• 한국식품영양과학회지
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• 제35권9호
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• pp.1151-1158
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• 2006

참나물 에탄올 추출물이 고콜레스테롤식이로 유발된 고콜레스테롤혈증 억제효과를 검토한 결과 고콜레스테롤식이만을 급여한 HC군은 정상식이만을 급여한 NC군에 비하여 높은 체중증가량을 나타내었다. 고콜레스테롤식이와 참나물 에탄올 추출물을 저용량과 고용량 병합투여한 HC-PBL군과 HC-PBH군은 HC군에 비하여 체중증가량이 저하되었으나 유의차는 없었다. 식이섭취량은 HC군이 다른 실험군들에 비하여 유의하게 저하되었다. 식이효율은 고콜레스테롤식이를 급여한 HC군, HC-PBL군 및 HC-PBH군은 NC군에 비하여 높았다. 체중 당 간 무게는 HC군이 다른 모든 실험군들에 비하여 유의하게 증가되었으나, 참나물 에탄올 추출물 병합투여로 체중 당 간 무게가 저하되었으며 NC군 보다는 높게 나타났다. 고콜레스테롤식이 급여로 증가된 혈청 중 AST, ALT 및 ALP 활성은 참나물 에탄올 추출물 병합투여로 활성이 감소되었으며, 참나물 에탄올 추출물 투여 용량이 증가할수록 농도 의존적으로 감소하였다. 혈청 중 지질 함량에서, 고콜레스테롤식이를 급여한 HC군은 정상식이를 급여한 NC군에 비하여 중성지질과 총콜레스테롤 함량이 유의하게 증가되었고, 고콜레스테롤식이와 참나물 에탄올 추출물을 병합투여로 감소되었으나 고용량 병합투여한 HC-PBH군만 유의하게 저하되었다. 혈청 중 인지질 함량은 HC군이 NC군에 비하여 감소하였고 참나물 에탄올 추출물 투여로 증가되었으나 NC군에 비하여는 낮았다. 혈청 중 유리콜레스테롤과 콜레스테릴 에스테르 함량은 고콜레스테롤식이와 참나물 에탄올 추출물을 병합투여한 HC- PBL군과 HC-PBH군은 HC군에 비하여 감소하였으며, 참나물 에탄올 추출물 투여 용량에 따른 유의차가 없었다. 총콜레스테롤에 대한 콜레스테롤 에스테르 비율은 각 실험군들 간에 유의차가 없었다. 혈청 중 LDL-콜레스테롤 함량은 HC군이 NC군에 비하여 유의하게 증가하였다. 고콜레스테롤식이와 참나물 에탄올 추출물을 병합투여한 HC-PBL군과 HC-PBH군은 HC군에 비하여 LDL-콜레스테롤 함량이 저하되었으나 참나물 에탄올 추출물 투여 용량에 따른 차이는 없었다. HC-PBL군과 HC-PBH군의 혈청 중 HDL-콜레스테롤 함량은 HC군에 비하여 증가하였으며, 심혈관위험지수와 동맥경화지수는 유의하게 저하되었으나 NC군 수준에는 미치지 못하였다. 간 중 중성지질 및 총콜레스테롤 함량은 HC군이 NC군에 비하여 유의하게 증가되었고, 고콜레스테롤식이와 참나물 에탄올 추출물을 병합투여한 HC-PBL군과 HC-PBH군은 HC군에 비하여 참나물 에탄올 추출물 투여로 저하되었으나 NC군보다는 높게 나타났다. 간 중 중성지질 함량은 참나물 에탄올 추출물 투여 용량에 따른 유의차가 없었으나, 총콜레스테롤 함량은 고용량 병합투여한 HC-PBH군만 유의하게 저하되었다. 혈청 및 간 중의 지질 함량 변화는 정상식이를 급여한 NC군과 NC-PB군 간에는 유의차가 없었다. 따라서 고콜레스테롤식이를 급여하면서 참나물 에탄올 추출물을 병합투여 시에만 지질대사 개선 효과가 있는 것으로 여겨지며, 고용량 병합투여 시 효능이 더 큰 것으로 나타났다. 고콜레스테롤식이로 인한 산화적 스트레스가 고콜레스테롤혈증을 유발하였으며, 이는 참나물 에탄올 추출물에 함유된 항산화물질을 포함한 여러 생리활성물질이 영향을 미친 것으로 사료된다. 이상의 실험 결과에서 참나물 에탄올 추출물은 고콜레스테롤식이로 증가된 총콜레스테롤, LDL-콜레스테롤 및 중성지질 함량은 감소시켰고, HDL-콜레스테롤과 인지질 함량은 증가시킴으로써 지방간 및 동맥경화의 예방과 치료에 효과적일 것으로 판단되어 진다.

