• Journal of information and communication convergence engineering
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• v.9 no.2
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• pp.235-243
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• 2011

With the recent trends and the adaptation of further advancement in personal healthcare system leads to develop some application which can work independent and user can operate that application without much interference of physician or any specialist user. To meet these needs, this paper proposes and implements a progressive architecture for the personal healthcare information system. This new architecture will not only play the role of middleware but also provide a analysis tool to process that different sensor data which is collected from different sensors implemented on patient body and environment. After collecting that data, with the help of various developed applications this data can be convert into useful information which will be stored in application server for further use and research. These features can be enabled by simple and effortless interactions of normal users and act autonomously to support their activities. This proposed personal healthcare architecture will also provide analysis report to the doctors and patient or various users for further instructions. The analysis report consists of healthcare data analysis results and history of patients. We are considering healthcare data like ECG, which is an important aspect for basic healthcare need.

• Korean Journal of Optics and Photonics
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• v.18 no.5
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• pp.303-308
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• 2007

We report here on the application of a digital holographic microscope as a metrology tool for the inspection and the micro-topography reconstruction of different micro-structures of phase shift photo-mask (PSM). The lithography by phase shift photo-mask uses the interference and the pattern of the PSM is not imaged by general optical microscope. The technique allows us to obtain digitally a high-fidelity surface topography description of the phase shift photo-mask with only one hologram image acquisition, allowing us to have relatively simple and compact set-ups able to give quantitative information of PSM.

• Bulletin of the Korean Chemical Society
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• v.26 no.9
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• pp.1385-1389
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• 2005

Human hepatitis B virus (HBV) is a pathogen related to the development of liver diseases including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). However, the efficient methods to suppress HBV replication have not been developed yet. Therefore, we have used RNA interference (RNAi) as a potential tool for the suppression of HBV replication. Here, we designed a 21 nt small intefering dsRNA (siRNA) against hepatitis B virus X (HBx) RNA with 3' overhanging ends derived from T7 promoter. It has been reported that HBV X protein plays an important role in HBV gene expression and viral replication. The suppression of HBx gene expression by the 21 nt siRNA was investigated by Northern blot analysis and chloramphenicol acetyl transferase (CAT) assay. The level of HBx mRNA was decreased by siRNA in a dose-dependent manner. We also found that the 21 nt siRNA inhibited the HBV replication in hepatocellular carcinoma cell.

• Environmental Mutagens and Carcinogens
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• v.15 no.2
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• pp.106-114
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• 1995

A method was developed to detect total mutagenicity of fried fish for S. typhimurium TA98, using Ames assay. Method described herein circumvented problems associated with the sample preparation for Ames assay, i.e., a multi-purification step of sample and interference with solvent residuals. Experiment A, the best method developed in the present study, consisted of two important steps: pH adjustment of the aqueous sample solution from fried fish samples to remove impurities, and simultaneous distillation extraction (SDE) for partially purified samples to remove volatile compounds from solvents. The procedure and results were described as below. Fillet of gizzard shad (Konosirus punctatus) fish sample fried for 10 min each side on the temperature-controlled fry-pan (210$\circ$C) was homogenized in an aqueous acidic solution (pH 2) with a homogenizer, followed by filtration through Celite. The tiltrate (pH 2), removed some impurities by extraction with chloroform:methanol (2:1, v/v) mixture, was adjusted pH to 10 and then centrifuged to remove precipitate. The ethylacetate extract from the tiltrate of pH 10 was rotoevaporated and purified by SDE apparatus for 2 hours. Experiment A revealed significantly higher revertants (1928 per 25 g fried sample) than other Experiment (B, C, or D) tested. Experiment A gave good results in the mutagenicity test of fried fish sample with few purification steps using only 25 g fried sample and 650 ml of solvents; and thus this method could be a useful tool for the screening the mutagenicity or antimutagenicity of other foods as well.

