• Title/Summary/Keyword: three target groups

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Study on natural killer cell activity and its characteristics during hepatocarcinogenesis in rats (랫드의 간암 발생과정에서 분리한 자연살해세포의 활성측정 및 특성연구)

  • Jeong, Ja-young;Lee, Kuk-kyung;Kil, Jwang-sup;Lee, Yong-soon
    • Korean Journal of Veterinary Research
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    • v.39 no.1
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    • pp.169-176
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    • 1999
  • The purposes of this study were to set up the method of the natural killer(NK) cell activity assay using the flow cytometer and to examine the characteristics and distribution of the NK cell during rat hepatocarcinogenesis. Forty five male 6 week-old specific pathogen free(SPF) Sprague-Dawley rats were randomly divided into three groups. Group I was the non-treated control and given normal diet and water. Group II was treated with diethylnitrosamine(DEN, 200mg/kg, i.p.) and partial hepatectomy. Group III was treated with DEN, partial hepatectomy and 0.05% phenobarbital sodium in water from 3 to 16 weeks. All animals were examined the morphology of the large granular lymphocyte(LGL), the LGL percent of the total lymphocytes and the LGL conjugation rate with YAC-1 cell in peripheral blood, spleen and liver. Moreover, activity of the LGL isolated from peripheral blood lymphocytes was determined using the flow cytometer. As results, LGL were observed in the peripheral blood, spleen and liver. LGL were observed the relatively faintly staining basophilic cytoplasm with granules, and eccentric, often kidney-shaped nuclei in Giemsa stain. Its size was $11{\sim}13{\mu}m$. LGL percentage of the isolated lymphocytes in peripheral blood, spleen and liver were 1.8~2.3%, 1.3~1.4% and 0.87~0.99%, respectively. LGL conjugation rate with YAC-1 cell was shown to be peripheral blood(9.3~10.3 %) > spleen(7.7~8.7%) > liver(5.6~7.0%). The activity of the LGL isolated from peripheral blood lymphocytes in Group I, II and III was 33.7%, 30.5% and 35.4%, respectively. However, all values were not significantly between groups.

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Tourism market segmentation in Cheju Island based on fashion image of clothing souvenir and characterisitcs of sub-segments (관광기념 의류상품 패션이미지 추구에 따른 시장세분화 및 세분시장 특성 연구 -제주 관광객 소비자들을 대상으로-)

  • 홍희숙;장애란;현지은;김현미
    • Journal of the Korean Society of Clothing and Textiles
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    • v.25 no.2
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    • pp.303-314
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    • 2001
  • The purposes of this study were 1) to identify different sub-segments of tourism market in Cheju island based on fashion image of clothing souvenir and 2) to provide manufactures with useful information for developing cultural fashion goods related to Cheju island. The data were collected via a self-administered questionnaire from 192 female tourist(20-59 years old) in Cheju and analyzed by factor analysis, cluster analysis, one-way ANOVA and $\chi$$^2$-test. Six factors of fashion image were found image were found and labeled as: Sexy/feminine, wild/mannish, easy/simple, Cheju, ecology, natural image. Four factors of benefit sought were also identified: Practicality/economic-value, fashionability/preference of design, reputation and souvenir-value. Three groups were identified based on fashion image sought: Image of primitive nature(G1: 37.7%), image of nature in the city(G2: 20.1%), sexy/feminine image(G3: 42.2%). There were significant differences among sub-groups in age, fashion innovation, benefit sought and intention of buying Gal-ot. Younger females(20-30 ages) were included more in group 1 than group 2 while older females(40-50 ages) were included more in group 2. Group 1 had a higher score of fashion innovation comparing group 3. Group 1 had the highest scores on practicality/economic-value and souvenir-value. However, group 2 placed the highest importance on reputation as well as practicality/economic-value and group 3 had the lowest scores on all types of benefit. Group 1 and group 2 had intention of buying Gal-ot more than group 1. Based on the results of this study, manufactures may implement target marketing strategies on group 1 which sought the image of primitive nature and group 2 which sought the image of nature in the city.

