• Smart Structures and Systems
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• 제20권4호
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• pp.451-460
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• 2017

This work produces a new model of nonlocal thermoelastic nanobeams of temperature-dependent physical properties. A nanobeam is excited by harmonically varying heat and subjected to an exponential decaying time varying load. The analytical solution is obtained by means of Laplace transform method in time domain. Inversions of transformed solutions have been preceded by using calculus of residues. Effects of nonlocal parameter, variability thermal conductivity, varying load and angular frequency of thermal vibration on studied fields of nanobeam are investigated and discussed.

• Toxicological Research
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• 제7권2호
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• pp.239-255
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• 1991

Several types of IFNs were tested for their ability to suppress TCDD-inducible P-450 dependent mixed function oxidase (MFO) system in mouse primary hepatocytes. Mouse IFN-gamma (IFN-G) markedly suppressed EROD activity when added at the same time as TCDD (10 nM). The antagonism of EROD activity by IFN-G exhibited both a dose-(10-100 U/ml) and time-depedence. In contrast, mouse IFN-A/B was only moderately suppressive and only at high concentrations (500 U/ml). Rat IFN-G was even more selective than mouse, wherase human IFN-G had no activity.

• 대한기계학회논문집B
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• 제25권10호
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• pp.1337-1345
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• 2001

Numerical investigation is made to study the effects of thermosolutal convection on the formation of macrosegregation in a Pb-Sn alloy solidification process in a two dimensional confined rectangluar mold. The basic equations are sovled using the Contrinum Model theory with the SIMPE algorithm during the solidification process. In addition, to track the liquid-solid interface with time variations, the moving boundary condition was adopted and moving irregular interface shapes were treated with the time-dependent, boundary-fitted coordinate system. As the temperature reduces from the liquidus to the solidus, the liquid concentration of Sn, the lighter constituent, increases. Then the buoyancy-driven flow due to temperature and liquid composition gradients occurs in the mushy region and forms the complicated macrosegregation maps. belated to this phenomena, effects on the macrosegregation formation depending on the cooling condition and gravity values are examined.

• International Journal of Naval Architecture and Ocean Engineering
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• 제12권1호
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• pp.297-313
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• 2020

An Arctic Spar is characterized by its conical shape near the waterline. In this case, the nonlinear effects from its irregular hull shape would be significant if there is either a large amplitude floater motion or steep wave conditions. Therefore, in this paper, the nonlinear effects of an Arctic Spar are numerically investigated by introducing a weakly nonlinear time-domain model that considers the time dependent hydrostatic restoring stiffness and Froude-Krylov forces. Through numerical simulations under multiple regular and irregular wave conditions, the nonlinear behavior of the Arctic Spar is clearly observed, but it is not shown in the linear analysis. In particular, it is found that the nonlinear Froude-Krylov force plays an important role when the wave frequency is close to the heave natural frequency. In addition, the nonlinear hydrostatic restoring stiffness causes the structure's unstable motion at a half of heave natural period.

• 대한한방내과학회지
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• 제36권1호
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• pp.1-12
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• 2015

Objectives : This study was performed to investigate the anti-cancer effects of Rhus verniciflua Stokes (RVS) extracted with sterile distilled water on cholangiocarcinoma cell lines. Materials and Methods : Two cholangiocarcinoma cell lines, SNU-1079 and SNU-1196, were used in this study. Cells were treated with different concentrations of RVS for 24, 48, and 72 hours. Cell count, viability, apoptosis, and mRNA expression of Bax, Bcl-2, Mcl-1, survivin, caspase-3, and cyclin D1 and P21 were determined with an automatic cell counter (ADAM-MC), MTT assay, apoptosis assay (Annexin-V/PI staining), and RT-PCR. Results : All cells treated with RVS showed decreased cell counts in a dose-dependent manner. RVS inhibited proliferation of SNU-1196 in a dose-dependent manner, but SNU-1079 proliferation was inhibited in the long-time culture group in a dose-dependent manner. The proportion of early and late-stage apoptotic cells was increased by RVS in a dose-dependent manner in SNU-1196. In contrast, it was increased significantly in SNU-1079 treated with high-dose RVS. After treatment with RVS, the mRNA expression of Bcl-2 was decreased while Bax was increased in SNU-1079. Cyclin D1 mRNA levels were decreased in SNU-1196 in a dose-dependent manner. P21 expression was increased in all cells after the treatment with RVS. Conclusions : RVS appears to have potential as a therapeutic agent for cholangiocarcinoma.

