• BMB Reports
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• v.52 no.8
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• pp.502-507
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• 2019

Translation is a costly, but inevitable, cell maintenance process. To reduce unnecessary ATP consumption in cells, a fine-tuning mechanism is needed for both ribosome biogenesis and translation. Previous studies have suggested that the ribosome functions as a hub for many cellular signals such as ribotoxic stress response, mammalian target of rapamycin (mTOR), and ribosomal S6 kinase (RSK) signaling. Therefore, we investigated the relationship between ribosomes and mitogen-activated protein kinase (MAPK) activation under ribotoxic stress conditions and found that the activation of c-Jun N-terminal kinases (JNKs) was suppressed by ribosomal protein knockdown but that of p38 was not. In addition, we found that JNK activation is driven by the association of inactive JNK in the 80S monosomes rather than the polysomes. Overall, these data suggest that the activation of JNKs by ribotoxic stress is attributable to 80S monosomes. These 80S monosomes are active ribosomes that are ready to initiate protein translation, rather than polysomes that are already acting ribosomes involved in translation elongation.

• Nuclear Engineering and Technology
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• v.50 no.8
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• pp.1298-1305
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• 2018

The use of System-on-Chip (SoC) solutions in the design of on-board data handling systems is an important step towards further miniaturization in space. However, the Total Ionizing Dose (TID) and Single Event Effects (SEE) characterization of these complex devices present new challenges that are either not fully addressed by current testing guidelines or may result in expensive, cumbersome test configurations. In this paper we report the test setups, procedures and results for TID testing of a SoC microcontroller both using standard $^{60}Co$ and low-energy protons beams. This paper specifically points out the differences in the test methodology and in the challenges between TID testing with proton beam and with the conventional gamma ray irradiation. New test setup and procedures are proposed which are capable of emulating typical mission conditions (clock, bias, software, reprogramming, etc.) while keeping the test setup as simple as possible at the same time.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.977-985
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• 2021

The main aim of the study is to provide empirical evidence about the association between stock market exchange data and weighted price index. This research utilized monthly reported data from the Amman stock exchange market (ASE) and the Central Bank of Jordan (CBJ). The weighted price index was employed as the dependent variable and the independent variables were weighted price index (WPI), turnover ratio (TOR), number of trading days (NTD), price-earnings ratio (PER), and dividends yield ratio (DY). The time period of the study was from January 2015 to October 2020. The study's methodology follows a quantitative approach using the multiple regression method to test the hypotheses of the study. The final results of the study provided conclusive evidence that the market-weighted price index is strongly and positively correlated to three predetermined variables, namely; turnover ratio, price-earnings ratio, and dividend yield but no evidence was obtained for the effect of the number of trading days. The finding of the current study proved that the market price index is not only influenced by macro factors, but also by other variables assumed to not beneficial for the judgment of price index movements.

• Molecules and Cells
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• v.45 no.7
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• pp.435-443
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• 2022

In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. N⁶-adenosine methylation (m⁶A) is one of the most common modifications on mRNA. It is a reversible chemical mark catalyzed by the enzymes that deposit and remove methyl groups. m⁶A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m⁶A processing. Conversely, m⁶A can modulate the activity of signal transduction networks via m⁶A modification of signaling pathway genes or by acting as a ligand for receptors. In this review, we discuss the current understanding of the crosstalk between m⁶A and signaling pathways and its implication for biological systems.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.1109-1114
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• 2022

The SMART (System-integrated Modular Advanced ReacTor) is an integral-type small modular reactor developed by KAERI (Korea Atomic Energy Research Institute). This paper discusses the feasibility and applicability of a 3D-based equivalent model using dynamic condensation method for seismic analysis of a SMART control rod drive mechanism. The equivalent model is utilized for complicated seismic analysis during the design of the SMART. While the 1D-based beam-mass equivalent model is widely used in the nuclear industry for its calculation efficiency, the 3D-based equivalent model is suggested for the seismic analysis of SMART to enhance the analysis accuracy of the 1D-based equivalent model while maintaining its analysis efficiency. To verify the suggested model, acceleration response spectra from seismic analysis based on the 3D-based equivalent model are compared to those from the 1D-based beam-mass equivalent model and experiments. The accuracy and efficiency of the dynamic condensation method are investigated by comparison to analysis results based on the conventional modeling methodology used for seismic analysis.

