• Journal of the Korea Society for Simulation
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• v.27 no.3
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• pp.45-52
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• 2018

We consider the busy period of an M/G/1/K queueing system with queue-length-dependent overload control policy. A variant of an oscillating control strategy that was recently analyzed by Choi and Kim (2016) is considered: two threshold values, $L_1({\leq_-}L_2)$ and $L_2({\leq_-}K)$, are assumed, and service rate and arrival rate are adjusted depending on the queue length to alleviate congestion. We investigate the busy period of an M/G/1/K queue with two overload control policies, and present the formulae to obtain the expected length of a busy period for each control policy. Based on the numerical examples, we conclude that the variability and expected value of the service time distribution have the most influence on the length of a busy period.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.229-237
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• 2020

Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings. Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods. Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract. Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1420-1424
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• 2010

강수량의 계절성은 수자원관리에 있어 매우 중요한 수문요소로서 계절성의 변동을 정량적으로 평가하는 것은 미래 수자원관리 및 정책 수립에 필수적이다. 이러한 점에서 본 연구의 목적은 강수량의 계절성을 평가하는데 유리한 방법론을 제시하고, 이를 통한 계절 변동성의 정량적인 해석을 목적으로 한다. 본 연구에서 적용한 순환통계치 분석은 시간을 각도로 변환하여 이용함으로써 미세한 시간적인 변화양상의 정량적인 해석이 가능한 방법이다. 강수량의 주기특성과 과거로부터 현재까지의 변화 양상을 평가하기 위해서, 우선 전국의 58개 강우관측소를 선별하고 각 관측소의 일강우자료를 이용하여 관측소별 연최대치계열(Annual maxima series)과 발생일자, 월최대강수계열(Monthly maxima series)과 발생일자를 추출하였다. 각 자료의 발생일자는 순환통계분석을 위해 해당 time scale을 한 주기로 하는 방향각 데이터로 변환하였으며, 변환된 시간속성 데이터의 통계특성치를 산정하여 발생시기에 대한 경향성을 분석하였다. 월최대강수량의 발생 시기는 자료 계열 연주기의 변동성을 평가하기 위해 사용되었고, 분석결과 남해안지역이 6월말에서 7월초이고, 북쪽으로 올라감에 따라 조금씩 발생시기가 늦어지는 것으로 분석되었다. 극치강수량의 발생 경향을 평가하기 위해 사용된 일최대강수량의 시공간적 변동성은 월최대강수량보다 크게 분석되었으며, 이는 일최대강수량의 경우 지형학적인 영향에 크게 좌우되며, 우리나라의 여름철 극치강수량이 태풍 발생빈도 및 경로와 연관성을 갖는다는 일반적인 사실을 반영한 결과라고 판단된다. 월최대강수량 및 일최대강수량 발생시기의 이동평균을 통해 발생시기의 변동을 분석한 결과, 서울과 강릉지방은 최대강수량의 발생시점이 늦어지고 있으며 반대로 목포와 부산지방은 최대강수량의 발생시점이 앞당겨지고 있었다. 이는 몬순시스템의 거동에 영향을 받는 것으로 사료된다.

• Tuberculosis and Respiratory Diseases
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• v.78 no.2
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• pp.78-84
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• 2015

Background: Reports of therapeutic drug monitoring (TDM) for second-line medications to treat multidrug-resistant tuberculosis (MDR-TB) remain limited. Methods: A retrospective cohort from the Virginia state tuberculosis (TB) registry, 2009-2014, was analyzed for TDM usage in MDR-TB. Drug concentrations, measured at time of estimated peak ($C_{max}$), were compared to expected ranges. Results: Of 10 patients with MDR-TB, 8 (80%) had TDM for at least one drug (maximum 6 drugs). Second-line drugs tested were cycloserine in seven patients (mean $C_{2hr}$, $16.6{\pm}10.2{\mu}g/mL$; 4 [57%] below expected range); moxifloxacin in five (mean $C_{2hr}$, $3.2{\pm}1.5{\mu}g/mL$; 1 [20%] below); capreomycin in five (mean $C_{2hr}$, $21.5{\pm}14.0{\mu}g/mL$; 3 [60%] below); para-aminosalicylic acid in five (mean $C_{6hr}$, $65.0{\pm}29.1{\mu}g/mL$; all within or above); linezolid in three (mean $C_{2hr}$, $11.4{\pm}4.1{\mu}g/mL$, 1 [33%] below); amikacin in two (mean $C_{2hr}$, $35.3{\pm}3.7{\mu}g/mL$; 1 [50%] below); ethionamide in one ($C_{2hr}$, $1.49{\mu}g/mL$, within expected). Two patients died: a 38-year-old woman with human immunodeficiency virus/acquired immune deficiency syndrome and TB meningitis without TDM, and a 76-year-old man with fluoroquinolone-resistant (pre-extensively drug-resistant) pulmonary TB and low linezolid and capreomycin concentrations. Conclusion: Individual pharmacokinetic variability was common. A more standardized approach to TDM for MDR-TB may limit over-testing and maximize therapeutic gain.

