• Physical Therapy Rehabilitation Science
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• v.11 no.2
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• pp.172-180
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• 2022

Objective: The purpose of this study was to investigate the effects of squat exercises using elastic bands of ballet dancers on muscle activity, arabesque angle, and static balance of ballet dancers during arabesque posture. Design: A randomized controlled trial Methods: A total of 25young female ballet dancer svoluntarily participated in the study. The participants were randomized to the elastic resistance squat group(n₁=13) and body squat group(n₂=12). The squats exercise was applied to a total of 12 exercises per four weeks and consisted of 15 times per one set in one to two weeks, 4 sets in three to four weeks. All subjects were evaluated muscle activity, arabesque angle, and static balance during arabesque posture at before-after intervention. All participants were measured muscle activity, arabesque angle, and static balance during arabesque posture at before-after intervention. Results: Elastic resistance squat group and body groups showed a significant increase in the muscle activity, angle, and static balance ability during arabesque posture(p<0.05). In the comparison between the groups, the elastic resistance squat group showed a significant increase in muscle strength, angle, and static balance during arabesque posture (p<0.05). The results showed that the elastic resistance squat exercise was more increased than the body squat exercise in all variables (p<0.05). Conclusions: Therefore, when planning a training program for a ballet dancer, the elastic resistance squat movement can be applied as an exercise method to improve the muscular performance and balance ability of the ballet dancer.

• The Journal of the Korean Society for Microbiology
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• v.35 no.2
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• pp.181-190
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• 2000

To investigate resistance to lamivudine (3TC), we examined the incidence of M184V in 20 HIV-1 patients treated with 3TC for $13.1{\pm}9$ months. Fourteen of 20 patients had been exposed to zidovudine (ZDV) or didanosine (ddI) prior to 3TC therapy. Nested PCR targeting to reverse transcriptase (RT) and direct sequencing were performed for peripheral blood mononuclear cells sampled serially. There were resistance mutations to ZDV in at least 9 patients at baseline, although there was no resistance mutation to 3TC. We could detect M184V in 6 (30%) out of 20 patients. The incidence of M184V increased as the duration of therapy prolongs (13% in samples <12 months; 47% in samples ${\ge}12$ months). The frequency of mutation M184V was higher in patients with previous mutation to ZDV than in patients with wild type. Resistance mutation was not detected in 7 patients. This study shows that resistance to 3TC tends to develop rapidly in patients with baseline mutations or two drugs combination therapy than in those treated simultaneously with triple drugs. This report is the first on resistance to 3TC in Korean AIDS patients.

• Journal of Korean Physical Therapy Science
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• v.9 no.3
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• pp.77-87
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• 2002

The purpose of this study was to compare the changes of muscle activities in deltoid with those in supraspinatus using electromyography(EMG) while subjects abducted their shoulder to different angles with different resistance. Methods : 20 volunteers who were comprised of 10 males(mean age: $21.2{\pm}2.0$) and 10 females(mean age: $20.2{\pm}1.6$) were collected. Surface electrodes were attached on deltoid and supraspinatus muscle for recording. Each reference electrode was located 3 cm to the each recording electrode. Muscle action potentials were recorded with changing the angle of shoulder abduction, $30^{\circ}$, $60^{\circ}$, $90^{\circ}$. This procedure was repeated with different resistance 0 pound, 2 pounds, 4.5pounds. The angle of shoulder abduction was determined by clinical goniometer. SPSS(Statistical Program for Social Science)/WIN 10.0 was used for statistics. Analysis included ANOVA, T-test. Results : The following results were obtained in this study. 1. There was significant differences during isometric shoulder abduction $30^{\circ}$, $60^{\circ}$, $90^{\circ}$ comparing muscle activity in deltoid and supraspinatus muscles at 0 pound, 2pound, 4.5pound resistance(p<0.05). 2. There was no useful significant in the deltoid and supraspinatus muscles activity EMG compared by physical condition. 3. Their was significant in the deltoid EMG compared by gender t=-5.41, P<0.01, but no difference in the supraspinatus EMG(P=0.333 >a=0.05). Conclusions: There are many previous studies on influence of shoulder angles and speeds of muscle activity. However most of them placed the focus on isotonic or isokinetic exercise, or shoulder function. But this study was done during isometric exercise, which is better for early assessment and treatment for injured patients. There is strong relationship between the shoulder angle with resistance in deltoid supraspinatus muscle activity. We conclude that it is important to apply isometric shoulder abduction exercise with correct angle and resistance especially in early stage.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.9 no.2
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• pp.25-45
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• 2003

