• 제목/요약/키워드: time course

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A Study of HME Model in Time-Course Microarray Data

  • Myoung, Sung-Min;Kim, Dong-Geon;Jo, Jin-Nam
    • The Korean Journal of Applied Statistics
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    • v.25 no.3
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    • pp.415-422
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    • 2012
  • For statistical microarray data analysis, clustering analysis is a useful exploratory technique and offers the promise of simultaneously studying the variation of many genes. However, most of the proposed clustering methods are not rigorously solved for a time-course microarray data cluster and for a fitting time covariate; therefore, a statistical method is needed to form a cluster and represent a linear trend of each cluster for each gene. In this research, we developed a modified hierarchical mixture of an experts model to suggest clustering data and characterize each cluster using a linear mixed effect model. The feasibility of the proposed method is illustrated by an application to the human fibroblast data suggested by Iyer et al. (1999).

In vitro Degradation of Saikosaponin-a in Physiological Condition

  • Sung, Chung-Ki
    • Korean Journal of Pharmacognosy
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    • v.20 no.2
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    • pp.128-130
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    • 1989
  • In vitro degradation of saikosaponin-a in physiological condition was conducted. Saikosaponin-a in 0.1 N-HCl of 25% 1,4-dioxane was incubated at $37^{\circ}$ and the products were analyzed and the time course of degradation was observed. Saikosaponin-a(Sa) was transformed to $saikosaponin-b_1(Sb_1)$ and saikosaponin-g(Sg) in the course of time. Sa was decreased drastically and not detected after 6 hours. $Sb_1$0 and Sg was increased with the time. After 6 hours the ratio of $Sb_1$ and Sg was about 4:1 and was maintained for 24 hours.

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A study on talc Production of Ginseng Extracts 2. Production of extracts from tail ginseng (인삼엑기스 제조에 관한 연구, 제2보. 미삼엑기스 제조)

  • 조규성;김해중;임무현;주현규;이석건
    • Journal of Ginseng Research
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    • v.4 no.1
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    • pp.8-14
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    • 1980
  • In order to establish effective production o( ginseng extracts from tail ginseng, the tail ginseng was soaked in the different concentration and the amount of ethanol, and iii course of the time and duration of the extraction. The yield of ginseng extract, proximate chemical components and its saponin pattern were investigated. The results obtained are as follows: 1. The amount of tail ginseng extracts decreased in accordance with the increment of ethanol concentration. The yield of the extracts were 50.86%, 44.42%, 37.82%, 35.52% and 33.42% extracted by water.30%. 50%, 70%, and 90% ethanol, respectively. 2. The reasonable proportion of tail ginseng and solvent (35% ethanol) u·as 1 : 4 (42.68%)∼1 : 6 (45.92%) 3. The yield of tail ginseng extract increased according to the extraction time, but it was the most suitable that the tail ginseng extracted for 5 hour (43.32%)∼10 hour (45.60%). 4. The chemical composition and viscosity of tail ginseng extract was decreased but it's transmittance was increased, and the saponin pattern of T.L.C. showed same tendency in the course of extraction time.

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Development of Evaluation Items for Play Ability & Operation Management in Golf Course (골프장의 경기성 및 운영관리 향상을 위한 평가항목 개발)

  • Seok, Young Han;Moon, Seok Ki;Lee, Eun Yeob
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.12 no.1
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    • pp.1-12
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    • 2009
  • The purpose of this study is to discovered assessment items for improving athletic efficiency and management of golf courses. Through this, the study intended to provide basic data for creating competitive golf courses and management. Important assessment items were selected by inducing preliminary assessment items and conducting a preliminary survey and a main survey for specialists through a theoretical study. For the survey results studied, reliability and average value for importance were calculated using SPSS/PC Window Release 12.0. As assessment of importance by assessment area, in athletic efficiency assessment, course management level was the highest, followed by fairness of games and operation of games. In management assessment, importance of service level, information management, facility management, management of game assistants, etc. were high. As assessment of importance by assessment item, it was found that 'variety of golf shot' and 'the length of a course' were important in course layout. Also 'start interval among teams' and 'disturbance of play' were assessed as important items in game operation, while 'fair reservation' and 'rounding rotation time' were important in fairness of games. In addition, in information management, 'kind service of golf course staffs' and 'prompt reservation and notification' were found to be important assessment items. In facility management, all assessment indexes were over 4.0, which means all of them are important for quality of golf course and competitiveness. In membership service, 'appropriate price of goods for sale' and 'service for members' were relatively important assessment items. Further, in management of game assistants, 'qualifications and skillfulness of game assistants' was assessed as a very important index. Although the current study only selected important items to assess excellent golf courses, it is necessary to apply the study results to the actual sites and verify them for golf course both at domestic and abroad.