• Korean Institute of Interior Design Journal
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• no.29
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• pp.281-288
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• 2001

It shows 21st century as a networking society that is moving up the concept of global town and being industrialized with regional and personal connections. Individual's original idea and variety of 21th century may be respected by such environmental change, and age (Literary, human axis, technology axis, nature axis, kaining farming axis are central keyword) of culture that cultural capacity of individual becomes important fetters that create added value is forecasted to become. The moaning for space that is unemployment enemy by change of conceptional environment about cultural life and agreeable quality of life by development of Information-Communication technology may be required newly. As it does interaction along with development of science technique and Information-Communication technology, the future environment of various that complex! Is predicted to form network environment (existence space, cyberspace) newly. Human central interest is risen in technology balance hereupon, and these characteristic escaped in physical system that do with functional special quality and require human central and sensitive interaction. First, if examine about phenomenon by Digitize and chance aspect that is risen in 21th century, Digitize is time that action occurs fusion Tuesday that is various and Blur phenomenon of city·space, and the period to collapse the border between several individual. Second, importance more than man-centered and sensitive aspect of functional physical system is risen by digital age with development of technology medium, and as the five digital senses showed up, it suggests a sensual of the times and therefore the interest and direction get set up for the sensual sides of consumers. Third, special quality is, medium enemy by that digital space connotes meaning disk floret, variability, transparency, space red of extensity etc.. to burn and is digitalised, can be risen by symbolic, original individualities and emotional communication's the importance is required sensitivity enemy who is sympathy horn by fusion anger of individual. Technology of new media may open direction of new communication through interface that did not enjoy so far is going to supply new means that can express own to human

• Journal of the Korean Society of Safety
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• v.29 no.4
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• pp.123-131
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• 2014

Whole amount of waste water, approximately 921.6 liter, for cleaning a ready mixed concrete truck should be used to produce concrete as a mixing water or cleaning water. Recycling water for concrete mixing contains solids, which cause decrease in slump, air and compressive strengths, so it may influence on poor concrete quality. Therefore, it has been maintained to use recycling water with less than 3 percent of solids. Since no evaluation system has been constructed to directly reflect on variability of recycling water from ready mixed concrete plants, it is necessary to develop "Automatic recycling solid measuring system" for quality controls in real time. In this research, sensors measuring waste water concentration in ultrasonic and inductance methods were developed, and automatic system using the sensors were established. The accuracy of measurement sensors developed for recycling water based on various conditions of concentration was proved, and application limits were evaluated. Also, concentration of recycling water using sensors developed from ready mixed concrete plant was measured, and curing method verified the accuracy of the sensors. Moreover, measurement sensors for recycling water in various locations were installed to evaluate the effects on measuring method and spots. The automatic measuring system for recycling water concentration, which is developed in the research, will contribute to improve concrete quality safety through reliable solids maintenance.

• Journal of the Korean Society of Safety
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• v.28 no.3
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• pp.107-113
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• 2013

