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http://dx.doi.org/10.7314/APJCP.2014.15.16.6715

Genetic Susceptibility to Esophageal Cancer due to CYP1A1 Gene Variant rs4646903 in Tobacco Addicted Patients of Pashtun Ethnicity: a Case Control Study in Khyber Pakhtunkhwa Province of Pakistan  

Zakiullah, Zakiullah (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar)
Saeed, Muhammad (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar)
Ali, Sajid (Centre of Biotechnology & Microbiology, Faculty of Life & Environmental Sciences, University of Peshawar)
Javed, Nabila (Institute of Radiotherapy & Nuclear Medicine (IRNUM))
Khisroon, Muhammad (Department of Zoology, Faculty of Life & Environmental Sciences, University of Peshawar)
Muhammad, Basir (Department of Clinical Oncology, BINOR Cancer Hospital)
Khuda, Fazli (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar)
Ahmad, Saeed (Department of Microbiology & Biotechnology, Faculty of Life & Environmental Sciences, Sarhad University of Science & Information Technology)
Ismail, Mohammad (Department of Pharmacy, Faculty of Life & Environmental Sciences, University of Peshawar)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.16, 2014 , pp. 6715-6720 More about this Journal
Abstract
The purpose of this study was to evaluate associations of the CYP1A1 gene variant rs4646903 polymorphism with the risk of developing esophageal cancer (EC). A case-control study was carried out in Pashtun population of Khyber Pakhtunkhwa province of Pakistan in which 140 hospital based EC cases and 196 population based healthy controls exposed to similar environmental conditions were included. A specific method based on the real time polymerase chain reaction (RT-PCR) was used to detect genotypes in case and control groups and results were then analyzed with SPSS version 20. In our population, individuals with CC and TC genotypes of the CYP1A1 rs4646903 polymorphism had significantly higher risk of EC (adjusted odds (OR): 15.709, 95%CI: 6.065-40.686, OR: 3.256 95%CI: 1.902-5.574 respectively). The 'C' allele was strongly associated with the disease (p< 0.0001). Adjusted OR was higher (1.5 times in C/C) in case of variant alleles that show the contribution of environmental and nutritional factors towards the development of EC. Our findings suggest that presence of the 'C' allele of rs4646903 (T>C) may be one of the risk alleles for EC susceptibility in Pashtun population.
Keywords
Esophageal cancer risk; CYP1A1 gene variant rs4646903; Pashtun population; Pakistan;
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1 Mao WM, Zheng WH, Ling ZQ (2012). Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev, 12, 2461-6.
2 Moore MA, Tsuda H (2002). Smoking-related research in the Asian-pacific countries. Asian Pac J Cancer Prev, 3, 291-304.
3 Olshan AF, Weissler MC, Watson MA, Bell DA (2000). GSTM1, GSTT1, GSTP1, CYP1A1, and NAT1 polymorphisms, tobacco use, and the risk of head and neck cancer. Cancer Epidemiol Biomark Prev, 9, 185-91.
4 Prokopczyk B, Cox JE, Hoffmann D, Waggoner SE (1997). Identification of tobacco specific carcinogen in the cervical mucus of smokers and non-smokers. J Natl Cancer Inst, 89, 868-73.   DOI   ScienceOn
5 Sabitha K, Reddy MV, Jamil K (2010). Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer. Cancer Epidemiol, 34, 587-92.   DOI   ScienceOn
6 Abbas M, Srivastava K, Imran M, Banerjee M (2014). Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer in a north indian population. Eur J Obstet Gynecol Reprod Biol. 176, 68-74.   DOI
7 Afridi SP, Khan A, Waheed I (2000). High risk factors in patient with carcinoma esophagus. J Coll Physicians Surg Pak, 10, 368-70.
8 Amani F, Ahari SS, Akhghari L (2013). Epidemiology of esophageal cancer in Ardabil province during 2003-2011. Asian Pac J Cancer Prev, 14, 4177-80.   과학기술학회마을   DOI   ScienceOn
9 Weng Y, Fei B, He P, Cai M (2012).Glutathione-s-transferase t1 polymorphism is associated with esophageal cancer risk in chinese han population. Asian Pac J Cancer Prev, 13, 4403-07.   과학기술학회마을   DOI
10 Sharma MK, Gour N, Pandey A, Wallia D (2011). Epidemiological study of risk factors for oral, laryngeal and esophageal cancers at a tertiary care hospital in India. Asian Pac J Cancer Prev, 12, 1215-18.
