• 대한화장품학회지
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• 제21권1호
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• pp.38-52
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• 1995

Liposome은 의약과 화장품 분야에서 많은 발전을 하였다. 본 연구에서는 세포 간지질의 주요 성분인 cholesterol, palmitic acid, cholesterol ester와 lecithin을 사용하여 swelling반응에 의해 MLV liposome을 제조 하였다. 지질베이스와 마이크로플루다이저를 사용하여 MLV liposome 형성에 대한 특성들을 연구 하였다. MLV liposome은 multilamellar vesicle로서 형성되었다. MLV liposome의 gelation효과는 고온(90$\pm$5도씨)에서 polyol과 water phase에 지질을 혼합한 것에 스웰링 반응을 하였다. MLV liposome에 alpha hydroxy acid 성분들을 투입 제조하였다. MLV liposome의 최적 조건은 마이크로플루다이저에 3회 통과하였으며 vesicle의 입자크기는 150-350nm범위이고 이것을 freeze-fracture electron microscopy로 확인 하였다.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.145-148
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• 2003

Previously, we reported that L-PCA enhanced blood circulation by modulating constitutive NO production. It was that L-PCA increased L-Arg uptake into endothelial cell, followed by the enhancement of NO production. Then we recommended the use of L-PCA for cosmetics, not only as humectants but also as enhancer of blood circulation. Since L-Arg is transported into endothelial cells by CAT (cationic amino acid transporter), it is expected that L-PCA also increase the uptake of basic amino acid, L-Lys. In this study, the uptakes of some amino acids into cells were evaluated by using 3H-labelled amino acid. Then we found the tendency that the uptake of L-Lys into endothelial cells was also enhanced by L-PCA. And the evident effect was observed in the epidermal fibroblasts, which had also CAT. Furthermore, it was found that the transportation of the other type of amino acids were not enhanced by L-PCA. That is to say, a famous moisturizer, L-PCA, has some effects on basic amino acid transport into cells.

• 한국자원식물학회지
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• 제22권6호
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• pp.522-527
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• 2009

Plants of the genus Taraxacum are well-known as a traditional herbal remedy with a long history, and they have also been extensively used as food, chemicals and cosmetics. In this study, four Taraxacum species distributed in Korea (T. mongolicum, T. officinale, T. mongolicum variation and T. officinale variation) were utilized for an efficient method for direct multiple shooting induction and regeneration, using leaf blade, transition zone, petiole and root as explants in MS media with various hormone concentration and combination. MS medium containing IAA 0.2 mg/L and TDZ 1.0 mg/L showed the highest induction frequency of all the hormone combinations. Besides, the induction of T. mongolicum variation was most effective comparing with the other three species by the average induction frequency of four explants. While the induction effect of leaf blade explant was more obvious than the other three explants. This system exhibited a rapid propagation of shoots from the leaf blade explants and makes it convenient to make use of these Taraxacum species to develop their diverse applications in the future.

• The Journal of Asian Finance, Economics and Business
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• 제7권10호
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• pp.885-896
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• 2020

The purpose of this study is to shed light on the driving motivations of contributing social word of mouth on social networking sites (sWOM) toward both tangible and intangible products. In order to develop a research model, this study adopts the motivation theory and TAM model. Data was collected from 904 members of the cosmetic and restaurant communities by using the snowball method. After assessing the validity of all constructs, the structural equation modeling (SEM) is used to test the proposed hypotheses. Results show that personal motivations (satisfaction, opinion leadership, self-enhancement, and economic incentives) and characteristics of sWOM (Perceived Usefulness and Ease of Use) have positive effect on exposure and engagement behaviors. Here are our specific findings, (1) customer satisfaction positively affects online interactions on SNSs such as Like or Sharing a content; (2) sWOM contribution behavior exists in two structures (Exposure and Engagement) and affects each other; (3) This study combines two groups of personal motivation and TAM to conceptualize a research model; and (4) The motivations of contributing sWOM between a specified service and product are rather similar. These findings help digital managers to understand consumers' behavioral contributions on SNSs and also provide interesting insights for marketers.

• 산경연구논집
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• 제14권4호
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• pp.33-46
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• 2023

Purpose: During the coronavirus disease-19 (COVID-19) outbreak, mask-wearing is required to protect against and limit the spread of infection, but it can directly affect skin problems. Change in skin condition might be related to mental health. This study explored the association between skin conditions and behavior of skin cares and stress levels during the Covid-19pandemics. Research design, data and methodology: A survey was conducted on 516 adults who were aware of damaged skin due to continuous wearing of masks for a long time during the COVID-19 Pandemic. The study included 164 men and 352 women in the Republic of Korea. Results: Skin conditions and behavior of skin cares associated with stress perceptions. A multiple linear regression model was used adjusting for potential confounder. Conclusion: Since management so far in the COVID-19 Pandemic can cause skin concerns and change the original skin type, it is necessary to redefine and improve the use of skin care, face-washing methods, and functional cosmetics. People with high and low interest in skin type recognition and management were evenly identified, and it was confirmed that stress awareness decreases as awareness of skin care attitude increases.

