• 한국균학회소식:학술대회논문집
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• 2015.05a
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• pp.15-15
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• 2015

Aspergillus fumigatus is a major cause of invasive aspergillosis (IA), a significant health issue worldwide with high mortality rates up to 95%. Our lab is interested in how A. fumigatus adapts to low oxygen conditions 'hypoxia', which is one of the important host microenvironments. A. fumigatus SrbA is a basic helix-loop-helix (bHLH) transcriptional regulator and belongs to sterol regulatory element binding protein (SREBP) family members. Loss of SrbA completely blocks growth in hypoxia and results in avirulence in murine models of IA suggesting an essential role of SrbA in hypoxia adaptation and virulence in A. fumigatus. We conducted chromatin immunoprecipitation sequencing (ChIP-seq) with A. fumigatus wild type using a SrbA specific antibody, and 97 genes were revealed as SrbA direct targets. One of the 'SrbA regulons' (AFUB_099590) was a putative bHLH transcriptional regulator whose sequence contained a characteristic tyrosine substitution in the basic portion of the bHLH domain of SREBPs. Therefore, we designated AFUB_099590 SrbB. Further characterization of SrbB demonstrated that SrbB is important for radial growth, biomass production, and biosynthesis of heme intermediates in hypoxia and virulence in A. fumigatus. A series of quantitative real time PCR showed that transcription of several SrbA regulons is coordinately regulated by two SREBPs, SrbA and SrbB in hypoxia. This suggests that SrbA and SrbB have both dependent and independent functions in regulation of genes responsible for hypoxia adaptation in A. fumigatus. Together, our data provide new insights into complicated roles of SREBPs in adaptation of host environments and virulence in pathogenic fungi.

• Journal of Oriental Neuropsychiatry
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• v.25 no.1
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• pp.1-12
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• 2014

Objectives: In this study, the meditation programs (${\alpha}$ version), which are properly coordinated according to the motion, breathing, and relaxation, are evaluated and researched upon to have positive effects on stress and in the area of psychology. Methods: Approved by the Clinical Trials Deliberation Committee in Oriental Medicine, Dongguk University, Ilsan Hospital, this study collected data according to the applicant's consents, demographic information and anthropometry for the Sasang Constitutional diagnosis. Sasang Constitutional diagnosis measured the beta tools by Institute of Oriental Medicine and a decision tree was made for the Sasang Constitutional questionnaires. The STAI, STAXI, BDI, and HRV were measured before and after the meditation in order to compare the effects of meditation according to Sasang Constitution. The HRV was used as a ProComP KM Tech (co). Results: 1) The positive changes available in the Time-domain analysis of heart rate variability assessment showed that the peace of mind is increased. By analyzing the Sasang constitution, So-eum In's peace of mind included a physical stability of the autonomic nervous system. 2) According to the psychological scale evaluation, each depression scale, trait anger, anger-in, state anxiety and trait anxiety index proved significantly positive effects. By analyzing the Sasang constitution, Eun-In which involved So-eum In and Tae-eum In, had positive effects. 3) The psychological scale changed the group of diagnosed depression or anxiety, it did not mean that the psychological scale changes in the depression group, but the index of the anxiety group had been significantly reduced. This program had clinical effects for anxious patients and Eum-In which involved Tae-eum In and So-eum In according to the analysis of Sasang constitution. 4) Correlations between the gender of each psychological scale showed that women have overall low correlations, but, there were no significant changes. Conclusions: The meditation program developed by adequately mixing Action, relaxation and breathing shows that it is effective for overall Eum-in physical and mental relaxation and concentration. In the future, It will have to be developed Meditation program to show the same effect for all people.

