• Physical Therapy Rehabilitation Science
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• v.9 no.4
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• pp.230-237
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• 2020

Objective: To investigate the physical appearance and therapeutic changes that occur with the performance of Schroth exercise in patients with scoliosis. Design: Randomized controlled trial. Methods: Fifteen subjects with maximum curvature of the lumbar who were diagnosed with idiopathic scoliosis had volunteered to participate in the study. Eight subjects were included in the experimental group where they performed the Schroth Therapeutic Exercise and the other seven were included in the control group. The experimental group underwent 2 hours of weekly treatment for 12 weeks, while the control group did not during the same period based on the decisions of patients or guardians. The Mann-Whitney rank test was carried out to compare the treatment results of the two groups, and the comparison within the group was done by Wilcoxon signed-rank test. The vertebral rotation angle (VRA) was by Scoliometer, and difference of rotated and curved portion volume (DV) between both sides on the major curvature portion measured by 3D human body scanning system. Results: In the experimental group, 12 weeks of Schroth exercise therapy has significant improved in correction rate (CR) in Cobb's angle (CA), VRA, and DV between both sides on the major curvature portion (p<0.05), while significant differences were not found between the groups regarding weight bearing difference in both feet (WD) and DV (p<0.05). Conclusions: Schroth exercise performance showed significant changes in the patient's therapeutic changes (CA, VRA), but the physical appearance (DV, WD) was not significant, indicating that external changes in the treatment goal setting are more difficult goals to achieve.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.2
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• pp.145-152
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• 2024

Chemotherapy-induced cognitive impairment is recognized as the most typical symptom in patients with cancer that occurs during and following the chemotherapy treatment. Recently many studies focused on pharmaceutical strategies to control the chemotherapy side effects, however it is far from satisfactory. There may be a need for more effective treatment options. The aim of this study was to investigate the protective effect of exercise on cisplatin-induced neurotoxicity. Eight-week-old C57BL6 mice were separated into three group: normal control (CON, n = 8); cisplatin injection control (Cis-CON, n = 8); cisplatin with aerobic exercise (Cis-EXE, n = 8). Cisplatin was administered intraperitoneally at a dose of 3.5 mg/kg/day. The Cis-EXE group exercise by treadmill running (14-16 m/min for 45 min daily, 3 times/week) for 12 weeks. Compared to the CON group, the cisplatin injection groups showed significant decrease in body weight and food intake, indicating successful induction of cisplatin toxicity. The Cis-CON group showed significantly increased levels of pro-inflammatory cytokines including IL-6, IL-1β, and TNF-α in the hippocampus, while the Cis-EXE group was significantly decreased in the expression of IL-6, IL-1β, and TNF-α. In addition, compared to the CON group, the levels of synapse-related proteins including synapsin-1 and -2 were significantly reduced in the Cis-CON group, and there was a significant difference between the Cis-CON and Cis-EXE groups. Antioxidant and apoptosis factors were significantly improved in the Cis-EXE group compared with the Cis-CON group. This study suggest that exercise could be meaningful approach to prevent or improve cisplatin-induced cognitive impairment.

• The Journal of Korean Physical Therapy
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• v.10 no.2
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• pp.33-40
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• 1998

This study was carried out to investigate the muscle strength of quadriceps muscles by means of isokinetic test. The experimental objects were devided into electrically stimulated, isotonic and isometric groups and trained for 4weeks. The results were as follows : 1. the values of total work, peak torque, average power and the ratio of peak torque between flexors and extensors revealed singnificant statistically in three experimental groups(p<0.05). 2. The endurance was increased slightly in electrically stimulated group, but decreased in isotonic and isometric group, 3. The value of post training on all items did not reveal significant statistically in three experimental groups(P>0.05). 4. The electrically stimulated groups effected on increasing of muscle strength as isotonic and isometric exercises.

• Korean Journal of Applied Biomechanics
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• v.18 no.1
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• pp.63-72
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• 2008

The purpose of this study was to compare and analyze the effects of exercise types on lower extremity muscle activity in stroke patients. For the purpose, the subjects of this study were classified into three groups such as therapeutic exercise group(n=7), elastic band group(n=7), and stretch reflex group(n=7). The three exercise programs were 5 times a week for 8 weeks. The stretch reflex group revealed higher in iliopsoas and biceps femoris %MVIC than the therapeutic exercise group and elastic band group, whereas elastic band group revealed lower in tibialis anterior %MVIC than therapeutic exercise group in the primary single-limb support. The stretch reflex group revealed higher in iliopsoas %MVIC than the therapeutic exercise group and elastic band group, whereas stretch reflex group revealed lower in medial gastrocnemius %MVIC than therapeutic exercise group in the secondary double support phase.

