• International Journal of Contents
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• v.10 no.2
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• pp.47-58
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• 2014

Physiological signals provide important clues in the diagnosis and prediction of disease. Analyzing these signals is important in health and medicine. In particular, data preprocessing for physiological signal analysis is a vital issue because missing values, noise, and outliers may degrade the analysis performance. In this paper, we propose PhysioCover, a system that can recover missing values of physiological signals that were monitored in real time. PhysioCover integrates a gradual method and EM-based Principle Component Analysis (PCA). This approach can (1) more readily recover long- and short-term missing data than existing methods, such as traditional EM-based PCA, linear interpolation, 5-average and Missing Value Singular Value Decomposition (MSVD), (2) more effectively detect hidden variables than PCA and Independent component analysis (ICA), and (3) offer fast computation time through real-time processing. Experimental results with the physiological data of an intensive care unit show that the proposed method assigns more accurate missing values than previous methods.

• Journal of Ecology and Environment
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• v.40 no.3
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• pp.136-143
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• 2016

Background: Mussels are stubborn organisms attached to solid substrata by means of byssus threads. The abundance of marine mussel Mytilus edulis in marine facilities like power stations was reason to select among fouling animals. Methods: Mortality patterns as well as physiological behavior (oxygen consumption, foot activity, and byssus thread production) of two different size groups (14- and 25-mm shell length) of M. edulis were studied at different hydrogen peroxide concentrations ($1-4mg\;l^{-1}$). Results: Studied mussels showed progressive reduction in physiological activities as the hydrogen peroxide concentration increased. Mussel mortality was tested in 30 days exposure, and 14 mm mussels reached the highest percentage of 90% while 25 mm mussels reached 81%. Produced data was echoed by Chick-Watson model extracted equation. Conclusions: This study points that, while it could affect the mussel mortality moderately in its low concentrations, hydrogen peroxide has a strong influence on mussels' physiological activities related to colonization. Therefore, hydrogen peroxide can be an alternative for preventing mussel colonization on facilities of marine environment.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.03a
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• pp.221-230
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• 1999

Automobile horn's psychoacoustic characteristic and significance as a anturalistic signal of danger makes it a valuable auditory stimulus to study such psychophysiological responses as startle, orienting and defense reactions. However, comparison and differentiation of physiological responses to commercially available horns is a complicated task due to small contrast of technical features of horns and influence of such processes as habituation on physiological outcome with increased number of auditory stimulation trials. In the study on 10 college students we performed comparative analysis of tonic and phasic reactivity of physiological responses mediated by autonomic nervous system in order to identify role of habituation and decrement of autonomic responsivity, as well as possibility o differentiate subjectively most and least preferred and subjectively more appropriate horns according to physiological manifestations. It was showed that electrodermal and cardiovascular reactivity have concurrent patterns of adaptation to repeated stimulation, namely skin conductance variables habituated, cardiac reactivity failed to show signs of habituation, while vascular component of response were facilitated demonstrating marked sensitization. Differentiation of Physiological responses to horns with respect to their subjective rating scores was possible, however electrodermal reactivity was effective only at the first block of trials, while phasic and tonic cardiovascular reactivity differentiate responses during whole course of experiment. There are discussed possible autonomic mechanisms involved in mediation of observed results.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.3
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• pp.39-47
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• 2016

PURPOSE : This study attempts to find the effects of water perturbation exercise performed on stroke patients in their physiological cost index and gait ability tests. METHOD : The subjects were 30 stroke patients, water perturbation exercise group was performed 3 day per week, for 40 minutes a day, for a period of eight weeks. The physiological cost index and gait of all subjects were assessed by using the polar, 6 Minute Walk Test (6MWT), and 10 meter Walk Test(10mWT) at pre training and post training. Paired t-test was used to analyze change before and after intervention in group. Pearson's correlation was used to analyze correlation of all variables. RESULT : Water perturbation exercise group showed increased physiological cost index. Water perturbation exercise increased gait ability, showing a significant difference. Showing the correlation between the relatively high amount between physiological cost index and 6 minutes walking test. CONCLUSION : From the result of the study, we found that water perturbation exercise was effective in improving physiological cost index and gait ability. The patient is considered to be used by itself to involve the treatment and the risk of falling from the lowered state into the treatment method for the intensive treatment of stroke patients to be useful in improving the cardiovascular system and ability to walk. Through underwater training for stroke patients in the future on the basis of this study it is considered to require additional clinical studies on the impact on daily living and quality of life of stroke patients.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.35D no.7
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• pp.40-47
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• 1998

This paper presents the physiological signal processing CMOS one chip for transmitting human bodys small electrical signals such as electrocardiogram(EKG) or electromyogram(EMG) and the external system for receiving signals was implemented by the commercial ICs. For simultaneous four-subject four-channel telemetry, a new enfored synchronization techniqeu using infrared bi-directional communication has been proposed. The telemeter IC with the size of 5.1*5.1mm$^{2}$ has the following functions: receiving of command signal, initialization of internal state of all functional blocks, decoding of subject-selection signal, time multiplexing of 4-channel modulated physiological signals, transmitting of telemetry signal to external system and auto power down control. The newly designed synchronized oscillator with low supply voltage dependence in the telemeter IC operates at a supply voltage from 4.6~6.0V and the nonlinearity error of PIM modulator was less than 1.2%F.S(full scale). The power saving block operates at the period of 2.5ms even if the telemetry IC does not receive command signal from external system for a constant time.