Problem solving and/or decision making process usually encountered in human living consists of a sequence of human behaviors based upon his/her knowledge. Thus, Rasmussen introduced Skill-Rule-Knowledge paradigm to countermeasure human errors that can occur in Nuclear Power Plants. Unfortunately however, it was not so easy as expected since objective evidence have not been obtainable with conventional research techniques. With the help of EEG band pawer ratio techniques, this study tried to get psycho-physiological symptoms of human errors, if any, while human beings perform knowledge-based behaviors such as simple arithmetic computations with different difficulty level. A set of simulated works was carried out with a computer station. Four kinds of arithmetic computation tasks were given to 10 health male under-graduate students on different day individually, and during the experiment, EEG and ECG was measured continuously for objective psycho-physiological analysis. According to the results, ${\alpha}$/(${\alpha}+{\beta}$) as well as ${\alpha}/{\beta}$ band power ratio were sensitive to task difficulty level which consistently decreased both. However, any one of them failed to reveal the influence of tasks with different difficulty level in the aspect of task duration time. On the contrary, Heart Rate Variability was more suggestive than expected. To make a conclusion, it can be said that band power of EEG waves will be helpful in not only assessment of work difficulty level but also assessment of workers' skill development if supported by cardiac function such as HRV.

• Journal of KIISE:Software and Applications
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• v.30 no.12
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• pp.1247-1254
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• 2003

Currently. the north american symptomatic carotid endarterectomy trial, european carotid surgery trial, and common carotid method are used to measure the carotid stenosis for determining candidate for carotid endarterectomy using the projection angiography from different modalities such as digital subtraction angiography. rotational angiography, computed tomography angiography and magnetic resonance angiography. A new computerized carotid stenosis measuring system was developed using MR angiography axial image to overcome the drawbacks of conventional carotid stenosis measuring methods, to reduce the variability of inter-observer and intra-observer. The gray-level thresholding is one of the most popular and efficient method for image segmentation. We segmented the carotid artery and lumen from three-dimensional time-of-flight MRA axial image using gray-level thresholding technique. Using the measured intima-media thickness value of common carotid artery for each cases, we separated carotid artery wall from the segmented carotid artery region. After that, the regions of segmented carotid without artery wall were divided into region of blood flow and plaque. The calculation of carotid stenosis degree was performed as the following; carotid stenosis grading is(area measure of plaque/area measure of blood flow region and plaque) * 100%.

• Korean Journal of Remote Sensing
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• v.31 no.6
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• pp.583-598
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• 2015

This paper presents derivation of background temperature from geostationary satellite and its validation based on ground measurements and Geographic Information System (GIS) for future use in weather and surface heat variability. This study only focuses on daily and monthly brightness temperature in 2012. From the analysis of COMS Meteorological Data Processing System (CMDPS) data, we have found an error in cloud distribution of model, which used as a background temperature field, and in examining the spatial homogeneity. Excessive cloudy pixels were reconstructed by statistical reanalysis based on consistency of temperature measurement. The derived Brightness temperature has correlation of 0.95, bias of 0.66 K and RMSE of 4.88 K with ground station measurements. The relation between brightness temperature and both elevation and vegetated land cover were highly anti-correlated during warm season and daytime, but marginally correlated during cold season and nighttime. This result suggests that time varying emissivity data is required to derive land surface temperature.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.458-458
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• 2012

Climate extreme variability is a major cause of disaster such as flood and drought types occurred in Korea and its effects is also more severe damage in last decades which can be danger mature events in the future. The main aim of this study was to assess the effectives of climate change on drought for an agriculture as Nakdong basin in Korea using climate change data in the future from data of General Circulation Models (GCM) of ECHO-G, with the developing countries like Korea, the developed climate scenario of medium-high greenhouse gas emission was proposed of the SRES A2. The Standardized Precipitation Index (SPI) was applied for drought evaluation. The drought index (SPI) applied for sites in catchment and it is evaluated accordingly by current and future precipitation data, specific as determined for data from nine precipitation stations with data covering the period 1980-2009 for current and three periods 2010-2039, 2040-2069 and 2070-2099 for future; time scales of 3month were used for evaluating. The results determined drought duration, magnitude and spatial extent. The drought in catchment act intensively occurred in March, April, May and November and months of drought extreme often appeared annual in May and November; drought frequent is a non-uniform cyclic pattern in an irregular repetitive manner, but results showed drought intensity increasing in future periods. The results indicated also spatial point of view, the SPI analysis showed two of drought extents; local drought acting on one or more one of sites and entire drought as cover all of site in catchment. In addition, the meteorology drought simulation maps of spatial drought representation were carried out with GIS software to generate for some drought extreme years in study area. The method applied in this study are expected to be appropriately applicable to the evaluation of the effects of extreme hydrologic events, the results also provide useful for the drought warning and sustainable water resources management strategies and policy in agriculture basins.