• 한국응용과학기술학회지
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• 제14권2호
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• pp.93-102
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• 1997

Isothiazoline derivatives is widely used to food, medical drug and industrial goods, cosmetics etcs, and it makes to restrain and to sterilize a breeding of microbe as a preservative and a sterilizing agent. It differs with the raw material of paraoxybenzoic acid derivatives or imidazolydinyl urea to be in use at present, on the efficacy and effect, and has various characteristics. This synthesis makes 3,3'-dithiodipropionic chloride to add a thionyl chloride in 3,3'-dithiodipropionic acid, and 3,3'-dithiodipropionic methyl amide makes to synthesize in a reflux reaction the mono methyl amine to 3,3'-dithiodipropionic chloride. And last synthesis becomes to make chlorination-cyclization molecule doing a reflux reaction in the temperature of $90{\sim}100^{\circ}C$ to mix excessively thionyl chloride and ethylene dichloride to 3,3'-dithiodipropionic methyl amide. The last synthesis material has got in the mixture of 5-chloro-2-methyl-4-isothiazoline-3-one and 2-methyl-4-isothiazoline-3-one, and it is so-called isothiazoline derivatives. The purification of isothiazoline derivatives makes to fuse in ethyl acetate, and makes to decolorize and to deodorize in recrystallization. This experiment has been in synthesis and purification of isothiazoline derivatives, and has tried to measure on the antisepsis and sterilization function of microbe according to pH or content change.

• 대한화장품학회지
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• 제23권3호
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• pp.9-23
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• 1997

Retinoids are essential regulators of spithelial cell growth and celluar differentiation. They are also known to be effective in photoaging. It was reported that topical application of retinoic acid improves facial wrinkle carsed by collagen synthesis reduction in photodamaged skin. Collagen synthesis by retinoic acid may contribute to the wrinkle effacement. Since celluar retinoic acid binding protein II is slsctively induced in human skin and dermal fibroblasts in vitro by retinoic acid, this response can be used to mesure retinoids potency and activity. In order to know the activity of retinoids and their relations with collagen synthesis, we treated dermal fibroblasts with retinoids for 48 hours at 10-6-10-7M and measured CRABPII mRNA level by quantitative Nortern blotting. We also measured the rate of collagen systhesis by retinoids using 3-dimensional dermal equivalent. CRABPII mRNA level was increased 3-fold by retinoic acid, 2.1-fold by retinol and 1.4-fold by retinaldehyde. Collagen systhesis was increased 34% by all-trans retinioc acid, 26% by retinol, 17% by retinaldehyde and 7% by retinyl palmitate. From the above results, retinoids were found to be a potent indecers of CRABPII mRNA and collagen synthesis. Though retinoic acid was the most effective, its use has been restricted because of the side effects. Instead, retinol can be a best candidate in cosmetics for the treatment of photodamaged skin in terms of efficacy and safety.

• Food Science and Biotechnology
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• 제17권3호
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• pp.464-469
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• 2008

In human beings, it is known that there is a correlation between the occurrence of acne and the ability to suppress sebum. Sebosuppression may be related to the inhibition of sebocyte proliferation, differentiation, and lipogenesis in sebaceous glands. To investigate the skin sebosuppressive activity of green tea extract, the in vivo effects of its flavonoid compounds on the androgen-dependent stimulation of pigmented macules in hamsters and performed in vitro experiments with human primary sebocytes were examined. Our results imply a dual activity of skin sebosuppression by green tea flavonoids; some catechins including epigallocatechin-3-gallate (EGCG) and gallocatechin-3-gallate (GCG) may reduce the differentiation of sebocytes by inhibiting PPAR-${\gamma}1$ mRNA expression, whereas some flavonol glycosides including kaempferol may inhibit lipogenesis in sebaceous glands by decreasing levels of the mature form of sterol-sensitive response elements binding protein-1c (SREBP-1c). Therefore, green tea is a potentially effective material for use in the development of health foods or cosmetics for skin sebosuppression.

• KSBB Journal
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• 제19권4호
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• pp.257-262
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• 2004

최근, 미세조류에 대한 생물공학적 관심이 급격히 증가하고 있으며 이의 응용범위는 식품이나 제약, 화장품 등 다양한 구도로 확장되어지고 있다. 고농도의 미세조류 배양을 위해서는 빛이 핵심적 제한요소로 작용되어지며 빛의 투과 깊이나 강도에 따라 균체의 성장속도가 결정되어지게 된다. 본 연구에서는 다양한 빛의 투과경로와 빛을 받는 면적/배양액의 부피 비율, 조도 그리고 단계적 조사에 따른 Chlorella sp.의 성장률을 조사하여 빛이 미세조류에 미치는 영향을 알아보았으며, 본 연구에 적용된 값들 중 4 cm의 직경, 57.6%의 면적/부피 비율, 62 $\mu$mo1/$m^2$/s의 조도에서 Chlorella sp. 성장에 필요한 빛 에너지를 가장 효율적으로 이용함을 확인할 수 있었다.

• Archives of Plastic Surgery
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• 제50권2호
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• pp.148-152
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• 2023

Soft tissue filler injection is the second most common nonsurgical cosmetic procedure. Despite the safety of fillers, as use has grown, so has the number of patients affected by adverse events. Ophthalmoplegia following cosmetic filler injection is a rare complication, mostly occurring after injection to the glabella, nasolabial fold, periorbital, and lateral nasal site. In all cases where ophthalmoplegia has been reported following fillers, patients have simultaneously experienced vision loss and other ocular symptoms. We report a case of isolated acute ophthalmoplegia following hyaluronic acid injection solely in the temple region. A 40-year-old woman, 3 hours after the procedure, presented to our hospital with left eye ophthalmoplegia, ptosis, and hypotropia. Treatment started with hyaluronidase, steroids, and anticoagulants. After 4 weeks, left eye ophthalmoplegia remained unchanged, and through a 10-week follow-up, all left ocular movements improved, and only mild hypotropia and ptosis persisted. This case report shows that ophthalmoplegia may also happen with temple region filler injections. We also review available prevention techniques and treatments to avoid such complications when performing soft tissue fillers for gaunt appearance correction.