• 한국식품영양과학회지
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• 제31권5호
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• pp.862-870
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• 2002

우리나라에도 심혈관질환으로 인한 사망률이 점차 증가하고 있다. 이에 본 연구에서는 채식과 혈청지질 수준 및 혈당, 혈압과의 관계를 규명하기 위한 연구의 일환으로 채식을 하는 비구니스님을 대상으로 하여 연구한 결과를 요약하면 조사대상자의 평균나이는 채식인 44.2세, 비채식인 40.5세, BMI는 각각 22.4, 21.0이었고, WHR은 0.8, 0.8이었고, %BF는 28.7,26.5였으며, 채식인의 평균채식기간은 13.1년이었다. 조사대상자의 total-cholesterol, LDL-cholesterol, HDL-chole-sterol, AI, 수축기혈압 및 혈당은 비채식인이 유의적으로 낮았으며, 심혈관질환 예견지수인 HDL-cholsterol/total-chol-esterol 비는 채식인이 유의적으로 높았다. 두군 모두 중성지방, 혈청 총 콜레스테롤, LDL-cholesterol, AI,는 BMI, WHR, %BF와는 유의적으로 높은 정의상관을 보였다. HDL-cho-lesterol은 BMI, WHR과는 유의한 부의상관을 보였다. 나이는 채식인에서는 BMI, WHR과는 높은 정의상관을 보였다. 나이는 채식인에서는 중성지방과는 정의상관, 비채식인에서는 중성지방, 혈청 총 콜레스테롤, LDL-cholesterol, AI, 수축기 혈압과는 정의 상관을 보였다. 이상의 결과에서 볼 때 두군 모두 BMI, RBW, WHR, %BF가 높을수록 총콜레스테롤, LDL-cholesterol, AI, 수축기 혈압이 유의적으로 높아졌으며 BMI, WHR이 높을수록 HDL-cholesterol은 유의적으로 낮아졌다. 그러나 채식군은 비채식군에 비해 BMI, RBW, WHR, %BF가 유의적으로 높았음에도 불구하고 심혈관 질환 관련인자인 총콜레스테롤, LDL-cholesterol, AI, 수축기 혈압 및 혈당이 비채식군에 비해 유의적으로 낮게 나타났다. 한편 나이와의 상관에서도 비채식인은 나이와 중성지방, 총 콜레스테롤, LDL-cholesterol, AI등이 모두 정의 상관을 보였으나 채식군에서는 나이와 중성지방만이 정의 상관을 보였다. 따라서 채식을 하면 비만인 사람이라도 혈중 지질수준 및 혈당, 혈압이 낮아져서 심혈관 질환 및 고혈압, 당뇨병 등의 예방 치료에 효과적일 것으로 사료된다.

• 대한한방소아과학회지
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• 제20권2호
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• pp.177-196
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• 2006

Objective : This experimental study was designed to determine the effects of BPT on obesity in vivo and in vitro. Methods : in vitro, BPTn extracts of various concentration(50, 100, 200 ${\mu}g/m{\ell}$) were added in 3T3-L1 cell. Adipocyte differentiation was measured by Oil Red O staining and Morphological examination. The expression of $C/EBP{\alpha}$ and $PPAR{\gamma}$ receptor was measured by western blot assay and RT-PCR in vivo, Rats were orally administered BPT daily for consecutive four weeks before poloxamer-407 induced hyperlipidemic state. The rats were sacrificed 24 hrs later for poloxamer-407 treated and then serum triglyceride, total cholesterol were measured ; Rats were orally administered BPT daily for consecutive four weeks before triton WR-1339 induced hyperlipidemic state. The rats were sacrificed 40 hrs later for triton WR-1339 treated and then serum triglyceride, total cholesterol were measured ; Rats with obesity were induced by the high fat-diet for six weeks and then serum triglyceride, total cholesterol, LDL-cholesterol, triglyceride, HDL-cholesterol, hydroxy radical, superoxide dismuatse activity were measured. Results : In vitro, The 3T3-L1 cells' differentiation was significantly decreased by BPT. The expression of $C/EBP{\alpha}$ and $C/EBP{\beta}$ was decreased by BPT. In vivo, BPT significantly reduced serum triglyceride, total cholesterol contents in poloxamer-407 treated rat. BPT significantly reduced serum triglyceride contents in Triton WR-1339 treated rat. Total cholesterol also reduced but did not show a significant change. BPT significantly reduced body weight gain of rat and adipose tissue mass of rats and serum triglyceride, LDL-cholesterol contents and significantly increased HDL-cholesterol, HTR(HDL-cholesterol/Total-cholesterol) in rats with obesity induced by the high fat-diet. BPT reduced blood lipid peroxide, hydroxy radical and increased superoxide dismuatse(SOD) activity.