• YAKHAK HOEJI
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• v.47 no.2
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• pp.104-109
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• 2003

The present paper reviews the notion and comparison of the Korea Food and Drug Administration(KFDA) general pharmacology and the International Conference on Harmonisation (ICH) safety pharmacology. General pharmacology or safety pharmacology is termed the study to determine the potential of a compound to induce adverse pharmacological effects. KFDA general pharmacology studies have been considered an important component in drug safety assessment and these were originally referred to those designed to examine effects other than the primary therapeutics effect of a drug candidate. The KFDA notified the Guideline for General Pharmacology in 1997. Safety pharmacology studies were focused on identifying adverse effects on physiological functions. In the ICH came into place S7A Safety Pharmacology Studies for Human Pharmaceuticals in 2001. A new chemical entity should be assessed for its side effects, initially in those physiological systems which are generally agreed to be the key systems that are essential for life; these "core system" include the central nervous system, cardiovascular system and respiratory system in safety pharmacology studies. These studies should be performed in compliance with Good Laboratory Practice (GLP).

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.95-98
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• 1997

In this paper, several nonlinear system identification theories and the application of these methods to the physiological system are reviewed by extracting significant results from the literature. Methods based on unctional series expansion, parameter estimation, block-oriented models are included. However, there is still considerable debate about the advantages and disadvantages of each approach. This is true primarily because each method has limitations on the types of assumption and interpretation, types of nonlinear elements, etc. This means that user must select an appropriate method and the selection will depend on the problem under investigation.

• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.591-600
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• 2015

Recently high interest in health and fitness has led to vibrant researches for the active fitness system to learn and enjoy the exercise program for oneself. In this paper, we design and implement the active spinning training system which enables user to have self-learning and experience of customized spinning training program by the biometric and movement information acquired from user's physiological signals. The proposed system provides the appropriate difficulty of spinning program which reflects the concordance rate of spinning dance gestures and the amount of exercising by analyzing the physical status of participant from his brain and pulse waves and recognizing the skeletal movement in real time. For the higher exercise effect, the system offers a virtual personal trainer to show the correct poses and controls the level of difficulty depending on the concordance rate of participant's motions. The experiment with various participants through the proposed system shows that it is able to help users in getting the available exercise effect in comparatively short time.

• Science of Emotion and Sensibility
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• v.13 no.2
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• pp.309-316
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• 2010

This paper proposes healthcare bathing system for improving the multisensory function and not washing. We designed various types of bathtub for developing bathing system. This system consists of whirlpool bathtub for multisensory stimulation, a cover of bathtub with visual-auditory stimulation function, a small size PC for main control, touch panel, digital multimedia broadcasting (DMB), color-changeable LED mood lighting system for improving visual sensibility and speaker. We investigate the effects on autonomic nervous system during bathing with healthcare bathing system for improving the multisensory functions. To analysis physiological parameter, body temperature, blood pressure, intraocular pressure and heart rate variability (HRV) were measured before, during and after bath using healthcare bathing system. Experiments were performed on partial immersion bath and the water temperature was kept $39{\pm}0.5^{\circ}C$. The body temperature and the heart rate variability of the subject were measured every 5 minutes before, during, and after the bath. In analysis of HRV, the parasympathetic nerve increased from starting bath and decreased after 15 minutes. So the subjects felt comfortable at 15 minutes after starting bath. Blood pressure decreased to 16mmHg maximumly however pulse increased. Bath using healthcare bathing system for improving the multisensory functions affects positively the circulation of the blood. From this results, it leaves something to be desired in evaluation of serviceability and physiological analysis using the healthcare bathing system, however, we expect to analyze more clearly the relationship between the serviceability of product, physiological change and sensibility by various physiological parameters.

• Journal of Sensor Science and Technology
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• v.5 no.1
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• pp.43-50
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• 1996

This paper presents a manufacture of the multiple subjects biotelemetry system using custom CMOS IC fabricated $1.5{\mu}m$ n-well process technology. The implantable circuits of the system except sensor interface circuits including FM transmitter are fabricated on a single chip with the sire of $4{\times}4mm^{2}$. It is possible to assemble the implantable system in a hybrid package as small as $3{\times}3{\times}2.5cm$ by using this chip, It's main function is to enable continuous measurement simultaneously up to 7-channel physiological signals from the selected one among 8 subjects. Another features of this system are to enable continuous measurement of physiological signals, and to accomplish ON/OFF switching of an implanted battery by subject selection signal with command signal from the external circuit. If this system is coupled with another appropriate sensors in medical field, various physiological parameters such as pressure, pH and temperature are to be measured effectively in the near future.