• Steel and Composite Structures
• /
• v.46 no.2
• /
• pp.279-292
• /
• 2023

Structural design against the progressive collapse has been a vital necessity for decades due to occasional tragic events. The question of whether designed structures against the progressive collapse are still robust if subjected to multi-hazard scenarios containing column removal and successive localized fires is ad-dressed in the current study. Two seven-story steel structures with an identical area but different structural configurations of 4- and 5-bays are designed against the progressive collapse; the structural components are also fireproofed for a 60 min fire resistance. The structures are then subjected to different column re-moval scenarios over different stories followed immediately by localized fires. Results indicate that the structures are not able to keep their stability under all of the considered scenarios; the 4-bay structure is more vulnerable than the 5-bay structure. It is also indicated that upper stories are more sensitive toward the considered scenarios than lower stories. To advance structural safety, two strategies are adopted: in-creasing the thickness of the insulation materials to reduce the thermal effects, or, increasing the safety fac-tor (ΩN) of the structures when designing against the progressive collapse. As for the first strategy, provid-ing a 35% and a 25% increase in the insulation thicknesses of the structural components of the 4-bay and 5-bay structures, respectively, can prevent a progressive collapse to trigger. As for the second strategy, in-creasing ΩN by 10% can enhance the structural integrity to where no collapse occurs under all of the sce-narios.

• Journal of Ginseng Research
• /
• v.48 no.1
• /
• pp.12-19
• /
• 2024

Skeletal muscle (SM) is the largest organ of the body and is largely responsible for the metabolism required to maintain body functions. Furthermore, the maintenance of SM is dependent on the activation of muscle satellite (stem) cells (MSCs) and the subsequent proliferation and fusion of differentiating myoblasts into mature myofibers (myogenesis). Natural compounds are being used as therapeutic options to promote SM regeneration during aging, muscle atrophy, sarcopenia, cachexia, or obesity. In particular, ginseng-derived compounds have been utilized in these contexts, though ginsenoside Rg1 is mostly used for SM mass management. These compounds primarily function by activating the Akt/mTOR signaling pathway, upregulating myogenin and MyoD to induce muscle hypertrophy, downregulating atrophic factors (atrogin1, muscle ring-finger protein-1, myostatin, and mitochondrial reactive oxygen species production), and suppressing the expressions of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in cachexia. Ginsenoside compounds are also used for obesity management, and their anti-obesity effects are attributed to peroxisome proliferator activated receptor gamma (PPARγ) inhibition, AMPK activation, glucose transporter type 4 (GLUT4) translocation, and increased phosphorylations of insulin resistance (IR), insulin receptor substrate-1 (IRS-1), and Akt. This review was undertaken to provide an overview of the use of ginseng-related compounds for the management of SM-related disorders.

• Oncology Letters
• /
• v.41 no.1
• /
• pp.361-368
• /
• 2019

Gliomas, the most highly malignant central nervous system tumors, are associated with an extremely poor patient survival rate. Given that gliomas are derived from mutations in glial precursor cells, a considerable number of them strongly react with glial precursor cell-specific markers. Thus, we investigated whether malignant gliomas can be converted to glial cells through the regulation of endogenous gene expression implicated in glial precursor cells. In the present study, we used three small-molecule compounds, [cyclic adenosine monophosphate (cAMP) enhancer, a mammalian target of rapamycin (mTOR) inhibitor, and a bromodomain and extra-terminal motif (BET) inhibitor] for glial reprogramming. Small-molecule-induced gliomas (SMiGs) were not only transformed into exhibiting a glial-specific morphology, but also showed positive reactions with glial-specific markers such as glial fibrillary acidic protein (GFAP), 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) and anti-oligodendrocyte (RIP). A microarray analysis indicated that SMiGs exhibited a marked increase in specific gene levels, whereas that of a malignant cancer-specific gene was greatly decreased. Moreover, proliferation of the cells was markedly suppressed after the conversion of malignant glioma cells into glial cells. Our findings confirmed that malignant gliomas can be reprogrammed to non-proliferating glial cells, using a combination of small molecules, and their proliferation can be regulated by their differentiation. We suggest that our small-molecule combination (with forskolin, rapamycin and I-BET151) may be the next generation of anticancer agents that act by reprogramming malignant gliomas to differentiate into glial cells.

