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Neurometabolic Improvement in Parkinson's Disease after Stereotactic Functional Neurosurgery by Follow-up MR Spectroscopy

  • Choe, Bo-Young;Baik, Hyeon-Man;Jeun, Sin-Soo;Son, Byung-Chul;Kim, Moon-Chan;Kim, Bum-Soo;Lee, Jae-Moon;Lee, Hyoung-Koo;Suh, Tae-Suk
    • Journal of the Korean Magnetic Resonance Society
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    • v.7 no.1
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    • pp.1-15
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    • 2003
  • PURPOSE - To investigate neurometabolism from the brain destructive lesions and striatal putamen-pallidus regions to the clinically worst side in patients with Parkinson's disease after stereotactic functional neurosurgery. METHODS - Using proton magnetic resonance spectroscopy ($^1$H MRS), fifteen patients (7 males and 8 females; mean age 56.5 years; age range 43-67 years) with Parkinson's disease (PD) were studied to measure N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho) and lactate (Lac) levels on the neurosurgical lesions of thalamus, globus pallidus and striatal putamen-pallidus regions in a brain. RESULTS - Brain destructive lesion and striatal putamen-pallidus region in PD compared with controls were highly and significantly related to NAA/Cho ratios reduction, respectively (P =0.002, P =0.04), but showed no difference from the same regions of PD prior to neurosergery (P =0.06, P =0.77). Increased lactate peaks at 1.3 ppm were present in all the cerebral lesions, and these resonances were confirmed at a long TE =136 ms, indicating that these signals distinguished from lipids. CONCLUSIONS - Our results suggest that NAA/Cho ratios may provide as a neurometabolite marker for neurochemical changes in brain surgical lesion, and the ratios might be related to functional change of neuropathophysiological status in the striatal putamen-pallidus region of PD. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of surgical necrosis. Therefore, MR spectroscopy could be a sensitive diagnostic tool in monitoring neurometabolic changes in PD with neurosurgical treatment.

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A Study of Warm-Mix Asphalt's Bonding Properties on the Change of Asphalt Film Thicknesses (아스팔트 피막두께 변화에 따른 중온 아스팔트의 접착성질에 관한 연구)

  • Yoo, In-Sang;Cho, Dong-Woo;Hwang, Sung-Do;Rhee, Suk-Keun
    • International Journal of Highway Engineering
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    • v.13 no.4
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    • pp.29-40
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    • 2011
  • Warm-Mix Asphalt(WMA) technologies have been developed since 15 years ago, which are internationally and domestically concerned with energy-saving and environmental-friendly technologies in public and private sectors of highway engineering. The performance of asphalt mass is traditionally evaluated by the penetration, viscosity, or Superpave tests. This research, however, is focused more on the properties depending on asphalt film thicknesses instead of evaluating asphalt mass behaviors by those tests. For this approach, a new testing protocol and analysis method are described by the bonding properties on each film thickness. This testing method and analysis tool are borrowed from those of DSR Moisture Damage test and applied by using ARES. The analysis results indicate that there is a limit film thickness between $200{\mu}m$ and $400{\mu}m$, which causes significant changes of the properties. In addition, the results show that the property changes of Hot-Mix Asphalt(HMA) and WMA on the limit film thickness are also different. Therefore, it is suggested that the properties on thin film thicknesses between $200{\mu}m$ and $400{\mu}m$ should be considered in order to evaluate WMA properly.

Calculation of Nuclear Characteristics of the TRIGA Mark-III Reactor (TRIGA Mark-III 원자로의 노심특성계산)

