• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.1
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• pp.79-84
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• 2007

Acute respiratory distress syndrome(ARDS) is severe acute hypoxic respiratory failure state with dynamic impairment in oxygen and carbon dioxide transfer with the need for high levels of supplementary oxygen and a high minute ventilation. This syndrome is caused by pulmonary edema due to increased permeability of the alveolar capillary barrier by various factors. ARDS is an uncommon, but a potentially life-threatening complication. Therefore, immediate diagnosis and appropriate therapy must be performed. The present case is post-extubation ARDS immediately occurred in an orthognathic surgery patient who are healthy 19-year-old man. He rapidly recovered from ARDS without complication by early diagnosis and proper treatment. This case report was aimed to describe the process of the development, possible causes and the management of ARDS occurred in an orthognathic surgery patient

• Journal of Korean Academy of Nursing
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• v.28 no.1
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• pp.70-80
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• 1998

This study is designed to contribute to the nursing intervention of adolescent domestic violence victims by describing specifically what they go through and on this basis work out a grounded theory on the adolescent's experience in domestic violence. The data were analyzed in the framework of grounded theory as mapped out by Strauss & Corbin(1990). The major findings of this research are as follows : The core category was found to be the the adaptation of "Joyudeum" or “Straight jacketing”. The sub-categories identified in the process of grounded data analysis were 'menacing', 'being harassed', 'being pressed', 'being attacked', 'being strapped', 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard', 'endurance', 'regulation', 'seriousness'. 'repitition'. 'being helpful', 'dependence', 'thinking oriented', 'blowing off', 'going astray', 'self-deprecating', 'shaking off', 'covering up', 'governing', 'being devoted', 'performing', 'being transformed'. 'bolting', 'being shaken', 'withdrawing', 'disliking', 'bitterness'. These categories were again grouped into 13 categories including 'threatening'. 'straight jacketing', 'tolerance', 'violence', 'supporter', 'supporting type', 'thinking oriented'. 'impulsive response', 'self-controlled', 'response', 'self-reliance', 'wandering', 'withdrawal' and pain'. Of these the five sub-categories 'being filled with anger'. 'getting angry', 'being oppressed', 'being strained', 'becoming hard' were grouped into a core category "straight jacketing". Those adolescents brought up in a violent family go through three stages of the adaptation of "straight Jacketing". that is, generation, response and adaptation. The following four theses were confirmed on the basis of repetitive relations : 1) If a subject's tolerance is strong, the episodes of the violence are frequent and serious, with the resulting straight jacketing being stronger but the subject's supporter is highly mature, the supporting type is concrete and the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is self-reliance with part of it resulted in withdrawal and pain. 2) If a subject's tolerance is weak, the episodes of the violence are frequent but not serious, with the resulting straight jacketing being weaker but the subject's supporter is immature, the supporting type is superficial and the thinking oriented is extemporary, the responses to the straight jacketing result in an impulsion whose consequence is wandering with part of it resulted in withdrawal and pain. 3) If a subject's tolerance is weak, the episodes of the violence are frequent and serious, the straight jacketing is strong, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in an impulsion whose consequence is withdrawal and pain with part of it resulted in wandering. 4) If a subject's tolerance is strong and the episodes of the violence are infrequent and not serious, the straight jacketing is weak, the subject's supporter is immature and the supporting type is superficial but the thinking oriented is wishful, the responses to the straight jacketing result in a self-control whose consequence is withdrawal and pain with part of it resulted in self-reliance.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.12 no.2
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• pp.96-100
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• 2016

Metachromatic leukodystrophy (MLD) is a progressive and degenerative neurological disease caused by a deficiency of the catabolic enzyme arylsulfatase A. Deficiency of arylsulfatase A results in accumulation of sulfatide in the white matter of the peripheral and central nervous system and it occurs demyelination as a result. The patient gradually goes through mental and motor failure. General symptoms of MLD include gait disturbance, mental deterioration, muscle rigidity and impaired swallowing. Inheritance of the disease is autosomal recessive. We report a dental caries treatment of a 3-year old boy with MLD. The patient underwent hematopoietic stem cell transplantation (HSCT) to slow the progression of the disease. He was suffered from difficulties of mastication and swallowing from the degenerative neurological symptom. He was ingesting food by both oral feeding and tubal feeding after he took percutaneous endoscopic gastrostomy (PEG). The cause of multiple caries was mainly presumed as patient's prolonged time of meal. The treatment was performed under general anesthesia considering patient's incompliance. Severely affected lower primary molars were treated with pulp treatment and restored with stainless steel crown. Others were restored with composite resin. There were no postoperative complications. MLD is life threatening progressive disease and also has an impact on unfavorable condition for oral health. Routine home oral care and periodic professional dental care should be emphasized to the caregiver of patient considering the susceptibility of dental caries. Not only the medical care, but periodic dental office visit would benefit the quality of life of the patient.

