• Journal of Radiation Protection and Research
• /
• 제30권1호
• /
• pp.45-54
• /
• 2005

원자력시설로부터 삼중수소 사고 누출시 시설 주변 농작물의 삼중수소 오염 평가를 위한 동적격실모델 ECOREA-H3를 개발하였다. 모델의 격실은 크게 대기, 토양, 농작물로 구성되며 농작물은 엽채류 곡물류, 근군류의 3개 소그룹으로 분류하여 각각 독립적으로 모델링하였다. 벼에 대한 삼중수소 피폭실험 해석을 통해 모델의 예측 정확도가 조사되었다. 모델링 결과 추수시 벼이삭의 TFWT 농도는 입력데이터 중 공기의 절대습도, 뿌리흡수비 강우량에 OBT 농도는 공기의 절대습도, 이삭의 성장기간, 유기물의 수소함량의 영향을 상대적으로 크게 받는 것으로 나타났다. 벼이삭 OBT 농도에 대한 모델 계산과 실험 측정값은 잘 일치하였다.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2000년도 추계학술대회논문집B
• /
• pp.385-390
• /
• 2000

In this study we propose the computational model for the coronary circulation. The bypass from left ventricle is also considered. Lumped parameter model with three compartments in the coronary circulation is implemented in this study. We connected the coronary artery compartment with left ventricle to explain the bypass procedure from left ventricle. The asymmetric resistance is assumed in the bypass line from left ventricle. The present numerical method is tested for normal coronary circulation and the results are compared with the existing computational work. The bypass simulation is conducted and the flow pattern is delineated. The effect of shunt resistance and coronary compliance to circulation is investigated for the better design of the bypass shunt.

• International Journal of Vascular Biomedical Engineering
• /
• 제2권2호
• /
• pp.16-26
• /
• 2004

The object of this study is to develop a mathematical model of the hemodialysis system including the mechanism of solute kinetics, water exchange and also cardiovascular dynamics. The cardiovascular system model used in this study simulates the short-term transient and steady-state hemodynamic responses such as hypotension and disequilibrium syndrome (which are main complications to hemodialysis patients) during hemodialysis. It consists of a 12 lumped-parameter representation of the cardiovascular circulation connected to set-point models of the arterial baroreflexes, a kinetic model (hemodialysis system model) with 3 compartmental body fluids and 2 compartmental solutes. We formulate mathematically this model in terms of an electric analog model. All resistors and most capacitors are assumed to be linear. The control mechanisms are mediated by the information detected from arterial pressoreceptors, and they work on systemic arterial resistance, heart rate, and systemic venous unstressed volume. The hemodialysis model includes the dynamics of urea, creatinine, sodium and potassium in the intracellular and extracellular pools as well as fluid balance equations for the intracellular, interstitial, and plasma volumes. Model parameters are largely based on literature values. We have presented the results on the simulations performed by changing some model parameters with respect to their basal values. In each case, the percentage changes of each compartmental pressure, heart rate (HR), total systemic resistance (TSR), ventricular compliance, zero pressure filling volume and solute concentration profiles are represented during hemodialysis.

• 한국임상약학회지
• /
• 제26권4호
• /
• pp.312-317
• /
• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Journal of Radiation Protection and Research
• /
• 제8권2호
• /
• pp.8-14
• /
• 1983

삼중수소의 단일 피폭과 만성피폭에 의한 한국인의 내부피복 선량을 삼단계형모델을 이용하여 계산하였다. 이 모델은 체내수분과 조직체 사이의 삼중 수소의 축적량을 잘 나타내 주는 것이다. 그 결과 삼단계형의 축적 반감기 9, 30과 450일을 사용한 단일 피폭의 총 선량은 1mCi/kg 섭취당 17.64mrad였고 이것의 97%는 체내수분에 있는 삼중수소에 의한 선량이고 나머지 3%는 조직내 삼중수소에 의한 것이다. 그리고 1 mCi/day의 삼중 수소를 섭취하는 만성 피폭의 경우, 총 선량은 85.5mrad/day이었다. 또한 본 연구에서는 한국인에 대한 최대허용 농도값을 선질계수 1을 사용하여 계산하였다. 그 결과, ICRP의 최대허용 농도값은 약 50%가량 낮게 평가되었으므로 한국인의 최대허용 농도값은 ICRP의 결과보다 약 50%높게 책정되어야만 한다.