  • Chong Chul Yook;Gee Yang Han;Byung Jin Jun;Ji Bok Lee;Chang Kun Lee
    • Nuclear Engineering and Technology
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    • v.13 no.4
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    • pp.264-276
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    • 1981
  • A simulation procedure which can represent time-dependent nuclear characteristics of TRIGA Mark-III reactor is developed. CITATION, a multi-group diffusion-depletion program, has been utilized as calculational tool. The group structure employed in this study consists of 7 groups: -3-fast and 4-thermal-which is conventionally utilized in TRIGA type reactor analysis. Three-dimensional nuclear characteristics are synthesized by combining results from two-dimensional plane calculation and two-dimensional cylinder calculation, since direct three-dimensional approach is not yet possible. An effort ia made to develope a method which can extract effective zone and group dependent bucklings by neutron diffusion theory rather than conventional zone and/or group independent Ducklings by neutron transport theory, since neutron leakage is quite high for small core such as research reactors. It is turned out that the method developed in this study gives satisfactory results. The calculation is performed under assumptions that all control rods are fully withdrawn, that no samples are inserted in the irradiation holes and that the core is located in the center of the reactor pool. Burnup-dependent variation of core excess reactivity, time dependent change of Xe-135 poisoning and reactivity worth of rotary specimen rack are calculated and compared with operation records. Neutron flux and power distribution as well as neutron spectrum in each irradiation .facility are presented.

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Relationship Between Color Characteristic and Reflectance Index by Ground-based Remote Sensor for Tobacco Leaves (연초 엽의 색 특성과 원격탐사 반사율지표의 상호관계)

  • Hong, Soon-Dal;Kang, Seong-Soo;Jeon, Sang-Ho;Jeong, Hyun-Cheol
    • Korean Journal of Soil Science and Fertilizer
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    • v.42 no.4
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    • pp.274-279
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    • 2009
  • To determine the critical level for optimum maturity of flue-cured tobacco leaves (KF118) at the stalk position from cutter to tips, the reflectance index using ground-based remote sensors and chlorophyll meter were investigated. The sensors estimated were Crop $Circle^{TM}$ (Holland Scientific), Green $Seeker^{TM}$ (Ntech Industries), Spectroradiometer (LICOR, LI-1800), Chlorophyll meter (SPAD502, Minolta), and Field $Scout^{TM}$ Chlorophyll meter (CM-1000, Spectrum). The L, a, b values and greenness for flue-cured leaf were measured and estimated for correlation with sensor's measurement of harvested leaf. On a reflectance curve of 340nm~1100 nm, the reflectance peaks on 550nm and 675 nm for the harvested leaf were lowered as change from light green to darker green. Darker green leaf harvested produced darker flue-cured leaf. The reflectance at 675 nm for flue-cured leaf decreased as greenness increased in the harvested leaf. This result means that the red edge band of 675 nm wavelength is related to the absorbance of chlorophyll for photosynthesis. The greenness of flue-cured leaf showed significantly positive correlation with the entire reflectance indexes for harvested leaf while the L value by colorimeter showed negative correlation with greenness of cured leaf. The critical level for optimum maturity of harvested leaf were less than 22, 135, and 0.43 for SPAD reading, CM-1000 reading, and gNDVI by Crop $Circle^{TM}$, respectively. Consequently, ground-based remote sensing providing a non-destructive real-time assessment of plant greenness could be a useful tool in the selection of optimum maturity of flue-cured tobacco leaves in relation to high quality of flue-cured tobacco.

A Study on Construction of Express Lane Applied by Bus Only Lane as Seperation Facility: Focused on Pangyo-Hannam Section of Gyeongbu Expressway (버스전용차로를 분리시설로 활용한 Express Lane 구축에 관한 연구: 경부고속도로 판교-한남 구간을 중심으로)

  • Kim, Min Kyoung;Kim, Ju Hyun;Shin, Eon Kyo
    • Journal of Korean Society of Transportation
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    • v.31 no.4
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    • pp.32-46
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    • 2013
  • Because of short length between interchanges, traffic congestion has been caused by a lot of short trip traffic in the urban section of interregional expressway. Also, in case of expressway with Bus Only Lane, bus causes dangerous situation by conflicting between vehicles and buses in order to access from Bus Only Lane to IC. Therefore, this study aims to propose Express Lane applied by Bus Only Lane as a new lane operation in order to efficiently operate and to analyze the effectiveness on constructing Express Lane to the Pangyo-Hannam section in Gyeongbu Expressway. The study analyzes effectiveness by scenario using the micro traffic simulation tool, VISSIM 5.4. For this, the indicators which evaluate construction effect of Express Lane, are used by average delay time, average speed and total travel time. The results of the study showed the best effectiveness when Express Lane installed one, and it represented an ideal traffic condition when long distance trip traffic of the whole traffic is 25% in the study section. Therefore, the construction of Express Lane using Bus Only Lane achieves positive effectiveness on safety and expense aspect as well as uncongested flow.

