• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.16
• /
• pp.6715-6720
• /
• 2014

The purpose of this study was to evaluate associations of the CYP1A1 gene variant rs4646903 polymorphism with the risk of developing esophageal cancer (EC). A case-control study was carried out in Pashtun population of Khyber Pakhtunkhwa province of Pakistan in which 140 hospital based EC cases and 196 population based healthy controls exposed to similar environmental conditions were included. A specific method based on the real time polymerase chain reaction (RT-PCR) was used to detect genotypes in case and control groups and results were then analyzed with SPSS version 20. In our population, individuals with CC and TC genotypes of the CYP1A1 rs4646903 polymorphism had significantly higher risk of EC (adjusted odds (OR): 15.709, 95%CI: 6.065-40.686, OR: 3.256 95%CI: 1.902-5.574 respectively). The 'C' allele was strongly associated with the disease (p< 0.0001). Adjusted OR was higher (1.5 times in C/C) in case of variant alleles that show the contribution of environmental and nutritional factors towards the development of EC. Our findings suggest that presence of the 'C' allele of rs4646903 (T>C) may be one of the risk alleles for EC susceptibility in Pashtun population.

• The Journal of Korean Society of Virology
• /
• v.28 no.1
• /
• pp.53-62
• /
• 1998

Human papillomavirus (HPV) 16, E7 proteins derived from the prototype (Bac73) and natural variant (Bac101) E7 open reading frame were produced in Sf9 insect cells. The variant E7 gene occurred naturally by substitution mutation at the position of 88 nucleotide, resulting serine instead of asparagine. Using E7 specific monoclonal antibody (VD6), both E7 proteins were identified in recombinant baculovirus infected SF9 cells. Radiolabelling and immunoprecipitation analysis revealed that both E7 proteins were phosphoproteins. Immunostaining result showed that E7 proteins were mainly localized in the cytoplasm. Nuclear form of E7 proteins was also detected after a sequential fractionation procedure for removing chromatin structure. Considering that the VD6 recognition site in E7 protein is located within 10 amino acid at the N-terminus, this region appears to be blocked by the nuclear component. Western blot analysis revealed that nuclear form was more abundant than cytoplasmic E7 proteins. Time course immunostaining showed that the primary location of E7 protein was the nucleus and exported to the cytoplasm as proteins were accumulated. These events occurred similarly in both Bac73 and Bac101 infected Sf9 cells, suggesting that these two proteins may have similar biological functions.

• The Journal of the Acoustical Society of Korea
• /
• v.36 no.6
• /
• pp.378-386
• /
• 2017

Accurate distance measurement between maneuver target in underwater and measuring devices is required to perform quantitative test evaluation in marine weapons system R&D process. In general, the target distance is measured using a one-way ToA (Time of Arrival) method that calculates the time difference between transmitted and received signals from the two accurately synchronized devices. However, the distance estimation performance is degraded because of the multi-path environments. In this paper, the time-variant transfer function of complex underwater environment is estimated from each received data frame using RBD (Ray-based Blind Deconvolution), and the estimated time-variant transfer function is then used to get rid of the effect about complex underwater environment and to recover the data signal using PTRM (Passive Time Reversal Mirror). The result from the simulation and experimental data show that the suggested method improve the distance estimation performance when comparing with the conventional ToA method.

• Korean Chemical Engineering Research
• /
• v.53 no.6
• /
• pp.682-689
• /
• 2015

