An anti-Dxidative Effect of Cheongeumyeonsudan of Rats Induced Aging by D-Galactose

천금연수단(千金延壽丹)이 노화 유발된 철쥐의 항산화효능에 미치는 영향

  • Song, Kyoung-Hye (Department of pediatrics, College of Oriental Medicine, Daegu Haany University) ;
  • Seo, Jung-Min (Department of pediatrics, College of Oriental Medicine, Daegu Haany University) ;
  • Beak, Jung-Han (Department of pediatrics, College of Oriental Medicine, Daegu Haany University)
  • 송경혜 (대구한의대학교 한의과대학 소아과교실) ;
  • 서정민 (대구한의대학교 한의과대학 소아과교실) ;
  • 백정한 (대구한의대학교 한의과대학 소아과교실)
  • Published : 2006.04.30

Abstract

Objectives : The purpose of this study is to find out the effect of antioxidation related to aging of Cheongeumyeonsudan which is written on Dongui-bogam experimentally. Method : 14 weeks aged SD albino rats were separated into uncontrolled group, controlled group and CGY group. As controlled and CGY groups were induced aging by subcutaneous injection of D-galactose, at the same time we administered the extract of Cheongeumyeonsudan to CGY group for 6 weeks. After then we drew blood from each group, and took measurements; the activity of SOD, GSH-px, catalase in erythrocytes, TBARS value, concentration of total lipid, tryglycende, total cholesterol, HDL-cholesterol in blood plasma. Results : The activities of SOD, GSH-px in erythrocytes were significantly increased in the CGY group compared with control group. The activity of catalase showed a tendency to increase, but it was nor remarkable. The concentration of total lipid, the values of TBARS and total cholesterol was significantly decreased in the CGY group compared with control group, and the concentration of plasma HDL-cholesterol was not remarkable. The concentration of tryglycende in plasma showed a tendency to decreased. Conclusions : it is suggested that Cheongeumyeonsudan decreased the activities of free radical, the concentration of lipid in plasma and generate enzyme which form lipid peroxide.

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