Consideration about Resident Participation Activities for Maintenance and Use OPen Space with Community Development in Hachioji New Town

  • Sakaguchi, Jiro
    • Journal of the Korean Institute of Landscape Architecture International Edition
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    • no.1
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    • pp.150-158
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    • 2001
  • Maintenance open spaces and community development in large scale housing development is one of the most important issues. We(UDC) established a resident participation activity for maintenance and use open space with community development in Hachioji New Town from 1997. The purpose of this study is to establish resident participation activities for maintenance and use open space with community development in Hajichioji New Town, and to clarify the characteristics and to on sider about efficiency of the activity. We established Minamino Shizen-Juku as a methodology for maintenance and use open spaces at the same time Hachioji New Town was opened in 1997. The activity has continued by now in 2001. We conducted questionnaire survey to make sure efficiency and characteristics of the activity past three years. Minamino Shizen-Juku (nature friendly lessons) is a resident participation activity in Hachioji New Town. It was established in 1997 as soon as the new town was opened, this year is fifth since it was started. It has three objects. 1)Maintenance and use woody environment, 2) Community development, 3) Continuation and renewal native culture. And it has general course, three special courses and one extra course were established in the activity. 1) General course is an activity participated all of member. It's included farming experience in the native field and seasonal events. 2) Rice growing and woods maintenance course is rice growing and wild wood maintenance in the park as a series of annual farming activities. 3) Benefaction from farm course is started from planting spring vegetable at Mizukoshi(Leader of Minamino Shezen-Juku)'s field. There is the number of participant limit because of the area of the field. 4) Watching nature course is watching seasonal wild flowers, trees, animals and plants to know about native nature. 5) Extra program is programmed to know about native history and tradition. It's planned including participant's ideas. Not member can participate in this course too.

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Incorporation of Brainteaser Game in Basic Organic Chemistry Course to Enhance Students' Attitude and Academic Achievement

  • Cha, Jeongho;Kan, Su-Yin;Wahab, Nurul Huda Abdul;Aziz, Ahmad Nazif;Chia, Poh Wai
    • Journal of the Korean Chemical Society
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    • v.61 no.4
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    • pp.218-222
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    • 2017
  • Game shows are capable of grabbing students' attention in a lecture, and at the same time offers much delight to students to learn in a more interesting and entertaining way. A mind game was developed and incorporated into the teaching of basic organic chemistry course at the Universiti Malaysia Terengganu. The modified brainteaser game is comprised of a set of problems associated with vocabulary or concepts in basic organic chemistry, whereby students were required to solve within a stipulated time frame. Students' attitude changes were then evaluated with the administration of Attitude toward the Subject of Chemistry Inventory Version 2 (ASCIv2) questionnaire. The result of this study revealed that the intervention group experienced a significant change in attitude towards the course as compared to the control group. The intervention group also experienced a positive learning environment, resulting in an increased academic performance and interest.

The Influence of Subjective Complaints to the Course of Treatment in Pulmonary Tuberculosis Patients (폐결핵(肺結核) 환자(患者)에서 수소(愁訴)가 치료과정(治療過程)에 미치는 영향(影響))

  • Kim, Sang-Soo
    • Journal of Preventive Medicine and Public Health
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    • v.15 no.1
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    • pp.125-130
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    • 1982
  • In order to investigate the relation of subjective complaints to objective course of treatment in pulmonary tuberculosis, one hundred and seventy four cases registered at the University Health Center in Chonnam University were divided into two groups, complaint group and non-complaint group. By analysing the record at the University Health Center during these seven years from 1973 to 1979, following results were obtained: 1. In complaint group who had subjective symtoms, thirty eight cases(77.6%) among forty nine cases were detected. at clinic visit. In non-complaint group who had not any symtoms, one hundred and twenty one cases (96.8%) among one hundred and twenty five cases were detected at compulsive physical examination. 2. Comparisons of complaint group with non-complaint group were not statistically significant in many aspects, but significantly higher cases were discharged at the University Health Center to receive other medical service in complaint group than in non-complaint group. (6.1% vs 0.8%, respectively) On the contrary, non-complaint group refused medication more than two times compared with complaint group in the course of treatment (29.9% vs 12.2%, respectively). 3. In the average time lag from initial diagnosis to initial treatment, comparisons between complaint vs non-complaint group were significant (7.8 vs 28.3 days, respectively). 4. Subjective symptoms were thought to create motivation to receive therapy, and influence of motivation to therapy was strong at initial stage but it become weaker as time passed.

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Current Status of Clinical Practice Education in Maternity Nursing in Korea - four-year course nursing schools centered - (모성간호학 실습교육의 현황 - 4년제 간호대학(학과)를 중심으로 -)

  • Kim, Il-Ok;Park, Chai-Soon
    • Women's Health Nursing
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    • v.12 no.1
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    • pp.12-21
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    • 2006
  • Purpose: This study was performed to provide data for improvement in clinical practice education through analyzing the status of clinical practice education in maternity nursing in four year course nursing schools in Korea. Method: Analyzed subjects were 43 schools out of 53 four year course nursing schools in Korea. Result: Credits in theory and clinical practice are on the decline. The relationship between goals and areas of clinical practice was not sufficient. The department was not efficient in meeting the demands between theory and practice. The number of students in a group according to clinical areas were thoughtfully assigned, and clinical practice was performed based on real situations. Instructors for clinical practice used practice lecturers, part-time lecturers, preceptors, and assistant instructors including faculty. Methods of practice education and evaluation were varied. Conclusion: A suitable philosophy and goals of clinical practice education maternity nursing should be established at this point in time. Furthermore, a study should be performed to analyze the relationship between goals and contents of clinical practice for maternity nursing. In addition, a standardized tool should be developed to evaluate clinical practice.

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