Sling exercise treatment(S-E-T) is a therapeutic exercise based on scientific studies for the purpose of treating musculoskeletal or neurological disorders thereby improving strength, endurance, and skills for sensory-motor integration. Exercise resistance and intensity can be modified in various ways by changing the length of rope, patient position, therapist's manual resistance, and using elastic rope. The therapist can also progress to successively higher levels of exercise resistance and intensity by changing the position of the hanging point: the subject of this article. In brief, there are three axial components in S-E-T; hanging point, motor axis, and suspension point. The hanging point can be changed in several ways in relation to the joint; axial, superior, inferior, medial, and posterior hanging points. The position of the hanging point affects the amount of load on agonist and antagonist muscles as well as on the range of motion. To create an advanced exercise program, selection of hanging point can be two-dimensional such as superior-lateral or anterior-medial. Therapists, therefore, can freely but carefully select the best hanging point based on the purpose of the exercise and their level of knowledge in S-E-T.

• PNF and Movement
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• v.17 no.3
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• pp.421-429
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• 2019

Purpose: This study evaluated the relationship between pelvic pressure and irradiation of the proprioceptive neuromuscular facilitation (PNF) upper arm pattern exercises with an elastic band while in a sitting position. Methods: Fourteen subjects with asymptomatic pelvic pressure participated in this study. Pelvic pressure was measured using a Gaitview® system while sitting and performing PNF bilateral upper arm patterns. Resistance strength was provided by the blue elastic band. The statistical significance of the results was evaluated using a repeated one-way ANOVA and the independent t-test. The Bonferroni method was used for the post-hoc test. Results: The results revealed a significant change in the pelvic pressure when performing the PNF arm pattern. The average resistance pressure on the pelvis, with the elastic band, significantly increased after the initial sitting position (F=3.91, 3.92; p<0.05). No significant pelvic pressure changes were noted for each PNF upper arm pattern (p>0.05). Conclusion: The results of this study showed a positive relationship between pelvic pressure and the irradiation of PNF upper arm pattern exercises with resistance in the sitting position.

• Journal of International Academy of Physical Therapy Research
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• v.11 no.4
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• pp.2197-2202
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• 2020

Background: If there is a difference in leg length, the center of gravity shifts unilaterally toward the short leg, causing loss of balance and secondary postural imbalance, trunk muscle tone changes, gait abnormalities and pelvic imbalance. Objectives: To investigate effects of self exercise program on leg length, balance in adults with leg-length discrepancy. Design: Single blind randomized controlled trial. Methods: Twenty-eight participants were selected and divided into resistance exercise, flexibility exercise, and core exercise. Each exercise was performed for 40 minutes, 3 times a week for 6 weeks. Leg length and balance before and after exercise were measured and analyzed. Results: Following the interventions, resistance exercise group showed significant improvement in balance, but leg length difference did not show significant results. Flexibility exercise group showed significant improvement in leg length difference, but balance did not show significant results. Core exercise group showed significant improvement in leg length difference and balance. There was no significant difference in the comparison between the three groups. Conclusion: This study suggests that customized exercise according to the patient's level is beneficial to the patients.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.134-140
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• 2021

