• Economic and Environmental Geology
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• v.51 no.6
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• pp.485-492
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• 2018

About 300 thousand tones of oyster shells are produced annually and, thus, their massive recycling methods are required. Recently, a method, utilizing them as wet desulfurization materials after removal of organic matters and changing $CaCO_3$ phase into CaO through calcination, is under consideration. This study investigates the mineralogical changes (specific surface area, phase changes, surface state, etc.) of oyster shells by calcination and their characteristics were compared with those of limestone. Uncalcined oyster shells showed the higher specific surface area than limestone because the former are composed of platy and columnar structures. In contrast, investigated limestone showed a dense structure. The phase change of oyster shells occurred at lower temperature than that of limestone. The specific surface area of oyster shell decreased significantly after calcination while limestone depicted a drastic increase. Small amount of Na contained in oyster shell was suggested as the cause of this phenomenon; in that, it acted as a flux causing melting and sintering of oyster materials at lower temperature. Because of this, an additional phenomenon was observed that a part of shell materials remained untransformed even at higher calcination temperature and after longer treatment period due to the sintered surface, which covers the rest parts. Further studies investigating the effect of this phenomena from the perspective of desulfurization is required.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.265-271
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• 2005

A rapid, selective and sensitive reversed-phase HPLC method for the determination of etodolac in human serum was developed, validated, and applied to the pharmacokinetic study of etodolac. Etodolac and internal standard, ibuprofen were extracted from human serum by liquid-liquid extraction with hexane/isopropanol (95:5, v/v) and analyzed on a Luna C18(2) column with the mobile phase of 1% aqueous acetic acid-acetonitrile (4:6, v/v). Detection wavelength of 227 nm and flow rate of 1.0 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^3$ factorial design using a fixed etodolac concentration $(1\;{\mu}g/mL)$ with respect to its peak area and retention time. And also, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of $0.05-40\;{\mu}g/mL$ with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of serum was 0.05 ${\mu}g/mL$, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the quality control samples ranged from 92.00 to 110.00% for etodolac with overall precision (% C.V.) being 1.08-10.11%. The percent recovery for human serum was in the range of 76.73-115.30%. Stability studies showed that etodolac was stable during storage, or during the assay procedure in human serum. The peak area and retention time of etodolac were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of etodolac in human serum samples for the pharmacokinetic studies of orally administered Lodin XL tablet (400 mg as etodolac) at three different laboratories, demonstrating the suitability of the method.

• Journal of Pharmaceutical Investigation
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• v.36 no.1
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• pp.45-51
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• 2006

A rapid, selective and sensitive reversed-phase HPLC method for the determination of dipyridamole in human serum was developed, validated, and applied to the pharmacokinetic study of dipyridamole. Dipyridamole and internal standard, loxapine, were extracted from human serum by liquid-liquid extraction with diethyl ether and analyzed on a Nova Pak $C_{I8}$ column with the mobile phase of 40 mM ammonium acetate:methanol:acetonitrile (35:35:30)(v/v/v, pH 7.8). Detection wavelength of 280 nm and flow rate of 1.0 mL/min were fixed for the study. The assay robustness for the changes of mobile phase pH, organic solvent content, and flow rate was confirmed by $3^3$ factorial design using a fixed dipyridamole concentration (50 ng/mL) with respect to its peak area and retention time. And also, the ruggedness of this method was investigated at three different laboratories using same quality control (QC) samples. This method showed linear response over the concentration range of 2-2000 ng/mL with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of serum was 2 ng/mL, which was sensitive enough for pharmacokinetic studies of dipyridamole. The overall accuracy of the quality control samples ranged from 103.94 to 105.86% for dipyridamole with overall precision (% C.V.) being 4.60-11.49%. The relative mean recovery of dipyridamole for human serum was 97.64%. Stability studies showed that dipyridamole was stable during storage, or during the assay procedure in human serum. The peak area and retention time of dipyridamole were not significantly affected by the changes of mobile phase pH, organic solvent content, and flow rate under the conditions studied. This method showed good ruggedness (within 15% C.V.) and was successfully used for the analysis of dipyridamole in human serum samples for the pharmacokinetic studies of orally administered Dimor tablet (75 mg as dipyridamole) at three different laboratories, demonstrating the suitability of the method.