The role of squamous cell carcinoma antigen as a prognostic and predictive factor in carcinoma of uterine cervix

  • Jeong, Bae-Kwon;Choi, Doo-Ho;Huh, Seung-Jae;Park, Won;Bae, Duk-Soo;Kim, Byoung-Gie
    • Radiation Oncology Journal
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    • v.29 no.3
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    • pp.191-198
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    • 2011
  • Purpose: Although the role of squamous cell carcinoma antigen (SCC-Ag) as a predictive and prognostic factor for uterine cervical cancer has been identified in previous studies, 1) the effective patient group of screening for recurrence with SCC-Ag, 2) the relationship between SCC-Ag and recurrence site, and 3) the relationship between the change of SCC-Ag and treatment outcome or recurrence have not been described. Materials and Methods: The study included 506 patients with histologically proven uterine cervical cancer between January 1994 and December 2010. We determining the serum SCC-Ag level before treatment and after treatment, and conducted a retrospective review of the patients' records. We evaluated the sensitivity and specificity of SCC-Ag for the detection of tumor recurrence by comparing biochemical recurrence with clinical recurrence. Results: The pretreatment SCC-Ag level and the proportion of patients over 1.5 ng/mL were higher in poor prognostic patient group. In the univariate and multivariate analysis, pretreatment SCC-Ag showed a statistically significant correlation with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology. In patients with biochemical recurrence vs. those without, 5-year DFS and OS were 27.6 vs. 92.7% (p ${\leq}$ 0.001) and 53.7 vs. 92.5% (p ${\leq}$ 0.001), respectively. Conclusion: Our study reconfirmed the known function of pretreatment SCC-Ag, but could not confirm the function of biochemical response as a predictive factor for treatment and as a prognostic factor. There was no statistically significant relationship between SCC-Ag level and recurrence site. We confirmed the role of SCC-Ag as a follow-up tool for recurrence of disease and which patient groups SCC-Ag was more useful for.

Evaluation on Organ Dose and Image Quality by Changing kVp and Ion Chamber Combination while Taking Digital Chest Lateral Decubitus PA Projection (디지털 흉부 측와위 후전방향 검사 시 Ion chamber조합 설정과 관전압 변화에 따른 장기선량 및 화질 평가)

  • Lee, Jin-Soo;Park, Hyong-Hu
    • The Journal of the Korea Contents Association
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    • v.15 no.1
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    • pp.316-323
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    • 2015
  • In this study, we analyzed radiation dose and MTF with setting of Ion chamber and changing kVp so that we are able to suggest acquiring optimized diagnostic images and minimizing patient dose. we assumed right lateral decubitus position among chest decubitus projection and set 7 combination of Ion chamber. By changing kVp(100, 110, 120, 130kVp), we exposed x-ray five times respectively and calculated average value after measuring entrance dose. we input the entrance dose value to PCXMC Monte carlo simulation tool and calculated organ dose and effective dose. Then we did physical image evaluation with MTF for the purpose to compare image quality. As a result, the high kVp, entrance dose is reduced. As change of ion chamber, when selecting second ion chamber, both organ dose and effective dose were the lowest. In contrast, selecting first ion chamber was the highest. MTF is superior to set second Ion chamber and using 120 kVp. Consequently, when taking chest right lateral decubitus using Digital radiography, the optimized combination which have both reducing dose efficiently without declining image quality and aquring good qualified image is set 120 kVp and selecting second Ion chamber.