A two-step process was investigated for pretreatment and fractionation of rice straw. The two-step fractionation process involves first, soaking rice straw in aqueous ammonia (SAA) in a batch reactor to recover lignin-rich hydrolysate. This is followed by a second-step treatment in a fixed-bed flow-through column reactor to recover xylo-oligomer-rich hydrolysate. The remaining glucan-rich solid cake is then subjected to an enzymatic process. In the first variant, SAA treatment in the first step dissolves lignin at moderate temperature (60 and $80^{\circ}C$), while in the second step, hot-water treatment is used for xylan removal at higher temperatures ($150{\sim}210^{\circ}C$). Under optimal conditions ($190^{\circ}C$ reaction temperature, 30 min reaction time, 5.0 ml/min flow rate, and 2.3 MPa reaction pressure), the SAA-hot-water fractionation removed 79.2% of the lignin and 63.4% of the xylan. In the second variant, SAA was followed by treatment with dilute sulfuric acid. With this process, optimal treatment conditions for effective fractionation of xylo-oligomer were found to be $80^{\circ}C$, 12 h reaction time, solid-to-liquid ratio of 1:12 in the first step; and 5.0 ml $H_2SO_4/min$, $170^{\circ}C$, and 2.3 MPa in the second step. After this two-step fractionation process, 85.4% lignin removal and 78.9% xylan removal (26.8% xylan recovery) were achieved. Use of the optimized second variant of the two-step fractionation process (SAA and $H_2SO_4$) resulted in enhanced enzymatic digestibility of the treated solid (99% glucan digestibility) with 15 FPU (filter paper unit) of CTec2 (cellulase)/g-glucan of enzyme loading, which was higher than 92% in the two-step fractionation process (SAA and hot-water).

• 한국지구물리탐사학회:학술대회논문집
• /
• 2004.06a
• /
• pp.103-113
• /
• 2004

We investigate the time-variational characteristics of power spectrum and transfer function of geomagnetic field by robust estimation technique. In the case of power spectrums of geomagnetic field, there are some the periodic fluctuations related with solar activity, Meanwhile, the geomagnetic transfer function shows so considerable weak time-variational fluctuation that the estimations of transfer function seem to be comparatively stable in time-variant view.

• ETRI Journal
• /
• v.31 no.3
• /
• pp.321-323
• /
• 2009

A wideband beamforming algorithm for estimating the azimuth angle, elevation angle, velocity, and range using a planar phased radar array with antenna switching is proposed. It uses the time-variant steering vector model. Simulation results illustrating the performance of the proposed beamformer are presented.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2007.06a
• /
• pp.315-316
• /
• 2007

• Journal of the Korean Society for Precision Engineering
• /
• v.17 no.5
• /
• pp.108-115
• /
• 2000

This paper presents a variant type process planning system for machining of dies for auto-body production. Through the analysis of dies and their manufacturing processes, the authors categorized the press dies into 15 groups according to the similarity of machining features. After critically reviewing current manufacturing procedures, a standard process plan was defined for each group. The authors present MP3D the process planning system built on the standard process plan database, and show how they apply it at the die manufacturing plant of an automobile company. MP3D is expected to reduce major losses in machining such as reworking caused by mistakenly uncut features and eventually to help to accumulate the knowledge of operators. The operation sheet MP3D produces is also used in monitoring the progress of manufacturing of dies. This paper explains the whole development cycle of a process planning system from process analysis to application so that it can help readers to develop and apply a process planning system to their machine shops.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.11
• /
• pp.3279-3283
• /
• 2013

We present an elementary pedagogical derivation of the Brillouin-Wigner and the Rayleigh-Schr$\ddot{o}$dinger perturbation theories with Epstein-Nesbet partitioning. A variant of the Brillouin-Wigner perturbation theory is also introduced, which can be easily extended to the quasi-degenerate case. A main advantage of the new theory is that the computing time required for obtaining the successive higher-order results is minimal after the third-order calculation. We illustrate the accuracy of the new perturbation theory for some simple model systems like the perturbed harmonic oscillator and the particle in a box.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.19 no.12
• /
• pp.2805-2812
• /
• 2015

For the purpose of estimation of time variant frequency selective transmission channels, reference symbols are usually employed. The bit error performance of LTE OFDM systems is analyzed in the case of LTE standard reference symbol arrangement. Results show that LTE OFDM system with this LTE reference symbol arrangement is robust against Doppler time variant fading. However, the performance of that system is degraded due to channel estimation error in frequency domain. An equidistant arrangement with a diamond shape structure of reference symbols, however having 4 subcarriers distance in frequency domain, is suggested for the optimal channel estimation.