• Preventive Nutrition and Food Science
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• 제4권3호
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• pp.200-202
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• 1999

The effectsof garlic vinegar supplementation on body weight, blood blucose, and plasma triglyceride and cholesterol were investigated in streptozotocin -induced diabetic rats fed high-cholesterol(1%) diet for 4 wk. The garlic vinegar was made by fermenting 20% frsh garlic juice. There was no effect of garlic vinegar on body weight, plasma glucose or triglyceride concentrations in the diabetic rats. Plasma total -cholesterol concentrations were unaffected by garlic vinegarr supplementation. However, plasma LDL-cholesterol concentrations and atherogenic index were significantly lower in the diabetic rats supplemented with garlic vinegar diet than tin the cotnrol rats. The diabetic-rats supplemented with garlic vinegar not only had increased HDL-cholesterol levels but had decreased LDL-cholesterol. This alteration in the HDL/LDL-cholesterol ratio in the diabetic rats may decrease the risk of atheroscelrosis. Therefore, the over-all effect of garlic vinegar supplement may contribute to the antiatherogenic role in streptozotocin-induced diabetic rats.

• 한국축산식품학회지
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• 제24권4호
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• pp.399-404
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• 2004

본 연구는 공시균인 Aspergillus terreus와 유산균을 이용하여 혈중 및 고기내 콜레스테롤이 저하된 육류 개발을 목표로 하였다. 따라서 거세돈 60두를 60일간 및 육계는 6주간을 공시하여 대조구는 일반 시판사료만 급여하였고, T1구는 Aspergillu terreus 배양체, T2구는 시판중인 EM-pro 배양체(Lactobacillus acidophilus, Bacillus subtilis와 Saccharmyces cervisiae의 3종 혼합배양물)를 각각 0.2%씩 첨가급여한 결과는 다음과 같다. 돼지고기내의 스테아린산은 T1구와 T2구가 높았으나, 올레인산은 대조구와 T1구가 높았다(p<0.05). 또한 닭고기의 스테아린산은 대조구가 높았으나, 올레인산은 T1구와 T2가 유의적으로 높았다(p<0.05). 혈액 중 돼지고기의 총 콜레스테롤과 HDL-cholesterol 함량은 T1구(63.77mg, 111.19mg)가 대조구(101.69mg, 132.37mg)보다 크게 낮아 통계적인 유의차를 보였고(p<0.05), 육계의 경우는 T1구(78.50mg, 143.61mg)가 대조구(119.26mg, 240.43mg)보다 크게 낮았다(p<0.05). 돼지고기의 총 콜레스테롤과 HDL-cholesterol 함량은 T1구(78.53mg, 117.64mg)가 대조구(140.5mg, 150.55mg)보다 크게 낮아 유의차를 나타내었고(p<0.05). 육계의 경우는 T1구 (93.35mg, 72.03mg)가 대조구(111.90mg, 116.88mg)보다 크게 낮았다.(p<0.05). 이상의 결과를 종합해 볼 때, Aspergillus terreus 처리한 T1구가 돼지와 육계의 혈액 및 고기내에서 총 콜레스테롤과 HDL-cholesterol 함량이 크게 낮아졌다. 따라서 Aspergillus terreus 배양체가 체내의 콜레스테롤 합성에 상당히 영향을 미친것으로 판단되며, 향후 저 콜레스테롤 고기 생산의 가능성을 보여주었다.

• Journal of Preventive Medicine and Public Health
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• 제39권6호
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• pp.477-484
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• 2006

Objectives : This study was conducted to examine the association between the carotid artery intima-media thickness (IMT), plaque and cardiovascular risk factors according to gender and age. Methods : The data used for this study were obtained from 1,507 subjects (691 men, 816 women), aged 20-74 years, who participated in 'Prevalence study of thyroid diseases' in two counties of Jeollanam-do Province during July and August of 2004. The body mass index (BMI) and waist hip ratio (WHR) were calculated by anthropometry The blood pressure, pulse rate, pulse pressure, total cholesterol, triglyceride, HDL cholesterol and fasting blood sugar level were also measured. Ultrasonography was used to measure the carotid artery IMT and plaque. IMT measurements were performed at 6 sites, including both common carotid arteries, and the bulb and internal carotid arteries. The definition of the 'mean IMT' was mean value obtained from these 6 sites. Results : The ${\pm}$ standard deviation IMT values were $0.65{\pm}0.14\;and\;0.60{\pm}0.13mm$ in men and women (p<0.001), respectively. The data were analyzed according to gender and the 50 year age groups. In a multiple linear regression analysis, age and hypertension were positively associated with the mean IMT in both men and women, aged<50 years. Age, total cholesterol and smoking (current) were positively associated with the mean IMT in men $(\geq50\;years)$. Age was positively associated with the mean IMT in women $(\geq50\;years)$, but the HDL cholesterol level was negatively associated. The prevalence of plaques was 44.2%(196/443) in men and 19.4%(89/459) in women, for those greater than 50 years of age. In a multiple logistic regression analysis, age (OR=1.090, 95%CI=1.053-1.129), HDL cholesterol (OR=0.964, 95%CI=0.944-0.984), total cholesterol (OR=1.009, 95%CI=1.002-1.017)and BMI (OH=0.896, 95%CI=0.818-0.983) were independently associated with plaques in men; whereas, age (OR=1.057, 95%CI=1.012-1.103), HDL cholesterol (OR=0.959, 95%CI=0.932-0.986), pulse pressure (OR=1.029, 95%CI=1.007-1.050) and triglycerides (OR=0.531, 95%CI=0.300-0.941) were independently associated with plaques in women. Conclusions: There were significant gender and aging differences in the association between the IMT, plaque and cardiovascular risk factors. Therefore, for the prevention of atherosclerosis, selective approaches should be considered with regard to gender and age factors.

