• 대한임상검사과학회지
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• 제56권3호
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• pp.207-216
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• 2024

Fludarabine은 STAT1의 선택적 억제제이다. 다양한 연구에서 SLE의 발병기전과 인터페론(IFN)과 같은 STAT1을 매개한 사이토카인 사이의 관계로 인해 STAT1 억제제는 SLE의 잠재적 치료법으로 여겨지고 있다. 본 연구에서 우리는 R848로 유도된 동물 모델에 대한 Fludarabine의 치료 효과를 확인하고 T세포 반응에 미치는 영향을 조사했다. 4주 동안 R848로 자극한 C57BL/6 마우스는 단백뇨, 자가항체, 신장 사구체 염증 세포침윤, C3 침착과 같은 루푸스 질병 표현형을 나타냈지만, 약물투여에 의해 질병 활성은 크게 개선되었다. 또한, Fludarabine은 동물 모델의 비장에서 CD4⁺ T 세포와 T helper 1 (Th1) 세포의 증가를 억제하고 in vitro 실험에서 Th1 세포의 분화와 관련 유전자의 발현을 효과적으로 억제했다. 이러한 결과는 Th1 세포가 루푸스 신염 발병에 중요한 역할을 한다는 것을 보여주는 결과이다. Fludarabine은 STAT1 억제를 통해 T 세포를 억제함으로써 루푸스 모델에 치료 효과를 나타냈다. 결론적으로 Fludarabine을 사용하여 STAT1 신호 전달을 억제하는 것이 루푸스에 대한 효과적인 치료법이 될 수 있다고 제안한다.

• 인간행동과 음악연구
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• 제3권2호
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• pp.29-44
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• 2006

치료사와 내담자의 관계에서 신뢰 형성과 이해는 효과적인 치료를 위한 기본적인 요소이다. 치료활동에 있어서 효과적인 동반자 관계는 치료 전 과정의 기초가 되기 때문이다. 이러한 점은 비단 음악치료 뿐만이 아니라 정신심리학적 치료나 상담치료 등에서도 같은 맥락을 가지고 중요시 하고 있다. 이러한 중요성 때문에 치료사와 내담자의 관계에 대한 연구는 상당히 폭넓게 이루어져 왔다. 여기에 최근의 연구는 치료사나 내담자 한 쪽의 일방적인 영향만을 고려하거나, 각자의 내적 변인들에 초점을 두어 연구하는 전통적인 견해를 탈피하여, 치료사와 내담자의 상호영향을 동시에 고려하는 연구가 이루어지고 있다. 본 연구는 최근의 연구동향에 주목하여 음악치료 환경에서 나타나는 치료사와 내담자의 관계에서, 음악이 어떠한 역할을 하였는지를 분석하고자 하였다. 본 연구를 위해 알코올 중독 판정을 받은 성인 여성을 대상으로 총 11회의 음악치료를 실시하였다. 처음 3회 세션은 연구 대상 여성을 포함한 그룹으로 진행되었으며, 4회부터 11회까지는 개인 세션으로 진행되었다. 이 중 개인 사례를 중심으로 연구를 진행하였고, 비디오 오디오 자료를 토대로 분석을 실시하였다. 분석 방법은 Amir(1990)가 음악 연구를 위해 사용한 Ferrara(1984)의 현상학적 연구 7단계를 변용한 것을 참조하였으며, 활동 중 나타나는 내담자의 언어적 비언어적 행동에서 나타나는 음악적 요소를 중심으로 분석하였다. 연구 분석에 있어서, 세션에서 얻어진 비디오 오디오 자료를 문서화하는 작업은 음악치료에서 qualitive research 연구를 위한 guide인 Henk Smeijsters,의 저서 "Multiple Perspective"에서 Researchers as Instruments 부분을 참조하였다. 즉흥연주 활동에서 나타난 내담자의 음악 분석은 Bruscia의 저서 "Improvisational Models of Music Therapy"에서 Bruscia의 모델인 Improvisation Assessment Profile과 Alvin모델인 Free Improvisation Therapy를 참조하였다. 연구 결과 음악과 악기는 치료사와 내담자의 관계를 중재하여 치료과정을 용이하게 해준다는 점을 보여 주었다. 음악과 악기가 감정전이의 주 역할을 맡음으로써, 치료사와 내담자 관계에 있어서 나타날 수 있는 부정적 감정전이로부터 치료사를 보호함과 동시에, 치료사-내담자 사이의 긍정적인 관계형성을 유지하게 해주었다. 이때 음악과 악기가 감정전이의 주 역할을 담당한다는 점은 내담자의 갈등이 대인 관계적 상황이 아닌 음악적 상황에서 나타났음을 증거 한다. 이는 세션 중 치료사와 내담자의 관계 형성에 있어서 음악이 그 중심이 되며, 치료에 긍정적 영향을 준다는 사실을 암시 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권9호
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• pp.4033-4037
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• 2014

