• 제목/요약/키워드: tolerance analysis

검색결과 1,372건 처리시간 0.037초

Esophageal tolerance to high-dose stereotactic radiosurgery

  • Lee, Bo Mi;Chang, Sei Kyung;Ko, Seung Young;Yoo, Seung Hoon;Shin, Hyun Soo
    • Radiation Oncology Journal
    • /
    • 제31권4호
    • /
    • pp.234-238
    • /
    • 2013
  • Purpose: Esophageal tolerance is needed to guide the safe administration of stereotactic radiosurgery (SRS). We evaluated comprehensive dose-volume parameters of acute esophageal toxicity in patients with spinal metastasis treated with SRS. Materials and Methods: From May 2008 to May 2011, 30 cases in 27 patients with spinal metastasis received single fraction SRS to targets neighboring esophagus. Endpoints evaluated include length (mm), volume (mL), maximal dose (Gy), and series of dose-volume thresholds from the dose-volume histogram (volume of the organ treated beyond a threshold dose). Results: The median time from the start of irradiation to development of esophageal toxicity was 2 weeks (range, 1 to 12 weeks). Six events of grade 1 esophageal toxicity occurred. No grade 2 or higher events were observed. $V_{15}$ of external surface of esophagus was found to predict acute esophageal toxicity revealed by multivariate analysis (odds radio = 1.272, p = 0.047). Conclusion: In patients with spinal metastasis who received SRS for palliation of symptoms, the threshold dose-volume parameter associated with acute esophageal toxicity was found to be $V_{15}$ of external surface of esophagus. Restrict $V_{15}$ to external surface of esophagus as low as possible might be safe and feasible in radiosurgery.

쩨르니케 계수의 민감도에 바탕을 둔 광부품 제작 및 조립 공차의 최적 관리 (Optimal Management of Fabrication and Assembly Tolerance of Optical Systems by Analyzing Its Influence on Zernike Coefficients)

  • 김현숙;김진승
    • 한국광학회지
    • /
    • 제26권4호
    • /
    • pp.209-216
    • /
    • 2015
  • 광부품 제작 및 조립 과정을 고려하여 완성된 광학계의 성능을 최적화하는 공차분석 방법을 제안하고 이를 적외선 광각 광학계에 적용하여 그 유용성을 확인하였다. 이 방법은 광학계에서 나오는 파면 오차를 쩨르니케 다항식으로 전개하고, 전개 계수인 쩨르니케 계수가 광부품 및 조립정렬 변수에 대해 변화하는 정도를 나타내는 민감도를 분석한다. 이 민감도를 바탕으로 광부품 제작 공차를 최적값으로 정하고 최선의 조립정렬 보상자를 고른다. 이 방법은 광부품의 제작 및 조립정렬 공차를 최적값으로 잡고, 또 그러한 공차에 의한 성능저하를 예측하고, 대비하므로 실제로 완성될 광학계의 성능을 최상으로 높일 수 있고, 또 정확하게 예측할 수 있다.

Identification of genes related to ER stress in bZIP28 gene transgenic potato plant

  • Kim, Dool Yi;Kim, Kyung Hwa;Choi, Man Soo;Ok, Hyun Choog;Kim, Jae Hyun
    • 한국작물학회:학술대회논문집
    • /
    • 한국작물학회 2017년도 9th Asian Crop Science Association conference
    • /
    • pp.153-153
    • /
    • 2017
  • Potato (Solanum tubersosum L.) is susceptible to various environmental stresses such as frost, high temperature, and drought. Enhancement of potato drought tolerance can reduce yield loss under drought that has negative effect on potato tuber growth. Genetic engineering can be utilized to achieve this goal, but such approaches using endogenous potato genes have rarely been applied. Since unpredictable global weather changes cause more severe and frequent water limiting conditions, improvement of potato drought tolerance can minimize such adverse effects under drought and can impact on sustainable potato production. Genetic engineering can be utilized to improve potato drought tolerance, but such approaches using endogenous potato genes have rarely been applied. We were obtained AtbZIP28 gene transgenic potato plants. It is identified transcript levels at various stress conditions, polyethylene glycol (PEG), NaCl, abscisic ${\underline{acid}}$ (ABA). Also, For identification to regulate ER stress response genes in AtbZIP28 gene transgenic potato plant, we screened seven potato genes from RNA-seq analysis under TM treatment. Five and two genes were up- and down-regulated by TM, respectively. Their expression patterns were re-examined at stress agents known to elicit TM, DTT, DMSO and salt stress.