Objective: The purpose of this study was to investigate the alteration of upper cervical manipulation to autonomic nervous system (ANS) through the heart rate variability(HRV) analysis in young healthy individuals. Design: Two-group pretest-posttest design. Methods: Thirty four young healthy participants (17 males and 17 females) were randomized into the 2 groups, such as the upper cervical manipulation group (UCM group, n=17), neck stretching group (NS group, n=17). UCM group received a upper cervical manipulation, especially on the atlas, and NS group did stretch for both side of upper trapezius and levator scapular. For the UCM, Atlas mobility was checked by therapist and thrust was given once at the posterior arch of Atlas. HRV was measured before and after intervention to investigate ANS alteration. After the intervention, both groups were given 3 minutes break-time before measuring HRV. Results: The UCM group showed significant differences in ANS Activity, Stress Resistance, Stress index and Fatigue Index (p<0.05) while no differences in NS group with before and after intervention. There were significant differences in ANS Activity, Stress Resistance, and Fatigue Index between groups (p<0.05). Conclusions: This study suggected that upper cervical manipulationhas positive effects on the ANS activity, stress resistance, and fatigue index.

• The Journal of Korean Physical Therapy
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• v.25 no.2
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• pp.110-116
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• 2013

Purpose: This study was conducted in order to determine the physical effect on grip strength and balance ability of progressive resistance training using an elastic band for middle elderly women. Methods: We randomly recruited 13 middle elderly female subjects (from 75 years old to 84 years old). They practiced the elastic band exercise for 50 minutes once every week and were instructed to perform the same exercise as a home exercise for 16 weeks. Subjects who participated voluntarily had not participated in any other exercise program. Grip strength, one leg stance, and TIme Up & Go Test (TUG) were measured before and after elastic band exercise using the one group pre-posttest design. Wilcoxon's signed ranks test and simple regression analysis were performed using SPSS 18.0. Results: Significant differences in TUG and grip strength test scores were observed pre and post exercise (p<0.05), except one leg stance test. Significant correlation was observed only between age and change of right one leg stance. Conclusion: Progressive resistance training using an elastic band for middle elderly women was effective for dynamic balance and grip strength, but was not effective for static balance. Therefore, investigation of factors that affect improvement of static balance using an elastic band and the lasting duration of the effect and its association with age will be necessary in the future.

• Physical Therapy Korea
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• v.28 no.2
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• pp.117-122
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• 2021

Background: Flat-back posture refers to a posture in which the pelvis is tilted backward, the lumbar spine is bent, the upper thoracic spine is increasingly bent, and the lower thoracic spine is straight. Given that most of the day is spent sitting, we need to develop exercise programs and devices that are suitable for people who spend less time exercising than sitting. Objects: This study investigated the effects of resistance footrest exercise on spine posture angles in visual display terminal (VDT) workers with flat back. Methods: We measured the upper lumbar angle (ULA) and lower lumbar angle (LLA) using a flexible ruler for the ULA and LLA. Then, after 1 week of resistance footrest exercise designed to strengthen the lumbar spine musculature, we measured these angles again. We measured each angle three times and then compared measurements from before and after exercise. Results: There were no significant differences in the ULA following the strengthening exercise, but significant differences were observed in LLA. Conclusion: The resistance footrest exercise strengthened the muscles affecting the pelvic and lumbar lordotic angles, and increases in the LLA were changed. This suggests that the role of the lower lumbar spine in the lumbar lordotic curve is greater than that of the upper lumbar spine. In addition, considering the contemporary tendency to lead fairly sedentary lives, these results indicate that exercising while seated can be effective.

• Molecules and Cells
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• v.44 no.5
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• pp.363-373
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• 2021

Immune checkpoint inhibitors have changed the paradigm of treatment options for non-small cell lung cancer (NSCLC). Monoclonal antibodies targeting programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have gained wide attention for their application, which has been shown to result in prolonged survival. Nevertheless, only a limited subset of patients show partial or complete response to PD-1 therapy, and patients who show a response eventually develop resistance to immunotherapy. This article aims to provide an overview of the mechanisms of acquired resistance to anti-PD-1/PD-L1 therapy from the perspective of tumor cells and the surrounding microenvironment. In addition, we address the potential therapeutic targets and ongoing clinical trials, focusing mainly on NSCLC.