• Radiation Oncology Journal
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• v.8 no.2
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• pp.255-260
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• 1990

From April 1985 to September 1989, 26 patients with stage I and II non-Hodgkin's lymphoma of unfavorable histology localized in head and neck region were treated with combined modality (combination chemotherapy plus radiotherapy) at the Department of Therapeutic Radiology in Kyungpook National University Hospital. Of the 26 patients, 23 showed complete response and 3 partial response. Between these two groups there were no statistical differences according to the variables. Three-year survival and disease-free survival rate were $62.4{\%}$ and $65.2{\%}$, respectively. Unilateral involvement of neck node (p<0.05), radiation dose over 5000 cGy (p<0.01), and 6 or more cycles chemotherapy (p=0.06) had a favorable effect on 3-year survival rate. There were 8 recurrences including 3 partial responders, 1 local failure, 1 distant failure, 1 contiguous failure, and 2 simultaneous local and distant failure. It could be suggested that combined modality treatment might be necessary for the treatment of stage I and II Non-Hodgkin's lymphoma of unfavorable histology.

• Health Policy and Management
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• v.21 no.2
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• pp.249-262
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• 2011

Since May 1st in 2008, the products of ginkgo biloba extract have had to be used with the patient's out-of-pocket payment due to reimbursement restriction guidelines. This study aims to analyze the policy effects of reimbursement restriction on pharmaceutical expenditures using interrupted time series(ITS) analysis. We retrieved monthly NHI claims data for the period between May, 2005 and December 2009. The ingredients identified as a substitute for ginkgo biloba have similar indications based on the similar pharmacological activities. The effects of changes in reimbursement scope were evaluated both for all relevant pharmaceuticals within the same therapeutic class and for 2 separate groups : ginkgo biloba's and its substitutes. According to the study results, restrictions on reimbursement scope resulted in savings of the drug expenditures in the targeted therapeutic class. Direct restriction on ginkgo biloba was associated with a decrease in expenditure level by 60.1% and changes in trend from an average increase rate of 1.4% to an average decrease rate of 1.5% for the therapeutic class, with a dramatic decrease in expenditure level(-191.5%) for ginkgo biloba itself, but with an increased expenditure level(+50.1%) and changes in trend from an average increase rate of 2.0% to an average decrease rate of 1.0% for the substitute group. Further policy to restrict nicergoline was associated with additional decrease in expenditure level for the therapeutic class. Additionally, we could identify the balloon effect - a new policy squeezing one part results in bulging out elsewhere. After the restriction of ginkgo biloba, the utilization of and expenditures on its substitutes increased significantly. In conclusion, we demonstrated that consecutively introduced policies effectively reduced overall expenditures on the therapeutic class of interest. Some ingredients played as a substitute while others did not. Further studies need to be conducted to identify which factors determine a substitute.

• Korean Journal of Radiology
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• v.25 no.2
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• pp.199-209
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• 2024

Objective: This study aimed to compare therapeutic efficacy and technical outcomes between adjustable electrode (AE) and conventional fixed electrode (FE) for radiofrequency ablation (RFA) of benign thyroid nodules. Materials and Methods: Between 2013 and 2021, RFA was performed on histologically proven benign thyroid nodules. For the AE method, AE length ≥ 1 cm with higher power and < 1 cm with lower power were utilized for ablating feeding vessels and nodules, especially those near anatomical structures, respectively. The therapeutic efficacy (volume reduction rate [VRR], complication rate, and regrowth rate) and technical outcomes (total energy delivery, ablated volume/energy, RFA time, and ablated volume/time) of FE and AE were compared. Continuous parameters were compared using a two-sample t-test or Mann-Whitney U test, and categorical parameters were compared using a chi-squared test or Fisher's exact test. Results: A total of 182 nodules (FE: 92 vs. AE: 90) in 173 patients (mean age ± standard deviation, 47.0 ± 14.7 years; female, 90.8% [157/173]; median follow-up, 726 days [interquartile range, 441-1075 days]) were analyzed. The therapeutic efficacy was comparable, whereas technical outcomes were more favorable for AE. Both electrodes demonstrated comparable overall median VRR (FE: 92.4% vs. AE: 84.9%, P = 0.240) without immediate major complications. Overall regrowth rates were comparable between the two groups (FE: 2.2% [2/90] vs. AE: 1.1% [1/90], P > 0.99). AE demonstrated a shorter median RFA time (FE: 811 vs. AE: 627 seconds, P = 0.009). Both delivered comparable median energy (FE: 42.8 vs. AE: 29.2 kJ, P = 0.069), but AE demonstrated higher median ablated volume/energy and median ablated volume/time (FE: 0.2 vs. AE: 0.3 cc/kJ, P < 0.001; and FE: 0.7 vs. AE: 1.0 cc/min, P < 0.001, respectively). Conclusion: Therapeutic efficacy between FE and AE was comparable. AE demonstrated better technical outcomes than FE in terms of RFA time, ablated volume/energy, and ablated volume/time.