  • PDF

Resistance of Cucumber Grafting Rootstock Pumpkin Cultivars to Chilling and Salinity Stresses

  • Xu, Yang;Guo, Shi-rong;Li, He;Sun, Hong-zhu;Lu, Na;Shu, Sheng;Sun, Jin
    • 원예과학기술지
    • /
    • 제35권2호
    • /
    • pp.220-231
    • /
    • 2017
  • Grafting using a pumpkin (Cucurbita sp.) rootstock is an effective way to improve cucumber (Cucumis sativus) resistance to a combination of chilling and salinity stresses. We evaluated the tolerance of 15 pumpkin cultivars to chilling, salinity, and combined stresses at the germination and seedling stages. Selected plant characteristics, including germination rate, germination potential, germination index, plant height, stem thickness, fresh weight, and dry weight, were analyzed. We used the unweighted pair group method with arithmetic mean for cluster analyses to determine the stress tolerance levels of the pumpkin cultivars. The 15 cultivars were divided into three clusters: tolerant, moderately tolerant, and susceptible to stress treatments. The stress tolerances of all cultivars were variable in the germination and seedling stages, and most cultivars were not tolerant to individual treatments of chilling or salinity stresses at both stages. These results suggest that identifying suitable cultivars for use as rootstock during cucumber grafting should involve the evaluation of stress tolerance during different growth stages. Additionally, cultivars tolerant to chilling stress may not be tolerant to salinity stress; therefore, the choice of pumpkin rootstock should depend on where the grafted plant will be grown. Cultivars tolerant to a combination of chilling and salinity stresses may be useful as rootstock for cucumber grafting. Our findings may serve as reference material for choosing appropriate pumpkin rootstocks for cucumber grafting.

Silane 화합물을 이용한 역삼투막 활성층의 표면개질 (Surface Modification of Reverse Osmosis Membrane Skin Layer by Silane Compound)

  • 이용택;신동호;김노원
    • 멤브레인
    • /
    • 제16권2호
    • /
    • pp.106-114
    • /
    • 2006
  • 방향족 폴리아미드 역삼투 복합 박막에 트리알콕시알킬 실란 화합물을 안정적으로 정착시켜 내염소성이 향상된 복합막을 제조하는 방법에 관하여 조사하였다. 실란 화합물의 알킬 그룹의 탄소가 1개인 methyltriethoxysilane (METES)와 8개인 octyltriethoxysilane (OCTES) 표면 개질에 사용하였다. 긴 알킬 체인을 갖는 실란(OCTES)이 정착된 멤브레인의 경우, 일반 폴리아미드 역삼투막 또는 짧은 알킬 체인을 갖는 실란(METES)에 비해 개염소성이 크게 향상됨을 알 수 있었다. 본 연구에서는 표면 분석을 통하여 OCTES 코팅막과 METES또는 상용막과의 내염소성 차이를 설명하고자 하였다. EDX 원소 분석을 통하여 실란 화합물 둘 다 폴리아미드상에 안정적으로 고정되었음을 볼 수 있었으나 표면 조도나 접촉각 분석에서는 긴 알킬 체인을 가진 OCTES가 혐수성에 큰 영향을 주고 있음을 확인할 수 있었다.

계절별 착의량이 안정시 에너지 대사량에 미치는 영향 (The Effect of Seasonal Clothing Weight on Resting Metabolic Rate)

