• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.781-784
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• 2016

The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.3
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• pp.255-261
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• 2014

Essential fatty acid (EFA) is known to be required for the body to function normally and healthily. However, the effect of EFA on glucose uptake in skeletal muscle has not yet been fully investigated. In this study, we examined the effect of two EFAs, linoleic acid (LA) and ${\alpha}$-linolenic acid (ALA), on glucose uptake of C2C12 skeletal muscle cells and investigated the mechanism underlying the stimulatory effect of polyunsaturated EFAs in comparison with monounsaturated oleic acid (OA). In palmitic acid (PA)-induced insulin resistant cells, the co-treatment of EFAs and OA with PA almost restored the PA-induced decrease in the basal and insulin-stimulated 2-NBDG (fluorescent D-glucose analogue) uptake, respectively. Two EFAs and OA significantly protected PA-induced suppression of insulin signaling, respectively, which was confirmed by the increased levels of Akt phosphorylation and serine/threonine kinases ($PKC{\theta}$ and JNK) dephosphorylation in the western blot analysis. In PA-untreated, control cells, the treatment of $500{\mu}M$ EFA significantly stimulated 2-NBDG uptake, whereas OA did not. Phosphorylation of AMP-activated protein kinase (AMPK) and one of its downstream molecules, acetyl-CoA carboxylase (ACC) was markedly induced by EFA, but not OA. In addition, EFA-stimulated 2-NBDG uptake was significantly inhibited by the pre-treatment of a specific AMPK inhibitor, adenine 9-${\beta}$-D-arabinofuranoside (araA). These data suggest that the restoration of suppressed insulin signaling at PA-induced insulin resistant condition and AMPK activation are involved at least in the stimulatory effect of EFA on glucose uptake in C2C12 skeletal muscle cells.

• Journal of Astronomy and Space Sciences
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• v.25 no.4
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• pp.383-394
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• 2008

We examine geoeffective directional parameters of coronal mass ejections (CMEs). We select 30 front-side halo CMEs from SOHO LASCO CMEs whose speed is larger than 1000km/s and longitude is less than ${\pm}30^{\circ}$. These are thought to be the most plausible candidate of geoeffective CMEs. We examine the relation between CMEs directional parameters (Earthward direction, eccentricity, ${\Delta}$ distance and central angle parameter) and the minimum value of the Dst index. We have found that the Earthward direction parameter has a good correlation with the Dst index, the eccentricity parameter has a much better correlation with the Dst index. The bo distance and central angle parameter has a poor correlation with the Dst index. It's, however, well correlated with the Dst index in very strong geomagnetic storms. Most of CMEs causing very strong storms (Dst ${\leq}$-200nT) are found to have large Earthward direction parameter $({\geq}0.6)$, small eccentricity, bo distance and central angle parameters $(E{\leq}0.4,\;{\Delta}X\;and\;sin\;{\theta}{\leq}0.2)$. These directional parameters are very important parameters that control the geoeffectiveness of very fast front-side halo CMEs.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2001.09a
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• pp.172-175
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• 2001

