• Korean Journal of Clinical Laboratory Science
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• v.38 no.2
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• pp.82-86
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• 2006

Leukemia arises in hematopoietic progenitor cells and is characterized by impaired or blocked differentiation, uncontrolled proliferation and resistance to apoptosis. Molecular mechanisms underlying cellular functions by $As_2O_3$, however, have been poorly investigated. The consensus of several reports is that $As_2O_3$ induces apoptosis in leukemia cells by activating genes for apoptosis. The present study aimed to investigate the effects of $As_2O_3$ on the cell cycle and its morphological change and a relationship between the caspase-3 and $As_2O_3$-induced apoptosis. Caspase-3 is involved in $As_2O_3$-induced apoptosis in K562 cells. In this study, to address whether $As_2O_3$-induced apoptosis is mediated by caspase-3 activity, the same samples were probed with a specific antibody. The pretreatment of $25{\mu}M$ Z-VAD-fmk, a specific inhibitor of caspase, decreased $As_2O_3$-induced cytotoxicity. And $As_2O_3$ significantly increased the percentages of the cells accumulated in the G2/M phase of the cell cycle in a time- and dose-dependent manner. Chromatin condensational changes were observed with Hoechst 33258 staining after treatment of $As_2O_3$. It was shown that $As_2O_3$-induced apoptosis is controlled through caspase-3 activation. These results may provide a useful rationale for CML treatment.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.445-452
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• 2014

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study.

• Korean Journal of Environmental Agriculture
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• v.41 no.4
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• pp.318-327
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• 2022

BACKGROUND: The mean annual temperature of the Korean Peninsula will continue to rise due to global warming. 'Shiranuhi' mandarin-a late-harvest cultivar-is primarily cultivated in plastic greenhouses where high temperatures cannot be directly avoided. Therefore, growth and fruit quality changes under elevated temperatures must be investigated. METHODS AND RESULTS: Elevated temperatures were divided into three groups [2℃ (T-I), 4℃ (T-II), and 6℃ (T-III) above the ambient temperature] during the 2019-2020 season. Mean temperatures were 17.1℃, 18.6℃, and 20.2℃ in T-I, T-II, and T-III, respectively. The bud bursts in T-II and T-III were earlier than that in T-I at 7 days and 11 days, respectibely. And the full blooms in T-II and T-III were earlier than that in T-I at 11 days and 23 days, respectively. Fruit size significantly increased with increased temperature. The citrus color index in the coloring phase markedly differed across treatments. Further, total soluble solid and acid contents markedly changed with temperature rise but the sugar-to-acid ratio did not. Sucrose content tended to decrease with increase in temperature, but citric acid content remained unaffected. CONCLUSION(S): Elevated temperature accelerated plant growth and development but delayed rind color development in 'Shiranuhi' mandarin. Therefore, rise in ambient temperature by >4.6℃ may negatively affect yield and fruit quality.

• Journal of KIISE:Software and Applications
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• v.35 no.8
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• pp.479-492
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• 2008

Nowadays, lots of requirements are changed quickly and variously. So, we need the ability to support the change of business process which is the asset of a company. To support this ability, the core asset that supports analyzing and describing about changes of business process should be exist from generating phase of a business process model. And a business process model that is satisfied the changed requirements should be automatically generated using core assets. In this paper, we present a business process family model (BPFM) which represents the commonalities and the variabilities of a set of business processes, we propose the automated tool using variabilities of BPFM and decision-making information for generation of business process model that is satisfied the changed requirements.

• Membrane Journal
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• v.23 no.2
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• pp.176-184
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• 2013

To investigate the performance of VOC separation, composite hollow fiber membrane was prepared which composed of poly (ether imide) support prepared by phase separation method and poly (dimethylsiloxane) coating active layer. The performances of the membranes for the application of recovery process in terms of their morphology, gas permeance test for $N_2$ and $O_2$ gases. Durability against benzene, toluene and xylene was also investigated. And permeation test for multi-component VOCS through the membrane with different feed concentration and stage-cut were investigated. Permeance of PEI supported membrane and the membranes coated with PDMS decreased from 45,000 GPU to 63 GPU and 49,450 to 30 GPU for $N_2$ and $O_2$, respectively. Recovery efficiency and concentration of VOCs in permeate increased with decreasing stage-cut. VOCs concentration in permeate proportionally increased with increasing feed concentration but concentration ratio and recovery efficiency showed any noticeable changes with feed concentration change.

• Spatial Information Research
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• v.20 no.1
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• pp.19-26
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• 2012

Since $CO_2$ emissions are recognized as the biggest contribution to climate change, the needs and international efforts for $CO_2$ emissions reduction are increasing. The developed countries are driving strategies to boost green industry as a new growth engine. Following this global trend, based on the ongoing U-City project as a new city model, it is required to analyze the changes of $CO_2$ emissions in U-City to identify its potential for reducing carbon dioxide emissions. This study aims at identifying the potential and effects on $CO_2$ reduction by analyzing the level of $CO_2$ emissions before and after introducing U-City. Bundang-Gu, Seongnam-City & Ilsan-Gu, Goyang-City among Phase I new tow ns were selected as model cities before introducing U-City and Dongtan-Dong, Hwaseong-City as a model city after introducing U-City. The result showed 30% reduction of $CO_2$ emissions in the comparison of tw o models.