• 약학회지
• /
• 제28권4호
• /
• pp.207-215
• /
• 1984

Effects of Ssang Wha Tang (SWT), a blended Chinease traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) in the rats of hepatic failure induced by carbon tetrachloride were examined. The disposition of plasma BSP in carbon tetrachloride-treated rats (Group I) and in carbon tetrachloride+SWT-treated rats (Group II) followed a three-compartment model, while those in control group followed two-compartment model. GOT, GPT level and some pharmacokinetic paramiters like plasma clearance but except distribution volume (Vdss) recovered in Group II compared to Group I. Therefore, SWT seemed to have an apparent restoring effect of hepatic function damaged by carbon tetrachloride treatment. From the fact that Vdss of BSP in Group II was considered as an one of the probable mechanisms. More intensive increase in BSP-free fraction ($f_p$) in Group II than that in Group I might also explain the increases of BSP clearance and Vdss in Group II compared to Group I. Assuming no changes in hepatic plasma flow(Q) in each group, hepatic intrinsic clearance($CL^h_{int}$) decreased in Group I did not recovered not at all in Group II. Therefore SWT seemed not to have any restoring effect of true hepaticfunction to biotransform and excrete BSP, and the apparent restoring effect of SWT might be due only to the replacement of BSP-plasma protein binding. Whether $f_p$ is actually higer in Group II than in Group I, and Q is constant in each group are being examined in our laboratory. The changes of Q, which might lead to another conculusions, also should be taken into consideration to clarify the apparent hepatorestoring effect of SWT.

• 한국화재소방학회논문지
• /
• 제22권2호
• /
• pp.49-56
• /
• 2008

대구 지하철 화재가 발생한 중앙로 역사를 1/20 축소모델로 제작하여 연기확산 실험을 수행하였다. 지하역사의 양쪽으로 연결된 터널을 모델 실험에서도 구현해야 하지만 실험실 공간의 제약으로 인해 짧은 길이의 덕트에 유동저항을 줄 수 있는 메쉬를 부착하여 터널을 대신하였다. 방화로 인해 좌석에서 화재가 발생하였기 때문에 화재 시나리오는 좌석의 가연물 특성을 고려하여 선정하였고 가시화 장치와 온도 측정으로 역사로의 연기 전파 시간을 측정하였다. 현재 지하역사 화재시 보편적 개념으로 확립되어있는 급기형태의 제연 방식이 연기확산을 촉진하는 것을 실험적으로 확인하였다. 화재 환기가 없을 때 지하 3층 승강장에서의 화재발생으로부터 지하역사 전체에 연기가 확산되는 데에는 약 10분의 시간이 필요하였다.

• 한국식품조리과학회지
• /
• 제7권4호
• /
• pp.103-109
• /
• 1991

The purpose of this study was to evaluate the foodservice management practices in day care centers in order to provide basic information and guideline for development of foodservice facilities standard model and sanitation manuals. Basic survey and evaluation were done for 24 day-care centers categorized in four groups. General foodservice management practies, status of equipment, and hygienic conditions were evaluated. The results of the survey showed the followings: the cost of lunch and the cost of interim snack varied very much among each group; development of standard recipe as well as purchase of foods were not done by an expert; the hygienic condition of kitchens and dining-room needed more attention for improvement; the sanitary practies of employees showed potential problems; kitchen facilites were not standardized, especially only 20.8% of the facilities were equipped with the three-compartment sink, which was regarded as essential.

• 한국화재소방학회논문지
• /
• 제17권3호
• /
• pp.7-12
• /
• 2003

지하철 역과 같이 대형 개구부가 있는 공간의 화재와 제연을 조사하기 위해, 지하철 역과 유사한 구조의 4 m ${\times}$ 1 m ${\times}$ 1.5m 크기의 공간 내 50 kW의 폴리우레탄 화재에 대한 수치모사를 수행하였다. 대와류모사를 난류모델로 사용하고, 혼합분율 연소모델과 복사 유한체적법을 사용하였다. 화재 발생 후 5초부터 급배기방식과 급기방식, 배기방식의 세가지 기계 제연방식이 각각 작동했을 때 제연방식에 따른 승강장과 출입통로의 공기온도와 연기이동을 비교하였다. 제연방식 가운데 급배기방식의 제연성능이 가장 좋고 안전한 것으로 나타났다. 그러나 지하철 역에 사용되고 있는 급기방식은 급기구를 통해 공급된 공기가 고온의 연기와 혼합됨으로써 제연성능이 오히려 자연제연방식보다 불량하므로 지하철 역과 같은 구조에서는 적합하지 않음을 확인하였다.

• Nuclear Engineering and Technology
• /
• 제35권2호
• /
• pp.108-120
• /
• 2003

In assessing the long term post closure radiological safety assessment of a potential HLW repository in Korea, three categories of uncertainties exist. The first one is the scenario uncertainty where series of different natural events are translated into written statements. The second one is the modeling uncertatinty where different mathematical models are applied for an identical scenario. The last one is the data uncertainty which can be expressed in terms of probabilistic density functions. In this analysis, three different scenarios are seleceted; a small well scenario, a radiolysis scenario, and a naturally discharged scenario. The MASCOT-K and the AMBER, probabilistic safety assessment codes based on connection of sub-modules and a compartment theory respectively, are applied to assess annual individual doses for a generic biosphere. Results illustrate that for a given scenario, predictions from two different codes fairly match well each other But the discrepancies for the different scenarios are significant. However, total doses are still well below the guideline of 2 mRem/yr. Detailed analyses with model and data uncertainties are underway to further assure the safety of a Korean reference dispsoal concept.