• Korean Journal of Exercise Nutrition
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• v.24 no.3
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• pp.32-38
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• 2020

[Purpose] Sarcopenia is considered one of the major causes of disability in the elderly population and is highly associated with aging. Exercise is an essential strategy for improving muscle health while aging and involves multiple metabolic and transcriptional adaptations. Although the beneficial effects of exercise modalities on skeletal muscle structure and function in aging are well recognized, the exact cellular and molecular mechanisms underlying the influence of exercise have not been fully elucidated. [Methods] We summarize the biochemical pathways involved in the progression and pathogenesis of sarcopenia and describe the beneficial effects of exercise training on the relevant signaling pathways associated with sarcopenia. [Results] This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia. [Conclusion] This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.

• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.148-160
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• 2023

Depression is a neuropsychiatric disorder associated with persistent stress and disruption of neuronal function. Persistent stress causes neuronal atrophy, including loss of synapses and reduced size of the hippocampus and prefrontal cortex. These alterations are associated with neural dysfunction, including mood disturbances, cognitive impairment, and behavioral changes. Synaptic plasticity is the fundamental function of neural networks in response to various stimuli and acts by reorganizing neuronal structure, function, and connections from the molecular to the behavioral level. In this review, we describe the alterations in synaptic plasticity as underlying pathological mechanisms for depression in animal models and humans. We further elaborate on the significance of phytochemicals as bioactive agents that can positively modulate stress-induced, aberrant synaptic activity. Bioactive agents, including flavonoids, terpenes, saponins, and lignans, have been reported to upregulate brain-derived neurotrophic factor expression and release, suppress neuronal loss, and activate the relevant signaling pathways, including TrkB, ERK, Akt, and mTOR pathways, resulting in increased spine maturation and synaptic numbers in the neuronal cells and in the brains of stressed animals. In clinical trials, phytochemical usage is regarded as safe and well-tolerated for suppressing stress-related parameters in patients with depression. Thus, intake of phytochemicals with safe and active effects on synaptic plasticity may be a strategy for preventing neuronal damage and alleviating depression in a stressful life.

• Wind and Structures
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• v.37 no.2
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• pp.133-151
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• 2023

This paper first provides a wide overview about the design codes and standards covering the use of Computational Wind Engineering / Computational Fluid Dynamics (CWE/CFD) for wind-sensitive structures and built environment. Second, the paper sets out the basic assumptions and underlying concepts of the new Annex T "Simulations by Computational Fluid Dynamics (CFD/CWE)" of the revised version "Guide for the assessment of wind actions and effects on structures" issued by the Advisory Committee on Technical Recommendations for Constructions of the Italian National Research Council in February 2019 and drafted by the members of the Special Interest Group on Computational Wind Engineering of the Italian Association for Wind Engineering (ANIV-CWE). The same group is currently advising UNI CT021/SC1 in supporting the drafting of the new Annex K - "Derivation of design parameters from wind tunnel tests and numerical simulations" of the revised Eurocode 1: Actions on structures - Part 1-4: General actions - Wind actions. Finally, the paper outlines the subjects most open to development at the technical and applicative level.

• Clean Technology
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• v.16 no.4
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• pp.254-257
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• 2010

[ $Mg(OH)_2$ ]slurry was prepared by using natural mineral brucite exploited from Liaoning province in China, and its de-SOx efficiency was examined. The effect of difference in particle size distribution of brucite and activation by hydrothermal treatment were investigated. The de-$SO_2$ efficiency of a finely-milled brucite sample below 1000 mesh with narrow particle size distribution was higher than that of the sample below 80 mesh. On the other hand, the de-$SO_2$ efficiency of brucite sample below 80 meshes was significantly improved by the hydrothermal treatment at 363 K tor 3 h.

• Proceedings of the Korean Society of Computer Information Conference
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• 2020.01a
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• pp.241-242
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• 2020

홈/개인 IoT 환경에서 모바일 기기나 유무선 공유기는 IoT 기기의 트래픽을 중계하는 경우가 많다. 본 논문에서는, 홈/개인 IoT 환경에서 IoT 기기들이 서버로 전송한 패킷들을 프라이버시 보호 측면에서 더 안전하게 상류로 전송하는 기능을 제공하는 트래픽 자동 분류기반의 상류 프라이버시 보호 계층을 제안한다. 트래픽의 목적지 주소를 기반으로, 직접 연결, 프락시를 통한 연결, VPN을 통한 연결, Tor 익명 네트워크를 통한 연결 방식 중 하나를 선택하고, 선택된 연결 방식으로 상류로 패킷을 전달한다. 별도의 사용자 인터페이스를 통해 목적지 주소 및 적합한 연결 방식을 설정할 수 있다. 제안 계층은 모바일 기기 및 유무선 공유기에 적용 가능하며, 현재 모바일 기기용 개념 증명 예제를 구현하였다.