• Journal of Korean Society for Atmospheric Environment
• /
• v.32 no.6
• /
• pp.603-612
• /
• 2016

The objective of this study was to estimate the emission characteristics for PM, $PM_{10}$, and $PM_{2.5}$ in the various stationary sources. The particulate matters collected in the various stationary sources such as power plants (Coal and B-C oil), incinerators(municipal and industrial waste), and glass furnaces. The PM and $PM_{10}$, PM and $PM_{2.5}$, $PM_{10}$ and $PM_{2.5}$ samples were collected using the cyclone type $PM_{10}$, $PM_{2.5}$ samplers and 30 species(19 inorganic species, 9 ionic species, OC and EC) were analyzed by ICP, IC, and TOR/IMPROVE methods. The mass concentrations of PM, $PM_{10}$, $PM_{2.5}$ from nine stationary sources ranged $0.63{\sim}9.58mg/Sm^3$, $0.26{\sim}7.47mg/Sm^3$ and $0.13{\sim}6.34mg/Sm^3$, respectively. The level of $PM_{10}$, $PM_{2.5}$ portion in PM calculated 0.63~0.99, 0.38~0.94, respectively. In the case of emission trend for species, power plant showed high concentrations for Al, Mg, Na, Si, V and $SO_4{^{2-}}$, respectively. Also, Ca, Fe, K, Si, $Cl^-$, and $K^+$ showed high in incinerator. In the case of glass furnace, Na, Pb, K, Si, $Na^+$ and $SO_4{^{2-}}$ represented high concentrations. Power plant showed higher EC/OC concentrations than other sampling sites. These results suggest the possible role for complement establishment process of emission inventory and emission management for PM.

• Nuclear Engineering and Technology
• /
• v.49 no.7
• /
• pp.1537-1546
• /
• 2017

Many thermal-hydraulic tests have been conducted at the Korea Atomic Energy Research Institute for verification of the SMART (System-integrated Modular Advanced ReacTor) design, the standard design approval of which was issued by the Korean regulatory body. In this paper, the contributions of these tests to the standard design approval of SMART are discussed. First, an integral effect test facility named VISTA-ITL (Experimental Verification by Integral Simulation of Transients and Accidents-Integral Test Loop) has been utilized to assess the TASS/SMR-S (Transient and Set-point Simulation/Small and Medium) safety analysis code and confirm its conservatism, to support standard design approval, and to construct a database for the SMART design optimization. In addition, many separate effect tests have been performed. The reactor internal flow test has been conducted using the SCOP (SMART COre flow distribution and Pressure drop test) facility to evaluate the reactor internal flow and pressure distributions. An ECC (Emergency Core Coolant) performance test has been carried out using the SWAT (SMART ECC Water Asymmetric Two-phase choking test) facility to evaluate the safety injection performance and to validate the thermal-hydraulic model used in the safety analysis code. The Freon CHF (Critical Heat Flux) test has been performed using the FTHEL (Freon Thermal Hydraulic Experimental Loop) facility to construct a database from the $5{\times}5$ rod bundle Freon CHF tests and to evaluate the DNBR (Departure from Nucleate Boiling Ratio) model in the safety analysis and core design codes. These test results were used for standard design approval of SMART to verify its design bases, design tools, and analysis methodology.

• Journal of the Korean earth science society
• /
• v.35 no.7
• /
• pp.501-517
• /
• 2014

Based on a summary of the previous studies on columnar joints, this study presents research strategies and subjects to understand a formation of columnar joints, and its application in South Korea as follows; geometry of colonnade and entablature, formation mechanism and pattern change, surface morphology and internal structure, platy joint at the top and the bottom of columnar joints, crack patterns in drying starch-water slurries, using numerical models and computer graphics on joint formation, scale and geometry concerned with occurrence of volcanic rock, petrological and mineralogical study of the host rock. Additionally, more research is needed, such as deformation of column pattern during the hot state, secondary landform by alteration and weathering on the Earth's surface such as rock stream, tor and tafoni. This study will take an active role in research of columnar joint and the Cenozoic lava flow of South Korea. Results of this study will be useful to the activation of geotourism and geological field study.