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Product Category and Shopping Options of Logistic Service Quality

  • KIM, Ok;CHEON, Hongsik J.
    • Journal of Distribution Science
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    • v.18 no.8
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    • pp.113-125
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    • 2020
  • Purpose: The purpose of this paper is to investigate the effect of interaction between product category (fresh vs. indulgent product) and shopping options (shipping charge and delivery time) on customer satisfaction and purchase intent in an e-commerce context. When ordering groceries online, consumers begin to allocate a larger share of their grocery budget toward product categories that generally contain healthier items at the expense of product categories that generally contain more indulgent products. Moreover, customers are extremely sensitive to shipping options such as shipping charges and delivery time. Therefore, this research investigates the issue at a more segmented level to focus on the impact that one dimension of logistics service quality - product category, shipping charge, and delivery time have on customer satisfaction and purchase intent. Research design, data, and methodology: To test the theoretically derived priori hypotheses concerning product category, shipping charges, delivery time, satisfaction, and purchase intent, this research presented a scenario-based experiment. Eight treatment groups were assigned by the method of product category (fresh produce vs. indulgent product), shipping charge (free vs. paid), and delivery time (one-day vs. two to three days). A total of 240 subjects were divided into groups and exposed to one of the eight scenarios. Participant's purchase intention was the dependent variable, and ANOVA and L-matrix were used to analyze for main and interactive effects between factors. Conclusions: Results indicated that in tests 1 and 2, free shipping and fast delivery time increased consumer satisfaction as well as purchase intent, and fast delivery moderated the impact of free shipping on consumer satisfaction and purchase intent. Test 3 showed that the effect of free shipping on consumer satisfaction and purchase intent moderated by fast delivery for indulgent products. In contrast, fast delivery for fresh products moderated the effect of paid shipping on consumer satisfaction and purchase intent. Consistent with this proposed mechanism, the relative importance of fresh produce versus indulgent products highlights the effect of shipping options on consumer satisfaction and purchase intent when ordering the target product in an e-commerce context. We conclude with a discussion of the theoretical and practical implications of our findings.

Prediction of Exposure to 1763MHz Radiofrequency Radiation Using Support Vector Machine Algorithm in Jurkat Cell Model System

  • Huang Tai-Qin;Lee Min-Su;Bae Young-Joo;Park Hyun-Seok;Park Woong-Yang;Seo Jeong-Sun
    • Genomics & Informatics
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    • v.4 no.2
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    • pp.71-76
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    • 2006
  • We have investigated biological responses to radiofrequency (RF) radiation in in vitro and in vivo models. By measuring the levels of heat shock proteins as well as the activation of mitogen activated protein kinases (MAPKs), we could not detect any differences upon RF exposure. In this study, we used more sensitive method to find the molecular responses to RF radiation. Jurkat, human T-Iymphocyte cells were exposed to 1763 MHz RF radiation at an average specific absorption rate (SAR) of 10 W/kg for one hour and harvested immediately (R0) or after five hours (R5). From the profiles of 30,000 genes, we selected 68 differentially expressed genes among sham (S), R0 and R5 groups using a random-variance F-test. Especially 45 annotated genes were related to metabolism, apoptosis or transcription regulation. Based on support vector machine (SVM) algorithm, we designed prediction model using 68 genes to discriminate three groups. Our prediction model could predict the target class of 19 among 20 examples exactly (95% accuracy). From these data, we could select the 68 biomarkers to predict the RF radiation exposure with high accuracy, which might need to be validated in in vivo models.

Effects of Myofascial Release and Posture Correction Exercise on the Neck Movement and the Quality of Sleep in Patients with Chronic Tension-Type Headaches

  • Cho, Sunghak
    • Journal of International Academy of Physical Therapy Research
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    • v.10 no.4
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    • pp.1897-1902
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    • 2019
  • Background: Tension-type headaches, which make up the highest proportion of headaches, are prone to develop into chronic tension-type headaches (CTTH). The characteristic of CTTH in patients is that the active myofascial trigger point (ATrP) which causes pain in the muscles of the back of the head is increased, compared to the normal headache and moves the head position forward. Objective: The aim of this study was to investigate the effects of myofascial release (MFR) and posture correction in effectively improving neck function and sleep quality in the symptoms of CTTH patients. Design: Observer-blind study Methods: To reduce ATrP, MFR was applied and exercise was also applied to correct posture. The subjects of this study were 48 individuals randomly divided into three groups; The MFR group using the MFR technique; The MFR with exercise group subject to both the MFR technique and forward head position correction exercises (MFREx), and the control group. MFR and MFREx groups were given the relevant interventions twice a week for four consecutive weeks, and went through the number ATrPs, range of motion (ROM) of neck, Neck Disability Index (NDI) and the Pittsburgh Sleep Quality Index (PSQI) before and after the intervention. A physical therapist, who was fully familiar with the measuring methods of the equipment, was the measurer and not aware of the target's condition was blinded to take measurements only before and after intervention. Results: There was a significant improvement in the ATrP, Neck ROM, NDI and PSQI in the group of patients to whom the MFR technique and MFREx were applied. MFREx was more effective in increasing neck mobility. Conclusions: According to this study, the application of MFR is effective in improving neck movement and sleep quality in chronic tension headache patients.

