• Clinical and Experimental Pediatrics
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• 제50권4호
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• pp.335-339
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• 2007

The link between upper airway disease (allergic rhinitis and sinusitis) and lower airway disease (asthma) has long been of interest to physicians. Many epidemiological and pharmacological studies have provided a better understanding of pathophysiologic interrelationship between allergic rhinitis and asthma. The vast majority of patients with asthma have allergic rhinitis, and rhinitis is a major independent risk factor for asthma in cross-sectional and longitudinal studies. The association between sinusitis and asthma has long been appreciated. Through the recent evidences, allergic rhinitis, sinusitis, and asthma may not be considered as different diseases but rather as the expression in different parts of the respiratory tract of same pathological process in nature. Various mechanisms have been proposed to explain the relationship between asthma and upper airway diseases, but the underlying mechanisms are not completely discovered. The implications for the one-airway hypothesis are important not only academically but also clinically for diagnostic and therapeutic purposes.

• Radiation Oncology Journal
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• 제11권1호
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• pp.143-148
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• 1993

From September 1985 through September 1989,56 patients with stage IIIB carcinoma of the cervix were treated with radiation therapy with curative aim. The overall survival at 5 year was $38{\%}$. The survival rate was better for patients treated with combined external radiotherapy and high dose rate intracavitary radiotherapy than with external radiotherapy alone. No significant survival difference was observed between the unilateral and bilateral parametrial extension of the tumor Seventeen patients experienced recurrence within the irradiated field with a loco-regional recurrence rate of $30{\%}$. Ten patients had complications ($18{\%}$). The complications were mild in three, moderate in four, and severe in three patients. A study was made on the relationship between the fraction numbers of intracavitary radiotherapy, vaginal packing and the complication rate, respectively. In this analysis author observed that the significant treatment factor influencing the survival of cervical cancer was the use of intracavitary radiation, and meticulous vaginal packing could decrease the late complication rate of radiotherapy of cervical cancer.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1999년도 춘계학술대회
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• pp.1-4
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• 1999

The potential therapeutic benefit of nicotinic ligands in a variety of neurodegenerative pathologies involving the CNS has energized research efforts to develop nicotinic acetylcholine receptor (nAChR) subtype-selective ligands. In particular, there has been a concerted effort to develop nicotinic compounds with selectivity for CNS nAChRs as potential pharmacological tools in the management of these disorders. The characterization of other novel nicotinic ligands such as epibatidine. showing a marked increase in potency at nAChRs, has provided additional support for the development of potent, selective ligands at individual nAChR subtypes. We have developed and studied a number of nicotinic compounds to identify potential candidates exhibiting such selectivity. In the present study, we report the synthesis and biological evaluations of some azabicyclic and azatricyclic nicotine analogs to decipher the relationship among steric requirements of the nicotine's pyrrolidine ring system, binding affinity and subtype-selectivity.

• 한국보건간호학회지
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• 제29권3호
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• pp.515-527
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• 2015

Purpose: This study was to the experiences hospital school programs health impaired children as perceived by mothers. Methods: The participants were 9 mothers of children with health impairment who had in hospital school program. ata were collected through in-depth interview using semi-structured questionnaire. The interviews were analyzed by content analysis. Results: domains and 13 categories were extracted from the analysis. The 5 domains related to the experience hospital school program were emotion, therapeutic course, interpersonal relationship, school reentry, and needs for hospital school management. Conclusion: The results of this study indicate that participation hospital school programs not only educational support but it is also helpful for physical, psychosocial adjustment of health impaired children and could be used develop effective hospital school programs to improve the adaption of children with health impairment.

• 생물정신의학
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• 제25권2호
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• pp.21-30
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• 2018

Attention deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder. Recently, it has been suggested that brain-derived neurotropic factor (BDNF) may play a role in the pathogenesis of ADHD. Our aim of this review is to understand the physiological functions of BDNF and its potential relationship with ADHD and therapeutic approaches of ADHD. Searches were conducted in Pubmed and Research Information Service System (RISS). In this review, we summarized important literatures for the physiological functions of BDNF in neurodevelopment, change of serum BDNF level in ADHD, association of BDNF polymorphism and ADHD and potential association of treatment of ADHD with serum BDNF level. Further studies are required to more clearly understand the source and the role of BDNF in ADHD and to develop BDNF based-ADHD treatement.

