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http://dx.doi.org/10.9799/ksfan.2016.29.2.290

Dietary Calcium Intake is associated with Blood Lipid Profile, Blood Pressure, Inflammatory State and Insulin Resistance in Type 2 Diabetes Patients  

Chung, Hae-Yun (Dept. of Food and Nutrition, Soongeui Women's College)
Publication Information
The Korean Journal of Food And Nutrition / v.29, no.2, 2016 , pp. 290-299 More about this Journal
Abstract
This study was conducted to determine the association between dietary calcium intake and biomarkers related to lipid and glucose metabolism and inflammation in Korean patients with type 2 diabetes. Seventy-five subjects (41 males, 34 females) were recruited from a group of patients who had visited the department of endocrine medicine. Data on anthropometric characteristics, clinical indices such as hemoglobin A1c and C-reactive protein (CRP), and dietary nutrient intakes were collected. Subjects were divided into three groups on the basis of their calcium intake [< EAR (below estimated average requirement), EAR-RNI (between EAR and recommended nutrient intake), > RNI (above RNI)]. Average calcium intake of < EAR, EAR-RNI, > RNI groups were $462.7{\pm}18.7$, $649.7{\pm}12.8$, and $895.7{\pm}21.7mg$, respectively. Energy intake was not different among groups but intakes of protein, total and saturated fatty acids were significantly higher in > RNI group than < EAR group. Analysis of covariance revealed that HDL cholesterol level was significantly higher in EAR-RNI group, as compared to < EAR group after adjustment with confounders such as age, sex, BMI and energy intake (p < 0.05). Levels of CRP and homeostasis model assessment 2-insulin resistance (HOMA2-IR) were significantly lower in EAR-RNI group. Total cholesterol level was higher in EAR-RNI and > RNI groups, although within the normal range. Our results suggest that dietary calcium intake may influence the levels of HDL-cholesterol, CRP and HOMA2-IR and subsequently, help management/treatment of type 2 diabetes patients.
Keywords
type 2 diabetes; dietary calcium intake; HDL-cholesterol; C-reactive protein; homeostasis model assessment 2-insulin resistance;
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