• Tuberculosis and Respiratory Diseases
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• v.61 no.5
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• pp.473-478
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• 2006

Transfusion related acute lung injury (TRALI) is a serious, potentially life-threatening complication of transfusion therapy that is sometimes under diagnosed and under reported. Patients with TRALI present with dyspnea/respiratory distress and fever. The symptoms, signs and chest radiological findings in TRALI are similar to transfusion associated circulatory overload, which makes it is difficult to distinguish it from circulatory overload. Although the mortality rate in cases of TRALI is relatively low, TRALI is the third most common cause of fatal transfusion reactions next to ABO blood type incompatibility and hepatitis. Mild-to-moderate cases of TRALI may be misdiagnosed as volume overload. Recently, we encountered two cases where the patients suffered from dyspnea and fever after a transfusion. and review of the relevant literature.

• Nuclear Engineering and Technology
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• v.48 no.1
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• pp.274-284
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• 2016

Purpose: The purpose of this work is to describe the spectrometric analysis of gaseous cloud formation over reactor mixed uranium-and-plutonium (UP) fuel $(U_{0.8}Pu_{0.2})O_2$ samples heated to a temperature $>2,000^{\circ}C$, and thus forecast and evaluate radiation hazards threatening humans who cope with the consequences of any accident at a fission reactor loaded by UP mixed oxide $(U_{0.8}Pu_{0.2})O_2$, such as a mixture of 80% U and 20% Pu in weight. Materials and methods: The UP nuclear fuel samples were heated up to a temperature of over $2,000^{\circ}C$ in a suitable assembly (apparatus) at out-of-pile experiments' implementation, the experimental in-depth study of metabolism of active materials in living organisms by means of artificial irradiation of pigs by plutonium. Spectrometric measurements were carried out on the different exposed organs and tissues of pigs for the further estimation of human internal exposure by nuclear materials released from the core of a fission reactor fueled with UP mixed oxide. Results: The main results of the research described are the following: (1) following the research on the influence of mixed fuel fission products (radioactive isotopes being formed during reactor operation as a result of nuclear decay of elements included into the fuel composition) on living organisms, the authors determined the quantities of plutonium dioxide ($PuO_2$) that penetrated into blood and lay in the pulmonary region, liver, skeleton and other tissues; and (2) experiments confirmed that the output speed of plutonium out of the basic precipitation locations is very small. On the strength of the experimental evidence, the authors suggest that the biological output of plutonium can be disregarded in the process of evaluation of the internal irradiation doses.

• Journal of Life Science
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• v.24 no.6
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• pp.700-706
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• 2014

Doxorubicin (trade name adriamycin), an anthracycline antibiotic, is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas. It is closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA. Its most serious adverse effect is life-threatening heart damage. Its anti-metastatic mechanisms in human prostate carcinomas are not fully understood. In this study, we used LNCap human prostate carcinoma cells to investigate the inhibitory effects of doxorubicin on cell motility and invasion, two critical cellular processes that are often deregulated during metastasis. Doxorubicin treatment inhibited cell migration and invasiveness of LNCap cells without showing any toxicity. Doxorubicin treatment also suppressed the activity and expression of matrix metalloproteinase (MMP)-2 and MMP-9, which were associated with up-regulated expression of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in LNCap cells. Doxorubicin treatment also attenuated the expression levels of claudin family members (claudin-1, -2,-3 and -4), major components of tightening of tight junctions (TJs) and increased the tightening of TJs, as demonstrated by an increase in transepithelial electrical resistance. The present findings demonstrate that doxorubicin reduces the migration and invasion of prostate carcinomas LNCap cells by modulating the activity of TJs and MMPs.

• Journal of Life Science
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• v.27 no.12
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• pp.1494-1499
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• 2017

Oral infection due to Candida albicans is a widely recognized and frequent cause of superficial infections of the oral mucosa (oral candidiasis). Although oral candidiasis is not a life-threatening fungemia, it can cause severe problems in individuals under certain conditions. MicroRNAs (miRNAs) are noncoding, small RNA molecules, which regulate the expression of other genes by inhibiting the translation of target mRNAs. The present study was designed to identify miRNAs in C. albicans and determine their possible roles in this organism. miRNA-sized small RNAs (msRNAs) were cloned in C. albicans by deep sequencing, and their secondary structures were analyzed. All the cloned msRNAs satisfied conditions required to qualify them as miRNAs. Bioinformatics analysis revealed that two of the most highly expressed C. albicans msRNAs, Ca-363 and Ca-2019, were located in the 3' untranslated region of the corticosteroid-binding protein 1 (CBP1) gene in a reverse orientation. miRNA mimics were transformed into C. albicans to investigate their RNA-inhibitory functions. RNA oligonucleotide-transformed C. albicans was then observed by fluorescent microscopy. Quantitative PCR analysis showed that these msRNAs did not inhibit CBP1 gene expression 4 hr and 8 hr after ectopic miRNA transformation. These results suggest that msRNAs in C. albicans possess an miRNA-triggered RNA interference gene-silencing function, which is distinct from that exhibited by other eukaryotic systems.

