). There was also a significant (P<0.001) correlation of radiological grading of RP with FEV1 and V20 (spearman rho 0.92 and 0.93, respectively). Conclusions: The high correlation of the proposed radiological grading with the FEV1 and the V20 is giving a satisfactory clinical validity. Although the proposed grading scale seems relevant to clinical practice, further studies are needed for the confirmation of its validity and reliability.

• 한국가축번식학회지
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• 제18권1호
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• pp.63-70
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• 1994

30마리의 암양에게 surgical embryo collection과정을 통해 oviduct와 uterine horn에 trauma를 생성시켰다. 수술시 절개부위를 봉합하기 직전 노출된 abdominal tissue에 irrigigant로 10% dexamethasone을 사용하였다. 처리군에게는 17mg의 colchicine(1ml/ewe)를 투여했으며, 대조군에게는 1.0ml의 placebo를 처리하였다. 처음 17mg/im의 colchicine를 처리한 15마리 양은 colchicine독성증세를 2∼5일 내에 보였기 때문에 본 연구에서 제외되었다. 17mg에서의 colchicine독성 때문에 colchicine수준은 8, 4 그리고 2mg으로 낮추어졌다. 8mg group에 있던 또 하나의 양은 5일째에 독성증세를 보였기 때문에 나머지 양들은 4와 2mg의 수준으로 이틀에 한번씩 처리되었다. 두 번째 laparotomy는 첫 번째 처리로부터 9주후에 실시되었다. 두 번째 laparotomy후 처리군은 4mg의 colchicine을 이틀에 한번씩 14일 동안 처리되었는데 아무런 독성증세를 나타내지 않았다. 세 번째 laparotomy는 마지막 처리 5주후에 실시되었고 adhesion score로 계산하였다. Adhesion grading은 0∼4의 분포에 근거하여, 4는 가장 심한 adhesion을 나타낸다. 두 번째 laparotomy 결과 adhesion grading( 3)은 두 group 사이에 큰 차리가 없었다(P>0.05). 세 번째 laparotomy결과는 처리군에서 약간 낮은 수치를 보였지만, 통계적으로 두 grouprks에는 큰 차이는 없었다(P>0.05). 10마리의 양(5마리는 대조구, 5마리는 처리구)들은 처리후 5일경에 bone marrow analysis를 통해 cytogenetically분석되었다. 두 grouprks 염색체수와 구조에 있어서 차이가 없었다(p>0.05).

• Korean Journal of Acupuncture
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• 제32권4호
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• pp.208-212
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• 2015

Objectives : We present a successful administration of acupuncture in alleviating persistant peripheral neuropathy due to bortezomib, a potent therapeutic agent of mutlple myeloma. Methods : A patient, experiencing numbness, coldness, tingling and weakness in her feet and hands after bortezomib treatment, was administered acupuncture for 32 weeks, 3 times/week for first 4 weeks and 2 times/week the last 28 weeks, in bilateral acupuncture points, ST36, ST40, EX-LE10, LI11, TE5, and EX-UE9. Responses were assessed at the end of every 4 weeks with Eastern Cooperative Oncology Group(ECOG) grading system, National Cancer Institute - Common Toxicity Criteria(NCIC-CTC) v4.0, Numeric Rating Scale(NRS) 0-10, and Neuropathy Pain Scale (NPS). Results : ECOG was improved from 2 to 1, NCIC-CTC from 2 to 1, NRS from 8 to 1, and NPS from 41 to 5 through 32 weeks of acupuncture treatment. Conclusions : It is conceivable that acupuncture can be a help to relieve bortezomib induced peripheral neuropathy.

• 대한임상독성학회지
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• 제17권2호
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• pp.58-65
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• 2019

Purpose: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and whether green tea extract (GTE) offers protection against hepatic damage caused by α-amanitin (AMA) induced apoptosis in vivo. Methods: The effects of GTE and SIL on the cell viability of cultured murine hepatocytes induced by AMA were evaluated using an MTT assay. Apoptosis was assessed by an analysis of DNA fragmentation and caspase-3. In the in vivo protocol, mice were divided into the following four groups: control group (0.9% saline injection), AMA group (α-amanitin 0.6 mg/kg), AMA+SIL group (α-amanitin and silibinin 50 mg/kg), and AMA+GTE group (α-amanitin and green tea extract 25 mg/kg). After 48 hours of treatment, the hepatic aminotransferase and the extent of hepatonecrosis of each subject was evaluated. Results: In the hepatocytes exposed to AMA and the tested antidotes, the cell viability was significantly lower than the AMA only group. An analysis of DNA fragmentation showed distinctive cleavage of hepatocyte nuclear DNA in the cells exposed to AMA. In addition, the AMA and GTE or SIL groups showed more relief of the cleavage of the nuclear DNA ladder. Similarly, values of caspase-3 in the AMA+GTE and AMA+SIL groups were significantly lower than in the AMA group. The serum AST and ALT levels were significantly higher in the AMA group than in the control and significantly lower in the AMA+GTE group. In addition, AMA+GTE induced a significant decrease in hepatonecrosis compared to the controls when a histologic grading scale was used. Conclusion: GTE is effective against AMA-induced hepatotoxicity with its apoptosis regulatory properties under in vitro and in vivo conditions.