Emerging evidence has shown associations of microRNA-205 (miR-205) with crucial cell processes such as the epithelial-mesenchymal transition (EMT) and aberrant expression with tumorigenesis in many types of human malignancy. This prospective study characterized the contribution of miR-205 to the colorectal cancer (CRC) tumorigenesis. The real-time reverse transcription-polymerase chain reaction was used to examine miR-205 levels prospectively in 36 pairs of samples of CRC tissue and adjacent noncancerous tissue (>2 cm from cancer tissue). In addition, the relationship between miR-205 levels and clinicopathological features was explored. The capability of miR-205 to function as a tumor marker was also examined. miR-205 expression levels did not show significant changes overall. However, miR-205 was significantly downregulated in a group of CRC samples compared with matched noncancerous tissue samples. Moreover, decreased miR-205 correlated significantly with lymphatic metastasis. A receiver operating characteristic (ROC) curve also showed an optimum cut off point of $1.4{\times}10^{-3}$ to distinguish lymphatic metastatic CRCs from non-metastatic CRCs. Interestingly we found lymphatic metastasis in almost 80% of the depressed samples. This study suggested that miR-205 could be reduced in the majority of metastatic CRCs and the risk of CRC metastasis may be predicted by monitoring miR-205 in patient samples collected at the time of the initial diagnosis. Therefore, targeting miR-205 and its potential environmental activators might be a promising therapeutic option to prevent malignant progression toward metastasis.

• 구강회복응용과학지
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• 제17권3호
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• pp.145-154
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• 2001

In the past, many dentist were interested mainly in the mechanical aspects such as tooth preparation and retainer types for making dental restoration. But, these days, the concept of restorative treatment emphasizes the importarce of gnatic system and masticatory muscles in addition to oral cavity. So, the current considerations for the fixed prosthodontic treatment include the stabilization of temporomandibular joint and neuromuscualr system and the relationship of periodontal ligament and occlusion. To achieve the above objectives, occlusal splint has been used as one of the mouth preparations for restorative treatment. The objectives of occlusal splint are as follows; 1. To use as preliminary application for periodontal-occlusal treatment 2. To provide proper vertical dimension 3. To control abnormal habits and parafunction 4. To treat the temporomandibular disease and myofascial pain 5. To establish the new therapeutic position In some cases, the patients had improper vertical dimension and occlusal interferences caused by prostheses reconstucted using centric relation recorded without considering the health of TMJ and manticatory muscle. And these prosthesis act as primary source that cause pathologic phenomenon in periodontal ligament, muscles and TMJ. Physiologically, in order to make the treatment occlusion guided by proper centric relation method, the method should be guided after the use of occlusal splint for some period. The main objective of prosthetic treatment is to maintain the function and health of stomatognathic system. So, one of the most important things that have to be performed by clinicians is a clinical ability to do the correct diagnosis and treatment planning based on the stomatognatic function and occlusion.

