• 한국축산시설환경학회지
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• 제10권1호
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• pp.59-66
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• 2004

맥주공장에서 얻어지는 맥주효모 슬러리를 육계사료의 첨가제로서 이용하기 위하여 8$0^{\circ}C$에서 건조하였으며, 육계사료에 0%, 2%, 4% 첨가ㆍ급여하여 육계의 성장과 장기발달 및 혈액 성상에 미치는 영향을 조사하였다. 4% 맥주효모 슬러리의 첨가시 육계의 성장률이 9% 향상되었고(P<0.05) 사료 효율은 8% 개선되었다(P＜0.05). 사료섭취량은 전처리구간에 차이가 없었다. 또한 전 처리구간에서 육계의 간장, 심장 및 복강지방의 무게에는 차이가 없었으나, 체중 대비 간장 무게의 비율에 있어서는 4% 첨가구에서 감소되었다. 맥주효모 슬러리의 첨가가 혈중 glucose 농도에는 영향을 미치지 못하였으나, 혈중 triglyceride 농도에 있어서는 4% 첨가구에서 31% 유의적으로 감소하였다.(P<0.05). 특히 맥주효모 슬러리의 첨가가 육계의 혈청 중 total-cholesterol 농도에는 영향을 미치지 않았으나, HDL 농도에 있어서는 2%와 4% 첨가구에서 대조구에 비하여 각각 33%와 26% 증가하여(P＜0.05), HDL/TC의 비율을 향상시켰다(P<0.05). 본 연구의 결과는 맥주효모 슬러리의 첨가가 육계의 성장 및 사료효율을 개선시켜 육계의 사료 첨가제로서 이용가능성을 확인시켜 주었으며, 특히 혈중에서는 triglyceride 농도를 감소시키고, HDL 농도 및 HDL/TC의 비율을 증가시켜 체내 지방대사에 영향을 미친다는 것을 보여준다.

• 한국식품영양과학회지
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• 제28권6호
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• pp.1339-1348
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• 1999

In present study possible hypolipidemic effects of garlic were investigated in an experimental model which consisted of 4 groups of Wistar rats(three weeks old): CO group received a basal diet(as a standard diet) contained 6.3% of corn oil. LO group was taken the experimental diet in which only 6.3% corn oil in basal diet was substituted by 12.6% of lard oil. So the experimental diet was somewhat high saturated fat diet. LG1 group was treated orally with garlic juice as 1% of raw garlic in the diet together with the same diet as the diet for LO group. LG2 group was taken 2% of garlic under the same dietary condition as that of LG1 group. The rat body weights prior and posterior to the experimental period were measured and the amount of the experimental dietary intake was determined at every 3 day interval. After the experimental dietary period of 30 days the blood obtained from all the sacrificed rats were analyzed for the biochemical parameters. Over the one month period of experiment there was no abnormality or apparent change in appearance and activity or diet consumption in all experimental rat groups. LO group fed a diet rich in lard showed significantly increased body weight gain rate by 30% and also elevated levels of triglyceride, total cholesterol and LDL cholesterol by 29.9%, 27.4% and 62.3% respectively and no significant difference in the levels of HDL cholesterol, GOT, GPT, blood glucose and blood urea nitrogen as compared to those of control group. So it seemed that the high calorie diet in LO group mainly contributed to the significant increase in body weight gain rate and other biochemical parameters. In spite of 1% garlic treatment LG1 group had significantly increased body weight gain rate by 25.2%, levels of triglyceride, total choesterol and LDL cholesterol by 25.2%, 24.6% and 50.5% respectively as compared to control and LO group, and no increase in the levels of HDL cholesterol, blood glucose and blood urea nitrogen. At garlic 1% diet there was no hypolipidemic efficacy in rat serum. Under the treatment with garlic 2% in diet LG2 group showed significantly increased body weight gain rate by 19.7% as compared to control and elevated levels of GOT, GPT and BUN by 85.8~96.4%, 127~148% and 88% respectively as compared to control, but LG2 group had significantly reduced levels of triglyceride, total cholesterol and LDL cholesterol as compared to LOand LG1 group. In present study there were no significant change in HDL cholesterol and blood glucose value. In LG2 group GOT, GPT and blood urea nitrogen values were slightly increased presumably due to the inhibiting effects of garlic on the hepatic or renal function of rats. Nevertheless in this study garlic may have some demonstrable hypolipidemic effects in rat.