• Journal of the Korean earth science society
• /
• v.38 no.7
• /
• pp.552-560
• /
• 2017

This study investigates the development process of Mt. Deok on Bigeum Island, Shinan, on the basis of geomorphological and geological analyses. K-Ar dating was carried out on two samples of the acidic lapilli tuff developed in the study area, and the obtained K-Ar ages are $70.4{\pm}1.4$ and $76.9{\pm}1.5Ma$, which correspond to the Late Cretaceous (Campanian). Mt. Deok is surrounded by rock cliff, and various weathering microtopographic features, such as tafoni, tor and gnamma, are developed. Tafoni with diverse morphologic types is the most dominant feature, indicative of intense salt weathering. Geological characteristics such as porous tuff and joint have played an important role in the development of tafoni and rock cliff. Geomorphology and geology of Mt. Deok reflect paleoenvironmental change and interaction between human and nature in the coastal area.

• Archives of design research
• /
• v.11 no.2
• /
• pp.143-152
• /
• 1998

The purpose of this study is to develop Korean-style tractors of international comp etitive advantage which satisfy consumers' needs based on the research of large size ones. The overall process of this study is to generate appropriate design process and to apply quantitative analysis method to each steps of it and finally to suggest objective product design development system. For this, we firstly selected important trac -tor design concepts from the analysis of current market and consumer perception, next did conjoint analysis with the extract -ed design attributes and attribute levels. Finally, we decided preferred designs of ea -ch segments based on conjoint analysis. Here we selected only one most preferred tractor design of all due to narrow domest -ic market situation. This study may contribute to the customer oriented design development with the appli cation to many other fields of design. Also, it may contribute to all design related not only academic fields but to practitional fields.

• Development and Reproduction
• /
• v.17 no.2
• /
• pp.99-109
• /
• 2013

Trophoblasts, in the placenta, play a role for placental development as well as implantation in the early pregnancy. The characteristics and functions of trophoblast are identified by their localization and potency for proliferation, differentiation, and invasion. Thus, inadequate trophoblast cell death induces trophoblast dysfunction resulting in abnormal placental development and several gynecological diseases. Recently, it was reported that increased immortalization-upregulated protein-2 (IMUP-2) by hypoxia influences trophoblast apoptosis. However, IMUP-2 function on autophagy, which is type II programmed cell death remains unclear. In this study, we analyzed IMUP-2 expression in trophoblast cells (HTR8-SVneo) and compared IMUP-2 effects on cell death including apoptosis and autophagy in trophoblast regardless of IMUP-2 expression. Increased IMUP-2 in trophoblast by IMUP-2 gene transfection induces cell death, especially, apoptosis increases more than autophagy (p<0.05). However, the decreased IMUP-2 in trophoblasts after siRNA treatment decreased apoptosis with the decreased activities of caspase 3 and 7. The expressions of LC3 and MDC as an autophagosome makers and phosphorylated mTOR, which is a negative regulator for autophagy, increased. In addition, the S phase of cell cycle increased in trophoblasts when IMUP-2 expression decreased. Taken together, the alteration of IMUP-2 can control the balance between apoptosis and autophagy of trophoblasts resulting in functional involvement in placental development and in gynecological diseases by regulating the function of trophoblasts.

• Journal of Korean Society for Atmospheric Environment
• /
• v.20 no.E2
• /
• pp.53-59
• /
• 2004

The roadway tunnels in urban areas give rise to problems such as a localized air pollution. Here, we report the results of a case study of an urban roadway tunnel measurement. The size-resolved particle sampling was carried out with a two 2-stage filter pack samplers and an Andersen impactor sampler at the center of Buk-Ak tunnel in November 2001. Particle Induced X-ray Emission (PIXE) was applied to determine the elemental composition of size-resolved particles divided into soluble and insoluble fractions. The Thermal/Optical Reflectance (TOR$^{(R)}$) method was also employed in analyzing of elemental carbon (EC) and organic carbon (OC). Mass concentrations of fine (< 1.2 ${\mu}{\textrm}{m}$) and coarse (> 1.2 ${\mu}{\textrm}{m}$) particles are 165 and 48 $\mu\textrm{g}$ m$^{-3}$ , respectively. Total elemental mass concentration (the sum of insoluble coarse, soluble coarse, insoluble fine, and soluble fine) is found to be 24$\mu\textrm{g}$ m$^{-3}$ and comprises only 11 % of total particle mass concentration. The concentrations of EC, OC, and mass show the clear dependency on particle size with the maximum between 0.1 and 0.43 ${\mu}{\textrm}{m}$ aerodynamic diameters. Total carbon (sum of EC and OC) accounts for approximately 70% of mass concentration.n.