이 연구에서는 5개의 시추공에 대한 양수시험을 실시하여 대수층의 수리학적 이방성과 지하수의 주 유동방향을 규명하고자 하였다. 코아검층 및 초음파주사검층을 통해 각각의 공에 대한 균열방향을 결정하고 이를 토대로 통합해본 결과 크게 세 방향의 균열군이 집중성을 보였다. 가장 빈도가 높은 균열의 방향은 N0$^{\circ}$~40$^{\circ}$E/30$^{\circ}$~50$^{\circ}$SE 그리고 N30$^{\circ}$~ 80 $^{\circ}$W/20$^{\circ}$~50$^{\circ}$ NE이 방향이 함께 나타났으며 두 번째 균열의 방향은 N0$^{\circ}$ ~50$^{\circ}$E/60$^{\circ}$ ~80$^{\circ}$NW로 나타났다. 세 번째 방향은 N30$^{\circ}$~50 $^{\circ}$W/70$^{\circ}$~80$^{\circ}$SW방향의 균열로 구성된다. 이처럼 지표하에서는 크게 세 방향의 균열이 다른 방향을 보이는 균열에 비해 상대적으로 큰 빈도를 가지며 발달하고 있음을 알 수 있다. 대수층이 이방성이고 균질하다는 가정하에 양수시험을 실시하여 각각의 공에 대한 최대 투수량계수 ( $T_{{\varepsilon}{\varepsilon}}$)와 최소 투수량계수 ( $T_{ηη}$)값을 산출하고 주 텐서방향 ($\theta$)을 결정하였다. 그 결과 BH-1, BH-4, BH=5공을 제외한 BH-2, BH-3호공에서의 이방성 투수량계수텐서값은 이 논문의 가정인 대수층이 이방성이고 균질하다는 가정에 일치하지 않았다. 따라서 원형좌표계에 도시하였을 때 다른 공에 비해서 비균질성이 심한 결과로 인해 이방성타원체 에서 많이 벗어남을 보였다. 이로인해 3개의 공 BH-1, BH-4, BH-5호공을 사용하여 대수층의 이방성을 분석하여 보았다. BH-1호공에서의 $T_{{\varepsilon}{\varepsilon}}$는 171.90 $m^2$/day, $T_{ηη}$는 71.0l $m^2$/day이고 주 텐서방향은 Nl5.39$^{\circ}$ E로 나타났다. BH-4호공의 $T_{{\varepsilon}{\varepsilon}}$는 268.20 $m^2$/day, $T_{ηη}$는 28.75 $m^2$/day이고 주 텐서방향은 N7.55$^{\circ}$E이며 BH-5호공에서의 $T_{{\varepsilon}{\varepsilon}}$는 168.40 $m^2$/day, $T_{ηη}$는 66.80 $m^2$/day이고 주 텐서방향은 N76.59$^{\circ}$E로 나타났다. 이처럼 연구지역에서의 각각의 공에 대한 투수량계수텐서는 서로 다르게 나타났으며 이에 따른 주 텐서방향도 서로 다름을 알 수 있다.

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.301-301
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• 2006

The physical properties of well-defined star-shape polystyrenes with high number of arms (6 to 57 arms) in good and theta solvents were studied using synchrotron X-ray scattering. The scattering profiles for multi-armed polystyrenes shown the molecular shape is changed according to increasing of number of arm. From various parameters which were obtained from scattering profiles, the molecular shape was determined more detail. As results, the molecular shape was changed from a fuzzy-ellipsoid for 6-armed PS to a fuzzy-sphere sphere for 57-armed PS according to increasing of number of arm.

• Food Science and Preservation
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• v.19 no.1
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• pp.74-80
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• 2012

To enhance the application of lotus roots and to provide basic data for processed foods with lotus roots, lotus root powder was processed under four different conditions, and their physicochemical properties were analyzed as follows. In the Hunter's color value results, the salted sample had the highest L value, and the vinegared sample had the highest a and b values. The water-holding capacities of the salted, vinegared, and blanched samples were higher than that of the control sample. The amylase contents were in the 19.57-20.43% range but were not significant. The swelling power and solubility of the processed samples increased as the temperature rose. The blanched sample had the highest swelling power and solubility (65 and $60^{\circ}C$, respectively). The crystallinity of the processed samples, as determined via X-ray diffraction, reached their peak at $16.9^{\circ}$, and the other peaks at 14.6, 22.2, and $23.8^{\circ}$ were typical of the B type. In addition, the relative crystallinity, gelatinization temperature, and enthalpy, as determined via DSC thermogram, were highest in the vinegared sample and lowest in the blanched sample. In the amylogram results, the vinegared sample had the highest maximum viscosity and breakdown. The retrogradation of the vinegared sample was the slowest as its setback value was the lowest.

• Journal of the Mineralogical Society of Korea
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• v.27 no.3
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• pp.159-168
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• 2014

Holocene plaeoenvironmental changes were interpreted by grain size and mineral analyses of a piston core (HB 13-2), obtained along the western slope of the Hupo Basin, Korea. The core sediments are characterized by two discrete, sedimentary facies: upper unit (0-0.4 mbsf) dominated by bioturbation structures with weak lamination, and lower unit (0.4-3.3 mbsf) characterized by intensified bioturbation toward bottom. Analysis of sensitive grain size and sortable silt demonstrated that the inflow of the Tsushima Warm Current (TWC) into the Hupo Basin strengthen from the period of sediment deposition over 0.82 mbsf. The minerals of the core sediments are composed mainly of quartz, microcline, orthoclase, albite and clay minerals including chlorite, kaolinite and illite. No noticeable changes of the mineral percentage was observed according to the grain size and depth of the samples. The integral breadth (${\Delta}^{\circ}2{\theta}$) of clay minerals from 1.4 mbsf to top layer shows an increasing trend, which clearly means climate warming from the period of sediment deposition above 1.4 mbsf. This interval correlates with the Holocene climate optimum at Mid Holocene.