• Preventive Nutrition and Food Science
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• 제11권1호
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• pp.36-41
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• 2006

Dongchunghacho rice, produced by cultivating Dongchunghacho fungus on rice, could be an effective functional food because it offers added value to rice and thus increases rice consumption. However, the physiological effect of Dongchunghacho rice has not been reported yet although there is increasing consumers demand. Therefore, we investigated the effect of Dongchunghacho rice (unpolished rice cultivated with Cordyceps militaris) on lipid metabolism in hyperlipidemic rats. Forty of 8 wk-old male Sprague-Dawley rats were divided into four groups after a 1 week of adaptation period and fed either a normal diet (66% polished rice diet, NC), high fat (12 g/100 g)-high cholesterol (1 g/100 g) diet with 53% polished rice (HC), or high fat-high cholesterol diets supplemented with 30% of the total rice as either unpolished rice (DR) or Dongchunghacho rice (DR). After 4 weeks, rats fed the Dongchunghacho rice diet with high fat and cholesterol had dramatically lower plasma LDL cholesterol concentrations and atherogenic indexes and higher plasma HDL cholesterol levels compared with the rats consuming polished rice or unpolished rice with high fat and cholesterol diet. Dongchunghacho rice led to less total lipid and total cholesterol accumulation in liver. However, these significant reductions in plasma or hepatic lipid profiles were not closely correlated with fecal total lipid or total cholesterol excretion. The plasma concentration of total cholesterol and triglycerides were not affected by Dongchunghacho rice. This hypolipidemic effect of Dongchunghacho rice seemed to be unrelated to unpolished rice itself, because the plasma and hepatic lipid profiles of DR group were not different from that of the HC group. These results suggest that unpolished rice containing cultivated Cordyceps militaris can improve plasma and hepatic lipid profiles in rats fed with high fat-high cholesterol diet.

• 한국가금학회지
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• 제37권3호
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• pp.221-228
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• 2010

본 시험은 육계에 마늘 부산물을 급여하여 5주간 사육한 육계의 생산성과 계육의 일반 성분, pH, 도체 특성, 콜레스테롤 함량 및 혈액 조성을 조사하였다. 실험구는 마늘 부산물을 첨가 급여하지 않은 처리구를 대조구, 마늘 부산물 1% 급여구는 T1, 마늘 부산물 2% 급여구는 T2 그리고 마늘 부산물 5% 급여구는 T3 등 4개 처리구로 나누어 사양하였다. 육계의 증체량, 사료 섭취량, 사료 요구율 등의 생산성은 유의적인 변화가 없었다. 계육의 일반 성분 중 조지방은 마늘 부산물을 급여함에 따라 감소하였고(P<0.05), T2에서 가장 낮은 함량을 보이고 있으며, 수분과 조회분은 처리구간에 유의성은 없었다. 도체 특성 중 간의 무게는 마늘 부산물 급여구에서 무거웠으며, 급여량이 증가할수록 다소 무거운 경향이었다(P<0.05). 계육의 총 콜레스테롤과 LDL-cholesterol은 마늘 부산물 급여구에서 낮았고, 특히 T3에서 가장 낮았으며 HDL-cholesterol은 높아지는 결과이었다(P<0.05). 혈액 성분중GOT는 마늘 부산물을 급여함으로 감소하는 경향이었고, GPT, triglyceride, glucose는 유의성이 없었다. 결론적으로 마늘 부산물 2%를 급여하면 육계의 생산성에는 영향을 미치지 않으면서 계육의 콜레스테롤 함량에 영향을 미칠 수 있을 것으로 사료된다.

• 한국식품영양학회지
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• 제29권2호
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• pp.290-299
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• 2016

