• Journal of the Korean Data and Information Science Society
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• v.18 no.4
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• pp.1005-1021
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• 2007

Traditional procedures for DNA microarray data analysis are to preprocess and normalize the gene expression data, and then to analyze the normalized data using statistical tests. Drawbacks of the traditional methods are: genuine biological signal may be unwillingly eliminated together with artifacts, the limited number of arrays per gene make statistical tests difficult to use the normality assumption or nonparametric method, and genes are tested independently without consideration of interrelationships among genes. A novel method using average rank in each array is proposed to eliminate such drawbacks. This average rank method monitors differentially regulated genes among genetically different groups and the selected genes are somewhat different from those selected by traditional P-value method. Addition of genes selected by the average rank method to the traditional method will provide better understanding of genetic differences of groups.

• The Korean Journal of Food And Nutrition
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• v.25 no.4
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• pp.980-989
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• 2012

This study examined 389 customers visiting restaurants located in the Guemo mountain resort who filled out self-administered questionnaires. The results showed that 60% of the participants dined out monthly. The 30 to 40-year-old age group did so the most frequently, dining out one to two times weekly. For men, the favorite menu item was the sanchejeongsik along side traditional liquor and for women was the samgaetang. By age, the 20, 30, and 60-year-olds selected samgaetang as their favorite, the 40-year-olds selected traditional liquor, and the 50-year-olds selected the sanchejungsik. The reasons for selecting the dishes were because participants previously enjoyed them or considered the dishes healthy, regardless of sex or age. Participants suggested that the sanchejeongsik and samgaetang be promoted for tourism, without significant differences between gender. The current findings suggest that the quality of certain local menu such as sanchejungsik and samgaetang could be improved to become more nutritious for future customers. Also, traditional Korean liquor may become even more popular with visitors to the Guemo mountain resort if paired with simple menu items such as jeon or muk.

• Journal of the Korean Institute of Landscape Architecture
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• v.24 no.3
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• pp.109-114
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• 1996

Generally, the size of our recreation sites is selected through use demand at the peak day. At same time, scale economic and diseconomic are applied to a recreation site. If you are a rational decision-maker, you would like to select the size of your park at profit-maximization point. This study is the first try for modelling a Gain-Loss by the size options of a theme park. For testing the validity of a financial model to select the size of theme parks. Ever-Land, Seoul-Land, Dream-Land's operating size was analyzed. By the size options, the revenue of each park was compared with cost. The profit-maximization point and break-even point of each park were found. Ever-Land and Dream-Land's size was selected between the profit-maximization point and the break-even point. In contrast with Ever-Land and Dream-Land's, Seoul-Land's was selected upper the break-even point. To increase the utility of this model in selecting the size of a theme park, a decision-maker must keep in mind a few limits of this study. That is, 1) this model can not be applied at public parks. 2) Sometimes the others can be more important than financial revenue and cost. Finally, there is the validity of Gain-Loss Model in estimating only the financial revenues and costs through the size options.

• Molecules and Cells
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• v.42 no.10
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• pp.721-728
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• 2019

Non-structural protein 1 (NS1) of influenza virus has been shown to inhibit the innate immune response by blocking the induction of interferon (IFN). In this study, we isolated two single-stranded RNA aptamers specific to NS1 with $K_d$ values of $1.62{\pm}0.30nM$ and $1.97{\pm}0.27nM$, respectively, using a systematic evolution of ligand by exponential enrichment (SELEX) procedure. The selected aptamers were able to inhibit the interaction of NS1 with tripartite motif-containing protein 25 (TRIM25), and suppression of NS1 enabled retinoic acid inducible gene I (RIG-I) to be ubiquitinated regularly by TRIM25. Additional luciferase reporter assay and quantitative real-time PCR (RT-PCR) experiments demonstrated that suppression of NS1 by the selected aptamers induced IFN production. It is noted that viral replication was also inhibited through IFN induction in the presence of the selected aptamers. These results suggest that the isolated aptamers are strongly expected to be new therapeutic agents against influenza infection.

• International journal of advanced smart convergence
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• v.11 no.4
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• pp.247-252
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• 2022

The purpose of the domestic physician scientist support program is to promote the development of various biotechnology. Therefore, it can be said that examining whether the purpose of support is being faithfully implemented has an important meaning for the future domestic biotechnology development ecosystem. Therefore, this study limited the subject of analysis to 79 MD-PhD experts who participated or participated in doctor scientist programs at major universities in Korea. Among them, a total of 25 researchers, one researcher from each classroom in parasitology, microbiology, pharmacology, biochemistry, physiology, and anatomy, which had the highest paper citations in the last five years (2016-2021), were selected to examine the relationship between joint research. It was selected as the subject of review. As a result, 25 selected pseudo-scientists(MD-PhD) identified domestic and foreign researchers who participated as co-researchers when publishing in overseas academic journals for the last 5 years(2016-2021), and identified the affiliation and name of the top 5 among them, as well as the pseudo-scientist(MD-PhD), it was possible to identify the relationship of a total of 123 co-researchers(excluding 2 missing values) of the top 5 co-researchers with a high degree of cooperation with respect to the researcher(25 in total), and the collaboration of pseudo-scientists. Relationships, major researchers, and research institutes were examined. Nodexl Basic 2018 ver. (Microsof) was used for the analysis, and the relationship between researchers could be visualized by applying network analysis techniques.