11 Taskiran C, Aktas D, Yigit-Celik N, et al (2006). CYP1A1 gene polymorphism as a risk factor for cervical intra epithelial neoplasia and invasive cervical cancer. Gynecol Oncol, 101, 503-6.   DOI
12 Velema JP, Ferrera A, Figueroa M, et al (2002). Burning wood in the kitchen increases the risk of cervical neoplasia in HPV-infected women in honduras. Int J Cancer, 97, 536-41.   DOI
13 Xia L, Gao J, Liu Y, Wu K, (2013). Significant association between CYP1A1 T3801C polymorphism and cervical neoplasia risk: a systematic review and meta-analysis. Tumor Biol, 34, 223-30.   DOI
14 Yamaji T, Inoue M, Sasazuki S, et al (2008). Fruit and vegetable consumption and squamous cell carcinoma of the esophagus in Japan: the JPHC study. japan public health center-based prospective study group. Int J Cancer, 123, 1935-40.   DOI   ScienceOn
15 Yang CX, Wang HY, Wang ZM et al (2005). Risk factors for esophageal cancer: a case control study in southwestern china. Asian Pac J Cancer Prev, 6, 48-53.
16 Yi SM, Li GY (2012). Null genotype of GSTT1 contributes to esophageal cancer risk in Asian populations: evidence from a meta-analysis. Asian Pacific J Cancer Prev, 13, 4967-71.   과학기술학회마을   DOI   ScienceOn
17 Cortes GR, Villasenor CR (1997). Cancer deesofago. Rev Gastroenterol Mex, 62, 149-59.
18 Badar F, Anwar N, Mahmood S (2005). Geographical variation in the epidemiology of esophageal cancer in pakistan. Asian Pac J Cancer Prev, 6, 139-42.
19 Castellsague X, Munoz N, De Stefani E, et al (1999). Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer, 82, 657-64.   DOI
20 Cook MB, Dawsey SM, Freedman ND, et al (2009). Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev, 18, 1174-82.   DOI   ScienceOn
21 D'Errico A, Taioli E, Xhen X, Vineis P (1996). Genetic metabolic polymorphisms and the risk of cancer: a review of the literature. Biomarkers, 1, 149-73.   DOI   ScienceOn
22 Eslick G (2009). Epidemiology of esophageal cancer. Gastroenterol Clin N Am, 38, 17-25.   DOI   ScienceOn
23 Jamal S, Ahmad M, Khan AH, et al (1997). Carcinoma esophagus-a clinicopathological study of 50 cases at Armed Forces Institute of Pathology, Rawalpindi, Pakistan. J Pathol, 8, 24-8.
24 Hajmanoochehri F, Mohammadi N, Nasirian N, Hosseinkhani M (2013). Patho-epidemiological features of esophageal and gastric cancers in an endemic region: a 20-year retrospective study. Asian Pac J Cancer Prev, 14, 3491-7.   과학기술학회마을   DOI   ScienceOn
25 Jamal S (2010). Esophageal cancer in Pakistan-is it really extension of Asian cancer belt? Pak Arm For Med J, 2.
26 Kollarova H, Machova L, Horakova D, et al (2007). Epidemiology of esophageal cancer-an overview article. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 151, 17-28.   DOI
27 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
28 Yun YX, Wang YP, Wang P, et al (2013). CYP1A1 genetic polymorphisms and risk for esophageal cancer: a casecontrol study in central China. Asian Pac J Cancer Prev, 14, 6507-12.   과학기술학회마을   DOI
29 Zakiullah, Saeed M, Muhammad N, et al (2012). Assessment of potential toxicity of smokeless tobacco product (naswar)- available on the pakistani market. Tob.Control, 21, 396-401.   DOI
30 Song QK, Zhao L, Li J, et al, (2013). Adverse effects of preserved vegetables on squamous cell carcinoma of esophagus and precancer lesions in a high risk area. Asian Pac J Cancer Prev, 14, 659-63.   과학기술학회마을   DOI   ScienceOn
31 Blot W, McLaughlin J, Fraumeni JF (2006). Esophageal Cancer. In Cancer Epidemiology and Prevention Edited by: Schottenfeld D, Fraumeni J. New York: Oxford University Press, 697-706.