This study was conducted to determine the association between dietary calcium intake and biomarkers related to lipid and glucose metabolism and inflammation in Korean patients with type 2 diabetes. Seventy-five subjects (41 males, 34 females) were recruited from a group of patients who had visited the department of endocrine medicine. Data on anthropometric characteristics, clinical indices such as hemoglobin A1c and C-reactive protein (CRP), and dietary nutrient intakes were collected. Subjects were divided into three groups on the basis of their calcium intake [< EAR (below estimated average requirement), EAR-RNI (between EAR and recommended nutrient intake), > RNI (above RNI)]. Average calcium intake of < EAR, EAR-RNI, > RNI groups were $462.7{\pm}18.7$, $649.7{\pm}12.8$, and $895.7{\pm}21.7mg$, respectively. Energy intake was not different among groups but intakes of protein, total and saturated fatty acids were significantly higher in > RNI group than < EAR group. Analysis of covariance revealed that HDL cholesterol level was significantly higher in EAR-RNI group, as compared to < EAR group after adjustment with confounders such as age, sex, BMI and energy intake (p < 0.05). Levels of CRP and homeostasis model assessment 2-insulin resistance (HOMA2-IR) were significantly lower in EAR-RNI group. Total cholesterol level was higher in EAR-RNI and > RNI groups, although within the normal range. Our results suggest that dietary calcium intake may influence the levels of HDL-cholesterol, CRP and HOMA2-IR and subsequently, help management/treatment of type 2 diabetes patients.

• 한국환경보건학회지
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• 제19권1호
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• pp.77-89
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• 1993

Effects of fermented milk were tested in Sprague-Dawley male rats. In six treatment 150 rats were fed for 12 months: (1) normal control synthetic pellets+water, (2) cholesterol control synthetic pellets containing 1% of cholesterol and 500, 000 IU of vitamin D2/100 g (cholesterol pellets) +water, (3) cholesterol pellets+25% fermented milk, (4) cholesterol pellets+50% fermented milk, (5) cholesterol pellets+75% fermented milk, (6) cholesterol pellets+100% fermented milk. In 3, 6, 9, 12 months, rats were sacrificed for analysis of samples. Rats received the fermented milk had significantly lower (p<0.05) serum cholesterol levels and higher ratios of HDL-cholesterol to total cholesterol than did the water fed rats. Stomach, heart, abdominal aorta and kidney of rat from fermented milk group showed slighter calcification or necrosis than did those of rat from cholesterol control group. Weight gain, diet intake, and drink consumption were significantly different among groups. Results indicate that fermented milk had a helpful effect of experimental hypercholesteremia and atherosclerosis.

• 대한예방한의학회지
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• 제12권1호
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• pp.127-134
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• 2008

This study was carried out in 14,443 subjects(8,706 men, 5,737 women, mean age $41.8{\pm}9.16$) who visited the health promotion center of one university hospital. Serum $T_3$, $T_4$ and TSH concentrations were measured with CIA using commercial kits on ADVIA Centaur Assay and Serum total cholesterol, triglyceride, and HDL-cholesterol were measured by auto-analyzer Hitach 7600 in enzyme method. 1. The prevalence of subclinical hypothyroidism was 12.6/1,000 population(men 6.0/1,000, women 22.7/1,000) and as high as about 4 times in women than in men. 2. In subclinical hypothyroidism, the values of total cholesterol and LDL-cholesterol were significantly high by 5.5 mg/dL, 4.6 mg/dL compared with normal group(p<0.05). 3. In all the tested hypercholesterolemia and hyperLDL-cholesterolemia, were correlated with TSH. There is higher correlation in women group than men group. These results indicate that the subclinical hypothyroidism and dyslipemia significantly correlated. Especially, it is very important to find that the hypercholesterolemia and hyperLDL-cholesterolemia are the high risk factors of atherosclerosis. Therefore, it is essential for the group of subclinical hypothyroidism to take the cholesterol, LDL-cholesterol and serum lipid test as well as thyroid function test.

• 대한물리의학회지
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• 제8권2호
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• pp.239-243
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• 2013

PURPOSE: The purpose of present study was to investigate effects of obesity, blood pressure and life style on lipid indices and blood pressure in men of age 40s. METHODS: One hundred forty five subjects in men of age 40s were participated in this study. All participants were taken physical examination, lifestyle survey and laboratory test. According to examination, participants were divided into two group in four categories ; obesity and normal group, hypertension and normal group, smokers and non-smokers, and drinkers and non-drinkers. The low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), total cholesterol (TC), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) were analyzed by independent t-test for comparison between two groups. RESULTS: The values of LDL, TC, SBP, DBP were higher and HDL was lower in obesity than in normal group (p<.05). The values of LDL, TC, SBP, DBP were higher in hypertension group than in normal group (p<.05). The values of TG was higher and HDL was lower in smokers than in non-smokers (p<.05). There's no significant differences between drinkers and non-drinkers (p>.05). CONCLUSION: It can be seen that obesity and blood pressure were more relative risk factors than smoking and alcohol indices in cardiovascular diseases.