• 기본간호학회지
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• 제6권2호
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• pp.320-330
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• 1999

Nursing, a behavior of caring, means a connection of patients and clients has done through the caring of clients. Nurses are always with patients. In fact, caring is very important and the core of nursing, the true meaning of caring was embedded in our custom and consciousness before the approach of academic research. As a result, the existence of caring has not seen and revealed. Therefore, there is a need to study and confirm that caring has been placed in nursing and, nurses are doing caring in practice. The purpose of this study is to present the basis of nursing theory and practice through careful analysis of presence being, an aspect of caring. The presence of nurse shows a personal and healing relationship between nurses and patients on the basis of the respect for the humanity, Also, the role of nurses is to help a patient to integrate one's physical, mental and spritual aspects. Thanks to role of nurse, the pratical nursing has the characteristic of art and becomes more aesthetic and artistic. As we have seen above, we define 'presence' as 'being there' and 'being with' a patient for the purpose of meeting the health care needs. The attributes for which presence would be most appropriate would include the following : (1) being with and being together (2) take attention (3) mutual openness (4) experience an empathy (5) have an intention (6) therapeutic interaction process A caring situation as a necessary condition must be presupposed and the factors in that situation are the nurse's intense attention to the patient and a humanistic philosophy of the institutions of the patient. In any nursing intervention skill, there is listening, touching, giving hope, reassurancing, comforting and so on ; as a result, some positive effects can be expected between nurse and patient.

• 인간행동과 음악연구
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• 제5권2호
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• pp.93-102
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• 2008

융의 발달이론에 따르면, 인생은 만 35에서 40세를 전후로 페르소나가 형성되어가는 전반기와 참자기를 찾아 나서게 되는 후반기의 두 단계로 나누어진다. 이러한 관점에서, 나는 발달적으로 개성화에 대한 고민을 하지 않을 수 없는 역치점에 서 있으며, 음악-중심 음악치료사라는 페르소나를 가지고 있는 한 인간으로서 나의 개성화 과정은 음악적 참자기와 음악 안에서의 자기실현을 찾아나서는 과정에서부터 시작되어야 한다고 생각하였다. 나는 이러한 과정을 음악적 개성화(musical individuation)라 명명하고자 하며, 음악적 성장과 변화가 곧 음악 외적 성장과 변화를 상징한다는 음악-중심 음악치료 철학의 기본전제를 바탕으로, 나는 내 자신의 음악적 개성화 과정이 곧 나의 음악 외적 개성화 과정을 대변하리라 믿는다. 이 글은 아직도 많은 여정이 남아있고, 어쩌면 참된 완성이 가능하지 않을 수도 있는 음악적 개성화 과정에 대한 나의 개인적 기록이며 진솔한 고백이다.

• 인간행동과 음악연구
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• 제5권2호
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• pp.41-66
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• 2008

본 연구는 전통타악기를 활용한 즉흥연주가 청각장애 대학생의 스트레스에 미치는 효과를 알아본 연구로 독순법이 가능한 21~22세의 후천적 청각장애대학생 4명을 선정해 40분의 개별세션과 50분의 그룹세션을 주 1회씩 총 20회기를 진행하였다. 전겸구 김교헌(1991)이 개발한 대학생용 생활스트레스 척도를 개선한 척도를 이용한 양적 자료와 연구자 및 음악치료사 2인의 관찰을 통해 수집한 질적 자료를 이용해 전통 타악기를 활용한 즉흥연주가 청각장애 대학생의 스트레스에 효과적으로 해소되었음을 확인하였다. 결과적으로 본 연구를 통한 양적분석과 기술적인 분석을 볼 때, 청각장애를 가진 대학생들에게도 소리가 중심이 되는 음악이 치료의 도구로 사용될 수 있음이 입증되었고, 대인관계와 생활 속에서 발생하는 스트레스의 대처관리에 음악이 사용될 수 있음이 확인되었다. 또한 이러한 결과는 향후 다양한 연령대의 청각장애인을 대상으로 하는 음악치료연구의 중요성을 시사한다.