  • 황수정;최정화;성화경
    • 한국의류학회지
    • /
    • 제23권3호
    • /
    • pp.483-494
    • /
    • 1999
  • This study investigated the relation between seasonal variation of clothing weight and its resting metabolic rate to determine the relation between proper living temperature and cold/heat tolerance. Thirty six subjects(18 males and females twenties) were composed to obtain the clothing weight(Total clothing weight) and resting metabolic rate for a year and grouped four seasons : spring (Mar-May) Summer(Jun-Aug) Fall(Sep-Nov) and Winter(Dec-Feb). The data of males and females were respectively divided into three groups by cluster analysis with clothing weight. 1. The resting metabolic rate of male(41.1kcal/m2/hr) was higher than that of female(33.2kcal/m2/hr). It is suggested there is gender difference in the resting metabolic rate(p<.001) 2. The resting metabolic rate of male and female was the highest in Winter. It is suggested there is seasonal variation in the resting metabolic rate(p<.001) 3. It was found that there was relation between clothing weight and resting metabolic rate. The difference of resting metabolic rate between Summer and Winter which is profitable to adaptation to living temperature was significant in light clothing weight in male as well as in female. 4. In comfortable sensation most subjects responded that he/she felt 'comfortable' except Winter. However the heavy clothing weight group felt 'a little uncomfortable' throughout all seasons. l In thermal sensation most subjects responded that he/she felt 'neutral' And then the heavy clothing weight group responded warmer in summer and cooler in winter than light clothing weight group. From the results it was confirmed that male and female showed seasonal variations in clothing weight and resting metabolic rate. Also the resting metabolic rate of male and female was influenced by the clothing weight. In short seasonal variation of resting metabolic rate was larger in light clothing weight group than in heavy clothing weight group. Therefore light clothing weight group is advantgeous in living temperature to improve cold/heat tolerance and it also shows that living with the light clothing weight may enhance the degree of adaptation to change of living environment

  • PDF

Proline Accumulation and P5CS ($\Delta^1$-pyrroline-5-carboxylate synthetase) Gene Expression in Response to Salt Stress in Zoysiagrasses

  • Lee, Dong-Joon;Hwang, Cheol-Ho
    • 한국작물학회지
    • /
    • 제48권1호
    • /
    • pp.20-24
    • /
    • 2003
  • Proline is known as an osmotrotectant to enhance tolerance against both salt and dehydration stresses. A P5CS ($\Delta^1$-pyrroline-5-carboxylate synthetase) plays a major role in regulation of synthesis of proline. An overexpression of the mothbean P5CS gene in transgenic tobacco plant increased the levels of proline and osmotolerance. In an attempt to look for the possibility to use content of proline as well as a level of P5CS gene expression as molecular markers for salt tolerance, the amounts of proline and transcript levels of P5CS were measured as functions of either concentration of NaCl or length of treatment period among different species of zoysiagrass. Hybridzoysia showed the highest level of proline ($329\mu\textrm{g}$/g.f.w.) among five different species of zoysiagrass at 250 mM NaCl in 24 hours. The level of P5CS transcript was also the highest in the hybridzoysia at 250 mM NaCl in 24 hours. The transcriptions of P5CS gene were induced at the rates of 1.2, 1.2, 1.8, and 1.8, upon treatment of 250 mM NaCl in Z. japonica, Z. matrella, Z. sinica and hybridzoysia respectively. Based on a correlation between the level of P5CS transcript and the proline content among different species of zoysiagrass, a comparative structural analysis of the gene for P5CS from either Z. sinica or hybridzoysia may lead to an understanding of mechanism for salt tolerance shown differently among zoysiagrasses.

배추 염 저항성 관련 유전자의 네트워크 모델 구축 (Construction of a Network Model to Reveal Genes Related to Salt Tolerance in Chinese Cabbage)

  • 이기호;유재경;박지현;박영두
    • 원예과학기술지
    • /
    • 제32권5호
    • /
    • pp.684-693
    • /
    • 2014
  • 저온, 건조, 염과 같은 비생물적 스트레스는 식물의 생리적 형태적 변화와 수확량 감소를 초래한다. 이러한 이유로 식물체는 불리한 환경을 극복하기 위해 다양한 대사과정에 관련된 유전자들간의 복잡한 상호 관계를 조절함으로써 저항성을 획득한다. 본 연구는 배추에서 염 스트레스에 반응하는 유전자를 다각적으로 분석하기 위해 상호발현 네트워크를 구축하였다. 네트워크를 구축하기 위하여 배추를 염스트레스 조건 하에서 시간 경과에 따라 KBGP-24K 마이크로어레이 분석을 실시한 [BrEMD (Brassica rapa EST and Microarray Database)] 실험 결과를 수집하여 분석하였다. 구축된 네트워크 모델은 1,853개 node, 5,740개 edge, 및 142개 connected component(상관계수 > 0.85)로 구성되었다. 구축된 네트워크 분석 결과, ROS 신호 전달을 통한 N$Na^+$ 수송활성화와 proline 축적이 배추의 염 저항성 획득과 밀접한 연관이 있는 것으로 판단하였다.