• Therapeutic Science for Rehabilitation
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• v.5 no.1
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• pp.23-32
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• 2016

Objective : To investigate the current international researches which identify the effect of stroke with hemiplegia after dual-task training Methods : We systematically examined journals published from 2007 to 2015, searching PubMed. Total 5 researches were selected for the analyses. Results : Selected studies were all in international journal and they used two group experimental design. In addition, all the paper got PEDro scores above 6. They conducted gait task for motor task, at the same time used various domain of cognitive task such as from sustain attention to working memory. The outcome measure tools used for evaluation by the standardized assessment tool and operational definition, further also included the assessment tool designed for the dual-task training such as a variety of tools make possible to assess various aspects of effect. Discussion : Dual-task training in this study was found to give a positive effect on the dual-task performance, as well as improving the motor and cognitive function in patients with stroke. However there were also limitation to the studies conducted so far. In order to apply the occupational therapy, this results can consider as the preliminary data which suggest supplement point and can be a evidence for effective treatment for stroke with hemiplegia.

• Journal of Korea Society of Industrial Information Systems
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• v.20 no.3
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• pp.11-18
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• 2015

Stress is one of the major causes threatening the mental and physical health of human today. In this paper, we analyzed the heart rate variability(HRV), galvanic skin response(GSR), and skin temperature data measured from the university subjects before and after the class to examine the influence on bio-signal in stress environment. Thirty subjects from university students (aged between 21 and 27 years; mean=22.31, STD=1.45) took part in this study. From the experiment results, RMSSD(p=0.033), LF peak(p=0.003), VLF(p=0.045) were statistically significant from those of the control group(p<0.05) of HRV both in time and frequency domain. We observed that mean skin conductivity after the class(mean=5.993(uS), SD=3.406) is higher than that before the class(mean=3.039(uS), SD=2.628) by 97.2% on average and the skin temperature after the class($34.835{\pm}0.305$) is slightly higher than that before the class($34.471{\pm}0.281$) by 1.055% on average. The results in this research could be used to examine the autonomic response in clinical stress related research.

• The Journal of Engineering Geology
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• v.21 no.3
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• pp.213-219
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• 2011

Transient/time-domain electromagnetic (TEM) soundings were carried out on reclaimed land, since the TEM sounding has good resolution of a conductive and thin overburden. The reclamation material is marine clay dredged from the seafloor, which is currently undergoing consolidation in the upper part of the dredged layer. The conductivity of the marine-origin clay is generally more than 0.3 S/m. The aim of the TEM sounding was to determine the depths of weathered and soft rocks overlain by thick and conductive overburden. The TEM responses were measured at delay times of 0.050-20.575 ms with a $30{\times}30$ m coincident loop array. Data from the TEM inversion and core logging indicate that the resistivities of the conductive overburden are less than 2 ${\Omega}$-m, while those of the weathered and soft rocks are 10-20 and 70 ${\Omega}$-m, respectively. The depth to weathered rock is 26-58 m and the depth to soft rock is 46-75 m.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.12
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• pp.1292-1299
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• 2014

Weather radar systems can provide weather information of the ground, sea, and air in extensive spatial coverage in near real time. However, it becomes problematic when ground clutter signal exists around precipitation because strong signals of ground can cause a false precipitation report. A large percentage of land coverage of Korea consists of mountainous regions where ground clutter needs to be mitigated for more accurate prediction. Thus, it is considered necessary to introduce a new suitable ground clutter removal technique specifically adequate for Korea. In this paper, the C-Map(Clutter Map) method using raw radar signals is proposed for removing ground clutter using a terrain-adaptive clutter map. A clutter map is generated using raw radar signals(I/Q) of clear days, then it is subtracted from received radar signals in frequency domain. The proposed method is applied to the radar data acquired from Sobaeksan rain radar and the result shows that the clutter rejection ratio is about 91.17 %.