• Journal of Acupuncture Research
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• 제24권5호
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• pp.113-125
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• 2007

Objectives : This research was performed to investigate the effect of herbal acupuncture(Raphanus sativus) at Bisu($BL_{20}$) on weight gain, food intake, food efficiency, serum of lipid concentrations, liver function and HDL to total cholesterol ratio of rats fed high fat diet for 5weeks. Methods : Experimental groups were divided into high fat diet group(Control), high fat diet and saline in $BL_{20}$ treated group(Saline), high fat diet and Raphanus sativus-herbal acupuncture in $BL_{20}$ treated group(RHA-1, 0.058mg/ml/g), high fat diet and Raphanus sativus-herbal acupuncture in $BL_{20}$ treated group(RHA-2, 0.029mg/ml/g), high fat diet and Raphanus sativus-herbal acupuncture in $BL_{20}$ treated group(RHA-3, 0.011mg/ml/g), Herbal acupuncture was bilaterally treated at 0.2cc per 4days, total 14 times in 56days. Results : Body weight and food efficiency were decreased in saline, RHA-1, RHA-2. Feed intake was increased in saline, RHA-1, RHA- 2, RHA- 3. The level of serum total cholesterol was decreased in saline, RHA-1. The level of serum HDL-cholesterol, LDL-cholesterol were not significant. The level of serum triglyceride, Total Bilirubin were decreased in saline, RHA-1, RHA-2, RHA-3.The level of serum AST was decreased in RHA-1. But the level of serum ALT was increased in RHA-1. The level of atherogenic index was decreased in saline, RHA-1. The level of HTR was increased in saline, RHA-1. Conclusions : Raphanus sativus-herbal acupuncture in Bisu($BL_{20}$) can control body weight, feed intake and feed efficency ratio, total cholesterol, total bilirubin, and prevention cardiovascular risk.

• 대한한방소아과학회지
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• 제20권1호
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• pp.31-47
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• 2006

Objectives : The purpose of this study is to find out the effect of antioxidation related to aging of Cheongeumyeonsudan which is written on Dongui-bogam experimentally. Method : 14 weeks aged SD albino rats were separated into uncontrolled group, controlled group and CGY group. As controlled and CGY groups were induced aging by subcutaneous injection of D-galactose, at the same time we administered the extract of Cheongeumyeonsudan to CGY group for 6 weeks. After then we drew blood from each group, and took measurements; the activity of SOD, GSH-px, catalase in erythrocytes, TBARS value, concentration of total lipid, tryglycende, total cholesterol, HDL-cholesterol in blood plasma. Results : The activities of SOD, GSH-px in erythrocytes were significantly increased in the CGY group compared with control group. The activity of catalase showed a tendency to increase, but it was nor remarkable. The concentration of total lipid, the values of TBARS and total cholesterol was significantly decreased in the CGY group compared with control group, and the concentration of plasma HDL-cholesterol was not remarkable. The concentration of tryglycende in plasma showed a tendency to decreased. Conclusions : it is suggested that Cheongeumyeonsudan decreased the activities of free radical, the concentration of lipid in plasma and generate enzyme which form lipid peroxide.

• 대한간호학회지
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• 제41권2호
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• pp.182-190
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• 2011

Purpose: This study was done to identify correlates and variables predicting daily activity among elders with Diabetes Mellitus (DM). Methods: Seventy-six elders registered in the Department of Endocrine Medicine at C university hospital participated in data collection. Data on daily activity and biochemical variables were collected via actigraph accelerator (Actical) and blood tests between September 2009 and July 2010. Data analysis was done using SPSS WIN 15.0 program and included one-way ANOVA, independent t-test, Pearson correlation coefficients, and stepwise multiple regression. Results: This study showed a positive correlation between daily activity and High Density Lipoprotein Cholesterol (HDL-C) and a negative correlation among Total Cholesterol (TC), Triglyceride (TG), and Low Density Lipoprotein Cholesterol (LDL-C). The variables predicting daily activity were frequency of exercise, HDL-C, and TC. These factors accounted for 40.0% of the variance of daily activity in elders with DM. Conclusion: The results indicate that it is necessary to improve daily activity to reduce Fasting Blood Glucose (FBG), TC, and TG in elders with DM.