Identification of Knowledge Structure of Pain Management Nursing Research Applying Text Network Analysis (텍스트네트워크분석을 적용한 통증관리 간호연구의 지식구조)

  • Park, Chan Sook;Park, Eun-Jun
    • Journal of Korean Academy of Nursing
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    • v.49 no.5
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    • pp.538-549
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    • 2019
  • Purpose: This study aimed to explore and compare the knowledge structure of pain management nursing research, between Korea and other countries, applying a text network analysis. Methods: 321 Korean and 6,685 international study abstracts of pain management, published from 2004 to 2017, were collected. Keywords and meaningful morphemes from the abstracts were analyzed and refined, and their co-occurrence matrix was generated. Two networks of 140 and 424 keywords, respectively, of domestic and international studies were analyzed using NetMiner 4.3 software for degree centrality, closeness centrality, betweenness centrality, and eigenvector community analysis. Results: In both Korean and international studies, the most important, core-keywords were "pain," "patient," "pain management," "registered nurses," "care," "cancer," "need," "analgesia," "assessment," and "surgery." While some keywords like "education," "knowledge," and "patient-controlled analgesia" found to be important in Korean studies; "treatment," "hospice palliative care," and "children" were critical keywords in international studies. Three common sub-topic groups found in Korean and international studies were "pain and accompanying symptoms," "target groups of pain management," and "RNs' performance of pain management." It is only in recent years (2016~17), that keywords such as "performance," "attitude," "depression," and "sleep" have become more important in Korean studies than, while keywords such as "assessment," "intervention," "analgesia," and "chronic pain" have become important in international studies. Conclusion: It is suggested that Korean pain-management researchers should expand their concerns to children and adolescents, the elderly, patients with chronic pain, patients in diverse healthcare settings, and patients' use of opioid analgesia. Moreover, researchers need to approach pain-management with a quality of life perspective rather than a mere focus on individual symptoms.

The Effects of 12week Line Dance on dementia and Aging-related factors in Elderly Women (12주간 라인댄스가 노인여성의 치매 및 노화관련인자에 미치는 영향)

  • kim, Ji-won;soon, A-rum;Kim, Chan-hoi
    • Journal of the Korea Convergence Society
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    • v.10 no.6
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    • pp.243-249
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    • 2019
  • This study was conducted on elderly women in their 60s and 70s, and the results of the study were as follows when line dancing for 60 minuctes every three times a week for 12 weeks on dementia and aging-related hormones. After 12 weeks of line dancing programs, BDNF, DHEA-s, and estrogen increased, but no statistically significant differences with control groups emerged. In addition, after 12 weeks of line dancing, Apolipoprotein B decreased in line dancing group but showed no statistically significant difference from control group. Although significant differences between groups were not identified in the results of this study, positive effects on preventing and aging of dementia were identified in the group applying the line dance program, and further studies considering the new target and hign kinetic strength, frequency, time, and athletic genre are needed to identify the distinct effects of line dancing in the future.

Feasibility Assessment of Physical Factors of Rectal Cancer Short-Course Chemoradiotherapy with Delayed Surgery