A Study on the Urban Growth Change using Satellite Imagery Data (위성영상자료를 활용한 도시성장변화에 관한 연구)

  • Kim, Yoon-Soo;Kim, Jung-Hwan;Jung, Eung-Ho;Ryu, Ji-Won
    • Journal of the Korean Association of Geographic Information Studies
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    • v.5 no.2
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    • pp.81-90
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    • 2002
  • Remote Sensing has been very useful tool in monitoring of cities and updating of GIS database compare to traditional methods due to its benefit; wide range covering on low cost and advanced data collection. However it had come to a limited method in limited researches because of its relatively poor spatial resolution in scanning. Recently launched satellites are able to produce improved imageries, and new commercial services have been commenced for the use of general public with higher spatial resolution up to $1m{\times}1m$. This study tackled a potential use of these improved satellite imageries in urban planning based on the Multi-temporal satellite imagery with particular reference to monitoring on urban areas, for example urbanization and its expanding. i) Portion of individual features and elements in each pixel of satellite imagery was computed based on 'Endmember' of targeted elements. ii) Urbanized areas were categorized based on the 'Fraction imagery' derived from the 'SMA algorithm'. iii) Alterations and expanding of urban areas were identified based on the Multi-temporal satellite imageries. Tested method showed a strong potential to produce more advanced monitoring skills of urban areas.

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A base study of an Ecological Mapping technique by using GIS and Remote Sensing (GIS와 RS를 이용한 생태지도 작성기법에 관한 기초연구)

  • Yi, Gi-Chul;Lee, Won-Hwa;Yoon, Hae-Soon;Nam, Chun-Hee;Kim, Gu-Yeon;Kim, Seong-Hwan;Suh, Sang-Hyun
    • Journal of the Korean Association of Geographic Information Studies
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    • v.7 no.3
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    • pp.57-69
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    • 2004
  • This study developed an ecological mapping technique with GIS database using the analyses of existing ecological survey reports and the change detection on the Nakdong river estuary. The data which are used to establish GIS DB include 2 Landsat TM images on Nov. 31, 1984 and May 17, 1997, 1:25,000 topographical maps established by National Geography Institution and various ecological survey reports published by Busan metropolitan city government. The details for producing ecological map are as follows. At first, the current methods of ecomapping efforts and previous ecological surveys of Nakdong river estuary were carefully examined. Secondly, the land cover maps were created from the classified Landsat images of 1984 and 1997 for the spatiotemporal ecosystem analysis. Thirdly, the ecosystem was evaluated by using GIS ecological database based on the criteria of botany, zoology and water quality etc. Each criteria was reclassified into 3 stages which describe the overall quality of ecological condition. At last, the comprehensive ecological map was suggested as a prototype of ecosystem assesment and management tool with the discussion of further study. The findings of this study would be a milestone for preserving and managing the ecosystem.

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Assessment of Hydrological Impact by Long-Term Land Cover Change using WMS HEC-1 Model in Gyeongan-cheon Watershed (WMS HEC-1 모형을 이용한 경안천 유역의 경년 수문변화 분석)

  • Lee, Jun-Woo;Kwon, Hyung-Joong;Shin, Sha-Chul;Kim, Seong-Joon
    • Journal of the Korean Association of Geographic Information Studies
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    • v.6 no.1
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    • pp.107-118
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    • 2003
  • The purpose of this study is to assess the hydrological impact on a watershed from long-term land cover changes. Gyeongan-cheon watershed($558.2km^2$) was selected and WMS(watershed modeling system) HEC-1 model was adopted as an evaluation tool. To identify land cover changes, five Landsat images(1980/2/15, 1986/4/15, 1990/4/26, 1996/4/26, 2000/5/17) were selected and analyzed using maximum likelihood method. As a result, urban areas have increased by 5.6% and forest areas have decreased by 6.1% between 1980 and 2000. SCS curve number increased by 9.8. To determine model parameters and evaluate HEC-1 model, five storm events(1998/5/2, 1998/8/23, 1998/9/30, 1999/5/3, 2000/7/29) were used. The simulated stream flow agreed well with the observed one with relative errors ranging from 9% to 36%. For 254 mm daily rainfall of 30 years frequency, due to the increase of urban areas peak flow increased by $455m^3/sec$ and the time of peak flow reduced about four hours for 20 years land cover changes.

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