• Journal of Nutrition and Health
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• 제14권3호
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• pp.117-123
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• 1981

The lipid composition of total serum lipids were investigated by latroscan TH-10 TLC analyzer in 69 healthy subjects and 62 patients with hypercholesterolemia. Total serum lipids level in healthy subjects was higher in females than males. There was a increase in total serum lipids level with increasing total serum cholesterol level in patients with hypercholesterolemia, regardless sex. Total serum lipids obtained from healthy subjects and patients with hypercholesterolemia were separated into phospholipids, free cholesterol, free fatty acids, triglycerides and cholesterol esters. Increasing the level of total serum cholesterol in the patients resulted in a decrease in the level of phospholipids, which was a major lipid fraction, indicating that HDL level in the patients was also decreased. However, cholesterol esters, triglycerides and free cholesterol levels in the patients were higher than those found in healthy subjects. The FC/CE ratio for male patients was lower than for healthy males, while in female patients, this ratio was similar to that observed in healthy females.

• 동아시아식생활학회지
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• 제16권2호
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• pp.165-173
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• 2006

To investigate the effects of yellow soybean powder on serum lipid level and enzyme activities, male Sprague-Dawley(SD) rats were given hyperlipidemic diets for 6 weeks. Rats(n=8) were divided into three groups consisting the normal group(N), hyperlipidemic diets group(C) and hyperlipidemic diets and yellow soybean powder group(YSP). YSP group lowered triglyceride, total lipid, phospholpid, ester-cholesterol and free-cholesterl than control group. YSP group lowered total-cholesterol, VLDL-cholesterol and LDL-cholesterol but increased HDL-cholesterol of the serum compared to the control group. Athergenic Index(AI) and LHR(LDL-cholesterol/HDL-cholesterol ratio) of YSP group was decreased by control group (p<0.05). On the other hand, glutamic oxaloacetate transaminase(GOT), glutamic pyruvate transaminase (GTP), lactate dehydrogenase(LDHase) and alkaline phosphatase(ALP) enzymes activities were decreased by hyperlipidemic diets group (C). These results suggest that yellow soybean powder fed a lipid lowering effect in serum of rats.

• 대한한방내과학회지
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• 제31권4호
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• pp.813-828
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• 2010

Objective : Yegangji-tang (YJT) is noted in China as effective medicine for hyperlipidemia. This experiment was performed to determine the effects of Yegangji-tang (銳降脂湯: YJT) on antioxidant activity and hyperlipidemia induced by hypercholesterolemic diet in mice. Methods : We observed three experimental groups: normal, control, and treatment. Rats were provided a normal diet in the normal group, and the other groups were provided a hypercholesterolemic diet to induce hyperlipidemia. After 2 weeks, YJT was treated to the treatment group. We observed the change of body and liver weight, change of serum total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides, lipid peroxidation and antioxidant activity of liver tissue, cholesterol gene revelation control efficiency, and histologic change of liver and abdominal aorta. Results : Total cholesterol, LDL cholesterol and triglycerides decreased significantly with YJT, whereas HDL cholesterol increased significantly. Lipid peroxidation decreased and antioxidant activity of the liver increased significantly. Gene revelation of ACAT and HMG-CoA reductase in hepatic tissue decreased significantly with YJT. We also found that tissue defects of the liver and abdominal aorta were controlled by YJT on histologic study. Conclusion : These results suggest that YJT might be effective in treatment and prevention of hyperlipidemia.