• International Journal of Precision Engineering and Manufacturing
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• v.9 no.3
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• pp.55-58
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• 2008

Hydroforming is a forming technology in which a steel tube is set in a die and formed to fit a specified shape by applying hydraulic pressure from inside the tube while also applying force in the tube axial direction (axial feed). In present study, the entire design process chain for an automotive cross-member was simulated and developed using hydroforming technology on high-strength steel. The part design stage required a feasibility study. The process was designed using computer-aided design techniques to confirm the actual hydroformability of the part in detail. The possibility of using hydroformable cross-member parts was examined using cross-sectional analyses, which were essential to ensure the formability of the tube material for each forming step, including pre-bending and hydroforming. The die design stage included all the components of a prototyping tool. Press interference was investigated in terms of geometry and thinning.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.761-765
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• 2008

This study presents an effective methodology on integrated monitoring system for a maglev guideway using WDM-based FBG sensors. The measuring quantities include both local and global quantities of the guideway response, such as stains, curvatures, and vertical deflections. The strains are directly measured from multiplexed FBG sensors at various locations of the test bridge followed by curvature calculations based on the plane section assumption. Vertical deflections are then estimated using the Bernoulli beam theory and regression analysis. Frequency contents obtained from the proposed method are compared with those from a conventional accelerometer. Verification tests were conducted on the newly-developed Korean Maglev test track. It has been shown that good agreement between the measured deflection and the estimated deflection is achieved. The difference between the two peak displacements was only 3.5% in maximum and the correlations between data from two sensing systems are overall very good. This confirms that the proposed technique is capable of tracing the dynamic behavior of the maglev guideway with an acceptable accuracy. Furthermore, it is expected that the proposed scheme provides an effective tool for monitoring the behavior of the maglev guideway structures without electro magnetic interference.

• Journal of the Optical Society of Korea
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• v.14 no.4
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• pp.316-320
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• 2010

We report an application of full-field optical coherence tomography (FF-OCT) for identifying counterfeit bank notes. The depth-resolved imaging capability of FF-OCT was used for tomographic identification of superficially-identical objects. By retrieving the internal structures of the security feature (cash hologram) of an original banknote, we could demonstrate the feasibility of FF-OCT to identify counterfeit money. The FF-OCT images showed that the hologram consisted of micron scale multi-coated layers including an air gap. Therefore, it is expected that FF-OCT has potential as a new non-invasive tool to discern imitation of currency, and it would find applications in a wide field of counterfeit sciences.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.125-130
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• 2004

The vibration and buckling characteristics of the capsule for fuel irradiation test are studied. The natural frequencies of the capsule in air and under water are obtained by modal testing and finite element(FE) analysis using ANSYS program, and accelerations with flow are measured to estimate the compatibility with the operation requirement of the HANARO reactor. The experimental fundamental frequency of the capsule in the x and z direction is 8.5Hz and 8.75Hz in air, and 7.5Hz and 7.75Hz under water, respectively. The maximum amplitude of accelerations under the normal operating condition is measured as 11.0m/s$^2$ that is within the allowable vibrational limit(18.99m/s$^2$) of the reactor structure. Also, the maximum displacement at 100% flow is calculated as 0.13mm which is not interference with other nearby structures. FE analysis results show that the natural frequencies are found to be similar to those of the modal testing when three supporting parts are considered as simply supported conditions. From the buckling analysis, when the loading tool is applied, the critical buckling load of the capsule is 233N.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.11
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• pp.978-984
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• 2015

In this paper, we designed a RF transceiver operating up to 200 km operating range and 45 Mbps data rate. The RF transceiver operates in Ku band and composed of up/down converter, high power amplifier, front-end elements. To satisfy the operating range of RF transceiver, 10W power amplifier was required and realized by using GaN power amplifier. Moreover, to mitigate mutual interference for different bandwidth signals due to the adaptive transmission speed control function, SAW filter bank structure was used. To verify system requirement satisfaction AWR simulation tool was used.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.875-880
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• 2015

Mediator 19 (Med19) is a component of the mediator complex which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II. Accumulating evidence has shown that Med19 plays important roles in cancer cell proliferation and tumorigenesis. The involvement of Med19 in sensitivity to the chemotherapeutic agent cisplatin was here investigated. We employed RNA interference to reduce Med19 expression in human non-small cell lung cancer (NSCLC) cell lines and analyzed their phenotypic changes. The results showed that after Med19 siRNA transfection, expression of Med19 mRNA and protein was dramatically reduced (p<0.05). Meanwhile, impaired growth potential, arrested cell cycle at G0/G1 phase and enhanced sensitivity to cisplatin were exhibited. Apoptosis and caspase-3 activity were increased when cells were exposed to Med19 siRNA and/or cisplatin. The present findings suggest that Med19 facilitates tumorigenic properties of NSCLC cells and knockdown of Med19 may be a rational therapeutic tool for lung cancer cisplatin sensitization.