• 대한공업교육학회지
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• v.42 no.2
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• pp.89-107
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• 2017

The purpose of this study was to analyze the perception of academic difficulties of middle school students and their influences variables in technology subject. The subjects of this study were middle school students in the whole country. A total of 420 students were selected considering the grade and area for the survey. The data were collected by mail and analyzed using SPSS 22.0K. The results of this study were as follows : First, The academic difficulties perceived by middle school students in the technology subject were recognized as normal. Second, Middle school students perceived it as a lack of experience (opportunity) in the technology domain as a cause of academic difficulties. Third, In the learning process, the female students were more difficult to understand the related terms and theories than the male students. In the problem solving activities, the female students were more difficult than the male students in identifying problems, designing solutions, selecting solutions, modeling, testing solutions, and correcting improvements. Fourth, the academic difficulty in learning technology lesson was difficult in terms of terminology, theory, and practice activities in the order of Second, Third, and 1st grade. Fifth, lack of understanding knowledge, confusion of contents knowledge, lack of technical interest, shortage of class hours, lack of understanding of evaluation criteria were all influenced by the difficulty of technical subject learning. Sixth, the academic difficulty influencing the problem solving process was explained by understanding comprehension, content knowledge confusion, technical interest, class time, understanding of evaluation criteria.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.18 no.2
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• pp.179-194
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• 2020

A Bayesian approach was introduced to improve the belief of prior distributions of input parameters for the probabilistic safety assessment of radioactive waste repository. A GoldSim-based module was developed using the Markov chain Monte Carlo algorithm and implemented through GSTSPA (GoldSim Total System Performance Assessment), a GoldSim template for generic/site-specific safety assessment of the radioactive repository system. In this study, sequential Bayesian updating of prior distributions was comprehensively explained and used as a basis to conduct a reliable safety assessment of the repository. The prior distribution to three sequential posterior distributions for several selected parameters associated with nuclide transport in the fractured rock medium was updated with assumed likelihood functions. The process was demonstrated through a probabilistic safety assessment of the conceptual repository for illustrative purposes. Through this study, it was shown that insufficient observed data could enhance the belief of prior distributions for input parameter values commonly available, which are usually uncertain. This is particularly applicable for nuclide behavior in and around the repository system, which typically exhibited a long time span and wide modeling domain.

• Journal of the Korean earth science society
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• v.32 no.1
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• pp.21-32
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• 2011

Using six-year (2004-2009) SKYNET measurements, MODIS-derived AOTs were validated at five SKYNET sites (Seoul, Chiba, Etchujima, Fukuejima, and Hedomisaki), in addition to climatological analysis of MODIS-derived optical properties over the East Asian domain ($20-50^{\circ}N$, $90-150^{\circ}E$). In so doing MODIS-SKYNET collocated AOT data were constructed if two measurements are taken within 25 km distance and within 30 minute time difference. From the comparison of two measurements, it is demonstrated that aerosol type insignificantly affects the accuracy of MODIS AOT. It is because the aerosol model combining predefined fine aerosol model and coarse aerosol model is used for the retrieval. However, positive bias between MODIS and SKYNET increases as fraction of the coarse aerosol model increases. In addition, MODIS AOT appears to be overestimated in case of lower aerosol loading while the overestimation tends to decrease with increased aerosol loading. Regression analysis between MODIS AOT and SKYNET AOT for 550 nm band yields 0.86, 0.16, and 0.61 of regression slope, intercept, and coefficient of determination, respectively. Those statistical results may draw a conclusion that MODIS AOTs over East Asia carry a reasonable accuracy compared to ground-based SKYNET measurements.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.8
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• pp.308-315
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• 2013

In this paper, Tapered slot antenna of IR-UWB was Designed and fabricated using HFSS and we suggest the beam width of the broadband antenna using group-delay and fidelity. For this purpose, acquired data from the Network Analyzer was analyzed in the time domain by using the chirp-Z transform and Simulation was conducted and confirmed with the CST microwave studio. Analysis of the antenna radiation pattern is the antenna separation at intervals of 0.5 metres and then transmit antenna is fixed and the receiving antenna 360 degree intervals of 10 degree each, The results of the analysis are as follows, and analyzer of the fidelity of the antenna's performance. An analysis of more than 90 percent of the cases is less than ${\pm}40$ degrees in good fidelity, more than 90% less than ${\pm}40$ degrees and lowe fidelity. In conclusion, Analysis of Beam width of wideband antenna with more precise is possible through using these radiation pattern using fidelity.