• Clinical and Experimental Reproductive Medicine
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• v.25 no.2
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• pp.153-160
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• 1998

The objective of this retrospective study was to evaluate whether the transvaginal ultrasonographic analysis of endometrial pattern and thickness could predict the stage of menstrual cycle. Endometrial pattern and thickness were observed in those patients receiving infertility work up from April, 1994 to July, 1998 at Seoul National University Hospital. The study group was 185 patients with normal regular menstrual cycles. Among them, 44 patients received endometrial biopsy, and the date of endometrium was compared with the observed endometrial pattern and thickness. The observed endometrial pattern was presence or absence of central cavity echogenicity, triple line sign, endometrial hypoechogenicity, ring sign, endometrial hyperechogenicity and posterior acoustic sonic enhancement. The results were as follows; Central cavity echogenicity was seen throughout menstrual cycle. Triple line sign was observed in 81.1% of patients during early secretory phase. However, in mid to late secretory phase, triple line sign was appeared in only 6.8%. The percentage of positive endometrial hypoechogenicity was highest in early secretory phase. In contrast to hypoechogenicity, positive endometrial hyperechogenicty was highest in mid to late secretory phase. Ring sign was observed in 73.5% of the patients during early secretory phase with peak incidence. Posterior acoustic enhancement was seen in 72.7% of the patients during late secretory phase. The sensitivity and specificity of being a secretory phase if the patients showed hyperechogenic endometrium, were 84.2%, 83.3% respectively. The sensitivity and specificity of being a secretory phase if the patients showed posterior acoustic enhancement were 93.8%, 58.3% respectively. Endometrial thickness was not correlated with endometrial dating. In conclusion, transvaginal ultrasonographical delineation of the endometrial pattern might be useful tool in predicting endometrial status during normal menstrual cycle. But, endometrial thickness could not predict the endometrial dating.

• Journal of the Korean Institute of Telematics and Electronics
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• v.27 no.2
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• pp.55-64
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• 1990

This paper concerned about a study on the direct pole placement PID self-tuning controller design for DC servo motor control system. The method of a direct pole placement self-tuning PID control for a DC servo motor of Robot manipulator tracks a reference velocity in spite of the parameters uncertainties in nonminimum phase system. In this scheme, the parameters of classical controller are estimated by the recursive least square (RLS)identification algorithm, the pole placement method and diophantine equation. A series of simulation in which minimum phase system and nonminimum phase system are subjected to a pattern of system parameter changes is presented to show some of the features of the proposed control algorithm. The proposed control algorithm which shown are effective for the practical application, and experiments of DC servo motor speed control for Robot manipulator by a microcomputer IBM-PC/AT are performed and the results are well suited.

• The Korean Journal of Malacology
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• v.20 no.1
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• pp.65-73
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• 2004

Gametogenesis, changes of gonad bulk index (GBI), monthly variation in oocyte diameter, reproductive cycle and spawning with lunar cycle of the top shell, Trochus niloticus were investigated by histological examination. The specimens were sampled in the coastal waters of Chuuk Island, Micronesia, form November 1999 to September 2000. T. niloticus is a gonochorism, and the female and male were present in an approximately 1:1 ratio (p > 0.05). The ovary contained with the oocyte of yolk stage, the testis composed of the spermatid and spermatozoa at around the year. Monthly GBI were higher at February, March, April and June than the other months. Major spawning occurred between April and May, and June and July but the individuals of partially spawning were presented throughout the year. GBI with lunar cycle were higher at the full moon than the other lunar phase. These results suggest that the spawning occurred between the full moon and last quarter moon.