  • Koo, Jihye;Chung, Mijoo;Chung, Weon Kuu;Jin, Sunsik;Kim, Dong Wook
    • Progress in Medical Physics
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    • v.29 no.4
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    • pp.143-149
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    • 2018
  • To verify the correlations between the clinical outcomes and physical factors of short-course chemoradiotherapy (SCRT) and long-course chemoradiotherapy (LCRT) with delayed surgery in patients with rectal cancer. Seventy-two patients with rectal cancer were enrolled in this study. Nineteen patients were treated with SCRT (25 Gy, 5 fractions) by intensity-modulated radiation therapy (IMRT), and 53 patients were treated with LCRT (50.4 Gy, 28 fractions) by three-dimensional conformal radiation therapy (3DCRT). Various physical factors for the target and organs at risk (OARs) were calculated to compare the clinical outcomes. The organ equivalent dose (OED) and lifetime attributable risk (LAR) of bowels and bladders were similar between the SCRT and LCRT groups, whereas the values of femurs were higher in the LCRT group. The equivalent uniform dose and normal tissue complication probability were higher in the LCRT than the SCRT group for most organs. Treatment complications, including anastomotic leakage, bowel adhesion, and hematologic toxicity, were not significantly different between SCRT and LCRT groups. CIs were $0.84{\pm}0.2$ and $0.61{\pm}0.1$ for SCRT and LCRT, respectively. The CVIs were $1.07{\pm}0.0$ and $1.10{\pm}0.1$, and the HIs were $0.09{\pm}0.0$ and $0.11{\pm}0.1$ for SCRT and LCRT, respectively. The sphincter-saving rates were 89.5% and 94.3% for SCRT and LCRT, respectively. The complete pathologic remission rates were 21.1% and 13.2%, and the down-staging rates were 47.4% and 26.4% for SCRT and LCRT, respectively. SCRT with IMRT is comparable to conventional LCRT in both physical indexes and clinical outcome. The preoperative SCRT, compensated by IMRT, is an effective and safe modality.

The Effects of a Shoulder Complex Stabilization Exercise Combined with Upper Extremity Patterns on Ball Control and Ball Speed in Elementary School Baseball Players (상지 패턴을 결합한 어깨 복합체 안정화 운동이 초등학교 야구선수들의 제구력과 구속에 미치는 영향)

  • Jeong, Yeon-Woo;Lee, So-Young;Seo, Tae-Hwa
    • PNF and Movement
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    • v.18 no.3
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    • pp.343-350
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    • 2020
  • Purpose: The purpose of this study was to determine how a shoulder complex stabilization exercise affects ball control and ball speed in elementary school baseball players with an instable scapula. Methods: The subjects of the study were 16 baseball players attending S elementary school in Kwangju Metropolitan City. A shoulder complex stabilization exercise was conducted three times per week for one hour for four weeks. Then, the participants were divided into a scapular instability group or stability group based on their lateral scapular slide test scores. The measurement tool was measured using the target, the ball speed tester (PR1000-BC). All inspections were measured before and after the mediation period to examine the change in the subjects according to the mediation period. Results: As a result of measuring ball control, there was a statistically significant difference in the variation over time (p < 0.05), and there was no statistically significant difference in the interaction between time and group (p > 0.05). As a result of the test of effectiveness between subjects, there was no statistically significant difference found among the groups (p > 0.05). In terms of ball speed, there was no statistically significant difference found in the variation over time (p > 0.05) as well as in the interaction between time and group (p > 0.05). In terms of the effectiveness between subjects, there was no statistically significant difference found among the groups (p > 0.05). Conclusion: It was found that the shoulder complex stabilization exercise could improve ball control for elementary school baseball players. It is believed that this will help prevent and solve possible sport damages experienced during training or competitions, thereby helping athletes use training methods to improve their exercise capacity and continue their careers.

A Exploratory Study on Topography of The Welfare Attitudes among Korean People by Generation (한국인의 세대별 복지태도지형 탐색 연구)

  • Kim, Sin-Young
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.4
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    • pp.189-193
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    • 2021
  • This study purports to depict the generational topography of welfare attitudes of Korean people. Three generational groups are made for analytical purpose, 'between 20-39 age group', 'between 40-59 age group', and '60 and older'. Two major statistical techniques are used, the analysis of variance and correspondence analysis. The analysis of variance shows that the respondents' attitudes upon 'social services target(universal vs selective)', 'education', 'housing', 'child-care', 'youth support', and 'employment' varies significantly by age groups. Correspondence analysis also shows that 'between 20-39 age group' is located with proximity with 'child-care', 'employment', and 'housing', while '60 and older' is located with 'poverty' and 'old age life care'. Clearly this study shows that there is generational difference on welfare consciousness in many areas of social policy. Overall, the results show that significant generational differences with regard to welfare attitudes clearly exist in current Korean society.