• Parasites, Hosts and Diseases
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• v.50 no.4
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• pp.365-369
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• 2012

Acanthamoeba spp. are single-celled protozoan organisms that are widely distributed in the environment. In this study, to understand functional roles of a mannose-binding protein (MBP), Acanthamoeba castellanii was treated with methyl-alpha-D-mannopyranoside (mannose), and adhesion and cytotoxicity of the amoeba were analyzed. In addition, to understand the association of MBP for amoeba phagocytosis, phagocytosis assay was analyzed using non-pathogenic bacterium, Escherichia coli K12. Amoebae treated with mannose for 20 cycles exhibited larger vacuoles occupying the most area of the amoebic cytoplasm in comparison with the control group amoebae and glucose-treated amoebae. Mannose-selected amoebae exhibited lower levels of binding to Chinese hamster ovary (CHO) cells. Exogenous mannose inhibited >50% inhibition of amoebae (control group) binding to CHO cells. Moreover, exogenous mannose inhibited amoebae (i.e., man-treated) binding to CHO cells by <15%. Mannose-selected amoebae exhibited significantly decreased cytotoxicity to CHO cells compared with the control group amoebae, 25.1% vs 92.1%. In phagocytic assay, mannose-selected amoebae exhibited significant decreases in bacterial uptake in comparison with the control group, 0.019% vs 0.03% (P<0.05). Taken together, it is suggested that mannose-selected A. castellanii trophozoites should be severely damaged and do not well interact with a target cell via a lectin of MBP.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.50 no.4
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• pp.268-275
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• 2005

Early predictions of crop yields call provide information to producers to take advantages of opportunities into market places, to assess national food security, and to provide early food shortage warning. The objectives of this study were to identify the most useful parameters for estimating yields and to compare two model selection methods for finding the 'best' model developed by multiple linear regression. This research was conducted in two 65ha corn/soybean rotation fields located in east central South Dakota. Data used to develop models were small temporal variability information (STVI: elevation, apparent electrical conductivity $(EC_a)$, slope), large temporal variability information (LTVI : inorganic N, Olsen P, soil moisture), and remote sensing information (green, red, and NIR bands and normalized difference vegetation index (NDVI), green normalized difference vegetation index (GDVI)). Second order Akaike's Information Criterion (AICc) and Stepwise multiple regression were used to develop the best-fitting equations in each system (information groups). The models with $\Delta_i\leq2$ were selected and 22 and 37 models were selected at Moody and Brookings, respectively. Based on the results, the most useful variables to estimate corn yield were different in each field. Elevation and $EC_a$ were consistently the most useful variables in both fields and most of the systems. Model selection was different in each field. Different number of variables were selected in different fields. These results might be contributed to different landscapes and management histories of the study fields. The most common variables selected by AICc and Stepwise were different. In validation, Stepwise was slightly better than AICc at Moody and at Brookings AICc was slightly better than Stepwise. Results suggest that the Alec approach can be used to identify the most useful information and select the 'best' yield models for production fields.

• Proceedings of the ESK Conference
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• 1995.04a
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• pp.106-110
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• 1995

A local manufacturing companyin which low back pain(LBP) complaints were frequently reported was selected, and regularly perfomed lifting tasks were investigated using questionnaires and the 1991 NIOSH lifting guide. Among several processes of manufacture in the company, three processes-forming, heating and packing-were studied, where most of tasks were perfomed through manual materials handling (MMH). Questionnaire surveys showed that anthropometric data such as stature, weight and someatotype did not affect and weight of load influenced significantly the incidence of LBP, and workers who expwrienced LBP was older than the inexperienced. In addition, safety education conducted at the company was found to be ineffective in preventing LBP injuries. Lifting indexes(LI) was ranged from 0.86 to 17.0 with an average of 4.49, which revealed that tasks performing in the selected factory were in danger of LBP, and should be ertonomically redesigned. The critical factor reducing LI was found to be the horizontal component in all three processes, and most of weight of load was heavier than load constant(23kg) of the 1991 NIOSH lifting equation in heating process and packing.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.278-281
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• 2004

Multiple sound sources are controlled to enhance sound power within a zone of interest. The problem of enhancing acoustic variable can be regarded as an optimization problem, which seeks an optimal control input that maximizes the acoustic variable. It should be noted that enhancing sound power of a selected region requires both the magnitude and direction to be controlled. For this reason, two kinds of cost functions that can represent the spatially distributed intensity are defined. Theoretical formulation shows the possibility of sound power control in a zone, and the detailed procedures of the proposed method are validated by numerical simulations.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.7 no.3
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• pp.118-125
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• 1998

Chip control is a major problem in automatic machining process, especially in finish turning operation. In this case, chip breaker is one of the important factors to be determined. As unbroken chips are grown. these deteriorate the surface roughness. and proces automation can not be carried out. In this study to get rid of chip curling problem while turning internal hole. optimal chip breaker is selected from the experiment. The experiment is planned with Taguchi's method that is based on the orthogonal arrary of design factors. From the response table. cutting speed, feedrate, depth of cut and tool geometry turn to be major factors affecting chip formation. Then, optimal chip breaker is selected. and this is verified as good enough for chip control from the experiment.