• The Korean Journal of Physiology and Pharmacology
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• 제26권5호
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• pp.397-404
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• 2022

Fesoterodine, an antimuscarinic drug, is widely used to treat overactive bladder syndrome. However, there is little information about its effects on vascular K⁺ channels. In this study, voltage-dependent K⁺ (Kv) channel inhibition by fesoterodine was investigated using the patch-clamp technique in rabbit coronary artery. In whole-cell patches, the addition of fesoterodine to the bath inhibited the Kv currents in a concentration-dependent manner, with an IC₅₀ value of 3.19 ± 0.91 μM and a Hill coefficient of 0.56 ± 0.03. Although the drug did not alter the voltage-dependence of steady-state activation, it shifted the steady-state inactivation curve to a more negative potential, suggesting that fesoterodine affects the voltage-sensor of the Kv channel. Inhibition by fesoterodine was significantly enhanced by repetitive train pulses (1 or 2 Hz). Furthermore, it significantly increased the recovery time constant from inactivation, suggesting that the Kv channel inhibition by fesoterodine is use (state)-dependent. Its inhibitory effect disappeared by pretreatment with a Kv 1.5 inhibitor. However, pretreatment with Kv2.1 or Kv7 inhibitors did not affect the inhibitory effects on Kv channels. Based on these results, we conclude that fesoterodine inhibits vascular Kv channels (mainly the Kv1.5 subtype) in a concentration- and use (state)-dependent manner, independent of muscarinic receptor antagonism.

• Toxicological Research
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• 제22권2호
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• pp.95-102
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• 2006

Exposure to soluble nickel compound produces toxic effects on immune system, but the mechanism of action remains to be elucidated. Differential gene expression was studied to understand the potential molecular mechanism responsible for acute toxicity induced by nickel acetate in spleen cells. We exposed mouse spleen cells to nickel acetate with a nontoxic dose ($40{\mu}M$) and then extracted total RNA at 6 h and 12 h after exposure. The RNA was hybridized onto 10K mouse oligonucleotide microarrays, and data were analyzed using GeneSpring 7.1. Nickel had a modest effects on expression of many genes, in the range of 1.3-3 fold. The expression profile showed time-dependent changes in expression levels of differentially expressed genes, including some important genes related to cell cycle, apoptosis and DNA repair. In hierarchical cluster analysis of duplicate experiments, 111 genes were screened out. Out of these, 44 genes showing time- dependent up-regulation (>1.5 fold) and 38 genes showing down-regulation (>1.5 fold) at all time points were chosen for further analysis. The change in the expression of three genes (GPX1, GADD45B and FAIM) after nickel treatment was validated using RT-PCR. As a rule, a number of genes appear to be coordinately regulated between cell survival and cell death from nickel toxicity. In conclusion, changes in the gene profile in the spleen after nickel treatment are complex and genes with diverse functions are modulated. These findings will be contributed to the understanding of the complicated biological effects of nickel.

• 아동학회지
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• 제29권4호
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• pp.181-197
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• 2008

A mobile phone usage survey was administered to a nationwide sample of 3,617 adolescents. Major motivations of mobile phone usage were mobility/real-time connection, show off, information acquisition, entertainment, dialogue, schedule management, and advice. Maintenance of social relationship with the peer group was most important in mobile phone use. Motivations influenced mobile phone dependency : show off had the strongest influence on anxiety/paranoia followed by dialogue, entertainment, mobility/real-time connection. Without their phones, fashion-oriented adolescents showed mobile phone dependency and anxiety. Stronger dialogue and entertainment motivations were associated with weaker real time connection motivation and stronger paranoia symptoms. Mobile phone dependent adolescents had lower grades, showed lack of attention, had little dialogue with their parents and showed withdrawal from the peer group.

• Geomechanics and Engineering
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• 제19권5호
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• pp.369-381
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• 2019

The objective of this paper is to study the two dimensional deformation in transversely isotropic thermoelastic medium without energy dissipation due to time harmonic sources using new modified couple stress theory, a continuum theory capable to predict the size effects at micro/nano scale. The couple stress constitutive relationships have been introduced for transversely isotropic thermoelastic medium, in which the curvature tensor is asymmetric and the couple stress moment tensor is symmetric. Fourier transform technique is applied to obtain the solutions of the governing equations. Assuming the deformation to be harmonically time-dependent, the transformed solution is obtained in the frequency domain. The application of a time harmonic concentrated and distributed sources have been considered to show the utility of the solution obtained. The displacement components, stress components, temperature change and couple stress are obtained in the transformed domain. A numerical inversion technique has been used to obtain the solutions in the physical domain. The effects of angular frequency are depicted graphically on the resulted quantities.

• 한국해양공학회지
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• 제13권2호통권32호
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• pp.129-137
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• 1999

The time of the onset of double-diffusive convection in time-dependent, nonlinear concentration fields is investigated theoretically. The initially quiescent horizontal fluid layer with a uniform temperature gradient experiences a sudden concentration change from below, but its stable thermal stratification affects concentration effects in such way to invoke convective motion. The related stability analysis, including Soret effect, is conducted on the basis of the propagation theory. Under the linear stability theory the concentration penetration depth is used as a length scaling factor, and the similarity transform for the linearized perturbation equations. The newlly obtained stability equations are solved numerically. The resulting critical time to mark the onset of regular cells are obtained as a function of the thermal Rayleigh number, the solute Rayleigh number, and the Soret effect coefficient. For a certain value of the Soret effect coefficient, the stable thermal gradient promote double-diffusive convective motion.