• Journal of Nutrition and Health
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• 제26권6호
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• pp.672-679
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• 1993

This study was designed to determine changes of serum glucose and lipid levels in noninsulin dependent diabetes mellitus patients during different doses of docosahexaenoic acid (DHA)-rich fish oil supplementation. All patients had a fasting blood glucose of less than 180mg/dl, a LDL-cholesterol of less than 160mg/dl, and a triglyceride of more than 160mg/dl. None had clinical evidence of renal, hepatic or coronary vascular disease. Sixteen patients served as control. Seven patients ingested 2.00g of fish oil(low dose group), consisting of 0.30g eicosapentaenoic acid(EPA) and 0.55g DHA. The group of modest dose(n=9) was provided 3.91g of fish oil, consisting 0.59g EPA and 1.08g DHA. After 4 weeks, serum triglyceride concentration showed a mild but nonsignificant elevation in control group, a 9% decrease(194 to 177mg/dl) in the group of low dose of fish oil and a 28% decrease(206 to 161mg/dl) in the group of modest dose. The level of high density lipoprotein(HDL), HDL2, HDL3 and total cholesterol in all groups were not changed. There was a mild increase in malondialdehyde and low density lipoprotein(LDL)-cholesterol concentration and decrease in $\alpha$-tocopherol concentration. However, these changes were not significant.

• 한국식품영양과학회지
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• 제41권3호
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• pp.345-350
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• 2012

본 실험은 CRE 80% 에탄올 추출물을 식이에 0.5%, 1% 혼합하여 5주간 섭취시켰을 때 CRE 추출물이 SHR의 혈압에 미치는 영향을 확인함으로써 CRE 추출물이 고혈압 흰쥐의 지질성분과 혈압에 미치는 영향을 조사함으로써 CRE의 기능성식품으로서의 이용 가능성을 확인하였다. 실험기간 중 실험쥐의 일일평균 체중변화량은 0.5% CRE 보충군(II)은 1.63 g/day로 정상식이 급여군보다 일일평균 체중증가량이 유의적으로 감소하는 결과를 나타내었다. 간, 신장, 비장의 무게 변화를 측정한 결과 유의적인 차이를 나타내지 않았으며, 혈청 내 포도당 농도 또한 정상식이 급여군에 비해서 0.5%, 1% CRE 추가 보충군이 감소하는 경향은 보였으나 유의적인 차이는 나타나지 않았다. 본 실험에서 총 cholesterol 함량은 정상식이 급여군보다 0.5%, 1% CRE 보충 급여군에서 유의적으로 증가하는 경향을 보였지만 HTR을 확인한 결과 정상식이 급여군보다 0.5%, 1% CRE 보충 급여군이 각각 11% 증가한 결과를 나타냈기 때문에 혈중 총 cholesterol 함량의 증가는 HDL-cholesterol의 농도 증가에 의한 것으로 생각된다. HDL-cholesterol 농도는 정상식이 급여군과 0.5%, 1% CRE 보충 급여군 모두에서 유의적으로 증가하는 경향을 나타냈다. LDL-cholesterol 역시 유의적으로 증가하는 경향을 나타냈지만 HDL-cholesterol/LDL-cholesterol의 증가 비율로 봤을 때 HDL-cholesterol이 정상식이 급여군보다 0.5% CRE 보충 급여군이 15%, 1% CRE 보충급여군이 36.5%로 유의적으로 증가하는 결과를 나타냈다. 실험기간 동안 SHR의 혈압 변화는 정상식이 급여군(I)의 경우 거의 일정하게 혈압이 유지되는 경향을 보이다가 5주차에는 다시 증가한 반면 CRE 0.5% 보충군(II)은 초기혈압에서 떨어지는 경향을 보이다가 2주째에 혈압이 다시 상승했다. 하지만 그 후 다시 감소하는 경향을 보였고, CRE 1% 보충군(III)은 일정하게 혈압이 감소하는 경향을 나타냈다. 따라서 CRE 추출물이 SHR의 혈압을 낮추고 지질대사 개선에 영향을 주어 혈관계 장애로 인해 발병되는 고혈압, 당뇨, 뇌혈관질환, 동맥경화증과 같은 질환을 예방하는 기능성식품으로서 이용 가능성이 기대된다.