석탄재의 건설재료로서의 활용에 관한 연구-환경적 특성 검토를 중심으로 (A Study on the Utilization of Coal Ash as Construction Materials ln Forcus on the Environmental Analysis)

  • 천병식;고용일
    • 한국지반공학회지:지반
    • /
    • 제11권2호
    • /
    • pp.99-106
    • /
    • 1995
  • 기본적인 성질 평가와 많은 실내실험을 통해 우리나라에서 부산되는 석탄재는 이제 실용화 단계에 있지만, 가장 문제 제기가 되고 있는 부분은 환경적 특성 검토이다. 본 연구에서는 석탄재 발생량의 대부분을 차지하고 있는, 역학적 특성이 열악한 fly ash.를 대상으로 우리나라 환경기 준에 의하여 폐기물 분류를 분석 확인하구 매립 및 대규모 토공재 등 건설재료로 처리 또는 사용하였을 시 오염물질 배출허용기준에 의한 문제점이 있는가를 검토하기 위하여 회분식 용출시험에 의하여 수소이온농도 및 오염물질 함유량을 조사.분석해 보았다. 그 결과 fly ash는 일반폐기물로 분류됨을 확인하였고, fly ash의 PH는 오염 물질 배출허용 기준치보다 알칼리성을 강하게 띠고 있어 문제가 되고 있으나 이는 산성화된 토양을 중성화하는 토량개량재로서 fly ash의 역할을 기대할 수 있으며, 그 외에는 오염물질 배출허용 기준치에 훨씬 못 미치는 것으로 나타나고 있다. 더구나 석탄재의 열악한 역학적 특성을 개량하기 위하여 사용되는 정도의 소량의 첨가제(시멘트 또는 석회 등)에 의하여 강도 및 내구성 증가, 투수성 억제는 물론 문제가 되는 수소이온농도가 오염물질 배출허용기준(pH 5.8~8.6) 이하로 낮아져, 석탄재의 건설재료로서의 활용에 있어 환경적인 문제의 여지는 없을 것으로 여겨진다.

  • PDF

입원환자가 지각하는 간호사의 친절에 관한 연구 (A Research on Inpatient Perception of Kindness on Nurse)

  • 강현숙;김일원;김원옥;장광자
    • 기본간호학회지
    • /
    • 제3권2호
    • /
    • pp.259-271
    • /
    • 1996
  • This reserch has been done in order to improve quality of nursing and medical service. In order to improve those qualities the study has been done to know inpatient perception of kindness and meaning of kindness which patients receive from nurse and also what effect inpatient have when they experience kindness from nurse. The subjects were 454 people who admitted in K Hospital. Time period was from October to December 1995. This survey has been done by personal interview with a written questionnaire. Analysis of data has been done by $X^2-test$ and percentage. The results of the research may be summarized as follows. 1. The inpatients perception of kindness on nurse were explanation(26.8%), tolerance(16.3%), warm-heartedness(12.8%), interest(9.5%), ability(8.4%), confidence(6.4%), respect(4.0%), support(2.65%). 2. In order to find out general moaning of kindness, study classified by age, sex, education, job, experience of hospitalization, inpatient ward. As a result of $X^2-test$, no special meaning of kindness was presented in inpatient perception of kindness. 3. Contents kindness which inpatient experienced were, warm-heartedness(23%), understanding(18.1%), interest(17.8%), ability(12.8%), tolerance(5.7%), confidence(2.6%), 4. Over half of subjects(59.1%) answered stability to effect on kindness of Nurse. Next are self-confidence(7.9%), respect(5.3%), confidence(4.6%), warm-heartedness(3.5%), understanding(2.6%). According to above results inpatient feels that meaning of kindness were explanation, tolerance, warm-heartedness. This meaning has no distinctive difference other than consistent meaning. Likewise, inpatient experience about contents of kindness is similar to meaning of kindness. As a result of this research, which show that kindness of nurse gives patient stability, respect and confidence, we would kindness is important for recovery of inpatient. Therefore, this research outcome could be able to help to improve quality of nursing and medical service.

  • PDF