• The Journal of Korean Physical Therapy
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• 제29권4호
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• pp.158-163
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• 2017

Purpose: The purpose of this study was to investigate the relationship among pain, range of motion of the neck, neck disability index and grip strength after thoracic manipulation and cervical stabilization training in patients with chronic neck pain. Methods: In this study, twelve subjects with chronic neck pain were included. All participants had thoracic manipulation and cervical stabilization training. Intervention was conducted three times per a week, for 4 weeks. The visual analogue scale (VAS), range of motion of neck, neck disability index (NDI), as well as the grip strength before and after intervention were measured in all participants. Paired t-test was used to compare variables before and after intervention. Pearson correlation analysis was used to identify the correlations between the variables. Results: All variables after the intervention were significantly improved. There was a significant negative correlation between VAS and flexion angle of the neck (r=-0.669, p<0.05). Moreover, there was a significant positive correlation between NDI and VAS (r=0.636, p<0.05), and a significant negative correlation between NDI and flexion angle of the neck (r=-0.692, p<0.05). Conclusion: Patients with reduced pain following therapeutic intervention illustrated that there would be an improvement in the flexion angle rather than the extension angle of the neck, and that those with increased flexion angle would have less restriction of activities in daily living.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.7-8
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• 2003

Since it was first reported in 1997, somatic cell cloning has been demonstrated in several other mammalian species. On the mouse, it can be cloned from embryonic stem (ES) cells, fetus-derived cells, and adult-derived cells, both male and female. While cloning efficiencies range from 0 to 20%, rates of just 1-2% are typical (i.e. one or two live offspring per one hundred initial embryos). Recently, abnormalities in mice cloned from somatic cells have been reported, such as abnormal gene expression in embryo (Boiani et al., 2001, Bortvin et al., 2003), abnormal placenta (Wakayama and Yanagimachi 1999), obesity (Tamashiro et ai, 2000, 2002) or early death (Ogonuki et al., 2002). Such abnormalities notwithstanding, success in generating cloned offspring has opened new avenues of investigation and provides a valuable tool that basic research scientists have employed to study complex processes such as genomic reprogramming, imprinting and embryonic development. On the other hand, mouse ES cell lines can also be generated from adult somatic cells via nuclear transfer. These 'ntES cells' are capable of differentiation into an extensive variety of cell types in vitro, as well assperm and oocytes in vivo. Interestingly, the establish rate of ntES cell line from cloned blastocyst is much higher than the success rate of cloned mouse. It is also possible to make cloned mice from ntES cell nuclei as donor, but this serial nuclear transfer method could not improved the cloning efficiency. Might be ntES cell has both character between ES cell and somatic cell. A number of potential agricultural and clinical applications are also are being explored, including the reproductive cloning of farm animals and therapeutic cloning for human cell, tissue, and organ replacement. This talk seeks to describe both the relationship between nucleus donor cell type and cloning success rate, and methods for establishing ntES cell lines. (중략)

• Radiation Oncology Journal
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• 제13권1호
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• pp.49-54
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• 1995

Purpose : To evaluate the prognostic importance of age in patients with Stage IB cervical cancer, we examined the relationship between age and survival in patients. Methods and Materials: Retrospective analysis was performed on 107 patients with Stage IB cervical cancer: 79 patients were treated with surgery followed by postoperative radiotherapy or radiation alone between October 1983 and August 1993 and 28 patients with Stage IB cervical cancer treated with surgery alone between January 1989 and August 1993 at Inje University Seoul Paik Hospital. Patients ranged in age from 26 to 74 (median 48) and were followed for a modian period of 39 months. Patients were divided into two groups; Group A comprising 32 Patients $with{\geq}$age 40 and Group B comprising 75 patients with>age 40. Both Group A and Group B patients were comparable with respect to all covariables studied. Results : The overall 5-year survival and the disease free 5-year survival for the 107 patients studied were $85.2\%$ and $82.1\%$, respectively. The overall survival for Group A and Group B was $92\%$ and $83\%$, respectively(p>0.05). The disease free 5-year survival for Group A and Group B was $82.3\%$ and $82.6\%$, respectively(p>0.05). There was no difference in both local and distant failure in Group A and Group B. Conclusion: On the basis of the this analysis it is concluded that age alone is a poor indicator of prognosis and should not be used as an indication for adjuvant treatment.