• Journal of Medicine and Life Science
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• v.20 no.4
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• pp.158-165
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• 2023

This study prospective randomized controlled trial aims to test the impact of adding health education, awareness of some contributing factors and clinical guidance to therapeutic cabergoline given to infertile women with unexplained resistant hyperprolactinemia. It comprised 120 infertile women with unexplained persistent hyperprolactinemia not responding to therapeutic doses of cabergoline 1.5-2 mg/week who were subjected to proper history taking to exclude concomitant drug intake or possible brain problems in all cases. They were classified into group A (60 cases) who received health education and clinical guidance to search for possible contributing factors and were instructed to avoid them in addition to proper therapeutic doses of cabergoline, while group B (60 cases) received proper therapeutic doses of cabergoline only without clinical guidance. After 1 month, serum prolactin (PRL) was measured for all cases. All cases had high PRL level at the start of the study (79.9±28.4 [39-195] and 78.2±19.9 [42-189] in group A and B, respectively) without any significant difference. Pretreatment counselling revealed that lifestyle factors, sexual behaviors or feeding habits may contribute to resistant hyperprolactinemia in all cases without a significant difference between both groups. Serum PRL dropped significantly more in group A (20.14±10.31 [11-45] vs. 49.32±37.03 [12-100]) after combined health education, clinical guidance of the couple and proper treatment. It is concluded that lifestyle factors, sexual behaviors, and feeding habits would affect the response of hyperprolactinemia to treatment. Health education and clinical guidance with some advice to avoid them, would concomitantly improve the response of resistant hyperprolactinemia to therapeutic doses of dopamine agonists.

• Radiation Oncology Journal
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• v.6 no.2
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• pp.253-258
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• 1988

To evaluate radiation effect on the hematopoietic system, we analyzed 44 patients who were treated with conventionally fractionated radiation therapy (RT) at Chonbuk National University Hospital. According to the treatment sites, we classified them into three groups: group I as head and neck, group II as thorax, and group III as pelvis. White blood cell, lymphocyte, platelet and hemoglobin were checked before and during RT The results were as follows; 1. White blood cell (WBC) and lymphocyte count were declined from the first week of RT to the third week, and then slightly recovered after the third or fourth week. There was prominent decrease in lymphocyte counts than WBC. 2. Platelet counts were declined until the second week of the RT, showed slight recovery at fourth week in all groups. Hemoglobin values were slightly decreased in the first week and then recovered the level of pretreatment value, gradually. 3. Lymphocyte count were declined significantly on group III(p<0.05), WBC and platelet counts were decreased on group II but statistically not significant.

• Korean Journal of Agricultural Science
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• v.12 no.2
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• pp.349-355
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• 1985

The effects of sulfadimethoxine administration on the residues in tissues and eggs were examined in Laying Hens. Sulfadimethoxine was administered orally to White Leghorns at a excessive dose level (300 mg/kg/day), therapeutic dose level (150mg/kg/day) and prophylactic dose level (50mg/kg/day). Sulfonamide residues were measured in blood, tissues (muscle, liver, kidney, lung and bile) and eggs (egg whites and egg yalks) with paper disc methods. The results obtained were summarized as follows: 1. Bacillus subtilis was very susceptible to sulfonamide, and detectable to the level of 0.5 ppm. 2. In blood serum levels, it was detectable until 48 hours post-treatment in once administration of therapeutic dose level, and also detectable until 60 hours post-treatment in all groups of three times administration with excessive, therapeutic and prophylactic doses. 3. As for the tissues residues, sulfonamides were detectable until 5 days post-treatment in muscle, liver, kidney, lung and bile of all groups, but were not detectable except bile on 10 days of post-treatment. 4. Sulfonamide residues in egg whites of all groups were detectable until 5 days, but in egg of all groups were not detectable but trace amounts at 5 days post-treatment. 5. The presence or absence of sulfonamide in bile may be standard to judge the edibility of organ tissues and eggs.