• Nutrition Research and Practice
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• 제1권1호
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• pp.65-69
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• 2007

We examined the associations between adiponectin or leptin and serum ICAM-1 levels in seventy-six hypercholesterolemic patients (mean age 59 yrs, 25 males and 51 females, LDL-cholesterol>=130mg/dL at screening). Blood lipid profiles and HOMA-IR derived from fasting glucose and insulin concentrations were determined. Serum levels of adiponectin, leptin and ICAM-1 were analyzed using ELISA The results showed that serum levels of leptin were positively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=0.392, p<0.001). Serum levels of adiponectin were negatively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=-0.343, p<0.005). Stepwise multiple linear regression analysis showed that serum leptin was an independent factor to be associated with serum ICAM-1 levels after adjusting for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.001). With respect to adiponectin, its association with serum ICAM-1 was attenuated but still significant when further adjustments were made for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.005). In conclusion, this study suggests that adiponectin and leptin are associated with endothelial derived inflammation.

• 대한한의학방제학회지
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• 제14권1호
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• pp.120-132
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• 2006

Hyperlipidemia is one of dangerous factors causing the arteriosclerosis. For the study of Cheunggansoyosan-gamibang( CGSYS) on antihyperlipidemic effect, we had fed mice divided to three groups (basal diet, hyperlipidemic diet, hyperlipidemic diet + CGSYS), and observed the change of weight, total cholesterol. triglyceride, HDL-cholesterol. LDL-cholesterol. sGOT, sGPT on the serum per every 7days for 6weeks. Also to compensate for the results above, we had tested rat liver. The results of this Study were obtained as fallows ; 1. Cholesterol change on blood was decreased by CGSYS. 2. Total cholesterol. triglyceride and LDL-cholesterol were significantly decreased by CGSYS. 3. HDL-cholesterol was significantly increasd by CGSYS. 4. sGPT was significantly decreased by CGSYS. 5. sGOT was not changed by CGSYS. 6. In case of supplying CGSYS. fatty degeneration was not observed in liver portal area. This study suggests that Cheunggansoyosan-gamibang was significant effect with hyperlipidemia.

• 생약학회지
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• 제27권3호
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• pp.246-253
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• 1996

Coptis rhizoma was extracted with methanol or hot water. Methanol extracts had higher berberine content than water extracts, whereas the contents of Ca, Mg, Zn and K were higher in the water extracts. Rats were fed on the purified diets rich in 0.12% cholesterol only or supplemented with 0.5% of each extracts for four weeks. The concentration of total serum cholesterol was significantly lower in the rats given the extracts, irrespective of the extractants. Although the concentration of serum HDL-cholesterol was comparable among the groups, the ratio of HDL-/total-cholesterol was higher in rats given the extracts. The concentration of serum free fatty acids and ketone body were significantly elevated in rats given the extracts. On the other hand, the extracts supplements significantly decreased the contents of liver cholesterol and triacylglycerol. The amount of fecal bile acids was markedly higher in rats given the extracts, especially in those given water extracts. The results show an effective hypocholesterolemic action of Coptis rhizoma and it seems that the lower concentration of serum and liver cholesterol is resulted from the increased fecal bile acids in rats.

• 동의생리병리학회지
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• 제27권1호
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• pp.118-123
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• 2013

This study was performed from April, 2007 to August, 2012 with female patients who were being treated for and suffering from chronic lumbar pain for periods of 6 months and over. The 53 female patients were diagnosed with osteoporosis by having a T-Score of <-2.5 in a bone mineral density(BMD), as well as showing signs of metabolic syndrome. This was deduced by taking measurements of blood pressure, carrying out blood-chemical examinations and physical measurements such as weight, height, waist measurement and body mass index(BMI). After 5 minutes rest, the patient's blood pressure, height and weight were measured. BMI was calculated using the equation BMI = weight (Kg)/height ($m^2$). The patients had their blood taken in a fasted state(more than 12hours), the fasting blood sugar, total cholesterol, triglyceride, HDL-cholesterol were measured. The average BMD and T-score were calculated by measuring BMD(mg/cc) of L1-L3 using QCT. In a correlation analysis of the physical examinations, clinical character of metabolic syndrome and T-score, the result showed that age and T-score had a negative correlation(r=-0.699, p<0.01) as did triglyceride and T-score (r=-0.047, p<0.01), where as weight(r=0.239, p<0.05) and height(r-=0.329, p<0.01) and T-score had a positive correlation. There was no significant correlation with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score. This study showed that there are significant correlations with age, weight, height and T-score. But there are no significant correlations with total cholesterol, HDL cholesterol, blood sugar, blood pressure and T-score and that these did not influence bone density. Further research with more subjects is required to determine whether there is a correlation of clinical character of metabolic syndrome and T-score.