• BMB Reports
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• 제41권7호
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• pp.495-510
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• 2008

It has become clear that complex interactions underlie the relationship between the skeletal and immune systems. This is particularly true for the development of immune cells in the bone marrow as well as the functions of bone cells in skeletal homeostasis and pathologies. Because these two disciplines developed independently, investigators with an interest in either often do not fully appreciate the influence of the other system on the functions of the tissue that they are studying. With these issues in mind, this review will focus on several key areas that are mediated by crosstalk between the bone and immune systems. A more complete appreciation of the interactions between immune and bone cells should lead to better therapeutic strategies for diseases that affect either or both systems.

• Journal of Oral Medicine and Pain
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• 제23권3호
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• pp.263-270
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• 1998

Considering various factors contributing oral malodor, the accurate prediction of prognosis is very important to both clinician and patients. The present study has been performed to invetigate the relationship between treatment effeicacy and pre-treatment volatile sulfur compounds (VSC) level. Ninety patients were divided into three groups, A(<150ppb), B(150< <200ppb), and C(>200ppb) groups, according to pre-treatment VSC level detected by Halimeter, and each group included 30 patients. Routine therapeutic measures for oral were provided to each patient which consisted of oral prophylaxis, tooth brushing and flossing instruction, tongue scraping by proper device, and gargling of 0.25% ZnCl2 Solution. The group with high pre-treatment VSC level (>150ppb) showed significant reduction of VSC level at 1 and 3 weeks after. However, the group with low pre-treatment VSC level (<150ppb) did not show any significant reduction during the experimental periods. Collectively, the results suggested that patients with high pre-treatment VSC level show better prognosis.

• Archives of Pharmacal Research
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• 제19권3호
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• pp.183-190
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• 1996

There are a wide variety of semi-solid ointments used for healing the skin diseases, whose therapeutic and skin penetration abililties may greatly differ from one another depending on the compositions of ointment vehicles. A computer optimization technique was applied to obtain the optimum formula of o/w type ointment giving the in vitro maximum absorption rate through hairless rat skin membrane. Some of the formulations were selected to find out a relationship between skin penetration of ointment and its Theological characteristics. The experimental value of absorption rate obtained from the ointment by optimum formula agreed well with the theoretical value obtained from a polynomial regression analysis, Three kinds of ointments selected among 15 formulations were obtained with a concentric cylinder type rheometer (Model; Rheolab SM-HM Physica, Germany) at 20, 30, 40 and $50^{\circ}C$ for rheograms of rhelolgical properties of o/w type ointments. As the temperature was raised, all products showed a decrease in both shear stress and yield values. The higher skin penetration, the lower shear stress showed.

• 대한전기학회논문지
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• 제34권7호
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• pp.257-266
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• 1985

A new method for the artificial beta cell which can be used to control the hyperglycemia in diabetic patients was represented. The relationship between the insulin infusion rate and the blood glucose concentration was described by the second order ARMA model, and the time varying parameters were identified by exponentially weighted least squares estimator. The design of controller was based on the pole assignment self tuning altorithm with discrete blood sampling and the constraints of input and output responsse rate were considered. The results of animal experiments show that this method may be a fruitful approach for regulating the blood glucose level. We expect that this device can be used as both therapeutic and research tools providing that its stability and reliability are improved a little more.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제11권1호
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• pp.69-77
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• 2005

The purpose of this study is to build fundamental data related to corridor space for nursing home design. Elderly with dementia were observed in corridor space at two nursing homes in In-cheon City. Two types of behavior were found out through in-depth observation; Group and Personal behaviors. Group behaviors were varying according to the type of programs such as rest, care, diet, and therapeutic services. Personal behaviors could be classified into wandering and private seclusion. These two behaviors were influenced by management programs of facilities, services of care-givers and individual characteristics of residents. The result of this study was discussed on the following matters: 1) Optimum size of residential unit; 2) Working spaces of care-givers; 3) Relationship between bedroom and common space for gathering; 4) Planning for wandering path; 5) Familiarity of interior finishing materials