• Journal of The Korean Society of Agricultural Engineers
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• v.65 no.5
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• pp.25-35
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• 2023

The estuary reservoir is a major source of agricultural water in Korea; for effective and sustainable water resource management of the estuary reservoir, it is crucial to comprehensively consider various water resource factors, including water supply, flood, and pollutant management, and analyze future runoff changes in consideration of environmental changes such as climate change. The objective of this study is to estimate the impact of future climate change on the runoff characteristics of an estuary reservoir watershed. Climate data on future Shared Socioeconomic Pathway (SSP) scenarios were derived from two Global Climate Models (GCMs) of the Coupled Model Intercomparison Project phase 6 (CMIP6). The Hydrological Simulation Program-Fortran (HSPF) was used to simulate past and future long-term runoff of the Ganwol estuary reservoir watershed. The findings showed that as the impact of climate change intensified, the average annual runoff in the future period was higher in the order of SSP5, SSP3, SSP1, and SSP2, and the ratio of runoff in July decreased while the ratio of runoff in October increased. Moreover, in terms of river flow regime, the SSP2 scenario was found to be the most advantageous and the SSP3 scenario was the most disadvantageous. The findings of this study can be used as basic data for developing sustainable water resource management plans and can be applied to estuary reservoir models to predict future environmental changes in estuary reservoirs.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.5
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• pp.2135-2146
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• 2013

Most researches about residential improvement projects deal with different process phase in order to examine important affecting variables. The main purpose of this study is to identify influential change of locational variables according to the process of residential improvement projects. Generally the residential improvement project consists of four phases such as site designation, project committee approval, residents association establishment and final project approval. The discriminant and correlation analyses are employed to examine the changes of locational variables by each phase of the project process. In residential redevelopment projects, the finding shows that locational variables in the final project approval phase act differently from those in the other phases. On the other hand, the variables act similarly among the four phases in the case of residental rebuilding projects although the significant level of discriminant analysis result, in the site destination phase, is relatively low significance. Therefore, there is no difference among the project process phase to examine to what extent of the residential improvement projects.

• Journal of Environmental Science International
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• v.4 no.5
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• pp.403-411
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• 1995

The atmospheric responses to a Sea Surface Temperature Anomaly(SSTA) over the equatorial eastern Pacific Ocean have been investigated using the horizontally fine resolution model based on OSU 2-layer Atmospheric General Circulation Model(AGCM). The SSTAS daring the peak phase of 1982-83 El Nino have been applied to the model as the boundary conditions of the experiment. The model simulates the eastward movement of the rising branch of the Walker circulation. That is, the major features associated with the El Nino such as the increase of the precipitation rate over the center of the Pacific and decrease over the Indonesia, and the 500hPa geopotential height anomaly in the middle latitude are properly describes in the fine resolution model experiment. The model results indicate that this horizontally fine resolution UM can successfully simulate the ENSO anomalies and be more effectivelly used for the study of the climate and the climate changes.

• Journal of the Korean Society of Systems Engineering
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• v.17 no.1
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• pp.21-34
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• 2021

The use of Field-Programmable Gate Arrays (FPGAs) in the development of safety-related Human-Machine Interface (HMI) systems has gained much momentum in nuclear applications. Recently, one of the application areas for the Advanced Power Reactor 1400 (APR1400) is in the development of the advanced Component Interface Module (CIM) of the Engineered Safety Features Actuation System (ESFAS). Using systems engineering approach, we have developed a new FPGA-based advanced CIM software. The first step of our software development process involves the Preliminary Hazard Analysis (PHA) based on the previous CIM design. In this paper, we describe the qualitative approach used in performing the preliminary hazard analysis. The paper presents the methodology for applying a modified Hazard and Operability (HAZOP) procedure for the conduct of PHA which resulted in a qualitative risk-ranking scheme that informed the decisions for the safety criteria in the requirements specification phase. The qualitative approach provided the justification for design changes during the advanced CIM software development process.