• Nutritional Sciences
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• 제6권3호
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• pp.141-147
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• 2003

Fruits and vegetables reportedly have a protective effect against hyperlipidemia and oxidative disease. Accordingly, this study aimed to investigate the lipid-lowering effect and antioxidative capacity of persimmon leaf extract (PLE) in rats fed a high-cholesterol diet. Male rats were fed a high-cholesterol (1% wt/wt) or high-cholesterol diet supplemented with Lovastatin (0.02% wt/wt) or PLE (0.2% wt/wt) for 5 weeks. The concentration of plasma total cholesterol was significantly lower in the PLE group than in the lovastatin group. However, the concentration of plasma HDL-cholesterol and the ratio of HDL-cholesterol/total-cholesterol (%) were significantly higher in the PLE group than in the control group. The PLE supplement also significantly lowered the contents of hepatic cholesterol and triglyceride. In comparing fecal sterol contents, the PLE group saw a significant increase of both neutral and acidic sterol compared to the other groups. The PLE supplement significantly lowered plasma GOT and GPT activity, which ave indices of hepatic toxicity. Plasma TBARS concentration was significantly lower in the PLE group than in the control group, while hepatic TBARS level was not significantly different between the groups. In a comparison of hepatic antioxidant parameters, SOD, catalase and GSH-Px activity were significantly higher in the PLE group than in the control group. However, the PLE supplement significantly towered antioxidant enzyme activity in the erythrocyte. Furthermore, these results suggest that supplementation of PLE promoted the excretion of fecal sterols, thereby leading to decreased absorption of dietary cholesterol. In addition, PLE may play an important role in regulating antioxidative capacities by altering SOD and ChT activity.

• 한국식품영양학회지
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• 제13권4호
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• pp.312-318
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• 2000

대두(Glycin max Merrill) 배아의 기능적 활성을 조사하기 위하여 대두를 발아시켜 만든 배아(soybean sprout)을 시료로 하여 0.75% 콜레스테롤 첨가식이로 유발된 고지혈증 Sprague Dawley계 수컷의 흰쥐에 대두 배아의 유기용매 추출물을 급여시킨 후 혈청의 지질 개선효과를 알아보기 위하여 4주간 동안 대두 배아를 섭취시켰다. 식이 급여가 대조군의 체중 및 장기 무게에 미치는 영향은 거의 찾아볼 수 없었으며 혈청 총 콜레스테롤 및 LDL-콜레스테롤의 농도는 대조군에 비하여 낮았고. 콜레스테롤 식이군에 비하여 콜레스테롤 식이와 대두 배아 메탄올 추출물의 혼합투여시 낮게 나타났다. 총 콜레스테롤에 대한 HDL-콜레스테롤의 비는 대두 배아 추출물 급여군이 높게 나타났으며, 동맥경화 지수는 고콜레스테롤 식이군에 비하여 대두 배아 추출물이 낮았다. 또한 혈청중의 유리 콜레스테롤 및 고콜레스테롤 에스테르의 농도는 고콜레스테롤 식이군에 비해 대두 배아의 혼합 급여군이 감소하였고, 인지질의 농도도 콜레스테롤 식이군 보다 콜레스테롤 식이와 대두 배아 급여군이 낮은 경향을 나타내었다.

• 한국식품영양과학회지
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• 제28권2호
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• pp.477-483
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• 1999

The effects of chitin and chitosan on the contents of plasma and liver lipids and the fecal excretion of neutral and acidic steroids were investigated in rats fed with atherogenic diet. Dietary chitin did not affect plasma total cholesterol, LDL cholesterol and HDL cholesterol, while chitosan diet de creased total cholesterol and LDL cholesterol. Plasma content of triglyceride was reduced signif icantly by chitin diet but not by chitosan. Increases in fecal weight were observed in rats fed with either chitin or chitosan, and the increase was greater with chitosan than with chitin. Dietary chitosan resulted in an increase of fecal excretion of neutral steroids without any changes in the excretion of acidic sterols. Putting the results together, dietary chitosan reduces plasma cholesterol probably due to the reduction of cholesterol absorption. The decrease in plasma triglyceride level by dietary chitin requires further research to understand the mechinism.

• 동아시아식생활학회지
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• 제17권2호
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• pp.198-204
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• 2007

The aim of this study was to investigate the effect of bread supplemented with silkpeptide and cholesterol of on the lipid metabolism in rats. When a rats were fed bread supplemented with silkpeptide and cholesterol, their net weight tended to decrease compared with the control. Although the food intake was increased, this was not significant., but the feed efficiency ratio was substantially decreased. The total and LDL-cholesterols were decreased, but the DHL-cholesterol was increased. The HDL-cholesterol to total cholesterol ratio and level of triglyceride were substantially increased. The atherogenic index was decreased when rats are fed bread supplemented with silkpeptide and; thus, would show an improvement in the effect of high-cholesterol symptoms.