• Polymer(Korea)
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• v.30 no.3
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• pp.210-216
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• 2006

To use the filter materials for selective removal of carbonyl compounds in cigarette mainstream smoke, hydrazine such as 2,4-dinitrophenylhydrazine (2,4-DNPH) and dansylhydrazine (DAH) impregnated adsorbents were prepared with perchloric acid or phosphoric acid as an accelerator in hydrazone formation reaction. Changes of molecular structure and morphology of adsorbents in various of impregnator were investigated by FTIR/ATR and SEM. Impregnation amount caused by reaction time, acid type and impregnation reagent, and the adsorption properties of carbonyl compounds in cigarette mainstream smoke were studied. Amounts of impregnation increased with increasing reaction time. The removal amount for vapor phase carbonyl compounds by 2,4-DNPH impregnated adsorbent was higher than that of dansylhydrazine impregnated adsorbent. The selectivity of 2,4-DNPH impregnated polyacrylic type adsorbent was superior to those of other adsorbents. This result indicates that the 2,4-DNPH impregnated polyacrylic adsorbent is applicable to cigarette filter material because of its fast reactivity and porosity.

• Journal of the Korean Society for Nondestructive Testing
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• v.18 no.4
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• pp.292-303
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• 1998

Recent study has demonstrated that some magnetic properties are sensitive to the microstructural state of material. The ASTM A 508 Gr. 3 reactor pressure vessel steel has various microstructural changes including martensitic and bainitic phases, and various sizes of grain and precipitates in the weld heat-affected zone (HAZ). To correlate the microstructural state with Barkhausen noise (BN), specimens were prepared through simulating various weld thermal cycles using a thermal simulator. The conventional magnetic properties, i.e. coercive force, remanence and maximum induction, did not change significantly, whereas the BN amplitude and energy during a magnetization cycle changed markedly with microstructural state. The BN increased with increasing grain and carbide sizes, and the tempered bainite structure showed higher BN parameter than tempered martensite.

• Investigative Magnetic Resonance Imaging
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• v.10 no.2
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• pp.98-107
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• 2006

Magnetization Transfer (MT) imaging generates contrast dependent on the phenomenon of magnetization exchange between free water proton and restricted proton in macromolecules. In biological materials in knee, MT or cross-relaxation is commonly modeled using two spin pools identified by their different T2 relaxation times. Two models for cross-relaxation emphasize the role of proton chemical exchange between protons of water and exchangeable protons on macromolecules, as well as through dipole-dipole interaction between the water and macromolecule protons. The most essential tool in medical image manipulation is the ability to adjust the contrast and intensity. Thus, it is desirable to adjust the contrast and intensity of an image interactively in the real time. The proton density (PD) and T2-weighted SE MR images allow the depiction of knee structures and can demonstrate defects and gross morphologic changes. The PD- and T2-weighted images also show the cartilage internal pathology due to the more intermediate signal of the knee joint in these sequences. Suppression of fat extends the dynamic range of tissue contrast, removes chemical shift artifacts, and decreases motion-related ghost artifacts. Like fat saturation, phase sensitive methods are also based on the difference in precession frequencies of water and fat. In this study, phase sensitive methods look at the phase difference that is accumulated in time as a result of Larmor frequency differences rather than using this difference directly. Although how MT work was given with clinical evidence that leads to quantitative model for MT in tissues, the mathematical formalism used to describe the MT effect applies to explaining to evaluate knee disorder, such as anterior cruciate ligament (ACL) tear and meniscal tear. Calculation of the effect of the effect of the MT saturation is given in the magnetization transfer ratio (MTR) which is a quantitative measure of the relative decrease in signal intensity due to the MT pulse.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.419-419
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• 2023

하천의 최종 유출부와 해양이 만나는 지점을 하구라고 하며, 우리나라는 주로 서해안 지역에 하구 방조제 건설에 따른 담수호가 조성되어 다양한 목적으로 수자원이 활용되고 있다. 이러한 하구 담수호는 바다로 유입되기 직전의 물을 저류시켜 수자원 확보에 긍정적이나, 일반적으로 유역의 최하류에 위치해 있어 오염물질 유입, 부영양화, 염분 침출로 인한 오염물질 용출 등에 취약하다. 따라서 담수호의 회복탄력성 향상과 지속가능한 수자원 관리를 위해서는 미래 기후변화에 따른 영향 분석이 필수적이다. 특히 기후변화는 거대규모의 홍수과 같은 자연재난, 농업가뭄 및 식생가뭄 등의 증가로 이어질 수 있으므로, 이에 효과적으로 대비하기 위해서는 미래 기후조건에 따른 하천의 미래 유출량 변화 예측이 수행되어야 한다. 본 연구에서는 불확실한 미래 수문변화를 예측하기 위해 CMIP6(Coupled Model Intercomparison Project Phase 6) GCMs(Global Climate Models)의 SSP(Shared Socioeconomic Pathways) 시나리오를 유역 유출모델에 적용하여 기후변화에 따른 미래 유출특성의 변화를 예측하였다. 충청남도 서산시에 위치한 간월호 유역을 대상유역으로 선정하고, HSPF(Hydrological Simulation Program-FORTRAN) 모형을 적용하여 상류유역의 과거 및 미래 장기유출량 모의를 수행하였다. 모의된 시나리오별 유출량을 기반으로 최빈유량곡선법을 적용하여 미래의 기준유량 발생시점 및 지속기간의 변화를 분석하였으며, CVDs(Center-of-volume dates)의 변화를 통해 기후변화에 따른 홍수기의 시기적 변화 양상을 파악하고자 하였다. 본 연구의 결과는 미래 유역 환경변화를 고려한 담수호의 수자원 보전관리계획 수립에 있어 기초자료로 활용될 수 있을 것으로 기대된다.