• The Korean Journal of Elementary Counseling
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• v.4 no.1
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• pp.237-262
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• 2005

The purpose of this study was to examine the effects of an empathy training program on the empathy and bullying's degree for bullies. The research hypotheses set to achieve this goal were as follows. 1. An experimental group that gets empathy training might make a better improvement in empathy immediately after the training than a control group that doesn't, and the effect of the training might last till eight weeks later. 2. An experimental group that undergoes empathy training might show a more significant decrease in bullying's degree for bullies immediately after the training than a control group that doesn't, and the effect of the training might last till eight weeks later. The subjects in this study were 20 children who were designated as bullies when 40 fifth graders from Y Elementary school and 31 children from S Elementary school in the city of T, south Gyeongsang province, took K-PNI. Those children were asked to tell about who were attackers and who were victims, and 10 children each were selected from the two elementary schools as bullies, who were respectively selected as an experimental group and a control group. The empathy training program used in this study was prepared by modifying the empathy training programs developed by Shin Gyeong- il(1994). That program was prepared to be appropriate at fifth grader level. To assess how much the selected children bullied their peers, Kim Seok-jin(1999)'s School Bullying Inventory was utilized. Besides, Song Ho-yeon's revised version to assess the change of counselee empathy was employed. In order to analyze the resulte, ANOVA was implemented. The conclusions obtained from the results and discussion of this study are as follows. First, the empathy training program was effective in changing the empathy of the bullies for the better, and their improved empathy remained the same eight weeks later. Second, the empathy training program had an effect in reducing bullying's degree for bullies, and there was no change in their reduced bullying's degree eight weeks later. Third, the empathy training program served to change their neglecting/ ostracizing and ridiculing/teasing behaviors. And the retention test that was implemented eight weeks later showed the effect of training remained unchanged. Fourth, the empathy training program was effective in changing their cursing/threatening actions according to the posttest results, but the retention test showed that its effect didn't keep on. Fifth, the empathy training program didn't bring any changes to their robbing/striking actions either immediately after the training or eight weeks later.

• Journal of Microbiology and Biotechnology
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• v.12 no.2
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• pp.318-326
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• 2002

The pathogenic marine bacterium Vibrio vulnificus is the causative agent of food-borne diseases such as life-threatening septicemia. To better understand this organism's strategies to survive osmotic stress, a mutant that was more sensitive to high osmolarity was screened from a library of mutants constructed by a random transposon mutagenesis. By a transposon-tagging method, putAP genes encoding a proline dehydrogenase and a proline permease were identified and cloned from V. vulnificus. The amino acid sequences deduced from nucleotide sequences of putAP from V. vulnificus were 38 to $59\%$ similar to those of PutA and PutP reported from other Enterobacteriaceae. Functions of putAP genes were assessed by the construction of mutants, whose putAP genes were inactivated by allelic exchanges. When proline as the sole carbon or nitrogen source was used, the putA mutant was not able to grow to the substantial level, revealing the proline dehydrogenase is the only enzyme for metabolic conversion of proline into other amino acids. Although the growth rate of the putP mutant on proline as the sole carbon or nitrogen source was significantly reduced, the mutant still grew. This indicated that at least one more proline permease is produced by V. vulnificus. The putP mutant decreased approximately $2-log_10$ CFU/ml after a hyperosmotic challenge, while the parent strain decreased approximately $l-log_10$ CFU/ml. This result suggests that the gene product of putP contributes to the osmotic tolerance of V. vulnificus.

• Journal of Navigation and Port Research
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• v.39 no.4
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• pp.285-291
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• 2015

Exposure to cold sea water can be life-threatening to the drowned individual. Although appropriate life jacket can be usually be provided for the buoyance at the drowning accident, heat loss can make the drowned individual experience the hypothermia. Inflatable life jackets filled with inflatable air pocket can increase the thermal protection as well as the buoyancy force. Because it is important to know how the human body behaves unde the different life jacket, present study compares the thermal insulation capacity of solid type life jacket with that of inflatable life jacket. In order to represent the insulation capacity of life jacket, thermal resistance is estimated based on the assumption of steady-state. Also, a transient three-dimensional thermal distribution of the thigh is analyzed by using finite element method implementing the Pennes bioheat equation. The finite element model is a segmental, multi-layered representation of the body section which considers the heat conduction within tissue, bone, fat and local blood flow rate.