• Journal of Acupuncture Research
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• v.29 no.5
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• pp.1-16
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• 2012

Objectives : The purpose of this study was to examine the effects of manual acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ on Electroencephalogram(EEG) of patients with stroke. Methods : 32 channel EEG measurement was carried out in 35 Stroke patients(23 males and 12 females). EEG was measured for 21 minutes(made up of 7 sessions, 1 session means 3 minutes time interval) including 15 minutes(5 sessions) of acupuncture time. Power spectrum analysis was used as a measure of complexity. Statistical analysis was performed using Linear mixed model and DUNNETT's multiple comparison. Results : The results were as follows; 1. EEG amplitude was reduced during acupuncture except electrodes PG1 and PG2. 2. There was a notable change during 6~9 minutes after needling in ${\delta}{\cdot}{\beta}{\cdot}{\gamma}$ wave, and during 6~9 minutes after needling in ${\Theta}{\cdot}{\alpha}$ wave. Overall, during 6~9 minutes after needling. 3. TP8 is a common significant electrode among five wave forms. Conclusions : These results suggest that TP8 could be typical electrodes and change of EEG compared to baseline happens most often during 6~9 minutes after manipulated acupuncture at the $LI_4$, $ST_{36}$ and $LR_3$ of patients with stroke.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.21 no.4
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• pp.158-163
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• 2011

$CuInS_2$ thin films were prepared using a sol-gel spin-coating method. That makes large scale substrate coating, simple equipment, easy composition control available. The structural and optical properties of $CuInS_2$ thin films that include less toxic materials (S) instead of Se, tetragonal chalcopyrite structure. Copper acetate monohydrate ($Cu(CH_3COO)_2{\cdot}H2O$) and indium acetate ($In(CH_3COO)_3$) were dissolved into 2-propanol and l-propanol, respectively. The two solutions were mixed into a starting solution. The solution was dropped onto glass substrate, rotated at 3000 rpm, and dried at $300^{\circ}C$ for Cu-In as-grown films. The as-grown films were sulfurized inside a graphite container box and chalcopyrite phase of $CuInS_2$ was observed. To determine the optical properties measured optical transmittance of visible light region (380~770 nm) were less than 30 % in the overall. The XRD pattern shows that main peak was observed at Cu/In ratio 1.0 and its orientation was (112). As annealing temperature increases, the intensity of (112) plane increases. The unit cell constant are a = 5.5032 and c = 11.1064 $\AA$, and this was well matched with JCPDS card. The optical transmittance of visible region was below than 30 %.

• Korean Chemical Engineering Research
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• v.44 no.5
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• pp.498-504
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• 2006

The etch rates of photoresist (PR) and the etch selectivity of $SiO_2$ to PR in a high density $CHF_3$ plasma were investigated at different ion-incident angles and bias voltages. A Faraday cage was employed for the accurate control of ion-incident angles. The ion energy was controlled by changing bias voltages. The etch rate of $SiO_2$ continuously decreased with ion-incident angles but the etch rate of PR remained constant up to the middle angle region and decreased afterwards. The etch rates of $SiO_2$ normalized to those at $0^{\circ}$ incident angle changed with the ion-incident angle following a cosine(${\theta}$) curve. On the other hand, the normalized etch rates of the PR changed showing a drastic over-cosine shape in the middle angle region. The etch selectivity of $SiO_2$ to PR decreased with an increase in the ion-incident angle because the etch yields of PR were enhanced by physical sputtering in the middle angle region compared to the case of $SiO_2$ etching. The etch selectivity of $SiO_2$ to PR decreased with an increase in the bias voltage at nearly all ion-incident angles.